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公开(公告)号:US09150500B2
公开(公告)日:2015-10-06
申请号:US14180479
申请日:2014-02-14
IPC分类号: A01N37/00 , A61K31/21 , C07C233/56 , C07C271/22 , C07D317/40 , C07C231/02 , C07C243/30 , C07D319/06 , C07D207/263
CPC分类号: A61K31/197 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/24 , A61K31/27 , A61K31/365 , A61K45/06 , C07C231/02 , C07C233/56 , C07C243/26 , C07C243/28 , C07C243/30 , C07C271/22 , C07D207/263 , C07D317/40 , C07D319/06
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及具有下式的化合物:其中R 1 -R 6,a,b和Z如说明书中所定义,或其药学上可接受的盐。 这些化合物具有去血清抑制活性。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US20130245260A1
公开(公告)日:2013-09-19
申请号:US13869174
申请日:2013-04-24
申请人: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
发明人: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号: C07D487/04 , C07D239/36 , C07D249/18 , C07D249/04 , C07D249/10
CPC分类号: C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要: In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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公开(公告)号:US09555041B2
公开(公告)日:2017-01-31
申请号:US14804407
申请日:2015-07-21
申请人: Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
发明人: Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
IPC分类号: A61K31/5377 , A61K31/4155 , A61K31/454 , A61K31/4196 , A61K31/4192 , A61K31/497 , A61K31/505 , A61K31/426 , A61K31/50 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/24 , C07D239/36 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D263/34 , C07D263/38 , C07D277/56 , C07D401/04 , C07D403/04 , C07D403/06 , C07D413/04 , C07D471/04 , C07D239/28 , C07D239/34 , C07D239/52 , C07D401/06 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/437
CPC分类号: C07D471/04 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/14 , C07D237/24 , C07D239/28 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/38 , C07D277/34 , C07D277/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/04 , Y02P20/55
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及具有下式的化合物:其中R 1 -R 6,a,b和X如说明书中所定义,或其药学上可接受的盐。 这些化合物具有去血清抑制活性。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US09334245B2
公开(公告)日:2016-05-10
申请号:US14470072
申请日:2014-08-27
申请人: Melissa Fleury , Roland Gendron , Adam D. Hughes
发明人: Melissa Fleury , Roland Gendron , Adam D. Hughes
IPC分类号: C07D249/04 , C07D249/10 , C07D249/12 , C07D231/20 , C07D471/04 , C07D401/04 , C07D233/90 , C07D249/18 , C07D235/08 , C07D405/14 , C07D403/06 , C07C229/34 , C07C271/22 , C07D231/14 , C07D231/18 , C07D233/70 , C07D237/14 , C07D239/34 , C07D261/12 , C07D263/18 , C07D309/40 , C07D405/12 , C07D319/06 , C07D295/10
CPC分类号: A61K31/675 , A61K31/351 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/50 , A61K31/505 , A61K31/5377 , A61K45/06 , C07B2200/07 , C07C229/34 , C07C271/22 , C07D231/14 , C07D231/18 , C07D231/20 , C07D233/70 , C07D233/90 , C07D235/08 , C07D237/14 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/18 , C07D261/12 , C07D263/18 , C07D295/10 , C07D309/32 , C07D309/40 , C07D319/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07F9/6518
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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公开(公告)号:US20160074352A1
公开(公告)日:2016-03-17
申请号:US14838842
申请日:2015-08-28
IPC分类号: A61K31/197 , A61K31/24 , C07D317/40 , A61K45/06 , C07C271/22 , A61K31/27 , C07C243/28 , C07C233/56 , A61K31/365
CPC分类号: A61K31/197 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/24 , A61K31/27 , A61K31/365 , A61K45/06 , C07C231/02 , C07C233/56 , C07C243/26 , C07C243/28 , C07C243/30 , C07C271/22 , C07D207/263 , C07D317/40 , C07D319/06
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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公开(公告)号:US20150133658A1
公开(公告)日:2015-05-14
申请号:US14460567
申请日:2014-08-15
申请人: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
发明人: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号: C07D471/04 , C07D249/10 , C07D231/14 , C07D261/12 , C07D239/34 , C07D249/04 , C07D249/18
CPC分类号: C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要: In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及具有下式的化合物:其中R1,R2a,R2b,R3-R6,a,b,Z和X如说明书中所定义,或其药学上可接受的盐。 这些化合物具有去血清抑制活性。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US20140046053A1
公开(公告)日:2014-02-13
申请号:US14050733
申请日:2013-10-10
申请人: Roland Gendron , Melissa Fleury , Adam D. Hughes
发明人: Roland Gendron , Melissa Fleury , Adam D. Hughes
IPC分类号: C07D498/08 , C07D403/06 , C07D239/36 , C07D498/04 , C07D249/04 , C07D249/10 , C07D401/04 , C07D413/06 , C07D207/34 , C07D261/18
CPC分类号: C07D498/08 , A61K31/42 , A61K31/422 , A61K31/5377 , A61K45/06 , C07D207/34 , C07D213/79 , C07D213/80 , C07D213/81 , C07D231/14 , C07D233/26 , C07D233/90 , C07D237/04 , C07D237/24 , C07D239/34 , C07D239/36 , C07D241/24 , C07D249/04 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D261/20 , C07D263/34 , C07D263/56 , C07D271/06 , C07D277/46 , C07D277/56 , C07D307/68 , C07D333/40 , C07D333/70 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D413/12 , C07D471/04 , C07D498/04
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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公开(公告)号:US20140011997A1
公开(公告)日:2014-01-09
申请号:US14024974
申请日:2013-09-12
申请人: Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
发明人: Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
IPC分类号: C07D231/14 , C07D401/06 , C07D261/18 , C07D249/10 , C07D249/04 , C07D471/04 , C07D249/18 , C07D249/12 , C07D257/04 , C07D263/34 , C07D239/52 , C07D239/28 , C07D239/34 , C07D263/38 , C07D277/56 , C07D413/04 , C07D237/24 , C07D403/06
CPC分类号: C07D471/04 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/14 , C07D237/24 , C07D239/28 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/38 , C07D277/34 , C07D277/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/04 , Y02P20/55
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及具有下式的化合物:其中R 1 -R 6,a,b和X如说明书中所定义,或其药学上可接受的盐。 这些化合物具有去血清抑制活性。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US20120213807A1
公开(公告)日:2012-08-23
申请号:US13398027
申请日:2012-02-16
申请人: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
发明人: Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号: A61K39/00 , C07D413/06 , C07D401/06 , C07D249/18 , C07D471/04 , C07D261/18 , C07D239/36 , A61K31/4192 , A61K31/4196 , A61K31/415 , A61K31/5377 , A61K31/454 , C07D249/10 , A61K31/437 , A61K31/42 , A61K31/505 , A61K31/56 , A61K31/7048 , A61P7/02 , A61P3/10 , A61P27/06 , C07D249/12 , A61P29/00 , A61P25/24 , A61P9/04 , A61P9/02 , A61P9/10 , C07D231/20 , C07D231/14 , C07D403/06 , A61K31/4155 , C07D403/04 , A61K31/497 , A61K38/22 , C07D319/06 , C07C271/22 , C07D249/04
CPC分类号: C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要: In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及具有下式的化合物:其中R1,R2a,R2b,R3-R6,a,b,Z和X如说明书中所定义,或其药学上可接受的盐。 这些化合物具有去血清抑制活性。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US09682052B2
公开(公告)日:2017-06-20
申请号:US14838842
申请日:2015-08-28
IPC分类号: A01N37/00 , A61K31/21 , A61K31/197 , C07C271/22 , C07D317/40 , C07C231/02 , C07C233/56 , C07C243/30 , C07D319/06 , C07D207/263 , A61K31/24 , A61K31/27 , A61K31/365 , A61K45/06 , C07C243/28 , C07C243/26 , A61K31/167 , A61K31/165 , A61K31/16 , A61K31/166 , A61K31/164
CPC分类号: A61K31/197 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/24 , A61K31/27 , A61K31/365 , A61K45/06 , C07C231/02 , C07C233/56 , C07C243/26 , C07C243/28 , C07C243/30 , C07C271/22 , C07D207/263 , C07D317/40 , C07D319/06
摘要: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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