公开(公告)号：US20120277697A1

公开(公告)日：2012-11-01

申请号：US13456394

申请日：2012-04-26

申请人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Li Yang Chu

发明人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Li Yang Chu

IPC分类号： A61M1/00

CPC分类号： A61B5/150099 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B10/0045 ,  A61B2010/008 ,  A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061

摘要： Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device.

摘要翻译： 用于从受试者例如皮肤递送和/或接收流体或其它材料（例如血液或间质液）的系统和方法。 珠粒破坏剂和/或毛细管可用于促进流体从受试者输送到装置中。 串珠破坏者可能会破坏皮肤表面上的体液如血液的汇集，并有助于以所需的方式影响流动。 毛细管可以将装置中的流体的流动例如传导到通向储存室的通道或其它流动路径的入口。 可以使用真空（相对于环境的减压）来将流体接收到装置中，例如通过使用相对低的压力将流体吸入通向存储室的通道的入口。 真空源可以是设备的一部分。

公开(公告)号：US09295417B2

公开(公告)日：2016-03-29

申请号：US13456394

申请日：2012-04-26

申请人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Li Yang Chu

发明人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Li Yang Chu

IPC分类号： A61B5/15 ,  A61B5/151 ,  A61B5/145

CPC分类号： A61B5/150099 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B10/0045 ,  A61B2010/008 ,  A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061

摘要： Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device.

摘要翻译： 用于从受试者例如皮肤递送和/或接收流体或其它材料（例如血液或间质液）的系统和方法。 珠粒破坏剂和/或毛细管可用于促进流体从受试者输送到装置中。 珠粒破坏者可能会破坏皮肤表面上的体液（如血液）的“汇集”，并有助于以期望的方式影响流动。 毛细管可以将装置中的流体的流动例如传导到通向储存室的通道或其它流动路径的入口。 可以使用真空（相对于环境的减压）来将流体接收到装置中，例如通过使用相对低的压力将流体吸入通向存储室的通道的入口。 真空源可以是装置的一部分。

公开(公告)号：US09119578B2

公开(公告)日：2015-09-01

申请号：US13456505

申请日：2012-04-26

申请人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Howard Bernstein ,  Kristin Horton

发明人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Howard Bernstein ,  Kristin Horton

IPC分类号： A61B5/00 ,  A61B5/15 ,  A61B5/145 ,  A61B5/151 ,  A61B5/154 ,  B01L3/00 ,  A61B5/1455 ,  A61B5/1486 ,  A61B10/00 ,  G01N33/18

CPC分类号： A61B5/150099 ,  A61B5/1411 ,  A61B5/1438 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150419 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15105 ,  A61B5/15142 ,  A61B5/154 ,  A61B10/0045 ,  A61B2562/0295 ,  A61M1/34 ,  A61M1/3486 ,  A61M1/3687 ,  A61M2202/0415 ,  A61M2205/3334 ,  B01L3/502753 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0688 ,  G01N33/18 ,  G01N33/1826

摘要： In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.

摘要翻译： 在一些实施方案中，本发明一般涉及在装置内分离血液以形成血浆或血清。 在一些实施方案中，本发明一般涉及去除包含在装置内的流体，例如血液。 例如，可以将装置施加到受试者的皮肤以从受试者接收血液，并将血液通过分离膜，该分离膜将血液分离成血浆，并将部分浓缩在血细胞中。 作为另一个例子，血液或血浆可能被允许在装置内凝结，血清（未经切开的血液部分）可以从装置中取出。 在一些情况下，该装置可以包含诸如预包装真空的真空源，以便于接收血液和/或使血液通过分离膜以产生血浆​​或血清。

公开(公告)号：US09033898B2

公开(公告)日：2015-05-19

申请号：US13166451

申请日：2011-06-22

申请人： Donald E. Chickering, III ,  Howard Bernstein ,  Shawn Davis ,  Ramin Haghgooie ,  Douglas A. Levinson ,  Mark Michelman ,  Ping Gong

发明人： Donald E. Chickering, III ,  Howard Bernstein ,  Shawn Davis ,  Ramin Haghgooie ,  Douglas A. Levinson ,  Mark Michelman ,  Ping Gong

IPC分类号： A61B5/00 ,  A61B17/14 ,  A61B17/32 ,  A61M37/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  A61B10/02 ,  A61B17/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/154

CPC分类号： A61B5/150984 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/150022 ,  A61B5/150091 ,  A61B5/150099 ,  A61B5/150106 ,  A61B5/150129 ,  A61B5/150145 ,  A61B5/15016 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150969 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15125 ,  A61B5/15134 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/154 ,  A61B5/157 ,  A61B17/00234 ,  A61B2010/0225 ,  A61B2562/0238 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046

摘要： Systems and methods for delivering and/or receiving a substance or substances, such as blood, from subjects. In one embodiment, devices and methods for receiving blood from a subject employ devices including a substance transfer component (such as one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the WONG BAKER FACES Pain Scale. The device may be self-contained, applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may be processed to determine the blood and/or an analyte within the blood using sensors or agents in the device or an external apparatus. Other aspects of the present invention are directed at other devices for receiving bodily fluids kits involving such devices, methods of making such devices, methods of using such devices, and the like.

摘要翻译： 用于从受试者传送和/或接收物质或物质如血液的系统和方法。 在一个实施例中，用于从受试者接收血液的装置和方法使用包括物质转移组分（例如一个或多个微针）的装置和在接收血液之前具有小于大气压的内部压力的储存室。 在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。 可以评估疼痛，​​例如，使用诸如黄巴克面霜疼痛量表的疼痛量表。 该装置可以是独立的，应用于皮肤，并被激活以从受试者接收血液。 可以使用装置或外部装置中的传感器或试剂处理装置或其一部分，以确定血液和/或血液内的分析物。 本发明的其它方面涉及用于接收涉及这种装置的体液套件的其他装置，制造这种装置的方法，使用这种装置的方法等。

公开(公告)号：US20110251562A1

公开(公告)日：2011-10-13

申请号：US13166611

申请日：2011-06-22

申请人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson ,  Mark Michelman

发明人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson ,  Mark Michelman

IPC分类号： A61M5/00

CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

摘要翻译： 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽取或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

公开(公告)号：US20130138058A9

公开(公告)日：2013-05-30

申请号：US13456570

申请日：2012-04-26

申请人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

IPC分类号： A61M1/00

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

公开(公告)号：US08827971B2

公开(公告)日：2014-09-09

申请号：US13456570

申请日：2012-04-26

申请人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

IPC分类号： A61M1/00 ,  A61B5/151 ,  A61B5/00 ,  A61B5/15 ,  A61M37/00 ,  A61B5/145 ,  A61B10/00 ,  A61B5/1486 ,  A61B5/1459

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

公开(公告)号：US08821412B2

公开(公告)日：2014-09-02

申请号：US13680351

申请日：2012-11-19

申请人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse ,  Howard Bernstein ,  Douglas A. Levinson

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse ,  Howard Bernstein ,  Douglas A. Levinson

IPC分类号： A61B5/00

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

摘要翻译： 本发明一般涉及通过装置开口接收体液。 在一个方面，该装置包括流动活化器，其布置成使流体从受试者释放。 部署致动器可以在展开方向上致动流动活化器，这又可导致流体从受试者释放。 流动活化剂也可以通过回缩致动器在回缩方向上移动。 在一个方面，设备可以包括真空源，其可以帮助促进流体流入设备的开口中和/或可以帮助促进流体从开口流到储存室。 在一个方面，设备致动器可以实现开口和真空源之间的流体连通，并且在启用流体连通之后可以启动流动活化器。

公开(公告)号：US20120277696A1

公开(公告)日：2012-11-01

申请号：US13456570

申请日：2012-04-26

申请人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

发明人： Javier Gonzalez-Zugasti ,  A. David Boccuti ,  Donald E. Chickering, III ,  Mark Michelman ,  Ramin Haghgooie ,  Shawn Davis ,  Scott James ,  Maisam Dadgar ,  Greg Fisher ,  Richard L. Miller ,  Christopher J. Morse

IPC分类号： A61M1/00

CPC分类号： A61B5/150374 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/154 ,  A61B5/411 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  A61B2010/008 ,  A61M37/0015 ,  G06F19/00 ,  G16H10/40

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

摘要翻译： 本发明一般涉及通过装置开口接收体液。 在一个方面，该装置包括流动活化器，其布置成使流体从受试者释放。 部署致动器可以在展开方向上致动流动活化器，这又可导致流体从受试者释放。 流动活化剂也可以通过回缩致动器在回缩方向上移动。 在一个方面，设备可以包括真空源，其可以帮助促进流体流入设备的开口中和/或可以帮助促进流体从开口流到储存室。 在一个方面，设备致动器可以实现开口和真空源之间的流体连通，并且在启用流体连通之后可以启动流动活化器。

公开(公告)号：US20120275955A1

公开(公告)日：2012-11-01

申请号：US13456505

申请日：2012-04-26

申请人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Howard Bernstein ,  Kristin Horton

发明人： Ramin Haghgooie ,  Donald E. Chickering, III ,  Shawn Davis ,  Mark Michelman ,  Howard Bernstein ,  Kristin Horton

IPC分类号： B01D71/68 ,  B01D71/10 ,  A61M1/34 ,  B01D63/00

CPC分类号： A61B5/150099 ,  A61B5/1411 ,  A61B5/1438 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150419 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15105 ,  A61B5/15142 ,  A61B5/154 ,  A61B10/0045 ,  A61B2562/0295 ,  A61M1/34 ,  A61M1/3486 ,  A61M1/3687 ,  A61M2202/0415 ,  A61M2205/3334 ,  B01L3/502753 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0688 ,  G01N33/18 ,  G01N33/1826

摘要： In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.

摘要翻译： 在一些实施方案中，本发明一般涉及在装置内分离血液以形成血浆或血清。 在一些实施方案中，本发明一般涉及去除包含在装置内的流体，例如血液。 例如，可以将装置施加到受试者的皮肤以从受试者接收血液，并将血液通过分离膜，该分离膜将血液分离成血浆，并将部分浓缩在血细胞中。 作为另一个例子，血液或血浆可能被允许在装置内凝结，血清（未经切开的血液部分）可以从装置中取出。 在一些情况下，该装置可以包含诸如预包装真空的真空源，以便于接收血液和/或使血液通过分离膜以产生血浆​​或血清。