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    BATTERY COOLING STRUCTURE
    1.
    发明申请
    BATTERY COOLING STRUCTURE 有权
    电池冷却结构

    公开(公告)号：US20130266840A1

    公开(公告)日：2013-10-10

    申请号：US13883157

    申请日：2011-10-13

    申请人： Ryo Fujii ,  Koichi Yamamoto ,  Goichi Katayama

    发明人： Ryo Fujii ,  Koichi Yamamoto ,  Goichi Katayama

    IPC分类号： H01M10/50

    CPC分类号： H01M10/60 ,  H01M2/1077 ,  H01M10/613 ,  H01M10/625 ,  H01M10/647 ,  H01M10/6563

    摘要： A battery cooling structure is provided in which since a battery support member (43) that is disposed above a lower layer battery group (B4, B5) and supports an upper layer battery group (B6) on its upper face is formed so as to be hollow, and the upper layer battery group (B6) is cooled by a cooling medium that flows in an interior of the battery support member (43), due to the battery support member (43) having the dual function of supporting the upper layer battery group (B6) and cooling the upper layer battery group (B6), it is possible to cut the number of components and simplify the structure. Moreover, since the cooling medium flows in the interior of the battery support member (43) and does not come into direct contact with the upper layer battery group (B6), the upper layer battery group (B6) is not contaminated by the cooling medium.

    摘要翻译： 提供了一种电池冷却结构，其中，由于在其上表面上设置设置在下层电池组（B4，B5）上方并且支撑上层电池组（B6）的电池支撑部件（43） 由于具有支撑上层电池的双重功能的电池支撑构件（43），上层电池组（B6）被流过电池支撑构件（43）的内部的冷却介质冷却， 组（B6）并冷却上层电池组（B6），可以减少部件数量并简化结构。 此外，由于冷却介质在电池支撑部件（43）的内部流动，不与上层电池组（B6）直接接触，所以上层电池组（B6）不被冷却介质污染 。

    Battery cooling structure
    2.
    发明授权
    Battery cooling structure 有权
    电池冷却结构

    公开(公告)号：US09287595B2

    公开(公告)日：2016-03-15

    申请号：US13883157

    申请日：2011-10-13

    申请人： Ryo Fujii ,  Koichi Yamamoto ,  Goichi Katayama

    发明人： Ryo Fujii ,  Koichi Yamamoto ,  Goichi Katayama

    IPC分类号： H01M10/50 ,  H01M2/10 ,  H01M10/625 ,  H01M10/60 ,  H01M10/6563 ,  H01M10/647 ,  H01M10/613

    CPC分类号： H01M10/60 ,  H01M2/1077 ,  H01M10/613 ,  H01M10/625 ,  H01M10/647 ,  H01M10/6563

    摘要： A battery cooling structure is provided in which since a battery support member (43) that is disposed above a lower layer battery group (B4, B5) and supports an upper layer battery group (B6) on its upper face is formed so as to be hollow, and the upper layer battery group (B6) is cooled by a cooling medium that flows in an interior of the battery support member (43), due to the battery support member (43) having the dual function of supporting the upper layer battery group (B6) and cooling the upper layer battery group (B6), it is possible to cut the number of components and simplify the structure. Moreover, since the cooling medium flows in the interior of the battery support member (43) and does not come into direct contact with the upper layer battery group (B6), the upper layer battery group (B6) is not contaminated by the cooling medium.

    摘要翻译： 提供了一种电池冷却结构，其中，由于在其上表面上设置设置在下层电池组（B4，B5）上方并且支撑上层电池组（B6）的电池支撑部件（43） 由于具有支撑上层电池的双重功能的电池支撑构件（43），上层电池组（B6）被流过电池支撑构件（43）的内部的冷却介质冷却， 组（B6）并冷却上层电池组（B6），可以减少部件数量并简化结构。 此外，由于冷却介质在电池支撑部件（43）的内部流动，不与上层电池组（B6）直接接触，所以上层电池组（B6）不被冷却介质污染 。

    Polypeptides their production and use
    6.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    Methods of screening for compounds which bind G protein-coupled receptors
    8.
    发明授权
    Methods of screening for compounds which bind G protein-coupled receptors 失效
    筛选结合G蛋白偶联受体的化合物的方法

    公开(公告)号：US07927821B2

    公开(公告)日：2011-04-19

    申请号：US11578325

    申请日：2005-04-11

    申请人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    发明人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： G01N33/76 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/4523 ,  A61K38/1796 ,  C07K14/705 ,  G01N2333/726

    摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.

    摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

    Ligands for G protein-coupled receptor protein and use thereof
    9.
    发明授权
    Ligands for G protein-coupled receptor protein and use thereof 失效
    G蛋白偶联受体蛋白质的配体及其用途

    公开(公告)号：US07833722B2

    公开(公告)日：2010-11-16

    申请号：US11587631

    申请日：2005-04-26

    申请人： Ryo Fujii ,  Masataka Harada ,  Shuji Hinuma

    发明人： Ryo Fujii ,  Masataka Harada ,  Shuji Hinuma

    IPC分类号： G01N33/53

    CPC分类号： C07K14/705 ,  A61K31/7088 ,  A61K38/00 ,  G01N33/6896 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04

    摘要： The present invention provides a method of screening an agonist/antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or its salt and a ligand or its salt; and so on. The screening method of the present invention is useful for screening an agent for the prevention/treatment of nervous system diseases or neuropathic pains.

    摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白激动剂/拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 等等。 本发明的筛选方法可用于筛选用于预防/治疗神经系统疾病或神经性疼痛的药剂。