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    Optical sensor and methods for measuring molecular binding interactions
    1.
    发明申请
    Optical sensor and methods for measuring molecular binding interactions 审中-公开
    光学传感器和测量分子结合相互作用的方法

    公开(公告)号：US20080153105A1

    公开(公告)日：2008-06-26

    申请号：US10631592

    申请日：2003-07-30

    申请人： Peter Martin ,  Keiki-Pau Dancil ,  Arthur Lee Morsell ,  Hus Tigli

    发明人： Peter Martin ,  Keiki-Pau Dancil ,  Arthur Lee Morsell ,  Hus Tigli

    IPC分类号： G01N33/53 ,  C12M3/00 ,  G06F19/00

    CPC分类号： G01N33/552 ,  G01N21/84 ,  G01N33/54373

    摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

    摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

    Optical sensor and methods for measuring molecular binding interactions
    2.
    发明授权
    Optical sensor and methods for measuring molecular binding interactions 有权
    光学传感器和测量分子结合相互作用的方法

    公开(公告)号：US07517656B2

    公开(公告)日：2009-04-14

    申请号：US10616251

    申请日：2003-07-08

    申请人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Lee Morsell ,  Hus Tigli

    发明人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Lee Morsell ,  Hus Tigli

    IPC分类号： C12M1/34

    CPC分类号： B01L3/502753 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/77 ,  G01N33/552 ,  G01N2021/752 ,  G01N2021/755 ,  G01N2021/757 ,  G01N2021/758 ,  G01N2021/7779 ,  G01N2021/7796 ,  G01N2035/0097 ,  Y10S435/808

    摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

    摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

    Optical sensor and methods for measuring molecular binding interactions
    4.
    发明申请
    Optical sensor and methods for measuring molecular binding interactions 有权
    光学传感器和测量分子结合相互作用的方法

    公开(公告)号：US20050019956A1

    公开(公告)日：2005-01-27

    申请号：US10616251

    申请日：2003-07-08

    申请人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Morsell ,  Hus Tigli

    发明人： Peter Martin ,  Keiki-Pua Dancil ,  Arthur Morsell ,  Hus Tigli

    IPC分类号： B01L3/00 ,  G01N21/84 ,  G01N33/552 ,  G01N35/00

    CPC分类号： B01L3/502753 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/77 ,  G01N33/552 ,  G01N2021/752 ,  G01N2021/755 ,  G01N2021/757 ,  G01N2021/758 ,  G01N2021/7779 ,  G01N2021/7796 ,  G01N2035/0097 ,  Y10S435/808

    摘要： Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.

    摘要翻译： 用于测量分子结合相互作用的方法和装置。 优选的实施方案提供动力学结合和分离的实时测量，包括蛋白质分子与其它蛋白质分子和其它分子的结合和解离。 在优选的实施方案中，将配体固定在硅衬底中产生的多孔硅相互作用区域的孔内，之后悬浮在流体中的分析物流过多孔硅区域。 结合反应发生在分析物分子向配体扩散得足够接近以成为结合物时。 优选地，使用白光源和薄膜干涉技术观察结合和随后的分离反应，其中光谱仪布置成检测发生结合和解离反应的区域中的折射指数的变化。 在优选实施方案中，配体和分析物通过计算机控制的机器人流体控制技术通过微流体流动通道传递到多孔硅相互作用区域。

    METHODS, SYSTEMS AND APPARATUS FOR PROMOTING THE POURABILITY OF SEMI-FROZEN AND SEMI-FLUIDIC BEVERAGES FROM BEVERAGE CONTAINERS
    7.
    发明申请
    METHODS, SYSTEMS AND APPARATUS FOR PROMOTING THE POURABILITY OF SEMI-FROZEN AND SEMI-FLUIDIC BEVERAGES FROM BEVERAGE CONTAINERS 审中-公开
    从饮料容器中提取半冷冻和半液体饮料的可行性的方法，系统和装置

    公开(公告)号：US20110199852A1

    公开(公告)日：2011-08-18

    申请号：US12705698

    申请日：2010-02-15

    申请人： Peter Martin

    发明人： Peter Martin

    IPC分类号： B01F11/00

    CPC分类号： A47J43/0716 ,  A47G19/12 ,  A47J43/046 ,  A47J43/0727

    摘要： A beverage container for a blender includes one or more vibrating mechanisms coupled to a bottom portion of the beverage container or integrated within one or more walls of the beverage container. After a beverage has been blended, the one or more vibrating mechanisms are activated as the beverage is being poured. Vibrations from the one or more vibrating mechanisms are mechanically transmitted to the beverage container, thereby promoting the pourability of the beverage from the beverage container, including dislodging ingredients in the beverage that became lodged or trapped in crevices of the beverage container during the prior blending process, and freeing up beverage ingredients that accumulated at the bottom of the beverage container during the prior blending process.

    摘要翻译： 用于搅拌器的饮料容器包括联接到饮料容器的底部或集成在饮料容器的一个或多个壁内的一个或多个振动机构。 在混合饮料之后，随着饮料被倒出，一个或多个振动机构被激活。 来自一个或多个振动机构的振动机械地传递到饮料容器，从而促进饮料从饮料容器中的倾倒性，包括在先前共混过程中在饮料中被移入或被捕获在饮料容器的裂缝中的成分 并且在先前的混合过程中释放积聚在饮料容器底部的饮料成分。

    Many million pixel image sensor
    9.
    发明授权
    Many million pixel image sensor 有权
    许多百万像素图像传感器

    公开(公告)号：US07906826B2

    公开(公告)日：2011-03-15

    申请号：US11904782

    申请日：2007-09-28

    申请人： Peter Martin ,  Paul Johnson ,  Chris Sexton

    发明人： Peter Martin ,  Paul Johnson ,  Chris Sexton

    IPC分类号： H01L31/062

    CPC分类号： H01L27/14634 ,  G03F7/70433 ,  G03F7/70475 ,  H01L27/14643 ,  H01L27/14647 ,  H01L27/14652 ,  H01L27/14683

    摘要： A CMOS image sensor with a many million pixel count. Applicants have developed techniques for combining its continuous layer photodiode CMOS sensor technology with CMOS integrated circuit lithography stitching techniques to provide digital cameras with an almost unlimited number of pixels. A preferred CMOS stitching technique exploits the precise alignment accuracy of CMOS stepper processes by using specialized mask sets to repeatedly produce a single pixel array pattern many times on a single silicon wafer with no pixel array discontinuities. The single array patterns are stitched together lithographically to form a pixel array of many million pixels. A continuous multilayer photodiode layer is deposited over the top of the many million pixel array to provide a many million pixel sensor with a fill factor of 100 percent or substantially 100 percent.

    摘要翻译： 具有数百万像素数的CMOS图像传感器。 申请人已经开发出将连续层光电二极管CMOS传感器技术与CMOS集成电路光刻拼接技术相结合的技术，为数码相机提供几乎无限数量的像素。 优选的CMOS拼接技术利用CMOS步进工艺的精确对准精度通过使用专门的掩模组在单个硅晶片上多次重复产生单个像素阵列图案，而不存在像素阵列不连续性。 将单阵列图案光刻地缝合在一起以形成数百万像素的像素阵列。 连续的多层光电二极管层沉积在数百万像素阵列的顶部，以提供百万像素传感器，其填充因子为100％或基本为100％。

    ANGULAR CONTACT ROLLING-ELEMENT BEARING, ESPECIALLY DOUBLE ROW BALL ROLLER BEARING IN TANDEM ARRANGEMENT
    10.
    发明申请
    ANGULAR CONTACT ROLLING-ELEMENT BEARING, ESPECIALLY DOUBLE ROW BALL ROLLER BEARING IN TANDEM ARRANGEMENT 失效
    角接触滚子元件轴承，特别是双向滚珠轴承，在TANDEM ARRANGE

    公开(公告)号：US20110033149A1

    公开(公告)日：2011-02-10

    申请号：US12989263

    申请日：2009-04-02

    申请人： Andreas Bohr ,  Horst Doeppling ,  Heinrich Hofmann ,  Peter Martin

    发明人： Andreas Bohr ,  Horst Doeppling ,  Heinrich Hofmann ,  Peter Martin

    IPC分类号： F16C33/48

    CPC分类号： F16C19/38 ,  F16C19/505 ,  F16C33/36 ,  F16C33/485 ,  F16C33/585

    摘要： A double roller bearing which has an outer and inner bearing ring and ball rollers, which have lateral faces and are arranged next to each other in rows, arranged between the bearing rings. The rollers roll in raceways incorporated into the inner face of the outer bearing ring and outer face of the inner bearing ring. The raceways run in parallel and have pressure angle axes that are pitched at a pressure angle relative to a bearing radial axis. The rollers have a distance relative to each other which excludes mutual frictional contacts. For this purpose, the distance of the pressure angle axes of the raceways is enlarged and both rows of rollers are guided in separate bearing cages, while the raceway of the rollers of the row with the larger reference circle arranged on the inner bearing ring has a one-sided axial extension using the distance.

    摘要翻译： 一种具有外轴承圈和内滚子轴承的双滚子轴承，其具有横向面并彼此排成一列布置在轴承环之间。 辊子滚动在并入到外轴承环的内表面和内轴承环的外表面的滚道中。 滚道平行运行并具有相对于轴承径向轴线以压力角倾斜的压力角轴。 辊子具有相对于彼此的距离，排除相互摩擦接触。 为此，滚道的压力角轴线的距离增大，两列滚子分开的轴承保持架被引导，而排列在内轴承环上的具有较大基准圆的列的滚道的滚道具有 单向轴向延伸使用距离。