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    Nanoparticle assembled hollow spheres
    2.
    发明授权
    Nanoparticle assembled hollow spheres 有权
    纳米颗粒组装中空球体

    公开(公告)号：US07563457B2

    公开(公告)日：2009-07-21

    申请号：US10263271

    申请日：2002-10-02

    申请人： Jennifer Cha ,  Timothy J. Deming ,  Galen D. Stucky ,  Michael Wong ,  Henrik Birkedal ,  Michael H. Bartl ,  Jan L. Sumerel

    发明人： Jennifer Cha ,  Timothy J. Deming ,  Galen D. Stucky ,  Michael Wong ,  Henrik Birkedal ,  Michael H. Bartl ,  Jan L. Sumerel

    IPC分类号： A61K9/16

    CPC分类号： B82Y5/00 ,  A61K47/6923 ,  A61K47/6925 ,  A61K48/00 ,  A61K48/0091 ,  C12Q1/6813 ,  Y10S977/705 ,  Y10T428/249995 ,  Y10T428/2982 ,  C12Q2563/155

    摘要： A design strategy for constructing hierarchically structured materials using nanoparticles and synthetic biopolymers has been developed. Block copolypeptides or homopolymer polyelectrolytes are used as structure-directing agents to arrange nanoparticles (composed of metals, metal non-oxides, metal oxides, or organics) into unusual microstructures, such as spheres, “apples” and “cups.” Hollow spheres can be made wherein nanoparticles of one composition are spatially oriented completely interior or exterior to nanoparticles of a second composition. These aggregates contain nanoparticles only in the shell walls, and maintain their hollowness upon calcination. These shapes can also be fabricated into films. These robust materials are anticipated to have great promise in applications that require surface catalysis, magnetic/electronic/optic properties, transport capabilities, and combinations thereof, such as drug delivery, packaging, catalysis, and sensors.

    摘要翻译： 已经开发了使用纳米颗粒和合成生物聚合物构建分层结构材料的设计策略。 使用嵌段共聚肽或均聚物聚电解质作为结构导向剂，将纳米颗粒（由金属，金属非氧化物，金属氧化物或有机物组成）排列到诸如球体，“苹果”和“杯”之类的不寻常微观结构中。 可以制备空心球，其中一种组合物的纳米颗粒在第二组合物的纳米颗粒的内部或外部完全在空间上定向。 这些聚集体仅在壳壁中含有纳米颗粒，并且在煅烧时保持其中空度。 这些形状也可以制成薄膜。 这些坚固的材料预期在需要表面催化，磁/电/光学性质，输送能力及其组合（例如药物递送，包装，催化和传感器）的应用中具有巨大的前景。

    VESICLES OF SELF-ASSEMBLING BLOCK COPOLYMERS AND METHODS FOR MAKING AND USING THE SAME
    5.
    发明申请
    VESICLES OF SELF-ASSEMBLING BLOCK COPOLYMERS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
    自组装块共聚物的制备方法及其制备与使用方法

    公开(公告)号：US20100003336A1

    公开(公告)日：2010-01-07

    申请号：US12517009

    申请日：2007-11-30

    申请人： Timothy J. Deming ,  Daniel T. Kamei ,  Eric P. Holowka ,  Victor Z. Sun

    发明人： Timothy J. Deming ,  Daniel T. Kamei ,  Eric P. Holowka ,  Victor Z. Sun

    IPC分类号： A61K9/14 ,  A61P43/00 ,  C07K14/00

    CPC分类号： A61K9/1273

    摘要： Vesicles of self-assembling block copolymers, e.g., diblock copolypeptides, as well as methods of making and using the same. Vesicles of the invention have a shell made up of block copolymers that include an intracellular transduction hydrophilic domain and a hydrophobic domain. In certain embodiments, the vesicles include an encapsulated active agent, e.g., a diagnostic or therapeutic agent. The vesicles find use in a variety of different application, including the intracellular delivery of active agents, e.g., diagnostic and therapeutic agents.

    摘要翻译： 自组装嵌段共聚物的囊泡，例如二嵌段共聚肽，以及制备和使用它们的方法。 本发明的囊泡具有由包含细胞内转导亲水结构域和疏水结构域的嵌段共聚物构成的壳。 在某些实施方案中，囊泡包括包封的活性剂，例如诊断或治疗剂。 囊泡可用于各种不同的应用，包括细胞内递送的活性剂，例如诊断和治疗剂。

    Methods and compositions for controlled polypeptide synthesis
    6.
    发明授权
    Methods and compositions for controlled polypeptide synthesis 有权
    受控多肽合成的方法和组合物

    公开(公告)号：US06686446B2

    公开(公告)日：2004-02-03

    申请号：US09877957

    申请日：2001-06-08

    申请人： Timothy J. Deming ,  Miaoer Yu ,  Scott A. Curtin ,  Jungyeon Hwang ,  Michael D. Wyrsta ,  Andrew Nowak ,  Scott W. Seidel

    发明人： Timothy J. Deming ,  Miaoer Yu ,  Scott A. Curtin ,  Jungyeon Hwang ,  Michael D. Wyrsta ,  Andrew Nowak ,  Scott W. Seidel

    IPC分类号： C07K100

    CPC分类号： C07K14/00 ,  C07K1/084 ,  C07K1/088 ,  C07K1/10 ,  C08G69/10

    摘要： Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

    摘要翻译： 本文公开了用于产生具有不同材料性质的多肽的方法和组合物。 方法包括通过将单体与含酰胺的金属环组合来引发氨基酸-N-羧酸酐（NCA）单体的聚合的手段，用于制备自组装两亲嵌段共聚肽和用于加入低聚（乙二醇）官能化的氨基酸-N-羧酸酐的相关方案 （NCAs）转化为聚氨基酸链。 另外的方法包括通过使分配保护的氨基酸酰胺与过渡金属给体配体络合物反应形成酰氨基脒化物金属环用于进一步聚合反应而将端基加入到聚氨基酸链的羧基末端的方法。 还公开了用于肽合成和设计的新型组合物，包括含有五元和六元的含酰胺的金属螯合物和嵌段共聚肽。

    Methods and compositions for controlled polypeptide synthesis
    7.
    发明授权
    Methods and compositions for controlled polypeptide synthesis 有权
    受控多肽合成的方法和组合物

    公开(公告)号：US06632922B1

    公开(公告)日：2003-10-14

    申请号：US09568121

    申请日：2000-05-10

    申请人： Timothy J. Deming ,  Miaoer Yu ,  Scott A. Curtin ,  Jungyeon Hwang ,  Michael D. Wyrsta

    发明人： Timothy J. Deming ,  Miaoer Yu ,  Scott A. Curtin ,  Jungyeon Hwang ,  Michael D. Wyrsta

    IPC分类号： C07K100

    CPC分类号： C07K1/088 ,  C07K1/084 ,  C07K1/10

    摘要： Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols adding oligo(ethyleneglycol) functionalized aninoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex, thereby forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

    摘要翻译： 本文公开了用于产生具有不同材料性质的多肽的方法和组合物。 方法包括使自组装两亲嵌段共聚肽和将寡聚（乙二醇）官能化的亚硝酸-N-羧酸酐（NCA）加入聚氨基酸链的相关方案的方法。 另外的方法包括通过使分配保护的氨基酸酰胺与过渡金属 - 给体配体配合物反应从而将末端基团加入到聚氨基酸链的羧基末端，由此形成用于进一步聚合反应的酰氨基脒化物金属环。 还公开了用于肽合成和设计的新型组合物，包括五元和六元的含酰胺的金属螯合物和嵌段共聚肽。

    Methods and compositions for controlled polypeptide synthesis
    10.
    发明授权
    Methods and compositions for controlled polypeptide synthesis 有权
    受控多肽合成的方法和组合物

    公开(公告)号：US07329727B2

    公开(公告)日：2008-02-12

    申请号：US10712967

    申请日：2003-11-14

    申请人： Timothy J. Deming

    发明人： Timothy J. Deming

    IPC分类号： C07K1/00

    CPC分类号： C07K14/00 ,  C07K1/084 ,  C07K1/088 ,  C07K1/10 ,  C08G69/10

    摘要： Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

    摘要翻译： 本文公开了用于产生具有不同材料性质的多肽的方法和组合物。 方法包括通过将单体与含酰胺的金属环组合来引发氨基酸-N-羧酸酐（NCA）单体的聚合的手段，用于制备自组装两亲嵌段共聚肽和用于加入低聚（乙二醇）官能化的氨基酸-N-羧酸酐的相关方案 （NCAs）转化为聚氨基酸链。 另外的方法包括通过使分配保护的氨基酸酰胺与过渡金属给体配体络合物反应形成酰氨基脒化物金属环用于进一步聚合反应而将端基加入到聚氨基酸链的羧基末端的方法。 还公开了用于肽合成和设计的新型组合物，包括含有五元和六元的含酰胺的金属螯合物和嵌段共聚肽。