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    Redoxindicators
    1.
    发明授权
    Redoxindicators 有权

    公开(公告)号：US10060907B2

    公开(公告)日：2018-08-28

    申请号：US15438859

    申请日：2015-08-21

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Peter Gebauer ,  Dieter Heindl ,  Carina Horn ,  Maksim Fomin

    IPC: G01N33/52 ,  G01N33/50 ,  C07D241/42 ,  C07D403/06

    CPC classification number: G01N33/52 ,  C07D241/40 ,  C07D241/42 ,  C07D401/06 ,  C07D403/06 ,  G01N33/5005

    Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine-isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.

    METHOD AND SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID
    2.
    发明申请
    METHOD AND SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID 审中-公开
    检测体液中分析物的方法和系统

    公开(公告)号：US20160091482A1

    公开(公告)日：2016-03-31

    申请号：US14963576

    申请日：2015-12-09

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Klaus Andreas Bauer-Espindola ,  Carina Horn ,  Michael Marquant ,  Christine Nortmeyer ,  Volker Unkrig

    IPC: G01N33/49 ,  G01N21/78 ,  G01N27/12 ,  G01N21/64

    CPC classification number: G01N33/492 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N27/02 ,  G01N27/12 ,  G01N27/3274 ,  G01N2021/7786

    Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

    Abstract translation: 公开了一种用于检测体液中的至少一种分析物的方法，包括执行光学测量，其中至少一种测试化学品接触体液。 测试化学品是适于执行至少一个检测反应的光学测试化学品，其中由于检测反应而改变至少一种可光学检测的性质以提供至少一种光学测量值。 产生至少一个阻抗测量，其中经由阻抗测量电极将至少一个交流电信号施加到体液，并记录至少一个应答信号，并且产生至少一个阻抗测量值。 执行至少一个评估步骤，其中使用至少一个评估算法，并且使用光学测量值和阻抗测量值来确定体液中分析物的浓度。

    Electrochemical Determination of Factor XA Inhibitors
    3.
    发明申请
    Electrochemical Determination of Factor XA Inhibitors 有权
    电化学测定因子XA抑制剂

    公开(公告)号：US20140106383A1

    公开(公告)日：2014-04-17

    申请号：US14136769

    申请日：2013-12-20

    Applicant: Roche Diagnostics Operations Inc.

    Inventor： Liesel Doerge ,  Margarete Galm ,  Carina Horn

    IPC: G01N27/26

    CPC classification number: G01N27/26 ,  C12Q1/005 ,  C12Q1/56 ,  G01N33/86

    Abstract: Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal.

    Abstract translation: 用于确定因子Xa抑制剂，特别是肝素和分级或低分子量肝素的方法和装置，以及血液样品中的直接因子Xa抑制剂。 所述方法包括使血液样品与含有至少一个凝血酶底物的检测试剂接触，所述凝血酶底物具有可被凝血酶切割的肽残基，并且经由羧基末端与电生物质酰胺结合，并且使用已知量的因子X试剂 和诱导因子X转化成因子Xa的活化剂。 随后，在第二步骤中，通过因子Xa介导的凝血酶活化和/或其时间过程将从凝血酶底物切割的电生物质的量或活性确定为使用电化学方法的测量信号。 在第三步骤中，基于该测量信号确定要分析的血液样品中的因子Xa抑制剂的量或与其相关的测量量，特别是与其相关的凝血时间。

    ANALYSIS SYSTEM HAVING A MEASUREMENT DEVICE AND TEST ELEMENT
    4.
    发明申请
    ANALYSIS SYSTEM HAVING A MEASUREMENT DEVICE AND TEST ELEMENT 审中-公开
    具有测量设备和测试单元的分析系统

    公开(公告)号：US20140041443A1

    公开(公告)日：2014-02-13

    申请号：US14038805

    申请日：2013-09-27

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Heino Eikmeier ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn ,  Ewald Rieger

    IPC: G01N33/49

    CPC classification number: G01N33/49 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1468 ,  A61B2560/04 ,  A61B2560/0406 ,  A61B2560/0418 ,  A61B2560/0425

    Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

    Abstract translation: 本文公开了用于确定体液的至少一个分析参数的便携式诊断测量装置，特别是用于确定在血糖测定中可能发生的体液中的分析物浓度。 还公开了包括测量装置和至少一个一次性测试元件的分析系统。 测试元件可以被设计为载体带，并且可以至少部分地以平坦的方式接触测量装置的接收表面，其中接收表面布置在测量装置的壳体的窄侧上。

    ENZYMATIC SYNTHESIS OF CARBA-NAD
    7.
    发明申请
    ENZYMATIC SYNTHESIS OF CARBA-NAD 审中-公开
    CARBA-NAD的酶促合成

    公开(公告)号：US20140142291A1

    公开(公告)日：2014-05-22

    申请号：US14045565

    申请日：2013-10-03

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Hartmut Duefel ,  Dieter Heindl ,  Carina Horn ,  Thomas Meier ,  Rainer Schmuck

    IPC: C07H19/207

    CPC classification number: C07H19/207 ,  C12P19/32

    Abstract: The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.

    Abstract translation: 本公开内容涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含 碳环糖代替核糖。

    STABLE NAD/NADH DERIVATIVES
    10.
    发明申请
    STABLE NAD/NADH DERIVATIVES 有权
    稳定的NAD / NADH衍生物

    公开(公告)号：US20140206024A1

    公开(公告)日：2014-07-24

    申请号：US14222645

    申请日：2014-03-23

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Dieter Heindl ,  Joachim Hoenes ,  Carina Horn ,  Claudia Gaessler-Dietsche

    IPC: C12Q1/32

    CPC classification number: C12Q1/32

    Abstract: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

    Abstract translation: 本发明提供式（I）的稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生物化学检测方法和试剂盒中的用途。

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