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    Apparatuses for Contactless Loading and Imaging of Microfluidic Chips and Related Methods
    3.
    发明申请
    Apparatuses for Contactless Loading and Imaging of Microfluidic Chips and Related Methods 有权

    公开(公告)号：US20210331178A1

    公开(公告)日：2021-10-28

    申请号：US17195206

    申请日：2021-03-08

    申请人： Pattern Bioscience, Inc.

    发明人： Ross Johnson ,  Jonathan Isom ,  David Bussian ,  Nicolas Arab

    IPC分类号： B01L9/00 ,  B01L1/02 ,  G01N21/31 ,  B01L3/00

    摘要： An apparatus for loading and imaging a microfluidic chip can comprise a housing having walls that define a vacuum chamber and a first receptacle disposed within the vacuum chamber, the first receptacle defining a space for receiving one or more microfluidic chips. The apparatus can also include a negative pressure source, a light source, and an optical sensor coupled to the housing. The negative pressure source can be configured to reduce pressure within the vacuum chamber, the light source can be positioned to illuminate at least a portion of the space for receiving the chip(s), and the optical sensor can be positioned to capture an image of at least a portion of the space for receiving the chip(s).

    Apparatuses for contactless loading and imaging of microfluidic chips and related methods
    4.
    发明授权
    Apparatuses for contactless loading and imaging of microfluidic chips and related methods 有权

    公开(公告)号：US10953404B1

    公开(公告)日：2021-03-23

    申请号：US16858282

    申请日：2020-04-24

    申请人： Pattern Bioscience, Inc.

    发明人： Ross Johnson ,  Jonathan Isom ,  David Bussian ,  Nicolas Arab

    IPC分类号： B01L3/00 ,  B01L9/00 ,  B01L1/02 ,  G01N21/31

    摘要： An apparatus for loading and imaging a microfluidic chip can comprise a housing having walls that define a vacuum chamber and a first receptacle disposed within the vacuum chamber, the first receptacle defining a space for receiving one or more microfluidic chips. The apparatus can also include a negative pressure source, a light source, and an optical sensor coupled to the housing. The negative pressure source can be configured to reduce pressure within the vacuum chamber, the light source can be positioned to illuminate at least a portion of the space for receiving the chip(s), and the optical sensor can be positioned to capture an image of at least a portion of the space for receiving the chip(s).

    Vacuum-loaded, droplet-generating microfluidic chips and related methods
    6.
    发明授权
    Vacuum-loaded, droplet-generating microfluidic chips and related methods 有权

    公开(公告)号：US11344890B2

    公开(公告)日：2022-05-31

    申请号：US16661829

    申请日：2019-10-23

    申请人： Pattern Bioscience, Inc.

    发明人： Nicolas Arab ,  Ross Johnson ,  David Bussian ,  Jon Isom

    IPC分类号： B01L3/00 ,  G01N35/08

    摘要： A microfluidic chip that can have a body defining a microfluidic network including a test volume, one or more ports, and one or more channels in fluid communication between the port(s) and the test volume. Gas can be removed from the test volume before a sample liquid is introduced therein by reducing pressure at a first one of the port(s), optionally while the liquid is disposed in the port. Liquid in the first port can be introduced into the test volume by increasing pressure at the first port. The microfluidic network can define one or more droplet-generating regions in which at least one of the channel(s) defines a constriction and/or two or more of the channels connect at a junction. Liquid flowing from the first port can pass through at least one of the droplet-generating region(s) and to the test volume.

    Methods for Screening and Subsequent Processing of Samples Taken from Non-Sterile Sites
    7.
    发明申请
    Methods for Screening and Subsequent Processing of Samples Taken from Non-Sterile Sites 有权

    公开(公告)号：US20210053065A1

    公开(公告)日：2021-02-25

    申请号：US16998646

    申请日：2020-08-20

    申请人： Pattern Bioscience, Inc.

    发明人： Nicolas Arab ,  Ross Johnson

    IPC分类号： B01L3/00 ,  C12M1/12 ,  C12M1/34 ,  C12Q1/04

    摘要： A method of analyzing a sample comprising one or more species of microorganisms can include generating first droplets such that each of one or more microorganisms of a first portion of the sample is encapsulated within one of the first droplets and, for each of one or more aliquots of a second portion of the sample, second droplets such that each of one or more microorganisms of the aliquot is encapsulated within one of the second droplets. First and second sets of data can be captured, the first set indicative of the identity and quantity of encapsulated microorganism(s) of the first portion of the sample and the second set indicative of a phenotypic response of encapsulated microorganism(s) of the aliquot(s) to one or more test reagents. A target species' phenotypic response to the test reagent(s) is determinable at least by referencing the second data set to the first data set.