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公开(公告)号：US20190316119A1
公开(公告)日：2019-10-17
申请号：US16400858
申请日：2019-05-01
Applicant: Raindance Technologies, Inc.
Inventor： Michael L. Samuels , Jeffrey Charles Olson , Andrew Watson , Keith Brown , Darren R. Link
IPC: C12N15/10 , C40B50/08 , C12Q1/6874 , G01N33/543 , G01N33/58
Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
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公开(公告)号：US20180223348A1
公开(公告)日：2018-08-09
申请号：US15947346
申请日：2018-04-06
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Michael L. Samuels
IPC: C12Q1/6844 , C12Q1/6858
CPC classification number: C12Q1/6844 , C12Q1/6858 , C12Q2535/122 , C12Q2563/159 , C12Q2563/179 , C12Q2565/629
Abstract: The invention generally relates to methods for distinguishing a rare genetic variation in a nucleic acid sequence.
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公开(公告)号：US20160201125A1
公开(公告)日：2016-07-14
申请号：US14995744
申请日：2016-01-14
Applicant: Raindance Technologies, Inc.
Inventor： Michael L. Samuels , Jeffrey Charles Olson , Andrew Watson , Keith Brown , Darren R. Link
IPC: C12Q1/68
Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
Abstract translation: 本发明提供条形码文件库及其制备和使用方法，包括获得多个核酸构建体，其中每个构建体包含独特的N-聚体和功能性N-聚体，并将构建体分离成流体隔室，使得每个隔室含有一个 或更多的独特构造的副本。 本发明还提供数字PCR和数字PCR中条形码库的使用方法。
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Patent Agency Ranking
公开(公告)号：US10139411B2
公开(公告)日：2018-11-27
申请号：US15415290
申请日：2017-01-25
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Michael L. Samuels
IPC: G01N33/58 , G01N33/573 , B01F5/06 , B01J19/00 , B01F13/00 , B01L3/00 , B01F3/08 , C40B40/04 , C40B50/08 , C40B60/10 , G01N33/50 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , G01N33/542 , B01L7/00 , G01N21/64
Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
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公开(公告)号：US20190094226A1
公开(公告)日：2019-03-28
申请号：US16199822
申请日：2018-11-26
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Michael L. Samuels
IPC: G01N33/573 , B01L3/00 , C12Q1/6804 , C12Q1/25 , C12Q1/6818 , G01N33/58 , G01N33/542 , C40B40/04 , C40B50/08 , B01F13/00 , B01F5/06 , B01J19/00 , G01N33/50 , B01F3/08 , C40B60/10 , C12Q1/6827 , B01L7/00 , G01N21/64
CPC classification number: G01N33/573 , B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C40B40/04 , C40B50/08 , C40B60/10 , G01N21/6428 , G01N21/6445 , G01N33/5008 , G01N33/542 , G01N33/582 , G01N2500/00
Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
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公开(公告)号：US20180353913A1
公开(公告)日：2018-12-13
申请号：US16105042
申请日：2018-08-20
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Brian Hutchison , Michael L. Samuels , Michael Weiner
CPC classification number: B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01F2215/0037 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C40B40/04 , C40B50/08 , G01N15/1459 , G01N33/5008 , G01N2015/1006 , G01N2500/00 , Y02A90/26
Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.
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公开(公告)号：US20170176429A1
公开(公告)日：2017-06-22
申请号：US15415276
申请日：2017-01-25
Applicant: Raindance Technologies, Inc.
Inventor： Michael L. Samuels , Darren Roy Link
IPC: G01N33/543 , C12Q1/68
CPC classification number: G01N33/54366 , B01F13/0062 , B01F13/0071 , C12Q1/6874 , C40B40/00 , C40B40/04 , C40B70/00 , G01N33/532
Abstract: The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
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公开(公告)号：US20170131279A1
公开(公告)日：2017-05-11
申请号：US15415290
申请日：2017-01-25
Applicant: Raindance Technologies, Inc.
Inventor： Darren Roy Link , Michael L. Samuels
IPC: G01N33/573 , G01N33/542 , C12Q1/68 , G01N33/58
CPC classification number: G01N33/573 , B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C40B40/04 , C40B50/08 , C40B60/10 , G01N21/6428 , G01N21/6445 , G01N33/5008 , G01N33/542 , G01N33/582 , G01N2500/00
Abstract: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
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