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公开(公告)号：US4266024A
公开(公告)日：1981-05-05
申请号：US38787
申请日：1979-05-14
申请人： Peter Swetly , Gunther R. Adolf , Gerhard Bodo , Silvia J. Lindner-Frimmel , Peter Meindl , Hans Tuppy
发明人： Peter Swetly , Gunther R. Adolf , Gerhard Bodo , Silvia J. Lindner-Frimmel , Peter Meindl , Hans Tuppy
IPC分类号： C07K14/555 , C12P21/00
CPC分类号： C07K14/555 , Y10S435/811 , Y10S530/808
摘要： This invention is directed to a process of producing interferon which comprises incubating permanent cell lines of lymphoblast origin or human fibroblast cells with interferon inducers and stimulator substances and recovering the interferon produced.
摘要翻译： 本发明涉及一种生产干扰素的方法，其包括将成淋巴母细胞源或人成纤维细胞的永久性细胞系与干扰素诱导剂和刺激物质一起孵育并回收所产生的干扰素。
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2.发明授权Hybrid interferons, their use as pharmaceutical compositions and as intermediate products for the preparation of antibodies and the use thereof and processes for preparing them 失效混合干扰素，它们作为药物组合物的用途以及用于制备抗体的中间产物及其用途及其制备方法
公开(公告)号：US4917887A
公开(公告)日：1990-04-17
申请号：US23634
申请日：1987-03-09
申请人： Rudolf Hauptmann , Peter Swetly , Peter Meindl , Gunther Adolf , Edgar Falkner , Gerhard Bodo , Ingrid Maurer-Fogy
发明人： Rudolf Hauptmann , Peter Swetly , Peter Meindl , Gunther Adolf , Edgar Falkner , Gerhard Bodo , Ingrid Maurer-Fogy
IPC分类号： C07K14/005 , A61K38/00 , A61K38/21 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/56 , C07K16/00 , C07K16/24 , C07K17/10 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/20 , C12N15/70 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/91
CPC分类号： C12N15/70 , C07K14/555 , C07K14/56 , C07K16/249 , C12N15/81 , A61K38/00
摘要： This invention relates to new hybrid interferons consisting of part of an .alpha.-interferon and part of an omega interferon, the N-terminal Met or N-formyl-Met derivatives thereof and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives thereof, their use as pharmaceutical compositions and as intermediate products for immunizing experimental animals and processes for producing them,new monoclonal antibodies and their use in purifying .alpha. and omega-interferons, the hybrid cell lines which secrete them and processes for preparing them,a new process for purifying .alpha. and omega-interferons by means of a new antibody affinity column containing the above-mentioned new monoclonal antibodies, and processes for the preparation thereof,new hybrid plasmids for improving the expression of omega-interferons and new intermediate plasmids for preparing the new plasmids and processes for the preparation thereof.
摘要翻译： 本发明涉及由α-干扰素和ω-干扰素的一部分组成的新的杂合干扰素，其N-末端Met或N-甲酰基-Mc衍生物，如果杂合干扰素的肽序列含有糖基化位点， 其N-糖基化衍生物，它们作为药物组合物的用途和用于免疫实验动物的中间产物及其制备方法，新的单克隆抗体及其在纯化α和ω-干扰素中的用途，分泌它们的杂交细胞系和 制备它们，通过含有上述新单克隆抗体的新抗体亲和柱纯化α和ω-干扰素的新方法及其制备方法，用于改善ω-干扰素表达的新型杂合质粒和新的 用于制备新质粒的中间质粒及其制备方法。
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3.发明授权Vascular anticoagulant proteins DNA which codes them, processer for preparing them and their use 失效编码它们的血管抗凝蛋白DNA，用于制备它们的处理器及其用途
公开(公告)号：US5837842A
公开(公告)日：1998-11-17
申请号：US376050
申请日：1995-01-23
申请人： Rudolf Hauptmann , Ingrid Maurer-Fogy , Gerhard Bodo , Peter Swetly , Christian Stratowa , Edgar Falkner , Gunther Adolf , Christiaan Maria Peter Reutelingsperger
发明人： Rudolf Hauptmann , Ingrid Maurer-Fogy , Gerhard Bodo , Peter Swetly , Christian Stratowa , Edgar Falkner , Gunther Adolf , Christiaan Maria Peter Reutelingsperger
IPC分类号： G01N33/50 , A61K35/14 , A61K38/00 , A61P7/02 , A61P29/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K19/00 , C12N1/20 , C12N5/10 , C12N15/09 , C12N15/70 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/86 , C07H21/04
CPC分类号： C12N15/70 , C07K14/4721 , C07K16/18 , G01N33/86 , A61K38/00
摘要： This invention relates to biologically active proteins, the DNA molecules coding for them, processes for preparing them and their use.
摘要翻译： 本发明涉及生物活性蛋白质，编码它们的DNA分子，其制备方法及其应用。
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公开(公告)号：US4820638A
公开(公告)日：1989-04-11
申请号：US495944
申请日：1983-05-19
申请人： Peter Swetly , Eva Dworkin-Rastl , Peter Meindl
发明人： Peter Swetly , Eva Dworkin-Rastl , Peter Meindl
IPC分类号： C07K14/52 , C07H21/04 , C07K14/555 , C07K14/56 , C12N1/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/21 , C12P21/00 , C12P21/02 , C12R1/19 , C12N1/20
CPC分类号： C12N15/1096 , C07K14/555 , Y10S930/142
摘要： A novel species of alpha interferon is taught. The alpha interferon amino acid sequence is disclosed and a gene corresponding thereto. The alpha interferon gene is expressed in Escherichia coli.
摘要翻译： 教导了一种新型的α干扰素。 公开了α干扰素氨基酸序列和与其对应的基因。 α干扰素基因在大肠杆菌中表达。
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公开(公告)号：US5798228A
公开(公告)日：1998-08-25
申请号：US805165
申请日：1997-02-24
申请人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
发明人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
IPC分类号： A61K38/21 , A61K38/00 , A61P31/12 , A61P35/00 , A61P37/04 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K16/00 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/20 , C12N15/21 , C12P21/02 , C12R1/19
CPC分类号： C07K14/555 , A61K38/00
摘要： This invention relates to a process for preparing recombinant horse and dog interferons and the interferons themselves.
摘要翻译： 本发明涉及一种制备重组马和狗干扰素和干扰素本身的方法。
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公开(公告)号：US5605688A
公开(公告)日：1997-02-25
申请号：US302391
申请日：1994-09-08
申请人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
发明人： Adolf Himmler , Rudolf Hauptmann , Norbert Hauel , Gunther Adolf , Peter Swetly
IPC分类号： A61K38/21 , A61K38/00 , A61P31/12 , A61P35/00 , A61P37/04 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K16/00 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/20 , C12N15/21 , C12P21/02 , C12R1/19
CPC分类号： C07K14/555 , A61K38/00
摘要： This invention relates to a process for preparing recombinant horse and dog interferons and the interferons themselves.
摘要翻译： 本发明涉及一种制备重组马和狗干扰素以及干扰素本身的方法。
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公开(公告)号：US4046879A
公开(公告)日：1977-09-06
申请号：US662374
申请日：1976-03-01
申请人： Peter Swetly
发明人： Peter Swetly
摘要： A topical pharmaceutical antiviral composition consisting essentially of an inert pharmaceutical carrier or diluent, a complex-former for bivalent cations, and a 5'-triphosphate of a nucleoside or deoxyribonucleoside.
摘要翻译： 主要由惰性药物载体或稀释剂，二价阳离子的络合物和核苷或脱氧核糖核苷的5'-三磷酸组成的局部药物抗病毒组合物。
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公开(公告)号：US5618712A
公开(公告)日：1997-04-08
申请号：US225280
申请日：1994-04-04
申请人： Andrzej Sledziewski , Ewa Chlebowicz-Sledziewska , Peter Swetly , Gunther Adolf , Rudolf Hauptmann , Maria J. Castanon , Walter Spevak
发明人： Andrzej Sledziewski , Ewa Chlebowicz-Sledziewska , Peter Swetly , Gunther Adolf , Rudolf Hauptmann , Maria J. Castanon , Walter Spevak
IPC分类号： C12N15/09 , A61K35/74 , A61K36/06 , A61K38/00 , A61K38/46 , C07K14/00 , C12N1/16 , C12N1/20 , C12N5/00 , C12N5/10 , C12N9/36 , C12N15/56 , C12N15/81 , C12R1/19 , C12R1/865 , C12R1/91 , C12N15/70
CPC分类号： C12N9/2462 , C12N15/81 , A61K38/00
摘要： This invention relates to a process for preparing human lysozyme and the human lysozyme protein itself.
摘要翻译： 本发明涉及一种制备人溶菌酶和人溶菌酶蛋白的方法。
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公开(公告)号：US4370312A
公开(公告)日：1983-01-25
申请号：US315213
申请日：1981-10-26
申请人： Gunther Jung , Hans Bruckner , Peter Swetly , Gerhard Bozler
发明人： Gunther Jung , Hans Bruckner , Peter Swetly , Gerhard Bozler
IPC分类号： C07K14/52 , C07K7/06 , C07K14/555 , C07K16/24 , C07K19/00 , G01N33/531 , G01N33/58 , G01N33/00 , A61K39/00 , C07C103/52
CPC分类号： C07K16/249 , C07K14/555 , G01N33/531 , G01N33/58 , Y10S530/806 , Y10S930/142
摘要： The decapeptide of the formulaH-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-OHand the use thereof as hapten, tracer or antibody.
摘要翻译： 式H-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-OH的十肽及其作为半抗原，示踪剂或抗体的用途。
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10.发明授权DNA encoding equine-gamma interferon and recombinant production of equine IFN-.gamma. polypeptides 失效编码马γ干扰素的DNA和马IFN-γ多肽的重组产生
公开(公告)号：US5602010A
公开(公告)日：1997-02-11
申请号：US263214
申请日：1994-06-17
申请人： Rudolf Hauptmann , Adolf Himmler , Peter Swetly
发明人： Rudolf Hauptmann , Adolf Himmler , Peter Swetly
IPC分类号： G01N33/53 , A61K38/00 , A61K38/21 , A61P43/00 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/57 , C07K16/00 , C07K16/24 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/23 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/865 , C12R1/91 , G01N33/577 , C12N1/21 , C12N15/71
CPC分类号： C07K16/249 , C07K14/57 , A61K38/00
摘要： The present invention relates to a process for preparing horse interferon-gamma (equine interferon gamma, EqIFN-.gamma., DNA sequences which encode this polypeptide, suitable vectors and host organisms containing these DNA sequences and the EqIFN-.gamma. itself. The invention further relates to partial DNA sequences which encode polypeptides which differ structurally from the natural EqIFN-.gamma. polypeptide. The use of the proteins is also described.
摘要翻译： 本发明涉及制备马干扰素-γ（马干扰素γ，EqIFN-γ，编码该多肽的DNA序列，合适的载体和含有这些DNA序列的宿主生物体和EqIFN-γ本身）的方法，本发明还涉及 编码与天然EqIFN-γ多肽结构不同的多肽的部分DNA序列也描述了蛋白质的用途。
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