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    Method of Separating a Selected Component from a Multiple Component Material
    2.
    发明申请
    Method of Separating a Selected Component from a Multiple Component Material 有权
    从多组分材料中分离所选组分的方法

    公开(公告)号：US20120145652A1

    公开(公告)日：2012-06-14

    申请号：US13400188

    申请日：2012-02-20

    申请人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    发明人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    IPC分类号： B01D43/00

    CPC分类号： B01D21/262 ,  A61M1/029 ,  A61M1/3693 ,  B01D21/26 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0409 ,  G01N33/491

    摘要： A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

    摘要翻译： 可操作以使用离心分离多组分材料（例如包括血液的悬浮液）的分离器系统包括浮标。 浮标可以携带在分离容器中，并且具有被配置为在多组分材料中达到平衡位置的调节密度。 引导表面承载在浮标上表面上并且倾斜于靠近浮标周界的堆积位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

    Method of separating a selected component from a multiple component material
    3.
    发明授权
    Method of separating a selected component from a multiple component material 有权
    将选择的组分与多组分材料分离的方法

    公开(公告)号：US08119013B2

    公开(公告)日：2012-02-21

    申请号：US12897401

    申请日：2010-10-04

    申请人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    发明人： Michael D. Leach ,  Randel Dorian ,  Jacy C. Hoeppner

    IPC分类号： B01D21/26

    CPC分类号： B01D21/262 ,  A61M1/029 ,  A61M1/3693 ,  B01D21/26 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0409 ,  G01N33/491

    摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

    摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

    Apparatus and method for preparing platelet rich plasma and concentrates thereof
    4.
    发明授权
    Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权
    制备富血小板血浆及其浓缩物的装置及方法

    公开(公告)号：US07866485B2

    公开(公告)日：2011-01-11

    申请号：US11831605

    申请日：2007-07-31

    申请人： Randel Dorian ,  Michael D. Leach

    发明人： Randel Dorian ,  Michael D. Leach

    IPC分类号： B01D33/067 ,  B01D35/00 ,  B01D24/32 ,  B04B3/00

    CPC分类号： A61M1/3496 ,  A61M1/3482 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  B04B5/0442 ,  B04B2005/0478

    摘要： A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.

    摘要翻译： 公开了一种富血小板血浆分离器组件。 组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。 底板，其具有向下倾斜到中心开口的上表面。 内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。 内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。 圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。

    Methods and apparatus for isolating platelets from blood
    5.
    发明授权
    Methods and apparatus for isolating platelets from blood 有权
    从血液中分离血小板的方法和装置

    公开(公告)号：US07837884B2

    公开(公告)日：2010-11-23

    申请号：US12344895

    申请日：2008-12-29

    申请人： Randel Dorian ,  Scott R. King ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Scott R. King ,  Richard Wood Storrs

    IPC分类号： C02F1/38 ,  B04B1/04 ,  B04B1/06 ,  B04B3/02 ,  B04B1/00

    CPC分类号： A61M1/3693 ,  A61K35/00 ,  A61M2202/0427 ,  B01D21/0012 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2200/026 ,  B01L2400/0633 ,  G01N33/49 ,  Y10T436/25375

    摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

    摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。

    Method and apparatus for preparing platelet rich plasma and concentrates thereof
    6.
    发明授权
    Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权
    制备富血小板血浆及其浓缩物的方法和装置

    公开(公告)号：US07708152B2

    公开(公告)日：2010-05-04

    申请号：US11342761

    申请日：2006-01-30

    申请人： Randel Dorian ,  Michael D. Leach

    发明人： Randel Dorian ,  Michael D. Leach

    IPC分类号： B01D21/26 ,  B04B7/08

    CPC分类号： B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

    摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

    摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。

    Method and apparatus for preparing platelet rich plasma and concentrates thereof
    8.
    发明申请
    Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权
    制备富血小板血浆及其浓缩物的方法和装置

    公开(公告)号：US20060175242A1

    公开(公告)日：2006-08-10

    申请号：US11342761

    申请日：2006-01-30

    申请人： Randel Dorian ,  Michael Leach

    发明人： Randel Dorian ,  Michael Leach

    IPC分类号： B01D63/00

    CPC分类号： B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

    摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

    摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。

    Plasma concentrate apparatus and method
    9.
    发明授权
    Plasma concentrate apparatus and method 有权
    等离子体浓缩装置及方法

    公开(公告)号：US06905612B2

    公开(公告)日：2005-06-14

    申请号：US10394828

    申请日：2003-03-21

    申请人： Randel Dorian ,  Richard Wood Storrs

    发明人： Randel Dorian ,  Richard Wood Storrs

    IPC分类号： B01D15/02 ,  B01L3/00 ,  G01N1/40 ,  G01N33/483 ,  B01D37/00 ,  B01D24/00 ,  B01D29/00

    CPC分类号： B01J20/28047 ,  B01D15/02 ,  B01J2220/64 ,  B01J2220/68 ,  B01L3/5635 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N1/40 ,  G01N1/405 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A plasma concentrator for producing plasma concentrate from a plasma from which erythrocytes have been substantially removed. The device comprises a concentrating chamber having an inlet port and an concentrate outlet, the concentrating chamber containing hydrogel beads and at least one inert agitator; and a concentrate chamber having an inlet communicating with the concentrator outlet through a filter, and having an plasma concentrate outlet port. A process for producing plasma concentrate from plasma from which erythrocytes have been substantially removed, comprising the steps of a) moving the plasma into a concentrating chamber containing hydrogel beads and an agitator to form a hydrogel bead-plasma mixture; b) causing the agitator to stir the hydrogel bead-plasma mixture, facilitating absorption of water by the beads from the plasma, until a hydrogel bead-plasma concentrate is formed; and c) separating the plasma concentrate from the hydrogel beads by passing the plasma concentrate through a filter. The concentrator can be one or more syringe devices coupled for multiple concentrations.

    摘要翻译： 用于从已经基本上除去红细胞的血浆中产生血浆浓缩物的血浆浓缩器。 该装置包括具有入口和浓缩物出口的浓缩室，该浓缩室含有水凝胶珠和至少一种惰性搅拌器; 以及浓缩物室，其具有通过过滤器与浓缩器出口连通并具有等离子体浓缩物出口的入口。 一种用于从已经基本上除去红细胞的血浆中产生血浆浓缩物的方法，包括以下步骤：a）将血浆移动到含有水凝胶珠和搅拌器的浓缩室中以形成水凝胶珠 - 等离子体混合物; b）使搅拌器搅拌水凝胶珠 - 等离子体混合物，促进珠粒从等离子体吸收水分，直到形成水凝胶珠 - 浆料浓缩物; 和c）通过使血浆浓缩物通过过滤器将血浆浓缩物与水凝胶珠分离。 浓缩器可以是连接多个浓度的一个或多个注射器装置。