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1.Salts and polymorphs of 9-(2,2-dimethylpropyl-aminomethyl) minocycline 有权
标题翻译: 9-(2,2-二甲基丙基氨基甲基)米诺环素的盐和多晶型物公开(公告)号:US08383610B2
公开(公告)日:2013-02-26
申请号:US12471758
申请日:2009-05-26
申请人: Raymond Cvetovich , Tadeusz Warchol
发明人: Raymond Cvetovich , Tadeusz Warchol
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: A61K31/65 , C07B2200/13 , C07C231/12 , C07C237/26 , C07C303/32 , C07C309/30 , C07C2603/46
摘要: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
摘要翻译: 本文提供了可用于治疗四环素化合物反应状态的化合物的结晶形式,包括盐和多晶型物。 结晶化合物可用于治疗或预防条件和病症,例如细菌感染和肿瘤,以及其他已知的四环素化合物的应用。
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公开(公告)号:US20100113399A1
公开(公告)日:2010-05-06
申请号:US12471758
申请日:2009-05-26
申请人: Raymond Cvetovich , Tadeusz Warchol
发明人: Raymond Cvetovich , Tadeusz Warchol
IPC分类号: A61K31/65 , C07C233/64
CPC分类号: A61K31/65 , C07B2200/13 , C07C231/12 , C07C237/26 , C07C303/32 , C07C309/30 , C07C2603/46
摘要: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
摘要翻译: 本文提供了可用于治疗四环素化合物反应状态的化合物的结晶形式,包括盐和多晶型物。 结晶化合物可用于治疗或预防条件和病症,例如细菌感染和肿瘤,以及其他已知的四环素化合物的应用。
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公开(公告)号:US20120283201A1
公开(公告)日:2012-11-08
申请号:US13547870
申请日:2012-07-12
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , C07C275/40 , C07C271/30 , C07D307/81 , C07D333/24 , C07D317/60 , C07F9/40 , A61K31/662 , C07C311/21 , C07C255/60 , C07F7/10 , A61K31/695 , C07D295/155 , C07C275/54 , C07C335/20 , C07C311/05 , C07D213/56 , C07C279/18 , C07H15/203 , A61K31/7034 , A61P31/04 , A61P35/00 , C07D213/64 , C07C237/26
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US20090156842A1
公开(公告)日:2009-06-18
申请号:US12217709
申请日:2008-07-07
申请人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
发明人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
IPC分类号: C07C237/26
CPC分类号: C07C231/12 , C07C2603/44 , C07C237/26
摘要: Methods of synthesizing substituted tetracycline compounds are provided.
摘要翻译: 提供了合成取代四环素化合物的方法。
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5.
公开(公告)号:US07405235B2
公开(公告)日:2008-07-29
申请号:US10700661
申请日:2003-11-03
申请人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号: A61K31/415 , C07D235/00
CPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法,以及其药物制剂,例如降低抗生素抗性和抑制生物膜。
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公开(公告)号:US06384032B1
公开(公告)日:2002-05-07
申请号:US09594362
申请日:2000-06-15
申请人: Mitsunori Ono , Yumiko Wada , Beatrice Brunkhorst , Tadeusz Warchol , Wojciech Wrona , Dan Zhou , Nha Huu Vo , Stephen Gillies
发明人: Mitsunori Ono , Yumiko Wada , Beatrice Brunkhorst , Tadeusz Warchol , Wojciech Wrona , Dan Zhou , Nha Huu Vo , Stephen Gillies
IPC分类号: C07D25146
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12
摘要: The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).
摘要翻译: 本发明涉及可抑制IL-12产生的式(I)化合物。 还公开了通过向有需要的患者施用有效量的式(I)化合物来抑制IL-12产生的方法。
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公开(公告)号:US07595309B2
公开(公告)日:2009-09-29
申请号:US10853635
申请日:2004-05-24
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号: A61K31/65 , C07C43/00 , C07D221/18
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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8.Methods for Synthesizing and Purifying Aminoalkyl Tetracycline Compounds 有权
标题翻译: 合成和纯化氨基烷基四环素化合物的方法公开(公告)号:US20080287401A1
公开(公告)日:2008-11-20
申请号:US12110627
申请日:2008-04-28
申请人: Sean Johnston , Tadeusz Warchol
发明人: Sean Johnston , Tadeusz Warchol
IPC分类号: A61K31/65 , C07C237/26 , A61P31/00
CPC分类号: C07C231/12 , C07C231/24 , C07C2603/46 , C07C237/26
摘要: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
摘要翻译: 描述了9-氨基烷基四环素化合物的合成和纯化方法。
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公开(公告)号:US09522872B2
公开(公告)日:2016-12-20
申请号:US12217709
申请日:2008-07-07
申请人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
发明人: Farzaneh Seyedi , Tadeusz Warchol , Mark Grier
IPC分类号: C07C237/12 , C07C231/12
CPC分类号: C07C231/12 , C07C2603/44 , C07C237/26
摘要: Methods of synthesizing substituted tetracycline compounds are provided.
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公开(公告)号:US09434680B2
公开(公告)日:2016-09-06
申请号:US12110627
申请日:2008-04-28
申请人: Sean Johnston , Tadeusz Warchol
发明人: Sean Johnston , Tadeusz Warchol
IPC分类号: C07C231/24 , C07C231/12
CPC分类号: C07C231/12 , C07C231/24 , C07C2603/46 , C07C237/26
摘要: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
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