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1.Substituted tetronic acids useful for treating HIV and other retroviruses 失效
标题翻译: 用于治疗HIV和其他逆转录病毒的替代的tetronic酸公开(公告)号:US5977169A
公开(公告)日:1999-11-02
申请号:US604937
申请日:1997-07-28
申请人: Robert A. Chrusciel , Linda L. Maggiora , Suvit Thaisrivongs , James M. Tustin , Clark W. Smith , Ruben A. Tommasi , Paul A. Aristoff , Harvey I. Skulnick , W. Jeffrey Howe , Gordon L. Bundy
发明人: Robert A. Chrusciel , Linda L. Maggiora , Suvit Thaisrivongs , James M. Tustin , Clark W. Smith , Ruben A. Tommasi , Paul A. Aristoff , Harvey I. Skulnick , W. Jeffrey Howe , Gordon L. Bundy
IPC分类号: C07D307/33 , A61K31/34 , A61K31/341 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/47 , A61P31/12 , C07D307/60 , C07D307/94 , C07D405/06 , C07D405/12 , C07D417/12 , C07D473/00 , C07D491/10 , C07D491/107 , A61K31/335 , A61K31/505
CPC分类号: C07D405/06 , C07D307/60 , C07D307/94 , C07D405/12 , C07D417/12 , C07D473/00 , C07D491/10
摘要: This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases. The compounds may be used in the attempt to retard the further replication of any retrovirus containing the aspartyl protease enzyme. Compounds are represented by the formula below. ##STR1##
摘要翻译: PCT No.PCT / US94 / 09533 Sec。 371日期1997年7月28日第 102(e)日期1997年7月28日PCT 1994年9月7日PCT PCT。 公开号WO95 / 07901 日期1995年3月23日本发明包括可用于抑制HIV蛋白酶的新型取代的tetronic酸型化合物2,4(3H,5H) - 呋喃二酮。 该化合物可用于治疗患有AIDS或AIDS相关疾病的人。 可以使用这些化合物来试图阻止含有天冬氨酰蛋白酶的任何逆转录病毒的进一步复制。 化合物由下式表示。
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2.Substituted tetronic acids useful for treating HIV and other retroviruses 失效
标题翻译: 用于治疗HIV和其他逆转录病毒的替代的tetronic酸公开(公告)号:US6060600A
公开(公告)日:2000-05-09
申请号:US913463
申请日:1997-09-17
申请人: Robert A. Chruscial , Linda L. Maggiora , Suvit Thaisrivongs , James M. Tustin , Clark W. Smith , Ruben A. Tommasi , Paul A. Aristoff , Harvey I. Skulnick , W. Jeffrey Howe
发明人: Robert A. Chruscial , Linda L. Maggiora , Suvit Thaisrivongs , James M. Tustin , Clark W. Smith , Ruben A. Tommasi , Paul A. Aristoff , Harvey I. Skulnick , W. Jeffrey Howe
IPC分类号: A61K31/365 , A61K31/443 , A61K31/445 , A61P31/12 , A61P31/18 , A61P37/04 , C07D307/60 , C07D307/94 , C07D405/12 , C07D491/10 , C07D491/107 , C07D307/00 , C07D491/02
CPC分类号: C07D405/12 , C07D307/60 , C07D307/94 , C07D491/10
摘要: This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
摘要翻译: PCT No.PCT / US96 / 02680 Sec。 371日期1997年9月17日 102(e)1997年9月17日PCT PCT 1996年3月7日PCT公布。 WO96 / 29333 PCT出版物 日期1996年9月26日本申请公开了用于治疗由逆转录病毒引起的AIDS等疾病的新型tetronic酸。
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公开(公告)号:US06169181A
公开(公告)日:2001-01-02
申请号:US09188998
申请日:1998-11-09
申请人: Karen Rene Romines , Gordon L. Bundy , Theresa M. Schwartz , Ruben A. Tommasi , Joseph W. Strohbach , Steven Ronald Turner , Suvit Thaisrivongs , Paul Adrian Aristoff , Paul D. Johnson , Harvey Irving Skulnick , Louis L. Skaletzky , David John Anderson , Joel Morris , Ronald B. Gammill , George P. Luke
发明人: Karen Rene Romines , Gordon L. Bundy , Theresa M. Schwartz , Ruben A. Tommasi , Joseph W. Strohbach , Steven Ronald Turner , Suvit Thaisrivongs , Paul Adrian Aristoff , Paul D. Johnson , Harvey Irving Skulnick , Louis L. Skaletzky , David John Anderson , Joel Morris , Ronald B. Gammill , George P. Luke
IPC分类号: C07D30777
CPC分类号: C07D405/12 , C07D309/32 , C07D309/38 , C07D311/02 , C07D311/74 , C07D405/14
摘要: The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. wherein R10 and R20 taken together are:
摘要翻译: 本发明涉及式I和II的化合物,其为吡喃-2-酮,5,6-二氢 - 吡喃-2-酮,4-羟基 - 苯并吡喃-2-酮,4-羟基 - 环烷基[b]吡喃 -2-酮及其衍生物,其可用于抑制感染该逆转录病毒的哺乳动物细胞中的逆转录病毒。其中R10和R20一起为:
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公开(公告)号:US5852195A
公开(公告)日:1998-12-22
申请号:US809224
申请日:1996-11-04
申请人: Karen Rene Romines , Gordon L. Bundy , Theresa M. Schwartz , Ruben A. Tommasi , Joseph W. Strohbach , Steven Ronald Turner , Suvit Thaisrivongs , Paul Adrian Aristoff , Paul D. Johnson , Harvey Irving Skulnick , Louis L. Skaletzky , David John Anderson , Joel Morris , Ronald B. Gammill , George P. Luke
发明人: Karen Rene Romines , Gordon L. Bundy , Theresa M. Schwartz , Ruben A. Tommasi , Joseph W. Strohbach , Steven Ronald Turner , Suvit Thaisrivongs , Paul Adrian Aristoff , Paul D. Johnson , Harvey Irving Skulnick , Louis L. Skaletzky , David John Anderson , Joel Morris , Ronald B. Gammill , George P. Luke
IPC分类号: A61K31/365 , A61K31/366 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/47 , A61K31/4709 , A61K31/505 , A61K31/506 , A61K31/54 , A61P31/12 , C07D20060101 , C07D309/32 , C07D309/38 , C07D309/40 , C07D311/02 , C07D311/08 , C07D311/74 , C07D311/94 , C07D401/12 , C07D403/12 , C07D405/00 , C07D405/12 , C07D405/14 , C07D407/00 , C07D409/00 , C07D417/00 , C07D417/12
CPC分类号: C07D405/12 , C07D309/32 , C07D309/38 , C07D311/02 , C07D311/74 , C07D405/14
摘要: The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl�b!pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R.sub.10 and R.sub.20 taken together are formulae (III) and (IV). ##STR1##
摘要翻译: PCT No.PCT / US95 / 05219 Sec。 371日期:1996年11月4日 102(e)日期1996年11月4日PCT提交1995年5月4日PCT公布。 公开号WO95 / 30670 PCT 日期:1月16日,1995本发明涉及式(I)和(II)的化合物,其为吡喃-2-酮,5,6-二氢 - 吡喃-2-酮,4-羟基 - 苯并吡喃-2-酮, 可用于抑制感染所述逆转录病毒的哺乳动物细胞中的逆转录病毒的4-羟基 - 环烷基[b]吡喃-2-酮及其衍生物,其中R 10和R 20一起为式(III)和(IV)。 (一)图像(二)<图像>(三)<图像>(四)
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公开(公告)号:US06624159B2
公开(公告)日:2003-09-23
申请号:US09887578
申请日:2001-06-22
申请人: David John Anderson , Gordon L. Bundy , Fred L. Ciske , David R. Graber , Michael J. Genin , Thomas M. Judge , Malcolm Wilson Moon , Mark E. Schnute , Joseph Walter Strohbach , Suvit Thaisrivongs , Atli Thorarensen , Steven Ronald Turner , Valerie A. Vaillancourt , Allison J. Wolf
发明人: David John Anderson , Gordon L. Bundy , Fred L. Ciske , David R. Graber , Michael J. Genin , Thomas M. Judge , Malcolm Wilson Moon , Mark E. Schnute , Joseph Walter Strohbach , Suvit Thaisrivongs , Atli Thorarensen , Steven Ronald Turner , Valerie A. Vaillancourt , Allison J. Wolf
IPC分类号: C07D47106
CPC分类号: C07D471/06
摘要: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6.4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl�b!pyran-2-ones useful to treat retroviral infections 失效
标题翻译: 可用于治疗逆转录病毒感染的4-羟基 - 苯并吡喃-2-酮和4-羟基 - 环烷基[b]吡喃-2-酮公开(公告)号:US5686486A
公开(公告)日:1997-11-11
申请号:US492068
申请日:1995-08-04
申请人: Paul Kosta Tomich , Michael John Bohanon , Steven Ronald Turner , Joseph Walter Strohbach , Suvit Thaisrivongs , Richard C. Thomas , Karen Rene Romines , Chih-Ping Yang , Paul Adrian Aristoff , Harvey Irving Skulnick , Paul D. Johnson , Ronald B. Gammill , Qingwei Zhang , Gordon L. Bundy , David John Anderson , Lee S. Banitt
发明人: Paul Kosta Tomich , Michael John Bohanon , Steven Ronald Turner , Joseph Walter Strohbach , Suvit Thaisrivongs , Richard C. Thomas , Karen Rene Romines , Chih-Ping Yang , Paul Adrian Aristoff , Harvey Irving Skulnick , Paul D. Johnson , Ronald B. Gammill , Qingwei Zhang , Gordon L. Bundy , David John Anderson , Lee S. Banitt
IPC分类号: C07D311/46 , A61K31/352 , A61K31/365 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4433 , A61K31/453 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P31/12 , A61P31/18 , A61P43/00 , C07D311/54 , C07D311/56 , C07D311/74 , C07D311/92 , C07D311/94 , C07D405/04 , C07D405/12 , C07D407/06 , C07D407/08 , C07D409/06 , C07D409/08 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , A61K31/35 , C07D311/20
CPC分类号: C07D405/04 , C07D311/56 , C07D311/74 , C07D311/94 , C07D405/12 , C07D407/06 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/582
摘要: The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl�b!pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. ##STR1## Wherein R.sub.10 and R.sub.20 taken together are: ##STR2##
摘要翻译: PCT No.PCT / US94 / 00938 Sec。 371日期:1995年8月4日 102(e)日期1995年8月4日PCT 1994年2月3日PCT PCT。 WO94 / 18188 PCT出版物 日期:1994年8月18日本发明涉及可用于抑制哺乳动物细胞感染的逆转录病毒的4-羟基 - 苯并吡喃-2-酮和4-羟基 - 环烷基[b]吡喃-2-酮的式I化合物 表示逆转录病毒。 其中R10和R20组合在一起:
II III -
公开(公告)号:US06310211B1
公开(公告)日:2001-10-30
申请号:US08924683
申请日:1997-09-05
申请人: Valerie Ann Vaillancourt , Karen Rene Romines , Arthur Glenn Romero , John Alan Tucker , Joseph Walter Strohbach , Olivier Bezencon , Suvit Thaisrivongs
发明人: Valerie Ann Vaillancourt , Karen Rene Romines , Arthur Glenn Romero , John Alan Tucker , Joseph Walter Strohbach , Olivier Bezencon , Suvit Thaisrivongs
IPC分类号: C07D40112
CPC分类号: C07D401/12 , C07D215/36 , C07D215/48 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14 , C07F7/1804
摘要: The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula IA These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).
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8.
公开(公告)号:US6093732A
公开(公告)日:2000-07-25
申请号:US203259
申请日:1998-12-01
申请人: John Alan Tucker , Valerie A. Vaillancourt , Joseph Walter Strohbach , Karen Rene Romines , Mark E. Schnute , Michele M. Cudahy , Suvit Thaisrivongs , Steven Ronald Turner
发明人: John Alan Tucker , Valerie A. Vaillancourt , Joseph Walter Strohbach , Karen Rene Romines , Mark E. Schnute , Michele M. Cudahy , Suvit Thaisrivongs , Steven Ronald Turner
IPC分类号: A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4738 , A61K31/4745 , A61P31/12 , A61P31/22 , C07D215/56 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/056 , C07D513/04 , C07F7/10 , C07F9/60 , C07D215/00
CPC分类号: C07F9/60 , C07D215/56 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D487/04 , C07D513/04
摘要: The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I ##STR1## These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.
摘要翻译: 本发明提供式I的4-羟基喹啉-3-甲酰胺和酰肼化合物。这些化合物可用于治疗或预防疱疹病毒感染,特别是人巨细胞病毒感染。
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公开(公告)号:US06500842B1
公开(公告)日:2002-12-31
申请号:US10014780
申请日:2001-10-23
IPC分类号: A61K3147
CPC分类号: C07D401/12 , C07D215/36 , C07D215/48 , C07D405/06 , C07D405/12 , C07D417/12 , C07D417/14 , C07F7/1804
摘要: The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula IA These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).
摘要翻译: 本发明提供8-羟基-7-取代的喹啉化合物,例如式IAT。这些化合物可用作抗病毒剂。 具体地说,这些化合物对疱疹病毒,巨细胞病毒(CMV)具有抗病毒活性。 许多这些化合物还对其他疱疹病毒,如水痘带状疱疹病毒,爱泼斯坦 - 巴尔病毒,单纯疱疹病毒和8型人疱疹病毒(HHV-8)也有活性。
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10.Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert 失效
标题翻译: 具有γ-内酰胺假二肽插入物的新型肾素抑制肽公开(公告)号:US4705846A
公开(公告)日:1987-11-10
申请号:US844716
申请日:1986-03-27
申请人: Suvit Thaisrivongs
发明人: Suvit Thaisrivongs
IPC分类号: C12N9/99 , A61K31/44 , A61K31/4427 , A61K38/00 , A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , C07D401/00 , C07D401/12 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08 , C07K14/81 , C07K5/10 , C07K7/06
CPC分类号: C07D401/12 , C07K5/0227 , C07K5/06139 , A61K38/00 , Y10S530/86
摘要: The present invention provides novel renin-inhibiting peptides of the formula X-A.sub.6 -B.sub.7 -C.sub.8 -D.sub.9 -E.sub.10 -F.sub.11 -G.sub.12 -H.sub.13 -I.sub.14 -Z, having a lactam pseudo-dipeptide at C.sub.8 -D.sub.9 positions, X and Z are terminal groups, and the remaining variables are absent or are amino acid residues. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension.
摘要翻译: 本发明提供了在C8-D9位具有内酰胺假二肽的X-A6-B7-C8-D9-E10-F11-G12-H13-I14-Z的新的肾素抑制肽,X和Z是 末端基团,其余的变量不存在或是氨基酸残基。 这种抑制剂可用于诊断和控制肾素依赖性高血压。
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