专利检索 ap:("Peter J. Kushner" OR "Claire L. Cofer" OR "Jeffrey S. Friedman" OR "Karen D. Talmadge") AND inv:"Karen D. Talmadge" 第 1 页

1.

发明授权
Superior mammalian expression system 失效
标题翻译：优良的哺乳动物表达系统

公开(公告)号：US5089397A

公开(公告)日：1992-02-18

申请号：US366342

申请日：1989-06-14

申请人： Peter J. Kushner , Claire L. Cofer , Jeffrey S. Friedman , Karen D. Talmadge

发明人： Peter J. Kushner , Claire L. Cofer , Jeffrey S. Friedman , Karen D. Talmadge

IPC分类号： C07K14/505 , C07K14/58 , C07K14/61 , C07K14/775 , C07K14/785 , C12N5/00 , C12N9/64 , C12N15/85

CPC分类号： C12N9/6486 , C07K14/505 , C07K14/58 , C07K14/61 , C07K14/775 , C07K14/785 , C12N15/85 , C12Y304/23015

摘要： An expression system for recombinant production of a desired protein comprises CHO cells transformed with a DNA sequence having the desired protein coding sequence under control of the human metallothionein-II promoter. The cells can be maintained on serum-free medium and induced in the presence of an induction mediator. In addition, the system may include an enhancer element and/or a resistance-conferring gene to provide increased levels of expression. The system can process genomic as well as intronless DNA, and is capable of producing proteins which have the same characteristics as those obtained from native sources. Human growth hormone which is indistinguishable from that produced by the pituitary has been thus produced.

摘要翻译： 用于重组产生所需蛋白质的表达系统包括用人金属硫蛋白-II启动子控制下用具有所需蛋白质编码序列的DNA序列转化的CHO细胞。细胞可以保持在无血清培养基上并在诱导介质存在下诱导。此外，该系统可以包括增强子元件和/或抗性赋予基因以提供增加的表达水平。该系统可以处理基因组和内含子DNA，并且能够产生与从天然来源获得的蛋白质相同的蛋白质。因此产生与垂体产生的人生长激素不可区分的人生长激素。

$Methods for treating a fractured and/or diseased and/or weakened bone$

2.

发明申请
Methods for treating a fractured and/or diseased and/or weakened bone 审中-公开
标题翻译：用于治疗骨折和/或患病和/或减弱的骨的方法

公开(公告)号：US20080140084A1

公开(公告)日：2008-06-12

申请号：US11978478

申请日：2007-10-29

申请人： Reynaldo A. Osorio , Marialulu Follmer , Richard W. Layne , Ryan P. Boucher , Karen D. Talmadge , Joseph J. Basista

发明人： Reynaldo A. Osorio , Marialulu Follmer , Richard W. Layne , Ryan P. Boucher , Karen D. Talmadge , Joseph J. Basista

IPC分类号： A61B17/56 , A61M29/00

CPC分类号： A61F2/4601 , A61B17/1604 , A61B17/1671 , A61B17/3472 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B2017/00261 , A61B2017/00464 , A61B2017/00539 , A61B2017/00557 , A61B2017/00867 , A61B2050/0065 , A61B2090/062 , A61F2/44 , A61F2002/2835 , A61F2002/3008 , A61F2002/30581 , A61F2002/4602 , A61F2002/4624 , A61F2002/4635 , A61F2002/4662 , A61F2250/0098 , A61F2310/00353

摘要： A vertebral body having an interior volume occupied, at least in part, by cancellous bone is selected for treatment. A percutaneous path is established into the vertebral body. A tool is introduced through the percutaneous path that creates a cavity in the cancellous bone. A bone filling material is conveyed to substantially fill the cavity. The bone filling material is pressurized within the cavity to enlarge the cavity.

摘要翻译： 选择具有至少部分由松质骨占据的内部体积的椎体用于治疗。椎体中建立经皮通路。通过经皮途径引入工具，在皮质骨中产生空腔。输送骨填充材料以基本上填充空腔。骨填充材料在空腔内被加压以扩大空腔。

3.

发明申请
Tissue extraction device and method of using the same 审中-公开
标题翻译：组织提取装置及其使用方法

公开(公告)号：US20080058673A1

公开(公告)日：2008-03-06

申请号：US11511529

申请日：2006-08-29

申请人： Lex Jansen , Art Ferdinand , Hugues F. Malandain , Claudia Orellana , Chris Phan , Derek Rothwell , Karen D. Talmadge , Jenifer Wong

发明人： Lex Jansen , Art Ferdinand , Hugues F. Malandain , Claudia Orellana , Chris Phan , Derek Rothwell , Karen D. Talmadge , Jenifer Wong

IPC分类号： A61B10/02

CPC分类号： A61B17/320016 , A61B10/0266 , A61B10/06 , A61B17/221 , A61B17/32053 , A61B17/320708 , A61B2017/00261 , A61B2017/00867 , A61B2017/22034 , A61B2017/2215 , A61B2017/32004 , A61B2017/320064

摘要： Apparatuses for performing minimally invasive medical procedures are disclosed herein. In one example, an apparatus includes an outer body that defines an opening at a distal end, and a cutting portion disposed at an edge of the opening. An inner body is movably disposed within the outer body and defines an opening at a distal end. The outer body and the inner body collectively have a first configuration in which the opening on the outer body is substantially aligned with the opening on the inner body and the opening on the outer body is configured to receive a portion of a tissue, and a second configuration in which the opening on the outer body and the opening on the inner body are substantially misaligned and the cutting portion on the outer body is configured to sever the portion of the tissue from a remaining portion of the tissue.

摘要翻译： 本文公开了用于执行微创医疗程序的装置。在一个示例中，设备包括限定在远端处的开口的外体和设置在开口的边缘处的切割部分。内部主体可移动地设置在外部本体内并在远端限定开口。外体和内体共同具有第一构造，其中外体上的开口基本上与内体上的开口对准，并且外体上的开口构造成容纳一部分组织，第二构造其中外壳上的开口和内体上的开口基本上不对准并且外体上的切割部分构造成从组织的剩余部分切断组织的部分。

4.

发明授权
Expandable structures for deployment in interior body regions 有权
标题翻译：可扩展结构，用于部署在室内区域

公开(公告)号：US07875035B2

公开(公告)日：2011-01-25

申请号：US11978802

申请日：2007-10-30

申请人： Ryan P Boucher , Mark A. Reiley , Robert M. Scribner , Karen D. Talmadge

发明人： Ryan P Boucher , Mark A. Reiley , Robert M. Scribner , Karen D. Talmadge

IPC分类号： A61B17/58 , A61B17/60 , A61F2/00

CPC分类号： A61B17/68 , A61B17/7095 , A61B17/8855 , A61B90/39 , A61B2017/00539 , A61B2017/00544 , A61M25/1027 , A61M25/1029

摘要： An expandable structure carried at the end of a catheter tube assembly can be contracted and/or wrapped to present a reduced profile during deployment and/or removal from a targeted tissue site.

摘要翻译： 在导管管组件的末端处承载的可膨胀结构可以在展开和/或从目标组织部位移除期间收缩和/或包裹以呈现减小的轮廓。

5.

发明申请
Devices and methods using an expandable body with internal restraint for compressing cancellous bone 审中-公开
标题翻译：使用具有用于压制松质骨的内部约束的可膨胀体的装置和方法

公开(公告)号：US20080172081A1

公开(公告)日：2008-07-17

申请号：US11827120

申请日：2007-07-10

申请人： Paul Reiss , Cesar Ico , Karen D. Talmadge , Mark A. Reiley , Arie Scholten

发明人： Paul Reiss , Cesar Ico , Karen D. Talmadge , Mark A. Reiley , Arie Scholten

IPC分类号： A61M29/00

CPC分类号： A61B17/8866 , A61B10/025 , A61B17/00234 , A61B17/02 , A61B17/7097 , A61B17/72 , A61B17/7275 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B90/94 , A61B2010/0258 , A61B2017/00539 , A61B2017/00544 , A61B2017/00557 , A61B2017/0256 , A61B2050/0065 , A61B2050/3015 , A61F2/28 , A61F2/2846 , A61F2/3601 , A61F2/389 , A61F2/44 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/2825 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/2853 , A61F2002/2871 , A61F2002/2892 , A61F2002/30113 , A61F2002/30115 , A61F2002/30125 , A61F2002/30131 , A61F2002/30133 , A61F2002/30204 , A61F2002/30225 , A61F2002/30228 , A61F2002/30242 , A61F2002/30247 , A61F2002/30253 , A61F2002/30285 , A61F2002/30288 , A61F2002/30308 , A61F2002/30311 , A61F2002/30313 , A61F2002/30448 , A61F2002/30462 , A61F2002/30464 , A61F2002/30581 , A61F2002/30586 , A61F2002/30599 , A61F2002/30677 , A61F2002/30686 , A61F2002/30909 , A61F2002/3611 , A61F2002/3625 , A61F2002/4062 , A61F2002/4217 , A61F2002/4602 , A61F2002/4627 , A61F2002/4635 , A61F2002/4636 , A61F2002/4685 , A61F2220/005 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0015 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076 , A61F2250/0063 , A61F2310/00293 , A61F2310/00353 , A61F2310/0097 , A61M25/10 , A61M25/1002 , A61M25/1006 , A61M25/1009 , A61M25/1011 , A61M29/02 , A61M2025/1059 , A61M2025/1072 , A61M2210/02 , A61M2210/1003

摘要： Devices and methods compress cancellous bone. In one arrangement, the devices and methods make use of an expandable body that includes an internal restraint coupled to the body. The internal restraint directs expansion of the body. In one arrangement, a method for treating bone inserts the device having the internal restraint inside bone and causes directed expansion of the body in cancellous bone. Cancellous bone is compacted by the directed expansion.

摘要翻译： 装置和方法压制松质骨。在一种布置中，装置和方法利用包括与身体联接的内部约束的可扩张体。内部约束指导身体的扩张。在一种布置中，用于治疗骨的方法将具有内部约束的装置插入骨内，并引起身体在松质骨中的定向膨胀。松质骨通过定向扩张进行压实。

$Inflatable device for use in surgical protocols relating to treatment of fractured or diseased bones$

6.

发明授权
Inflatable device for use in surgical protocols relating to treatment of fractured or diseased bones 失效
标题翻译：用于与治疗骨折或患病骨骼有关的外科手术的充气装置

公开(公告)号：US5827289A

公开(公告)日：1998-10-27

申请号：US659678

申请日：1996-06-05

申请人： Mark A. Reiley , Arie Scholten , Karen D. Talmadge

发明人： Mark A. Reiley , Arie Scholten , Karen D. Talmadge

IPC分类号： A61B17/56 , A61B20060101 , A61B10/00 , A61B10/02 , A61B17/00 , A61B17/02 , A61B17/12 , A61B17/58 , A61B17/68 , A61B17/72 , A61B17/74 , A61B17/78 , A61B17/88 , A61B19/00 , A61B19/02 , A61F2/00 , A61F2/28 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2/46 , A61F2/958 , A61L27/00 , A61M25/00 , A61M37/00

CPC分类号： A61B10/025 , A61B17/7258 , A61B17/8855 , A61B90/94 , A61F2/28 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61M25/10 , A61M25/1002 , A61B17/00234 , A61B17/025 , A61B17/742 , A61B17/744 , A61B2010/0258 , A61B2017/00539 , A61B2017/00544 , A61B2017/00557 , A61B2017/0256 , A61B2050/0065 , A61B2050/3015 , A61B50/33 , A61B90/39 , A61F2/2846 , A61F2/3601 , A61F2/389 , A61F2/44 , A61F2002/2817 , A61F2002/2825 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/2853 , A61F2002/2871 , A61F2002/2892 , A61F2002/30113 , A61F2002/30115 , A61F2002/30125 , A61F2002/30131 , A61F2002/30133 , A61F2002/30204 , A61F2002/30225 , A61F2002/30228 , A61F2002/30242 , A61F2002/30247 , A61F2002/30253 , A61F2002/30285 , A61F2002/30288 , A61F2002/30308 , A61F2002/30311 , A61F2002/30313 , A61F2002/30448 , A61F2002/30462 , A61F2002/30464 , A61F2002/30581 , A61F2002/30586 , A61F2002/30599 , A61F2002/30677 , A61F2002/30686 , A61F2002/30909 , A61F2002/3611 , A61F2002/3625 , A61F2002/4062 , A61F2002/4217 , A61F2002/4602 , A61F2002/4635 , A61F2002/4636 , A61F2002/4685 , A61F2220/005 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0015 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076 , A61F2250/0063 , A61F2310/00293 , A61F2310/00353 , A61F2310/0097 , A61M2025/105 , A61M2025/1072 , A61M2210/02 , A61M2210/1003 , A61M25/1011

摘要： A balloon for use in compressing cancellous bone and marrow (also known as medullary bone or trabecular bone) against the inner cortex of bones whether the bones are fractured or not. The balloon comprises an inflatable, non-expandable balloon body for insertion into said bone. The body has a shape and size to compress at least a portion of the cancellous bone to form a cavity in the cancellous bone and to restore the original position of the outer cortical bone, if fractured or collapsed. The balloon is prevented from applying excessive pressure to the outer cortical bone. The wall or walls of the balloon are such that proper inflation the balloon body is achieved to provide for optimum compression of all the bone marrow. The balloon is able to be folded so that it can be inserted quickly into a bone. The balloon can be made to have a suction catheter. It can also be coated with therapeutic substances. The main purpose of the balloon is the forming or enlarging of a cavity or passage in a bone, especially in, but not limited to, vertebral bodies. Another important purpose is to deliver therapeutic substances to bone in an improved way.

摘要翻译： 一种用于压缩松质骨和骨髓（也称为髓质骨或小梁骨）的球囊，无论骨头是否断裂，均可抵抗骨内皮质。气球包括用于插入所述骨中的可膨胀的，不可膨胀的气囊体。身体具有形状和尺寸以压缩松质骨的至少一部分以在松质骨中形成空腔，并且如果骨折或塌陷则恢复外皮质骨的原始位置。防止气囊对外皮质骨施加过大的压力。球囊的壁或壁使得实现气囊体的适当充气以提供所有骨髓的最佳压缩。气囊能够被折叠，使得其可以快速插入骨骼。可以使气囊具有吸引导管。它也可以涂上治疗物质。气囊的主要目的是形成或扩大骨骼中的腔或通道，特别是但不限于椎体。另一个重要的目的是以一种改进的方式将治疗物质递送到骨骼。

$Methods and devices for treating bone after high velocity and/or trauma fracture$

7.

发明授权
Methods and devices for treating bone after high velocity and/or trauma fracture 失效
标题翻译：在高速和/或创伤骨折后治疗骨的方法和装置

公开(公告)号：US07959638B2

公开(公告)日：2011-06-14

申请号：US10397049

申请日：2003-03-25

申请人： Reynaldo A. Osorio , Marialulu Follmer , Richard W. Layne , Ryan P. Boucher , Karen D. Talmadge , Joseph J. Basista

发明人： Reynaldo A. Osorio , Marialulu Follmer , Richard W. Layne , Ryan P. Boucher , Karen D. Talmadge , Joseph J. Basista

IPC分类号： A61B17/58 , A61B17/60 , A61F2/00

CPC分类号： A61F2/4601 , A61B17/1604 , A61B17/1671 , A61B17/3472 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B2017/00261 , A61B2017/00464 , A61B2017/00539 , A61B2017/00557 , A61B2017/00867 , A61B2050/0065 , A61B2090/062 , A61F2/44 , A61F2002/2835 , A61F2002/3008 , A61F2002/30581 , A61F2002/4602 , A61F2002/4624 , A61F2002/4635 , A61F2002/4662 , A61F2250/0098 , A61F2310/00353

摘要： An expandable body is inserted into an area of cancellous within a vertebral body through a percutaneous access path. A bone filler is conveyed into the expandable body to expand the expandable body and displace cancellous bone and create a cavity occupied at least in part by the expandable body and the bone filler. The expandable body and the bone filler are left within the cavity to strengthen the vertebral body.

摘要翻译： 通过经皮进入路径将可扩张体插入椎体内的松质骨区域。骨填料被输送到可膨胀体中以膨胀可膨胀体并且置换松质骨并产生至少部分地由可膨胀体和骨填充物占据的空腔。可膨胀体和骨填充物留在腔内以加强椎体。

8.

发明申请
Systems and methods for treating bone using expandable bodies 审中-公开
标题翻译：使用可膨胀体治疗骨骼的系统和方法

公开(公告)号：US20080269795A1

公开(公告)日：2008-10-30

申请号：US11977522

申请日：2007-10-25

申请人： Mark A. Reiley , Arie Scholten , Karen D. Talmadge , Robert M. Scribner

发明人： Mark A. Reiley , Arie Scholten , Karen D. Talmadge , Robert M. Scribner

IPC分类号： A61M29/00 , A61B17/58 , A61B19/00

CPC分类号： A61B17/8855 , A61B10/025 , A61B10/0283 , A61B17/00234 , A61B17/7061 , A61B17/7097 , A61B17/7098 , A61B17/7258 , A61B17/7291 , A61B17/742 , A61B17/744 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B50/33 , A61B90/39 , A61B90/94 , A61B2010/0258 , A61B2017/00539 , A61B2017/00544 , A61B2017/0256 , A61B2050/0065 , A61B2050/3015 , A61F2/28 , A61F2/2846 , A61F2/44 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/2825 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/2853 , A61F2002/2871 , A61F2002/2892 , A61F2002/30113 , A61F2002/30115 , A61F2002/30125 , A61F2002/30133 , A61F2002/30225 , A61F2002/30228 , A61F2002/30242 , A61F2002/30247 , A61F2002/30253 , A61F2002/30285 , A61F2002/30288 , A61F2002/30308 , A61F2002/30311 , A61F2002/30313 , A61F2002/30448 , A61F2002/30462 , A61F2002/30464 , A61F2002/30581 , A61F2002/30586 , A61F2002/30599 , A61F2002/30677 , A61F2002/30909 , A61F2002/4217 , A61F2002/4602 , A61F2002/4627 , A61F2002/4635 , A61F2002/4636 , A61F2002/4685 , A61F2220/005 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076 , A61F2250/0063 , A61F2310/00293 , A61F2310/00353 , A61F2310/0097 , A61M25/10 , A61M25/1002 , A61M29/00 , A61M29/02 , A61M2210/02 , A61M2210/1003

摘要： A vertebral body is selected for treatment. The vertebral body has a cortical wall enclosing a cancellous bone volume. The vertebral body also has at least one cortical plate that is depressed due to fracture. At least one maximum dimension for the cancellous bone volume is ascertained, and an expandable device is provided that has a predefined dimension when substantially expanded that is less than the maximum dimension. The expandable device is introduced into the vertebral body through a percutaneous access path while in an unexpanded condition. The expandable device is expanded while disposed within the cancellous bone volume from the unexpanded configuration toward the expanded configuration. An expansion barrier is provided in association with the expandable device that directs expansion of the expandable device in a desired direction to move the fractured cortical plate toward a desired anatomic position.

摘要翻译： 选择椎体进行治疗。椎体具有包围松质骨体积的皮质壁。椎体还具有至少一个由于骨折而压下的皮质板。确定松质骨体积的至少一个最大尺寸，并且提供可扩展装置，其在基本上扩展时具有小于最大尺寸的预定尺寸。可扩张装置在未膨胀状态下通过经皮通路进入椎体。扩张装置在从松散构型向膨胀构型放置在松质骨容积内时扩张。与可扩张装置相关联地提供膨胀阻挡件，其将可扩张装置的膨胀引导到期望的方向以将断裂的皮质板移动到期望的解剖位置。