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    Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
    4.
    发明授权
    Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives 失效
    用取代的2-咪唑或咪唑衍生物治疗CNS障碍的方法

    公开(公告)号：US07875645B2

    公开(公告)日：2011-01-25

    申请号：US11655468

    申请日：2007-01-19

    申请人： Guido Galley ,  Katrin Groebke Zbinden ,  Marius Hoener ,  Sabine Kolczewski ,  Roger Norcross ,  Henri Stalder

    发明人： Guido Galley ,  Katrin Groebke Zbinden ,  Marius Hoener ,  Sabine Kolczewski ,  Roger Norcross ,  Henri Stalder

    IPC分类号： A61K31/415 ,  C07D233/56

    CPC分类号： C07D233/06 ,  A61K31/4164 ,  A61K31/4178 ,  C07D233/20 ,  C07D233/22 ,  C07D233/56 ,  C07D233/64 ,  C07D401/10 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06

    摘要： The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.

    摘要翻译： 本发明涉及治疗抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍，应激相关障碍，精神病如精神分裂症，神经系统疾病如帕金森病，神经变性疾病如阿尔茨海默病，癫痫，偏头痛， 高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病，其包括给予 个体治疗有效量的式I化合物，其中R，R 1，R 2，A和n如说明书中所定义，并且其药物活性盐。 本发明还涉及式I的新型化合物，含有它们的药物组合物及其制备方法。

    Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
    5.
    发明申请
    Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives 失效
    用取代的2-咪唑或咪唑衍生物治疗CNS障碍的方法

    公开(公告)号：US20070197621A1

    公开(公告)日：2007-08-23

    申请号：US11655468

    申请日：2007-01-19

    申请人： Guido Galley ,  Katrin Groebke Zbinden ,  Marius Hoener ,  Sabine Kolczewski ,  Roger Norcross ,  Henri Stalder

    发明人： Guido Galley ,  Katrin Groebke Zbinden ,  Marius Hoener ,  Sabine Kolczewski ,  Roger Norcross ,  Henri Stalder

    IPC分类号： A61K31/415 ,  C07D233/56

    CPC分类号： C07D233/06 ,  A61K31/4164 ,  A61K31/4178 ,  C07D233/20 ,  C07D233/22 ,  C07D233/56 ,  C07D233/64 ,  C07D401/10 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06

    摘要： The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.

    摘要翻译： 本发明涉及治疗抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍，应激相关障碍，精神病如精神分裂症，神经系统疾病如帕金森病，神经变性疾病如阿尔茨海默病，癫痫，偏头痛， 高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病，其包括给予 个体治疗有效量的式I化合物，其中R，R 1，R 2，A和n如说明书中所定义，并且其药物活性盐 。 本发明还涉及式I的新型化合物，含有它们的药物组合物及其制备方法。

    Method for treating central nervous system disorders with substituted 2-imidazoline derivatives
    7.
    发明申请
    Method for treating central nervous system disorders with substituted 2-imidazoline derivatives 审中-公开
    用取代的2-咪唑啉衍生物治疗中枢神经系统障碍的方法

    公开(公告)号：US20070197569A1

    公开(公告)日：2007-08-23

    申请号：US11655484

    申请日：2007-01-19

    申请人： Marius Hoener ,  Sabine Kolczewski ,  Henri Stalder

    发明人： Marius Hoener ,  Sabine Kolczewski ,  Henri Stalder

    IPC分类号： A61K31/415 ,  A61K31/505 ,  C07D233/44 ,  C07D239/02

    CPC分类号： A61K31/4164 ,  A61K31/4168 ,  A61K31/4174

    摘要： The present invention relates to a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, X, A, and n are as defined in the specification and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms thereof.

    摘要翻译： 本发明涉及一种治疗抑郁症，焦虑障碍，双相情感障碍，注意缺陷多动障碍（ADHD），应激相关疾病，精神病如精神分裂症，神经系统疾病如帕金森病，神经变性疾病如阿尔茨海默病， 癫痫，偏头痛，高血压，药物滥用和代谢障碍如进食障碍，糖尿病，糖尿病并发症，肥胖症，血脂异常，能量消耗和同化障碍，体温平衡紊乱和失调，睡眠和昼夜节律紊乱以及心血管疾病 其包括向个体施用治疗有效量的式I化合物，其中R，X，A和n如说明书中所定义，以及药学活性盐，外消旋混合物，对映异构体，旋光异构体及其互变异构形式。