利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

36 条记录 (耗时 0.033 秒)

    Neurofibrillary labels
    4.
    发明授权
    Neurofibrillary labels 有权
    神经原纤维标签

    公开(公告)号：US07335652B2

    公开(公告)日：2008-02-26

    申请号：US10665008

    申请日：2003-09-22

    申请人： Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley

    发明人： Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley

    IPC分类号： A61K31/54

    CPC分类号： C07D417/12 ,  C07D277/66 ,  C07D279/20 ,  G01N33/583 ,  G01N33/6896

    摘要： Disclosed are methods for determining the stage of neurofibrillary degeneration associated with a tauopathy in a subject believed to suffer from the disease, by (i) introducing into the subject a ligand capable of labeling aggregated paired helical filament (PHF) tau protein, (ii) determining the presence and/or amount of ligand bound to extracellular aggregated PHF tau in the medial temporal lobe of the brain of the subject, (iii) correlating the result of the determination made in (ii) with the extent of neurofibrillary degeneration in the subject. The methods can be used for pre-mortem diagnosis and staging of tauopathies such as Alzheimer's Disease. Preferred ligands include sulphonated-benzothiazole-like compounds and diaminophenothiazines.

    摘要翻译： 公开了用于确定被认为患有疾病的受试者中与tau蛋白病相关的神经原纤维变性的阶段的方法，方法是（i）向受试者引入能够标记聚集的成对螺旋丝（PHF）tau蛋白的配体，（ii） 确定与受试者的脑内侧颞叶结合的细胞外聚集的PHF tau的配体的存在和/或量的量，（iii）将（ii）中确定的测定结果与受试者的神经原纤维变性程度相关联 。 这些方法可用于妊娠前诊断和分期的阿尔茨海默病等tau蛋白病。 优选的配体包括磺化苯并噻唑类化合物和二氨基吩噻嗪。

    PWM-based measurement interface for a micro-machined electrostatic actuator
    7.
    发明授权
    PWM-based measurement interface for a micro-machined electrostatic actuator 有权
    用于微加工静电执行器的基于PWM的测量接口

    公开(公告)号：US06674383B2

    公开(公告)日：2004-01-06

    申请号：US10012688

    申请日：2001-10-30

    申请人： David Horsley ,  Robert Conant ,  William Clark

    发明人： David Horsley ,  Robert Conant ,  William Clark

    IPC分类号： H03M166

    CPC分类号： G01R31/2829 ,  H02N1/002

    摘要： Methods and apparatus for varying and measuring the position of a micromachined electrostatic actuator using a pulse width modulated (PWM) pulse train are disclosed. One or more voltage pulses are applied to the actuator. In each of the pulses, a voltage changes from a first state to a second state and remains in the second state for a time tpulse before returning to the first state. The position of the actuator may be varied by varying the time &Dgr;tpulse. A position of the actuator may be determined by measuring a capacitance of the actuator when the voltage changes state, whether the time t is varied or not. An apparatus for varying the position of a MEMS device may include a pulse width modulation generator coupled to the MEMS device an integrator coupled to the MEMS device and an analog-to-digital converter coupled to the integrator. The integrator may measure a charge transferred during a transition of a pulse from the pulse generator. The integrator may include an amplifier, an integrator capacitor, a hold capacitor, a compensation voltage generator and three switches. The hold capacitor and integrator capacitor may be coupled to a MEMS device. The integrator capacitor, hold capacitor, and compensation voltage generator may be selectively coupled to the amplifier by two of the switches. The MEMS device and hold capacitor may be selectively coupled to ground by a third switch.

    摘要翻译： 公开了使用脉冲宽度调制（PWM）脉冲串来改变和测量微加工静电致动器的位置的方法和装置。 一个或多个电压脉冲被施加到致动器。 在每个脉冲中，电压从第一状态改变到第二状态，并且在返回到第一状态之前保持在第二状态一段时间t脉冲。 致动器的位置可以通过改变Deltatpulse的时间来改变。 致动器的位置可以通过在电压改变状态时测量致动器的电容，时间t是否变化来确定。 用于改变MEMS器件的位置的装置可以包括耦合到MEMS器件的耦合到MEMS器件的积分器和耦合到积分器的模数转换器的脉宽调制发生器。 积分器可以测量在来自脉冲发生器的脉冲的转变期间传送的电荷。 积分器可以包括放大器，积分电容器，保持电容器，补偿电压发生器和三个开关。 保持电容器和积分电容器可以耦合到MEMS器件。 积分器电容器，保持电容器和补偿电压发生器可以通过两个开关选择性地耦合到放大器。 MEMS器件和保持电容器可以通过第三开关选择性地耦合到地。