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公开(公告)号：US5378469A
公开(公告)日：1995-01-03
申请号：US772529
申请日：1991-10-07
IPC分类号： A61F2/06 , A61F2/00 , A61K38/17 , A61L27/00 , A61L27/24 , A61L27/36 , A61P43/00 , D01F4/00 , A61F2/28 , A61K9/14 , A61K37/12 , C07K15/20
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3808 , A61L27/3813 , A61L27/60 , D01F4/00 , A61F2310/00365 , Y10S623/901
摘要： The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.
摘要翻译： 本发明提供了改进的胶原线以及制造和使用这种丝线的方法，包括生产纱线，以及包括这种纱线的编织，针织和编织制品。
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公开(公告)号：US5256418A
公开(公告)日：1993-10-26
申请号：US505678
申请日：1990-04-06
IPC分类号： A61F2/06 , A61F2/00 , A61L27/00 , A61L27/24 , A61L27/36 , D01F4/00 , A61F2/28 , A61K9/14 , A61K37/12 , C07K15/20
CPC分类号： D01F4/00 , A61L27/24 , A61L27/3808 , A61L27/3813 , A61L27/507 , A61L27/60 , A61F2310/00365 , Y10S623/901
摘要： The present invention provides collagen constructs and methods of making and using such constructs. The present invention also provides tissue equivalents having improved characteristics and methods of making and using such tissue equivalents. This invention also provides methods of producing highly concentrated solutions of collagen.
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公开(公告)号：US06599690B1
公开(公告)日：2003-07-29
申请号：US09450577
申请日：1999-11-30
IPC分类号： A01N102
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US06893653B2
公开(公告)日：2005-05-17
申请号：US10615623
申请日：2003-07-08
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61K35/12 , A61L27/24 , A61L27/36 , C12N5/08 , A61F38/17
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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5.发明授权Reconstituted collagen fiber segment compositions and methods of preparation thereof 失效重组胶原纤维节段组合物及其制备方法
公开(公告)号：US5997896A
公开(公告)日：1999-12-07
申请号：US973571
申请日：1998-05-11
CPC分类号： A61L27/24 , A61K38/1841 , A61K38/39 , A61F2310/00365
摘要： The invention provides injectable collagen compositions that are reconstituted collagen fiber segments made from acid extracted collagen with telopeptides in a biocompatible carrier, with the collagen concentration in the composition ranging up to 200 mg/mL.
摘要翻译： PCT No.PCT / US96 / 09861 Sec。 371日期：1998年5月11日 102（e）日期1998年5月11日PCT提交1996年6月7日PCT公布。 出版物WO96 / 40216 PCT 日期：1996年12月19日本发明提供了可注射的胶原组合物，其是由生物相容性载体中的具有端肽的酸提取胶原构成的重组胶原纤维片段，组合物中的胶原浓度范围高达200mg / mL。
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6.发明授权Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix 失效化学处理，无洗涤剂或酶，组织形成无细胞，胶原基质
公开(公告)号：US5993844A
公开(公告)日：1999-11-30
申请号：US853372
申请日：1997-05-08
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61K35/12 , A61L27/24 , A61L27/36 , C12N5/08
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US08064987B2
公开(公告)日：2011-11-22
申请号：US12446644
申请日：2007-10-15
申请人： Robert M. Carr, Jr.
发明人： Robert M. Carr, Jr.
CPC分类号： A61B5/6842 , A61B90/39 , A61B2090/3908 , A61B2090/3987
摘要： Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.
摘要翻译： 组织标记，用于标记组织的系统和使用组织标记的方法。 组织标记可以具有带有第一表面和第二表面的主体，多个联接位置和多个细长构件。 组织标记可以包括远程可见的材料。 组织标记可以具有不同于展开配置的传送配置。
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公开(公告)号：US20100030149A1
公开(公告)日：2010-02-04
申请号：US12446644
申请日：2007-10-15
申请人： Robert M. Carr, Jr.
发明人： Robert M. Carr, Jr.
IPC分类号： A61M5/00
CPC分类号： A61B5/6842 , A61B90/39 , A61B2090/3908 , A61B2090/3987
摘要： Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.
摘要翻译： 组织标记，用于标记组织的系统和使用组织标记的方法。 组织标记可以具有带有第一表面和第二表面的主体，多个联接位置和多个细长构件。 组织标记可以包括远程可见的材料。 组织标记可以具有不同于展开配置的传送配置。
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公开(公告)号：US07060103B2
公开(公告)日：2006-06-13
申请号：US10376788
申请日：2003-02-28
IPC分类号： A61F2/02
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 一种假体，当植入哺乳动物患者时，其用作身体部位或组织结构的功能替代物，并将经受受控制的生物降解，伴随着患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，假体在其各种实施例中具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US06334872B1
公开(公告)日：2002-01-01
申请号：US08889079
申请日：1997-07-07
IPC分类号： A61F200
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient's living cells.
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