公开(公告)号：US20180346859A1

公开(公告)日：2018-12-06

申请号：US15781078

申请日：2016-12-02

Applicant: President and Fellows of Harvard College

Inventor： Antonio Varone ,  Norman Wen ,  Daniel Levner ,  Richard Novak ,  Lori McPartlin ,  Donald E. Ingber ,  Youngjae Choe ,  Lian Leng ,  Justin K. Nguyen

IPC: C12M3/06 ,  C12M3/00 ,  C12M1/12 ,  C12N5/071 ,  C12N5/077

CPC classification number: C12M25/02 ,  C12M21/08 ,  C12M23/16

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：US20220403313A1

公开(公告)日：2022-12-22

申请号：US17820174

申请日：2022-08-16

Applicant: President and Fellows of Harvard College

Inventor： Antonio Varone ,  Norman Wen ,  Daniel Levner ,  Richard Novak ,  Lori McPartlin ,  Donald E. Ingber ,  Youngjae Choe ,  Lian Leng ,  Justin K. Nguyen

IPC: C12M3/06 ,  C12M3/00 ,  C12M1/12 ,  C12N5/071 ,  C12N5/077

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：US20230159872A1

公开(公告)日：2023-05-25

申请号：US18056035

申请日：2022-11-16

Applicant: President and Fellows of Harvard College

Inventor： Antonio Varone ,  Norman Wen ,  Daniel Levner ,  Richard Novak ,  Lori McPartlin ,  Donald E. Ingber ,  Youngjae Choe ,  Lian Leng ,  Justin K. Nguyen

IPC: C12M3/06 ,  C12M3/00 ,  C12M1/12 ,  C12N5/071 ,  C12N5/077

CPC classification number: C12M23/16 ,  C12M21/08 ,  C12M25/02 ,  C12M25/14 ,  C12N5/0629 ,  C12N5/0656 ,  C12N5/0679 ,  C12N5/069 ,  B01L3/5027

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：US20180080925A1

公开(公告)日：2018-03-22

申请号：US15563140

申请日：2016-03-31

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Kambez Hajipouran Benam ,  Richard Novak ,  Josiah Sliz ,  Thomas Charles Ferrante ,  Donald Elliot Ingber ,  Youngjae Choe

IPC: G01N33/50 ,  B01L3/00 ,  F04B49/06

CPC classification number: G01N33/5064 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/14 ,  B01L2300/0861 ,  B01L2400/0478 ,  B01L2400/049 ,  C12M1/16 ,  C12M3/04 ,  C12M23/16 ,  C12M25/02 ,  C12M29/10 ,  C12M35/04 ,  F04B17/03 ,  F04B19/22 ,  F04B49/06

Abstract: A microfluidic system for determining a response of cells comprises one or more fluid pumps. The one or more fluid pumps move a fluid across cells within a microfluidic device. The microfluidic device includes a microchannel at least partially defined by a surface having cells adhered thereto, a first port at one end of the microchannel, and a second port at an opposing end of the microchannel. The one or more fluid pumps move the fluid across the cells in a first direction toward the second port and then move the fluid across the cells in a second direction toward the first port.

公开(公告)号：US12187996B2

公开(公告)日：2025-01-07

申请号：US18056035

申请日：2022-11-16

Applicant: President and Fellows of Harvard College

Inventor： Antonio Varone ,  Norman Wen ,  Daniel Levner ,  Richard Novak ,  Lori McPartlin ,  Donald E. Ingber ,  Youngjae Choe ,  Lian Leng ,  Justin K. Nguyen

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M3/00 ,  C12M3/04 ,  C12N5/071 ,  C12N5/077

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：US20240218309A1

公开(公告)日：2024-07-04

申请号：US18604469

申请日：2024-03-13

Applicant: President and Fellows of Harvard College

Inventor： Antonio Varone ,  Norman Wen ,  Daniel Levner ,  Richard Novak ,  Lori McPartlin ,  Donald E. Ingber ,  Youngjae Choe ,  Lian Leng ,  Justin K. Nguyen

IPC: C12M3/06 ,  C12M1/12 ,  C12M3/00 ,  C12N5/071 ,  C12N5/077 ,  B01L3/00 ,  C12M1/00 ,  C12M1/34 ,  C12M3/04

CPC classification number: C12M23/16 ,  C12M21/08 ,  C12M25/02 ,  C12M25/14 ,  C12N5/0629 ,  C12N5/0656 ,  C12N5/0679 ,  C12N5/069 ,  B01L3/5027 ,  B01L2300/069 ,  C12M3/04 ,  C12M29/10 ,  C12M41/46

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.

公开(公告)号：US11505773B2

公开(公告)日：2022-11-22

申请号：US15781078

申请日：2016-12-02

Applicant: President and Fellows of Harvard College

Inventor： Antonio Varone ,  Norman Wen ,  Daniel Levner ,  Richard Novak ,  Lori McPartlin ,  Donald E. Ingber ,  Youngjae Choe ,  Lian Leng ,  Justin K. Nguyen

IPC: C12M3/00 ,  B01L3/00 ,  C12M1/00 ,  C12M3/06 ,  C12M1/12 ,  C12N5/071 ,  C12N5/077 ,  C12M3/04 ,  C12M1/34

Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.