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公开(公告)号：US5736100A
公开(公告)日：1998-04-07
申请号：US531199
申请日：1995-09-19
申请人： Ryo Miyake , Koichi Tsuzuki , Isao Yamazaki , Hideo Enoki , Hiroshi Mitsumaki
发明人： Ryo Miyake , Koichi Tsuzuki , Isao Yamazaki , Hideo Enoki , Hiroshi Mitsumaki
CPC分类号： B01F11/0283 , B06B3/00 , G01N35/025 , G01N2035/00554 , Y10T436/11 , Y10T436/113332 , Y10T436/25
摘要： A chemical analyzer has turn tables respectively carrying reaction vessels, sample containers and reagent containers disposed thereon in circular rows. A sample pipetting mechanism and a reagent pipetting mechanism are provided to transfer predetermined amounts of sample and reagent solution from a sample container and from a reagent container into a reaction vessel. The thus transferred sample and reagent solution are mixed in the reaction vessel by a stirrer comprising a piezoelectric element which is disposed in non-contacting relationship to the sample and reagent solution in the reaction vessel and is electrically energized to generate a sound wave which causes a circulating flow of the reagent solution in the reaction vessel whereby the sample and the reagent solution are mixed in a non-invasive manner.
摘要翻译： 化学分析仪具有分别承载设置在其上的反应容器，样品容器和试剂容器的转台。 提供样品移液机构和试剂吸移机构，以将预定量的样品和试剂溶液从样品容器和试剂容器转移到反应容器中。 将这样转移的样品和试剂溶液通过搅拌器混合在反应容器中，所述搅拌器包括与反应容器中的样品和试剂溶液非接触关系设置的压电元件，并且被电通电以产生声波， 在反应容器中循环流动试剂溶液，由此将样品和试剂溶液以非侵入性的方式混合。
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公开(公告)号：US5519635A
公开(公告)日：1996-05-21
申请号：US301028
申请日：1994-09-06
申请人： Ryo Miyake , Masaharu Ishii , Hideo Enoki , Isao Yamazaki , Kazumichi Imai , Tadafumi Kuroishi , Yu-ming Hsueh
发明人： Ryo Miyake , Masaharu Ishii , Hideo Enoki , Isao Yamazaki , Kazumichi Imai , Tadafumi Kuroishi , Yu-ming Hsueh
IPC分类号： G01N1/00 , B01L3/00 , B01L9/00 , G01N30/02 , G01N30/34 , G01N30/60 , G01N30/86 , G01N30/88 , G01N35/00 , G01N35/08 , G01N37/00 , G01N35/10
CPC分类号： B01F13/0059 , B01F5/0475 , B01F5/0485 , B01L3/502715 , B01L9/527 , G01N30/88 , G01N35/085 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L3/0268 , B01L3/502753 , G01N2030/027 , G01N2030/8881 , G01N2035/00326 , G01N30/60 , G01N30/6095 , Y10T436/11 , Y10T436/25375 , Y10T436/2575
摘要： In order to provide an apparatus for chemical analysis capable of eliminating time consuming changing connections of flow paths and analytical elements, and of operating for analysis without any special knowledge, the apparatus for chemical analysis comprises a main body of analytical apparatus provided with sampling device for sucking sample, liquid controller for transferring the sucked sample and reagents, and detector for measuring the sample, and analytical unit provided with a liquid connector and a signal connector for connecting to the main body of analytical apparatus, and memory storing at least analytical method, and analysis of the sample is performed by attaching and fixing the analytical unit to said main body of analytical apparatus, transferring at least analytical method stored in the memory to the main body of analytical apparatus, and analyzing the sample in accordance the said analytical method.
摘要翻译： 为了提供一种用于化学分析的设备，其能够消除流路和分析元件的耗时变化的连接以及在没有任何特殊知识的情况下进行分析的操作，所述用于化学分析的装置包括分析装置的主体，其具有采样装置 吸取样品，用于转移吸取的样品和试剂的液体控制器和用于测量样品的检测器;以及分析单元，其具有连接到分析装置的主体的液体连接器和信号连接器，以及至少存储至少分析方法的存储器， 通过将分析单元附着并固定在分析装置的主体上，至少将存储在存储器中的分析方法转移到分析装置的主体，并根据所述分析方法分析样品来进行样品的分析。
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公开(公告)号：US08757864B2
公开(公告)日：2014-06-24
申请号：US11745669
申请日：2007-05-08
CPC分类号： G01N35/02 , G01N2035/00534
摘要： A chemical analyzer supplies a sample and a reagent into a reaction container provided with an opening mixes a fluid which is to be measured and contains the sample and reagent supplied into the reaction container, measures a property of the fluid in the reaction container, and controls the drive for the mixer. The mixer has a vertical drive machine to move the mixing tool up and down. The control unit controls the vertical drive machine to move the mixing tool up and down in the fluid to be measured in the reaction container so as to cause upward and downward flow of the fluid which is to be measured and is positioned below the mixing tool.
摘要翻译： 化学分析仪将样品和试剂供应到设置有开口的反应容器中，混合待测量的流体并且包含供应到反应容器中的样品和试剂，测量反应容器中的流体的性质，并控制 搅拌机的驱动。 搅拌机有一个垂直驱动机器来上下移动搅拌机。 控制单元控制垂直驱动机器，使反应容器中要测量的流体中的上下移动混合工具，以使被测量流体和位于混合工具下方的上下流动。
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公开(公告)号：US07922885B2
公开(公告)日：2011-04-12
申请号：US11430857
申请日：2006-05-10
申请人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Isao Yamazaki
发明人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Isao Yamazaki
IPC分类号： G01N27/26
CPC分类号： G02B26/004 , G01N35/08 , Y10T436/2575
摘要： In a device for transporting liquid, liquid to be transported is enclosed by an oil droplet, which is fractionated with air, for manipulation. Moreover, as a method for supplying liquids wherein a plurality of liquids are enclosed by an oil droplet sequentially and treated, liquid enclosed by an oil droplet is formed by associating one oil with one liquid in a liquid introducing section. According to the present invention, even in the case where a plurality of liquids are manipulated, it is possible to manipulate stably without affecting other liquids. Moreover, it is possible to treat as a liquid enclosed by an oil droplet successively in the device for transporting liquid, thereby allowing the invention to be applied to a system for analyzing easily.
摘要翻译： 在用于输送液体的装置中，待运输的液体被用空气分馏的油滴包围，用于操纵。 此外，作为用于供给液体的方法，其中多个液体被油滴依次包围并进行处理，通过在液体引入部分中将一种油与一种液体相关联来形成由油滴包围的液体。 根据本发明，即使在操作多种液体的情况下，也可以稳定地操作而不影响其他液体。 此外，可以在用于输送液体的装置中连续地将油封包围的液体作为液体进行处理，从而将本发明应用于容易分析的系统。
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公开(公告)号：US20070264156A1
公开(公告)日：2007-11-15
申请号：US11745669
申请日：2007-05-08
IPC分类号： G01N33/00
CPC分类号： G01N35/02 , G01N2035/00534
摘要： A chemical analyzer supplies a sample and a reagent into a reaction container provided with an opening, mixes a fluid which is to be measured and contains the sample and reagent supplied into the reaction container, measures a property of the fluid in the reaction container, and controls the drive for the mixer. The mixer has a vertical drive machine to move the mixing tool up and down. The control unit controls the vertical drive machine to move the mixing tool up and down in the fluid to be measured in the reaction container so as to cause upward and downward flow of the fluid which is to be measured and is positioned below the mixing tool.
摘要翻译： 化学分析仪将样品和试剂供给到设置有开口的反应容器中，将待测量的流体和包含样品的试剂和供应到反应容器中的试剂混合，测量反应容器中的流体的性质，以及 控制搅拌机的驱动。 搅拌机有一个垂直驱动机器来上下移动搅拌机。 控制单元控制垂直驱动机器，使反应容器中要测量的流体中的上下移动混合工具，以使被测量流体和位于混合工具下方的上下流动。
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公开(公告)号：US20060254933A1
公开(公告)日：2006-11-16
申请号：US11430857
申请日：2006-05-10
申请人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Isao Yamazaki
发明人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Isao Yamazaki
CPC分类号： G02B26/004 , G01N35/08 , Y10T436/2575
摘要： In a device for transporting liquid, liquid to be transported is enclosed by an oil droplet, which is fractionated with air, for manipulation. Moreover, as a method for supplying liquids wherein a plurality of liquids are enclosed by an oil droplet sequentially and treated, liquid enclosed by an oil droplet is formed by associating one oil with one liquid in a liquid introducing section. According to the present invention, even in the case where a plurality of liquids are manipulated, it is possible to manipulate stably without affecting other liquids. Moreover, it is possible to treat as a liquid enclosed by an oil droplet successively in the device for transporting liquid, thereby allowing the invention to be applied to a system for analyzing easily.
摘要翻译： 在用于输送液体的装置中，待运输的液体被用空气分馏的油滴包围，用于操纵。 此外，作为用于供给液体的方法，其中多个液体被油滴依次包围并进行处理，通过在液体引入部分中将一种油与一种液体相关联来形成由油滴包围的液体。 根据本发明，即使在操作多种液体的情况下，也可以稳定地操作而不影响其他液体。 此外，可以在用于输送液体的装置中连续地将油封包围的液体作为液体进行处理，从而将本发明应用于容易分析的系统。
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公开(公告)号：US4983038A
公开(公告)日：1991-01-08
申请号：US178651
申请日：1988-04-07
申请人： Hiroshi Ohki , Ryo Miyake , Isao Yamazaki , Fujiya Takahata
发明人： Hiroshi Ohki , Ryo Miyake , Isao Yamazaki , Fujiya Takahata
CPC分类号： G01N15/1404 , B01F13/0062
摘要： A sheath flow type flow-cell device for photo-particle-analyzer comprises a substantially flat top surface, at least one first inlet for sheath fluid, at least one first flow passage communicated with the at least one first inlet and contracted toward downstream to be a straight capillary flow passage, a discharge port provided at a terminal end of the straight capillary flow passage, a second inlet for sample fluid, a second flow passage for sample fluid communicated with the second inlet and contracted toward downstream, and coupling portions for sealingly coupling with the particle photo-analyzer. The second flow passage is opened within the at least one first flow passage so as to keep a part of the at least one first flow passage above and below an opening of the second flow passage. The opening is faced in the same direction as the straight capillary flow passage. A wall portion on which the opening locates is rounded. The wall portion is further chamfered and a pair of projections are extended from the wall portion.
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公开(公告)号：US5690895A
公开(公告)日：1997-11-25
申请号：US761143
申请日：1996-12-06
申请人： Masaetsu Matsumoto , Isao Yamazaki , Ryo Miyake , Masaharu Ishii , Ryohei Yabe , Hiroshi Ohki , Hideyuki Horiuchi , Shinichi Sakuraba
发明人： Masaetsu Matsumoto , Isao Yamazaki , Ryo Miyake , Masaharu Ishii , Ryohei Yabe , Hiroshi Ohki , Hideyuki Horiuchi , Shinichi Sakuraba
CPC分类号： G01N21/05 , G01N15/1404 , G01N2021/0346
摘要： A flow cell apparatus, useful in an apparatus for measuring particles suspended in a liquid, comprises a sample liquid, supply device, a sheath liquid supply device, a flow cell which has a flow passage passing through a transparent measuring portion, and a nozzle for causing the sample liquid, from the supply device to flow in the flow passage of the flow cell. The nozzle has at least one discharge port which is disposed in the flow passage in a spaced relation from the inner wall of the flow cell flow passage. The sheath liquid supply device causes the sheath liquid to flow around the nozzle discharge port and surround the sample liquid flow to form a sheath flow. The flow passage of the flow cell and the nozzle are so formed as to ensure a sample liquid flow of a fixed width through the measuring portion. A stable sample flow having a fixed width can be formed in the measuring portion even when the flow is at a high velocity, and particles in the sample liquid can efficiently be photographed with high accuracy.
摘要翻译： 一种用于测量悬浮在液体中的颗粒的装置中的流动池装置，包括样品液体，供给装置，皮肤液体供应装置，具有通过透明测量部分的流动通道的流动池，以及用于 使来自供给装置的样品液体流入流动池的流路。 喷嘴具有至少一个排出口，该排出口以与流动池流动通道的内壁隔开的关系设置在流动通道中。 皮肤液体供给装置使皮肤液体在喷嘴排出口周围流动并且围绕样品液体流动形成鞘流。 流动池和喷嘴的流动通道形成为确保通过测量部分具有固定宽度的样品液体流动。 即使在流速高的情况下，也可以在测量部分形成具有固定宽度的稳定的样品流，并且可以高精度地有效地拍摄样品液体中的颗粒。
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9.发明授权Photoanalysis apparatus with means for correcting flow rate of fluid carrying particles and/or position of applied light beam for examination and photoanalysis method therefor 失效具有用于校正流体携带颗粒的流速和/或施加的光束的位置用于检查和光分析方法的光分析装置
公开(公告)号：US4863264A
公开(公告)日：1989-09-05
申请号：US203457
申请日：1988-06-07
申请人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki
发明人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki
CPC分类号： G01N15/1404 , G01N2015/1409 , G01N2015/1452
摘要： A photoanalysis apparatus includes marker pouring device for pouring markers into one of sheath fluid and fluid carrying particles in a flow-cell device, second optical device for applying a light beam for correction to the markers in the flow-cell device to measure strength of fluorescence or light scattering caused by said markers to generate a signal for correction, second signal processing device for calculating from the signal for correction at least one of a difference in position between a center of the fluid carrying particles in the flow-cell device and a center of a light beam for examination and a difference in flow rate between a predetermined flow rate and an actual flow rate of the fluid carrying particles in the flow-cell device to generate correspondingly at least one of a first command signal for position correction and a second command signal for flow rate correction, and correspondingly at least one of first correcting device for shifting the center of the light beam for examination to the center of the flow of the fluid carrying particles in accordance with the first command signal and second correcting device for correcting the flow rate of the fluid carrying particles to the predetermined flow rate in accordance with the second command signal.
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公开(公告)号：US5270212A
公开(公告)日：1993-12-14
申请号：US841487
申请日：1992-02-26
申请人： Hideyuki Horiuchi , Shinichi Sakuraba , Toshio Kaneko , Nobuyuki Tatara , Ryohei Yabe , Hiroshi Ohki , Isao Yamazaki , Ryo Miyake
发明人： Hideyuki Horiuchi , Shinichi Sakuraba , Toshio Kaneko , Nobuyuki Tatara , Ryohei Yabe , Hiroshi Ohki , Isao Yamazaki , Ryo Miyake
CPC分类号： G01N35/1095 , G01N1/28 , G01N2015/0069 , G01N2015/0076 , G01N2015/1409 , G01N2021/6439 , Y10T436/111666
摘要： This invention relates to an apparatus for analyzing cells in a biological liquid sample, such as blood, in which apparatus a flow passage in a sample pretreatment system can be shortened with a simple construction. A sample metering chamber, a mixing chamber and a measurement liquid extracting chamber are formed in a rotary sliding member of a pretreatment portion. The rotary sliding member is intermittently rotated so as to shift a sample from one chamber to another to perform a necessary treatment. Fluorescence or scattering light with respect to the sample, mixed with a reagent in the pretreatment portion, is detected by a flow cell.
摘要翻译： 本发明涉及用于分析生物液体样品如血液中的细胞的装置，其中可以用简单的结构缩短样品预处理系统中的流动通道。 样品计量室，混合室和测量液体提取室形成在预处理部分的旋转滑动构件中。 旋转滑动构件间歇地旋转，以将样品从一个室移动到另一个室进行必要的处理。 通过流动池检测相对于样品的荧光或散射光与预处理部分中的试剂混合。
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