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公开(公告)号：US20090221075A1
公开(公告)日：2009-09-03
申请号：US12395085
申请日：2009-02-27
CPC分类号： C12M47/04 , B01L3/5021 , B01L3/50825 , B01L3/5635 , B01L2200/026 , B01L2300/046 , C12M47/02 , G01N1/286 , G01N1/4077
摘要： Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
摘要翻译： 公开了从生物组织如组织样品分离，富集和/或纯化细胞群的系统。 例如，可以获取并破坏脂肪组织样品。 然后可以分离和纯化破碎的组织样品。 分离的组分可以包括多能，多能或其他细胞群体。
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公开(公告)号：US07901584B2
公开(公告)日：2011-03-08
申请号：US12476838
申请日：2009-06-02
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译： 具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。
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公开(公告)号：US08337711B2
公开(公告)日：2012-12-25
申请号：US12395085
申请日：2009-02-27
CPC分类号： C12M47/04 , B01L3/5021 , B01L3/50825 , B01L3/5635 , B01L2200/026 , B01L2300/046 , C12M47/02 , G01N1/286 , G01N1/4077
摘要： Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
摘要翻译： 公开了从生物组织如组织样品分离，富集和/或纯化细胞群的系统。 例如，可以获取并破坏脂肪组织样品。 然后可以分离和纯化破碎的组织样品。 分离的组分可以包括多能，多能或其他细胞群体。
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公开(公告)号：US20120027746A1
公开(公告)日：2012-02-02
申请号：US12846944
申请日：2010-07-30
CPC分类号： C12N9/6429 , A61K38/00 , A61K38/4833 , C12Y304/21005
摘要： Methods of generating thrombin and methods of applying a clotting tissue sealant to a site on a subject are provided. A blood component comprising platelets can be obtained from the subject. A hypotonic composition is contacted with a solid matrix to form a thrombin-containing liquid, where the hypotonic composition includes water, calcium, a blood component comprising platelets, and optionally a chelator. Calcium is present in the hypotonic composition in an amount greater than the amount of calcium that can be complexed by the chelator. Thrombin-containing liquid is then separated from the hypotonic composition and can be applied to the site on the subject to form a clot, for example, by combination with fibrinogen.
摘要翻译： 提供产生凝血酶的方法和将凝结组织密封剂施用于受试者的部位的方法。 可以从受试者获得包含血小板的血液成分。 低渗组合物与固体基质接触以形成含凝血酶的液体，其中低渗组合物包括水，钙，包含血小板的血液成分和任选的螯合剂。 钙在低渗组合物中的存在量大于可由螯合剂络合的钙的量。 然后将含凝血酶的液体与低渗组合物分离，并且可以应用于受试者的位点以形成凝块，例如通过与纤维蛋白原组合。
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公开(公告)号：US08187477B2
公开(公告)日：2012-05-29
申请号：US12951701
申请日：2010-11-22
申请人： Randel Dorian , Scott R. King , Richard W. Storrs
发明人： Randel Dorian , Scott R. King , Richard W. Storrs
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US20120230890A1
公开(公告)日：2012-09-13
申请号：US13480849
申请日：2012-05-25
申请人： Randel Dorian , Scott R. King , Richard W. Storrs
发明人： Randel Dorian , Scott R. King , Richard W. Storrs
IPC分类号： B01L3/00
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US5512294A
公开(公告)日：1996-04-30
申请号：US286555
申请日：1994-08-05
申请人： King C. Li , Mark D. Bednarski , Richard W. Storrs , Henry Y. Li , Francois D. Trooper , Curtis K. H. Song , Dorothy A. Sipkins , Jeremy K. Kuniyoshi
发明人： King C. Li , Mark D. Bednarski , Richard W. Storrs , Henry Y. Li , Francois D. Trooper , Curtis K. H. Song , Dorothy A. Sipkins , Jeremy K. Kuniyoshi
CPC分类号： A61K49/1812 , A61K49/22 , A61K51/1237 , Y10S436/829 , Y10S977/797 , Y10S977/898 , Y10S977/927 , Y10S977/928
摘要： Polymerized liposome particles based upon lipids having a polymerizable functional group and a metal chelator to attach an imaging enhancement agent and lipids having an active targeting group to provide targeted polymerized liposome contrast agents. The polymerized imaging enhancement liposome particles interact with receptor targets holding the image enhancement agent to specific sites providing in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology.
摘要翻译： 基于具有可聚合官能团的脂质和附着成像增强剂的金属螯合剂和具有活性靶向基团的脂质以提供靶向聚合的脂质体造影剂的聚合脂质体颗粒。 聚合成像增强脂质体颗粒与保持图像增强剂的受体靶物相互作用，通过磁共振，放射性，X射线或光学成像在疾病和病理学中在细胞和组织中表达分子，提供体内研究。
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公开(公告)号：US09345869B2
公开(公告)日：2016-05-24
申请号：US13650003
申请日：2012-10-11
CPC分类号： A61F13/00991 , A61F13/00021 , A61F13/00029 , A61F13/00042 , A61F13/00046 , A61F13/00068 , A61F13/00995 , A61M1/0088 , A61M35/00 , A61M37/00 , A61M2202/0208 , A61M2207/00
摘要： Oxygen diffusive wound dressings and methods of manufacturing and use are described herein. The wound dressing may generally provide a ready supply of oxygen to a wound being treated via one or more oxygen conduits which are designed to pass oxygen from ambient air or other oxygen reservoirs into proximity to the wound, and may also provide for exudate removal through transecting channels in fluid communication with both the wound surface and a hydrophilic absorbent material.
摘要翻译： 本文描述了氧扩散伤口敷料及其制造和使用方法。 伤口敷料通常可以通过一个或多个氧气导管来处理的伤口提供便宜的氧气供给，其中氧气导管被设计成将氧气从环境空气或其他氧气储存器传递到伤口附近，并且还可以通过横切方式提供渗出物去除 与伤口表面和亲水性吸收材料流体连通的通道。
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