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公开(公告)号：US20080248566A1
公开(公告)日：2008-10-09
申请号：US12040467
申请日：2008-02-29
CPC分类号： A61K49/0039 , A61K38/00 , A61K49/0056 , A61K49/0058 , A61K51/10 , C12Q1/37 , G01N33/573 , G01N2333/96433 , G01N2500/20
摘要： The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.
摘要翻译： 本发明涉及通过检测组织中单链或双链形式的matriptase的存在来检测乳腺或其他组织或病理状况中的恶性肿瘤或恶性前病变的方法。 本发明进一步涉及通过施用抑制有效量的Bowman-Birk抑制剂（BBIC）浓缩物或其它片剂酶抑制剂的肿瘤形成来治疗恶性肿瘤的方法，所述恶性肿瘤具有基质酶产生的表型。 本发明还涉及编码matriptase蛋白质或其片段的核酸，以及其用于结构阐明和建模以鉴定其它抑制剂的用途，以及鉴定片段酶调节剂（包括活化剂和抑制剂）的方法。
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公开(公告)号：US07960163B2
公开(公告)日：2011-06-14
申请号：US12040467
申请日：2008-02-29
CPC分类号： A61K49/0039 , A61K38/00 , A61K49/0056 , A61K49/0058 , A61K51/10 , C12Q1/37 , G01N33/573 , G01N2333/96433 , G01N2500/20
摘要： The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.
摘要翻译： 本发明涉及通过检测组织中单链或双链形式的matriptase的存在来检测乳腺或其他组织或病理状况中的恶性肿瘤或恶性前病变的方法。 本发明进一步涉及通过施用抑制有效量的Bowman-Birk抑制剂（BBIC）浓缩物或其它片剂酶抑制剂的肿瘤形成来治疗恶性肿瘤的方法，所述恶性肿瘤具有基质酶产生的表型。 本发明还涉及编码matriptase蛋白质或其片段的核酸，以及其用于结构阐明和建模以鉴定其它抑制剂的用途，以及鉴定片段酶调节剂（包括活化剂和抑制剂）的方法。
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公开(公告)号：US07355015B1
公开(公告)日：2008-04-08
申请号：US09936333
申请日：2000-03-10
CPC分类号： A61K49/0039 , A61K38/00 , A61K49/0056 , A61K49/0058 , A61K51/10 , C12Q1/37 , G01N33/573 , G01N2333/96433 , G01N2500/20
摘要： The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.
摘要翻译： 本发明涉及通过检测组织中单链或双链形式的matriptase的存在来检测乳腺或其他组织或病理状况中的恶性肿瘤或恶性前病变的方法。 本发明进一步涉及通过施用抑制有效量的Bowman-Birk抑制剂（BBIC）浓缩物或其它片剂酶抑制剂的肿瘤形成来治疗恶性肿瘤的方法，所述恶性肿瘤具有基质酶产生的表型。 本发明还涉及编码matriptase蛋白质或其片段的核酸，以及其用于结构阐明和建模以鉴定其它抑制剂的用途，以及鉴定片段酶调节剂（包括活化剂和抑制剂）的方法。
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公开(公告)号：US10900311B2
公开(公告)日：2021-01-26
申请号：US16046823
申请日：2018-07-26
申请人： YingQing Xu , Michael Johnson , Matthew Stone , Colin Andrew , Zhiyue Xu
发明人： YingQing Xu , Michael Johnson , Matthew Stone , Colin Andrew , Zhiyue Xu
摘要： An object removal enhancement arrangement including a second object comprising a material configured to enhance degradation of a first object. A resource recovery system including a tubular string disposed in a formation, a first seat disposed in the tubular string, a second seat disposed in the tubular string, an object receivable in the second seat upstream of the first seat, the object comprising a material to enhance degradation of an object receivable in the first seat. A method for enhancing response time for degrading degradable objects in a system including landing a first object on a first seat, pressuring against the first object, landing a second object on a second seat uphole of the first object, releasing a material of the second object to an environment between the first seat and the second seat.
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公开(公告)号：US10851619B2
公开(公告)日：2020-12-01
申请号：US15998426
申请日：2018-08-15
申请人： Matthew C. Stone , Colin Andrew , Omar Balcazar , Partha Ganguly , Michael Johnson , Alexander Kendall , Daniel Sequera
发明人： Matthew C. Stone , Colin Andrew , Omar Balcazar , Partha Ganguly , Michael Johnson , Alexander Kendall , Daniel Sequera
摘要： A production system and a frac sleeve assembly of a frac assembly of the production system. The frac sleeve assembly includes a funnel section that reduces in diameter in a direction of an outlet of the frac assembly, a throat section having a selected diameter, and a ball seat at an intersection of the funnel section and the throat section for receiving a ball. When seated in the ball seat, an entire portion of a ball extending into the funnel section is exposed to disintegrating fluid in the funnel section.
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公开(公告)号：US20200281349A1
公开(公告)日：2020-09-10
申请号：US16058975
申请日：2018-08-08
摘要： A height adjustable work surface is described that may be utilized as a standalone desk or table, or integrated with a larger work surface to provide selective height adjustability to only a portion of a work surface. The height adjustable work surface preferably utilizes a modular trapezoidal frame structure, including trapezoid tube weldments, corner castings and machined hardened connector pins. The lift mechanism preferably includes parallelogram linkages, pneumatic gas cylinders, sliding brake bar mechanism and brake release handles to provide height adjustment functionality.
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公开(公告)号：US09366106B2
公开(公告)日：2016-06-14
申请号：US14158055
申请日：2014-01-17
申请人： Zhiyue Xu , Michael Johnson
发明人： Zhiyue Xu , Michael Johnson
CPC分类号： B22F7/04 , B05D7/14 , B22F5/00 , B22F7/02 , B22F7/06 , B22F2007/045 , B22F2207/00 , B33Y80/00 , E21B17/00 , E21B23/00 , E21B29/00 , E21B33/12 , E21B34/06 , E21B2034/007 , Y10T29/49826
摘要： A method of making a composite downhole article is disclosed. The method include forming at least one removable core member comprising a first metallic material that is removable in a wellbore fluid at a first removal rate; and disposing at least one outer member on the core member, the outer member comprising a second material that is removable in the wellbore fluid at a second removal rate, wherein the removable core member has a composition gradient or a density gradient, or a combination thereof, and wherein the first removal rate is substantially greater than the second removal rate. A method of using a composite downhole article is also disclosed. The method includes forming a composite downhole article as described above; using the article to perform a first wellbore operation; exposing the article to the wellbore fluid; and selectively removing the second removable member.
摘要翻译： 公开了制备复合井下制品的方法。 该方法包括形成至少一个可拆卸的芯构件，其包括以第一移除速率在井眼流体中可移除的第一金属材料; 并且在所述芯构件上设置至少一个外部构件，所述外部构件包括第二材料，所述第二材料可以第二移除速率在所述井眼流体中移除，其中所述可移除芯构件具有组成梯度或密度梯度，或其组合 ，并且其中所述第一去除速率基本上大于所述第二去除速率。 还公开了一种使用复合井下制品的方法。 该方法包括形成如上所述的复合井下制品; 使用该文章执行第一次井眼操作; 将物品暴露于井眼液体; 并且选择性地移除第二可移除构件。
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公开(公告)号：US20150065401A1
公开(公告)日：2015-03-05
申请号：US14538427
申请日：2014-11-11
申请人： Zhiyue Xu , Michael Johnson
发明人： Zhiyue Xu , Michael Johnson
IPC分类号： C09K8/80
CPC分类号： C09K8/805 , E21B41/00 , Y10T428/24942 , Y10T428/24992
摘要： A composite downhole article is disclosed. The article is selectively corrodible in a wellbore fluid. The article includes at least one corrodible core member comprising a metallic first material that is corrodible in a wellbore fluid at a first corrosion rate. The article also includes at least one outer member disposed on the core member and comprising a second material that is corrodible in the wellbore fluid at a second corrosion rate, wherein the corrodible core member has a composition gradient or a density gradient, or a combination thereof, and wherein the first corrosion rate is substantially greater than the second corrosion rate.
摘要翻译： 公开了复合井下制品。 该物品在井眼流体中选择性腐蚀。 该制品包括至少一个可腐蚀的芯构件，其包括以第一腐蚀速率在井眼流体中被腐蚀的金属第一材料。 所述制品还包括设置在所述芯构件上的至少一个外部构件，并且包括在所述井眼流体中以第二腐蚀速率被腐蚀的第二材料，其中所述可腐蚀的芯构件具有组成梯度或密度梯度，或其组合 ，并且其中所述第一腐蚀速率基本上大于所述第二腐蚀速率。
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公开(公告)号：US20140370176A1
公开(公告)日：2014-12-18
申请号：US14368009
申请日：2012-12-24
申请人： Mamoru Imura , Michael Johnson
发明人： Mamoru Imura , Michael Johnson
CPC分类号： A47J27/04 , A47J27/08 , A47J36/06 , A47J2027/043
摘要： A cookware object, system and method of cooking are provided. The cookware object includes raised ridges and recessed channels within a base of the object that is designed to hold water (or other liquid), and a lid to retain/promote steam.
摘要翻译： 提供炊具对象，系统和烹饪方法。 炊具物体包括被设计成保持水（或其他液体）的物体的基部内的凸脊和凹槽，以及用于保持/促进蒸汽的盖。
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公开(公告)号：US08789023B2
公开(公告)日：2014-07-22
申请号：US13414263
申请日：2012-03-07
申请人： Michael Lindahl , Andre Yew , Mallory Morgan Green, II , Michael Johnson , Allan Craig Franklin , Daniel O'Dowd , Neil Puthuff
发明人： Michael Lindahl , Andre Yew , Mallory Morgan Green, II , Michael Johnson , Allan Craig Franklin , Daniel O'Dowd , Neil Puthuff
CPC分类号： G06F11/364 , G05B2219/23283 , G06F11/3636
摘要： A method finds an error in a computer program. A plurality of execution breakpoints are set in the computer program. A portion of the execution of the computer program is simulated as recorded in the trace data in the reverse order until one a plurality of conditions is met, wherein one of the plurality of conditions is an attempt to execute a machine instruction associated with one of the plurality of execution breakpoints.
摘要翻译： 一种方法在计算机程序中发现错误。 在计算机程序中设置多个执行断点。 计算机程序的执行的一部分以相反的顺序被记录在跟踪数据中，直到满足多个条件之一为止，其中多个条件之一是尝试执行与其中一个条件相关联的机器指令 多个执行断点。
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