公开(公告)号：US06197255B1

公开(公告)日：2001-03-06

申请号：US09398046

申请日：1999-09-17

申请人： Ryo Miyake ,  Yoshihiro Nagaoka ,  Akira Koide ,  Naruo Watanabe ,  Yasuhiko Sasaki ,  Hajime Kato ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida ,  Takeshi Shibuya ,  Yasuhiro Yoshimura

发明人： Ryo Miyake ,  Yoshihiro Nagaoka ,  Akira Koide ,  Naruo Watanabe ,  Yasuhiko Sasaki ,  Hajime Kato ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida ,  Takeshi Shibuya ,  Yasuhiro Yoshimura

IPC分类号： G01N3502

CPC分类号： G01N35/00663 ,  B01F11/0283 ,  G01N35/025 ,  G01N2035/00673 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A chemical analyzing apparatus comprises a reaction cell holder which holds a plurality of reaction cells that are supplied with samples and reagents at a predetermined position, a measurer for measuring characteristics of the sample, a plurality of reagent containers, a liquid deliverer provided below each of the plurality of reagent containers, one or more sound wave generators provided outside the reaction cells, and storage containers for storing cleansing liquid with different contamination states. The cleansing liquid with different contamination states is reused according to the contamination levels of the reaction cells.

摘要翻译： 化学分析装置包括：反应池保持器，其保持在预定位置处供给样品和试剂的多个反应池，用于测量样品特性的测量器，多个试剂容器，下方设置的液体输送器 多个试剂容器，设置在反应室外的一个或多个声波发生器和用于存储具有不同污染状态的清洁液的储存容器。 具有不同污染状态的清洁液体根据反应池的污染水平重新使用。

公开(公告)号：US06193933B1

公开(公告)日：2001-02-27

申请号：US09179090

申请日：1998-10-27

申请人： Yasuhiko Sasaki ,  Ryo Miyake ,  Akira Koide ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida

发明人： Yasuhiko Sasaki ,  Ryo Miyake ,  Akira Koide ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Hiroyasu Uchida

IPC分类号： G01N3500

CPC分类号： G01N35/00663 ,  G01N35/1002 ,  G01N2035/00673 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： Heretofore, there has been demanded an automatic analysis apparatus which can prevent cross-contamination between reagents, which can prevent dust and gas from entering a reagent supply device, which can always know a remaining quantity of the reagent while can reduce the quantity of waste. According to the present invention, there is provided an automatic analysis apparatus in which a reagent supply device for supplying a reagent from a reagent container into a reaction container is removably attached to the reagent container, a protective door is provided in the reagent supply port in order to aim at preventing dust from entering the reagent supply device, and further the reagent container and the reagent supply device are provided with recording mediums for recording therein conditions thereof, a time of replacement thereof or the like, and which can inform whether the setting is proper or not.

摘要翻译： 迄今为止，已经要求能够防止试剂之间的交叉污染的自动分析装置，其可以防止灰尘和气体进入试剂供应装置，这可以总是知道试剂的剩余量，同时可以减少废物的量。 根据本发明，提供了一种自动分析装置，其中用于将试剂从试剂容器供给到反应容器中的试剂供应装置可移除地附接到试剂容器，在试剂供应口中设置有保护门 为了防止灰尘进入试剂供应装置，进一步地，试剂容器和试剂供应装置设置有用于在其中记录条件的记录介质，其更换时间等，并且可以通知设置 是否适用

公开(公告)号：US06283730B1

公开(公告)日：2001-09-04

申请号：US09441230

申请日：1999-11-16

申请人： Yasuhiko Sasaki ,  Yasuhiro Yoshimura ,  Akira Koide ,  Ryo Miyake ,  Naruo Watanabe ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Yasuhiko Ishida ,  Tomonari Morioka

发明人： Yasuhiko Sasaki ,  Yasuhiro Yoshimura ,  Akira Koide ,  Ryo Miyake ,  Naruo Watanabe ,  Takao Terayama ,  Hiroshi Mitsumaki ,  Yasuhiko Ishida ,  Tomonari Morioka

IPC分类号： F04B1700

CPC分类号： F04B43/043

摘要： A micro pump is made compact and can prevent members constituting the micro pump from being chemically reacted with a working fluid, and a method of producing the same. After each of substrates constituting the micro pump is formed by a member containing a silicone as a main composition and a plurality of metal membranes are formed on a whole of a bonding surface of each of the substrates so as to form bonding surfaces, the bonding surfaces are cleaned, and the bonding surfaces are opposed to each other under a vacuum condition, overlapped, heated and pressed so as to be bonded. The valve portion has a beam and a protrusion for sealing as provided in the valve side, whereby a pressure applied to the protrusion becomes smaller than the bonding pressure.

摘要翻译： 微型泵制造紧凑，并且可以防止构成微型泵的构件与工作流体发生化学反应，及其制造方法。 在构成微型泵的基板的每一个由含有硅酮作为主要成分的构件形成，并且在每个基板的整个接合表面上形成多个金属膜以形成接合表面， 被清洁，并且粘合表面在真空条件下彼此相对，重叠，加热和压制以便粘合。 阀部具有设置在阀侧的梁和用于密封的突起，由此施加到突起的压力变得小于接合压力。

公开(公告)号：US07118662B2

公开(公告)日：2006-10-10

申请号：US10041597

申请日：2002-01-10

申请人： Hironobu Yamakawa ,  Ryo Miyake ,  Yasuhiko Sasaki ,  Akira Koide

发明人： Hironobu Yamakawa ,  Ryo Miyake ,  Yasuhiko Sasaki ,  Akira Koide

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44721 ,  G01N27/44791

摘要： The windows 5a, 5b are configured so that the thickness of the upper and lower parts of the substrate formed therein with the channels becomes thinner in these parts than in other parts. An air space is defined in the vicinity of the one side wall of the channel within a part where the first outgoing window 5a is formed, so as to serve as a window, and the second outgoing window 5b has a shape such as to be recessed inward from the one side wall of the planar plate 10, in comparison with the other part thereof. Further, the fluorescence transmission path 6b is also formed on opposite sides with air spaces. It is noted that a rod-like fiber or the like may be embedded in the planar plate 10 on the outgoing side of the planar plate 10 at the time of forming the separation channel 21 and the like.

摘要翻译： 窗口5a，5b构造成使得在其中形成有通道的基板的上部和下部的厚度在这些部分比在其它部分中更薄。 在形成第一输出窗口5a的部分内的通道的一个侧壁的附近限定空气空间，以便用作窗口，并且第二出口窗口5b具有如下形状： 与平板10的一个侧壁向内凹入，与其他部分相比较。 此外，荧光传输路径6b也形成在具有空气空间的相对侧上。 注意，在形成分离通道21等时，可以在平板10的出口侧的平板10中嵌入棒状纤维等。

公开(公告)号：US08409850B2

公开(公告)日：2013-04-02

申请号：US11964154

申请日：2007-12-26

申请人： Kei Takenaka ,  Yasuhiko Sasaki ,  Ryo Miyake

发明人： Kei Takenaka ,  Yasuhiko Sasaki ,  Ryo Miyake

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： G01N21/6428 ,  G01N15/1484 ,  G01N2015/1486

摘要： A microorganism testing device includes a measurement chip having a specimen container; a reaction container for mixing a specimen and a dyeing reagent; a bacteria detection portion irradiated with excitation light; a detection liquid waste container a solution flow path which connects the specimen container, the reaction container and the bacteria detection portion, and ventilation ports which are connected to the specimen container, the reaction container and the detection liquid waste container, through a air flow path and is connected to a chip connecting tube. Bacteria are detected in the bacteria detection portion by switching of the states of the containers between a sealed state and a state open to the atmospheric pressure, by moving the specimen to the reaction container to mix and stir the specimen and the dyeing reagent, and by moving of the liquid mixture to the detection liquid waste container.

摘要翻译： 微生物检测装置包括具有检体容器的测量片; 用于混合试样和染色试剂的反应容器; 用激发光照射的细菌检测部分; 检测用废液容器，将检体容器，反应容器和细菌检测部连接的溶液流路和通过空气流路连接到检体容器，反应容器和检测用废液容器的通气口 并连接到芯片连接管。 通过在密封状态和大气压开放状态之间切换容器的状态，通过将样品移动到反应容器中来混合并搅拌样品和染色试剂，并通过 将液体混合物移动到检测液体废物容器。

公开(公告)号：US08288156B2

公开(公告)日：2012-10-16

申请号：US11858571

申请日：2007-09-20

申请人： Hisao Inami ,  Yasuhiko Sasaki ,  Ryo Miyake

发明人： Hisao Inami ,  Yasuhiko Sasaki ,  Ryo Miyake

IPC分类号： C12M1/36 ,  C12M1/38 ,  C12M3/00

CPC分类号： B01L3/5027 ,  B01L2200/16 ,  B01L2300/023 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1894 ,  B01L2400/0481 ,  B01L2400/0677 ,  G01N35/00871

摘要： An analytical chip and analyzer are disclosed. The analytical chip comprises a substrate and reaction cells that are formed in the substrate for receiving a sample collected from a living body. A reagent storage portion is used to store reagents to be supplied to the reaction cells. Flow paths are provided to connect the reaction cells to the reagent storage portions, thereby allowing the reagents stored in the reagent storage portions to flow into the reaction cells.

摘要翻译： 公开了一种分析芯片和分析仪。 分析芯片包括基板和形成在基板中的用于接收从活体收集的样品的反应池。 试剂储存部分用于储存供应给反应池的试剂。 提供流路以将反应池连接到试剂储存部分，从而使存储在试剂储存部分中的试剂流入反应池。

公开(公告)号：US20080248562A1

公开(公告)日：2008-10-09

申请号：US10586730

申请日：2005-01-20

申请人： Tadashi Sano ,  Ryo Miyake ,  Yasuhiko Sasaki ,  Tatsuo Sumino ,  Kazuichi Isaka ,  Hajime Ikuta

发明人： Tadashi Sano ,  Ryo Miyake ,  Yasuhiko Sasaki ,  Tatsuo Sumino ,  Kazuichi Isaka ,  Hajime Ikuta

IPC分类号： C12M1/00

CPC分类号： G01N15/10 ,  G01N2015/0088

摘要： A microorganism separation device includes: sample solution supply means (30) for supplying a sample solution (40) stored within a sample solution reservoir (32) to a first flow path (12); a microorganism sensor (22) that is capable of detecting a monadelphous microorganism in the sample solution (40) that passes through the first flow path (12); a controller (24) that stops to supply the sample solution (40) to the first flow path (12) and discharges the detected microorganism together with the sample solution (40) from a termination side of the first flow path (12) on the basis of a detection result of the microorganism by the microorganism sensor (22); and an acceptor (52) that receives a droplet (28) of the sample solution (40) that is discharged from the termination side of the first flow path (12).

摘要翻译： 微生物分离装置包括：样品溶液供给装置（30），用于将存储在样品溶液储存器（32）内的样品溶液（40）供应到第一流动路径（12）; 微生物传感器（22），其能够检测通过所述第一流路（12）的所述样品溶液（40）中的单位微生物; 控制器（24），停止向第一流路（12）供应样品溶液（40），并将检测到的微生物与样品溶液（40）一起从第一流路（12）的终止侧排出到 微生物传感器（22）对微生物的检测结果的基础; 以及接收从第一流路（12）的终端侧排出的样品溶液（40）的液滴（28）的受体（52）。

公开(公告)号：US20050048540A1

公开(公告)日：2005-03-03

申请号：US10870064

申请日：2004-06-18

申请人： Hisao Inami ,  Yasuhiko Sasaki ,  Ryo Miyake

发明人： Hisao Inami ,  Yasuhiko Sasaki ,  Ryo Miyake

IPC分类号： G01N33/50 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N37/00

CPC分类号： B01L9/527 ,  B01L3/5027 ,  B01L3/52 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487

摘要： The present invention provides an analytical chip that is easy to handle, inexpensive, and for which the extraction of gene from a sample and analysis thereof can be automated to one process, and a small-sized and portable analytical apparatus equipped therewith. The chip for processing of gene that is equipped with an injection port into which a sample containing gene is delivered, a gene extraction part into which a solution containing said sample is introduced and which has a gene-binding carrier that binds to said gene, a washing solution-storing part that stores the washing solution to be introduced into said gene extraction part, and a reaction part into which said gene captured in said extraction part is introduced, wherein a fluid channel through which said washing solution is introduced from said washing solution-storing part has been connected to a region more remote from said injection port than from a region into which a solution containing said sample is introduced in said gene extraction part is obtained.

摘要翻译： 本发明提供一种易于处理，价格便宜的分析芯片，并且可以将样品中的基因提取及其分析自动化为一个过程，以及配备有该样品的小型便携式分析装置。 用于加工含有含有基因的样品的注入口的基因的加工用芯片，导入了含有所述样品的溶液的基因提取部，其具有与所述基因结合的基因结合载体， 将要引入所述基因提取部分的洗涤溶液的洗涤溶液储存部分和引入所述提取部分中捕获的所述基因的反应部分，其中从所述洗涤溶液引入所述洗涤溶液的流体通道 获得了与从所述注入口更远的区域连接到从所述基因提取部引入含有所述样品的溶液的区域。

公开(公告)号：US20070059736A1

公开(公告)日：2007-03-15

申请号：US11450366

申请日：2006-06-12

申请人： Hisao Saito ,  Yasuhiko Sasaki ,  Ryo Miyake

发明人： Hisao Saito ,  Yasuhiko Sasaki ,  Ryo Miyake

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  G01N1/2813 ,  G01N2001/2833

摘要： A bio-analysis chip which is convenient in use and can promptly detect microbes with high accuracy. The bio-analysis chip comprises a collection member for collecting microbes in the atmosphere with the microbes adhering to the collection member, and a substrate in the form of a thin plate on which the collection member is mounted. The substrate has a collection member receiving section in which the collection member is placed, and a plurality of reagent reservoirs in which reagents for treating and analyzing the microbes are stored. The plurality of reagent reservoirs are connected to the collection member receiving section.

摘要翻译： 一种生物分析芯片，使用方便，可以高精度地及时检测微生物。 生物分析芯片包括收集构件，用于在微生物粘附到收集构件的情况下收集大气中的微生物，以及薄板形式的基板，收集构件安装在该基板上。 基板具有收集部件收纳部，收纳部件被放置在该收集部件收纳部中，并存储有用于处理和分析微生物的试剂的多个试剂储存器。 多个试剂储存器连接到收集构件接收部分。

公开(公告)号：US20050060599A1

公开(公告)日：2005-03-17

申请号：US10901965

申请日：2004-07-30

申请人： Hisao Inami ,  Yasuhiko Sasaki ,  Hajime Katou ,  Ryo Miyake

发明人： Hisao Inami ,  Yasuhiko Sasaki ,  Hajime Katou ,  Ryo Miyake

IPC分类号： G01N33/50 ,  G01N21/27 ,  G01N35/00 ,  G06F11/00 ,  G06F11/273 ,  G06F19/18 ,  G06Q50/00 ,  G06Q50/10 ,  G06Q50/22

CPC分类号： G06F11/2294

摘要： There is provided a group of testing apparatuses that realizes high-level testing and high quality medical treatment by conducting tests using apparatuses and facilities that are located in a distributed condition. A distributed testing apparatus is configured to be connectable to a network system to which a host testing apparatus is connected, wherein the distributed testing apparatus has a testing part that assays genetic information of a specimen, a transmission part that transmits test results information of the testing part and a specimen ID corresponding to the specimen to the host testing apparatus through the network, a receiver part that receives through the network assessment information from the host testing apparatus that corresponds to the transmitted test results information, and an output part that outputs the received information.

摘要翻译： 提供了一组通过使用位于分布状态的设备和设施进行测试来实现高水平测试和高质量医疗的测试装置。 分布式测试装置被配置为可连接到主机测试设备连接到的网络系统，其中分布式测试设备具有测试样本的遗传信息的测试部分，传送测试结果信息的传输部分 通过网络向主机测试装置对应于样本的部分和样本ID，通过来自主机测试装置的与所发送的测试结果信息相对应的网络评估信息接收的接收机部分和输出所接收到的测试结果信息的输出部分 信息。