公开(公告)号：US5736100A

公开(公告)日：1998-04-07

申请号：US531199

申请日：1995-09-19

申请人： Ryo Miyake ,  Koichi Tsuzuki ,  Isao Yamazaki ,  Hideo Enoki ,  Hiroshi Mitsumaki

发明人： Ryo Miyake ,  Koichi Tsuzuki ,  Isao Yamazaki ,  Hideo Enoki ,  Hiroshi Mitsumaki

IPC分类号： B01F11/02 ,  B06B3/00 ,  G01N35/00 ,  G01N35/02 ,  G01N37/00

CPC分类号： B01F11/0283 ,  B06B3/00 ,  G01N35/025 ,  G01N2035/00554 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25

摘要： A chemical analyzer has turn tables respectively carrying reaction vessels, sample containers and reagent containers disposed thereon in circular rows. A sample pipetting mechanism and a reagent pipetting mechanism are provided to transfer predetermined amounts of sample and reagent solution from a sample container and from a reagent container into a reaction vessel. The thus transferred sample and reagent solution are mixed in the reaction vessel by a stirrer comprising a piezoelectric element which is disposed in non-contacting relationship to the sample and reagent solution in the reaction vessel and is electrically energized to generate a sound wave which causes a circulating flow of the reagent solution in the reaction vessel whereby the sample and the reagent solution are mixed in a non-invasive manner.

摘要翻译： 化学分析仪具有分别承载设置在其上的反应容器，样品容器和试剂容器的转台。 提供样品移液机构和试剂吸移机构，以将预定量的样品和试剂溶液从样品容器和试剂容器转移到反应容器中。 将这样转移的样品和试剂溶液通过搅拌器混合在反应容器中，所述搅拌器包括与反应容器中的样品和试剂溶液非接触关系设置的压电元件，并且被电通电以产生声波， 在反应容器中循环流动试剂溶液，由此将样品和试剂溶液以非侵入性的方式混合。

公开(公告)号：US06197255B1

公开(公告)日：2001-03-06

申请号：US09398046

申请日：1999-09-17

申请人： Ryo Miyake ,  Yoshihiro Nagaoka ,  Akira Koide ,  Naruo Watanabe ,  Yasuhiko Sasaki ,  Hajime Kato ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida ,  Takeshi Shibuya ,  Yasuhiro Yoshimura

发明人： Ryo Miyake ,  Yoshihiro Nagaoka ,  Akira Koide ,  Naruo Watanabe ,  Yasuhiko Sasaki ,  Hajime Kato ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida ,  Takeshi Shibuya ,  Yasuhiro Yoshimura

IPC分类号： G01N3502

CPC分类号： G01N35/00663 ,  B01F11/0283 ,  G01N35/025 ,  G01N2035/00673 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A chemical analyzing apparatus comprises a reaction cell holder which holds a plurality of reaction cells that are supplied with samples and reagents at a predetermined position, a measurer for measuring characteristics of the sample, a plurality of reagent containers, a liquid deliverer provided below each of the plurality of reagent containers, one or more sound wave generators provided outside the reaction cells, and storage containers for storing cleansing liquid with different contamination states. The cleansing liquid with different contamination states is reused according to the contamination levels of the reaction cells.

摘要翻译： 化学分析装置包括：反应池保持器，其保持在预定位置处供给样品和试剂的多个反应池，用于测量样品特性的测量器，多个试剂容器，下方设置的液体输送器 多个试剂容器，设置在反应室外的一个或多个声波发生器和用于存储具有不同污染状态的清洁液的储存容器。 具有不同污染状态的清洁液体根据反应池的污染水平重新使用。

公开(公告)号：US06599477B1

公开(公告)日：2003-07-29

申请号：US09136070

申请日：1998-08-19

申请人： Ryo Miyake ,  Akira Koide ,  Takeo Takagi ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

发明人： Ryo Miyake ,  Akira Koide ,  Takeo Takagi ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

IPC分类号： G01N3504

CPC分类号： G01N35/1002 ,  F04B43/043 ,  G01N35/025 ,  G01N35/1016 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A chemically analyzing apparatus includes a plurality of reaction containers, a reaction container holder for holding the plurality of reaction containers and for supplying a sample and reagent at predetermined positions, a plurality of reagent containers for holding reagent adapted to be supplied into the reaction containers, a reagent container holder provided above the reaction container holder, for holding the plurality of reagent containers, a measuring part for measuring physical properties of the sample, a liquid feed mechanism provided in a lower part of each of the plurality of reagent containers, for supplying a predetermined quantity of reagent from each of the reagent container into the associated reaction containers by means of the liquid feed mechanism. With this arrangement, it is possible to provide a chemically analyzing apparatus incorporating a reagent supply mechanism which can prevent reagent from being uselessly consumed, which does not substantially require washing liquid, which does not require periodical disassembly and washing, and which can easily change the feed quantity of reagent.

摘要翻译： 化学分析装置包括多个反应容器，用于保持多个反应容器并用于在预定位置供应样品和试剂的反应容器保持器，用于保持适于供应到反应容器中的试剂的多个试剂容器， 设置在反应容器保持器上方的用于保持多个试剂容器的试剂容器保持器，用于测量样品的物理性质的测量部件，设置在多个试剂容器的每个的下部的液体供给机构，用于供给 通过液体供给机构将来自每个试剂容器的预定量的试剂输送到相关联的反应容器中。 通过这种布置，可以提供一种化学分析装置，其包括试剂供给机构，该试剂供给机构能够防止不需要定期拆卸和洗涤的基本上不需要洗涤液的试剂被无用地消耗，并且可以容易地改变 试剂的供料量。

公开(公告)号：US06193933B1

公开(公告)日：2001-02-27

申请号：US09179090

申请日：1998-10-27

申请人： Yasuhiko Sasaki ,  Ryo Miyake ,  Akira Koide ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida

发明人： Yasuhiko Sasaki ,  Ryo Miyake ,  Akira Koide ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida

IPC分类号： G01N3500

CPC分类号： G01N35/00663 ,  G01N35/1002 ,  G01N2035/00673 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： Heretofore, there has been demanded an automatic analysis apparatus which can prevent cross-contamination between reagents, which can prevent dust and gas from entering a reagent supply device, which can always know a remaining quantity of the reagent while can reduce the quantity of waste. According to the present invention, there is provided an automatic analysis apparatus in which a reagent supply device for supplying a reagent from a reagent container into a reaction container is removably attached to the reagent container, a protective door is provided in the reagent supply port in order to aim at preventing dust from entering the reagent supply device, and further the reagent container and the reagent supply device are provided with recording mediums for recording therein conditions thereof, a time of replacement thereof or the like, and which can inform whether the setting is proper or not.

摘要翻译： 迄今为止，已经要求能够防止试剂之间的交叉污染的自动分析装置，其可以防止灰尘和气体进入试剂供应装置，这可以总是知道试剂的剩余量，同时可以减少废物的量。 根据本发明，提供了一种自动分析装置，其中用于将试剂从试剂容器供给到反应容器中的试剂供应装置可移除地附接到试剂容器，在试剂供应口中设置有保护门 为了防止灰尘进入试剂供应装置，进一步地，试剂容器和试剂供应装置设置有用于在其中记录条件的记录介质，其更换时间等，并且可以通知设置 是否适用

公开(公告)号：US07204961B2

公开(公告)日：2007-04-17

申请号：US09259306

申请日：1999-03-01

申请人： Akira Koide ,  Ryo Miyake ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Tomonari Morioka

发明人： Akira Koide ,  Ryo Miyake ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Tomonari Morioka

IPC分类号： B01L3/02 ,  G01N1/10 ,  F04B23/06 ,  F16K16/00 ,  F16K7/07

CPC分类号： F04B43/043 ,  F04B53/1042 ,  Y10T137/87788 ,  Y10T137/87893 ,  Y10T436/2575

摘要： Provided is a liquid feed apparatus for feeding liquid by operating a diaphragm at a high frequency, in which an inlet valve and an outlet valve are integrally incorporated with a liquid feed chamber, the positions of the valve are shifted into peripheral parts of the liquid feed chamber so as to allow fluid to smoothly flow from the inlet to the outlet in order to prevent air bubbles from causing pressure fluctuation during liquid feed, from remaining in the liquid feed chamber. Further, the valve has a center beam structure in which a protrusion having a height greater than several micron meters, is formed in the seat part of the valve so as to deform a center beam for pressurizing the valve in order to enhance the shut-off ability of the valve, and the center beam has a small surface area in the direction of displacement of the valve.

摘要翻译： 本发明提供一种液体供给装置，其通过以高频操作隔膜，其中入口阀和出口阀与液体供给室一体地结合在一起，阀的位置移动到液体进料的周边部分 以允许流体从入口到出口平滑地流动，以防止气泡在液体进料期间引起压力波动，从而保留在液体进料室中。 此外，阀具有中心梁结构，其中高度大于几微米的突起形成在阀的阀座部分中，以便使用于加压阀的中心梁变形，以便增强切断 阀的能力和中心梁在阀的位移方向上具有小的表面积。

公开(公告)号：US06383452B1

公开(公告)日：2002-05-07

申请号：US09526565

申请日：2000-03-16

申请人： Ryo Miyake ,  Naruo Watanabe ,  Hajime Katou ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

发明人： Ryo Miyake ,  Naruo Watanabe ,  Hajime Katou ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

IPC分类号： G01N3500

CPC分类号： G01N35/1002 ,  G01N35/0099 ,  G01N35/028 ,  Y10T436/2575

摘要： A chemical analyzer for measuring a concentration of components of a sample liquid, by mixing the sample liquid with reagents, so as to react the reagents upon the components thereof. The chemical analyzer includes a carrier which is constructed on a substrate and has an introducing portion through which the sample liquid is injected, distributing flow passages for distributing the sample liquid injected from the introducing portion, and plural reactor portions, each holding the sample liquid therein to be mixed with the reagent, thereby to react. A movable driver portion is provided for mounting the carrier thereon, and a reagent charging device is provided for ejecting the reagents, which are different for the respective reactor portions of the carrier. Further, a detector is provided for detecting the components after mixing the reagents with the sample liquid.

摘要翻译： 一种用于通过将样品液体与试剂混合来测量样品液体组分浓度的化学分析仪，以便将试剂与其组分反应。 该化学分析装置包括：载体，其构造在基板上，具有引入部，通过该引入部分注入样品液体;分配用于分配从引入部分注入的样品液体的流路;以及多个反应器部分，每个反应器部分将样品液体保持在其中 与试剂混合，进行反应。 提供了用于将载体安装在其上的可移动的驱动部分，并且提供了用于喷射对于载体的各反应器部分不同的试剂的试剂装料装置。 此外，提供了一种用于在将试剂与样品液体混合之后检测组分的检测器。

公开(公告)号：US06852282B2

公开(公告)日：2005-02-08

申请号：US10121734

申请日：2002-04-15

申请人： Ryo Miyake ,  Naruo Watanabe ,  Hajime Katou ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

发明人： Ryo Miyake ,  Naruo Watanabe ,  Hajime Katou ,  Takao Terayama ,  Yasushi Nomura ,  Hiroshi Mitsumaki

IPC分类号： G01N35/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N35/1002 ,  G01N35/0099 ,  G01N35/028 ,  Y10T436/2575

摘要： A chemical analyzer for measuring a concentration of components of a sample liquid, by mixing the sample liquid with reagents, so as to react the reagents upon the components thereof, includes a carrier having an introducing portion through which the sample liquid is injected, passages for distributing the sample liquid injected from the introducing portion, and plural reactor portions which hold the sample liquid therein to be mixed with the reagent, thereby to react. A movable driver portion is provided on which the carrier is mounted and a reagent charging device is provided for ejecting the reagents which are different for the respective plural reactor portions of the carrier, sequentially. Further, a detector is provided for detecting the components after mixing the reagents with the sample liquid.

摘要翻译： 一种用于测量样品液体组分浓度的化学分析仪，通过将样品液体与试剂混合以使试剂与其组分反应，包括具有引入部分的载体，通过该引入部分注入样品液体，通道用于 分配从引入部分注入的样品液体，以及将样品液体保持在其中以与试剂混合的多个反应器部分，从而进行反应。 提供了可移动的驱动器部分，其上安装有载体，并且提供了试剂充电装置，用于顺序地喷射对于载体的各个反应器部分不同的试剂。 此外，提供了一种用于在将试剂与样品液体混合之后检测组分的检测器。

公开(公告)号：US06500388B1

公开(公告)日：2002-12-31

申请号：US09154698

申请日：1998-09-17

申请人： Yoshihiro Nagaoka ,  Ryo Miyake ,  Masaharu Nishida ,  Takeshi Shibuya ,  Takao Terayama ,  Hiroshi Mitsumaki

发明人： Yoshihiro Nagaoka ,  Ryo Miyake ,  Masaharu Nishida ,  Takeshi Shibuya ,  Takao Terayama ,  Hiroshi Mitsumaki

IPC分类号： G01N3510

CPC分类号： G01N35/02 ,  G01N2035/00376 ,  G01N2035/0437 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/25625 ,  Y10T436/2575

摘要： An automatically analyzing apparatus includes a plurality of reaction containers for reacting a sample with a reagent, and a reaction container washing unit for washing the reaction containers through a plurality of washing steps. The reaction container washing unit includes a plurality of storage parts in each of which washing liquid containing therein reacted substance is reserved. The plurality of storage parts are sorted with different reacted substance concentrations. A supply part of the reaction container washing unit selects washing liquid of a desired reacted substance concentration among the plurality of storage parts in accordance with respective washing conditions of the reaction containers and supplies the selected washing liquid into the reaction containers for washing the respective reaction containers.

摘要翻译： 自动分析装置包括用于使样品与试剂反应的多个反应容器和用于通过多个洗涤步骤洗涤反应容器的反应容器洗涤单元。 反应容器洗涤单元包括多个储存部件，每个储存部件保留含有反应物质的洗涤液体。 以不同的反应物质浓度对多个储存部分进行分选。 反应容器洗涤单元的供应部分根据反应容器的各个洗涤条件选择多个储存部分中所需反应物质浓度的洗涤液，并将所选择的洗涤液供应到用于洗涤各反应容器的反应容器中 。

公开(公告)号：US06283730B1

公开(公告)日：2001-09-04

申请号：US09441230

申请日：1999-11-16

申请人： Yasuhiko Sasaki ,  Yasuhiro Yoshimura ,  Akira Koide ,  Ryo Miyake ,  Naruo Watanabe ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Yasuhiko Ishida ,  Tomonari Morioka

发明人： Yasuhiko Sasaki ,  Yasuhiro Yoshimura ,  Akira Koide ,  Ryo Miyake ,  Naruo Watanabe ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Yasuhiko Ishida ,  Tomonari Morioka

IPC分类号： F04B1700

CPC分类号： F04B43/043

摘要： A micro pump is made compact and can prevent members constituting the micro pump from being chemically reacted with a working fluid, and a method of producing the same. After each of substrates constituting the micro pump is formed by a member containing a silicone as a main composition and a plurality of metal membranes are formed on a whole of a bonding surface of each of the substrates so as to form bonding surfaces, the bonding surfaces are cleaned, and the bonding surfaces are opposed to each other under a vacuum condition, overlapped, heated and pressed so as to be bonded. The valve portion has a beam and a protrusion for sealing as provided in the valve side, whereby a pressure applied to the protrusion becomes smaller than the bonding pressure.

摘要翻译： 微型泵制造紧凑，并且可以防止构成微型泵的构件与工作流体发生化学反应，及其制造方法。 在构成微型泵的基板的每一个由含有硅酮作为主要成分的构件形成，并且在每个基板的整个接合表面上形成多个金属膜以形成接合表面， 被清洁，并且粘合表面在真空条件下彼此相对，重叠，加热和压制以便粘合。 阀部具有设置在阀侧的梁和用于密封的突起，由此施加到突起的压力变得小于接合压力。

公开(公告)号：US20080181817A1

公开(公告)日：2008-07-31

申请号：US12055447

申请日：2008-03-26

申请人： Tomonori MIMURA ,  Hiroshi Mitsumaki ,  Tadashi Ohishi ,  Taku Sakazume

发明人： Tomonori MIMURA ,  Hiroshi Mitsumaki ,  Tadashi Ohishi ,  Taku Sakazume

IPC分类号： G01N35/02

CPC分类号： G01N35/00663 ,  G01N35/0092 ,  G01N35/02 ,  G01N35/026 ,  G01N2035/00326 ,  G01N2035/00673 ,  G01N2035/0453 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/115831

摘要： A plurality of analyzer units for serum, a plurality of analyzer units for blood plasma and a plurality of analyzer units for urine are arranged along a main transfer line for transferring a sample rack from a rack providing portion to a rack storage portion. A reagent bottle for inspecting liver function is contained in each reagent delivery mechanism of two analyzer units among the plurality of analyzer units for serum. When the reagent for inspecting liver function in one of the two analyzer units is to be short, analysis for the liver function analysis item to samples can be continued by transferring a sample rack from the rack providing portion to the other analyzer unit.

摘要翻译： 用于血清的多个分析器单元，用于血浆的多个分析器单元和用于尿液的多个分析器单元沿着用于将样品架从架子提供部分转移到架子存储部分的主传送线布置。 用于检查肝功能的试剂瓶包含在用于血清的多个分析器单元中的两个分析器单元的每个试剂递送机构中。 当两个分析器单元之一检查肝脏功能的试剂较短时，通过将样品架从架子提供部分转移到另一个分析器单元，可以继续对样品的肝功能分析项目进行分析。