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公开(公告)号：USD499035S1
公开(公告)日：2004-11-30
申请号：US29180894
申请日：2003-05-01
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2.发明授权Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrate 有权N端规则泛素化的底物和测量这些底物的泛素化的方法公开(公告)号：US08530408B2
公开(公告)日：2013-09-10
申请号：US12606787
申请日：2009-10-27
申请人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
发明人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
IPC分类号： C07K14/00
CPC分类号： G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
摘要翻译： 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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3.发明申请SUBSTRATES OF N-END RULE UBIQUITYLATION AND METHODS FOR MEASURING THE UBIQUITYLATION OF THESE SUBSTRATE 有权用于测量这些基板的非均匀性的N端规则UBIQUITYLATION的基板和方法公开(公告)号：US20100048485A1
公开(公告)日：2010-02-25
申请号：US12606787
申请日：2009-10-27
申请人： Ilia DAVYDOV , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
发明人： Ilia DAVYDOV , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
IPC分类号： A61K38/16 , C07K14/00 , C12Q1/37 , C40B30/04 , G01N33/53 , C12P21/00 , C12N15/00 , A61P43/00
CPC分类号： G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
摘要翻译： 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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4.发明授权Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates 有权N端规则泛素化的底物和测量这些底物的泛素化的方法公开(公告)号：US07608682B2
公开(公告)日：2009-10-27
申请号：US10693999
申请日：2003-10-28
申请人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
发明人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
CPC分类号： G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
摘要翻译： 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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公开(公告)号：US07553448B2
公开(公告)日：2009-06-30
申请号：US10600164
申请日：2003-06-19
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译： 一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。 电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。 电极可以用作电化学发光单元中的对电极和/或作为工作电极。 电池优选包括反电极和附接到对电极的支撑体。 支撑件包括与工作电极对准的透明部分。 对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。 场延伸元件优选地是梯子或栅格。
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公开(公告)号：US20090246076A1
公开(公告)日：2009-10-01
申请号：US12477063
申请日：2009-06-02
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译： 一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。 电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。 电极可以用作电化学发光单元中的对电极和/或作为工作电极。 电池优选包括反电极和附接到对电极的支撑体。 支撑件包括与工作电极对准的透明部分。 对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。 场延伸元件优选地是梯子或栅格。
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公开(公告)号：US20090001049A1
公开(公告)日：2009-01-01
申请号：US12187070
申请日：2008-08-06
申请人： George M. Whitesides , Younan Xia , James L. Wilbur , Rebecca J. Jackman , Enoch Kim , Mara G. Prentiss , Milan Mrksich , Amit Kumar , Christopher B. Gorman , Hans Biebuyck , Karl K. Berggren
发明人： George M. Whitesides , Younan Xia , James L. Wilbur , Rebecca J. Jackman , Enoch Kim , Mara G. Prentiss , Milan Mrksich , Amit Kumar , Christopher B. Gorman , Hans Biebuyck , Karl K. Berggren
IPC分类号： C03C15/00
CPC分类号： B01L3/5085 , B01J2219/00382 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01L3/5088 , B01L2300/0654 , B01L2300/0819 , B01L2300/0851 , B05D1/283 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C40B60/14 , G02B5/1857 , G02B6/124 , G02B6/136 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G03F7/0002 , G03F7/165 , H01L21/4867 , H01L21/768
摘要： Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface.
摘要翻译： 提供了在表面和衍生物品上形成图案化自组装单层的改进方法。 根据一种方法，弹性印模在使用印模期间和/或之前变形，以在表面上印刷自组装分子单层。 根据另一种方法，在单层印刷过程中，表面与与分子单层形成物质不混溶的液体接触，以实现单层在表面上的受控的反应性扩散。 提供了在非平面表面和衍生物上印刷自组装分子单层的方法，以及用自组装单层蚀刻表面的方法，包括蚀刻硅的方法。 提供包括柔性衍射光栅，反射镜和透镜的光学元件，以及用于使用光刻成型形成光学器件和其它制品的方法。 提供了一种用于控制制品表面上的液体形状的方法，包括将液体施加到表面上的自组装单层，并控制表面的电位。
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公开(公告)号：US20110105354A1
公开(公告)日：2011-05-05
申请号：US12977271
申请日：2010-12-23
申请人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译： 使用具有多个测定域的测定模块进行多重测试测量。 在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：US07858321B2
公开(公告)日：2010-12-28
申请号：US10238391
申请日：2002-09-10
申请人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC分类号： G01N33/53
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译： 使用具有多个测定域的测定模块进行多重测试测量。 在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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10.发明授权Encapsulation of organic light emitting devices using Siloxane or Siloxane derivatives 失效使用硅氧烷或硅氧烷衍生物封装有机发光器件
公开(公告)号：US5895228A
公开(公告)日：1999-04-20
申请号：US821218
申请日：1997-03-20
申请人： Hans Biebuyck , Eliav Haskal
发明人： Hans Biebuyck , Eliav Haskal
CPC分类号： H01L51/5253 , H01L51/524 , H01L51/5243
摘要： An organic light emitting device (10) is provided which is encapsulated by a Siloxane buffer layer (17.1). This Siloxane buffer layer (17.1) is applied to the diode (10) providing for protection against contamination, degradation, oxidation and the like. The Siloxane buffer layer (17.1) carries at least a second encapsulation layer (17.2).
摘要翻译： 提供了由硅氧烷缓冲层（17.1）封装的有机发光器件（10）。 该硅氧烷缓冲层（17.1）被施加到二极管（10），用于防止污染，降解，氧化等。 硅氧烷缓冲层（17.1）携带至少第二封装层（17.2）。
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