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14 条记录 (耗时 0.022 秒)

    Synthetic analogs of sphingolipids
    3.
    发明授权
    Synthetic analogs of sphingolipids 有权
    鞘脂的合成类似物

    公开(公告)号：US08962891B2

    公开(公告)日：2015-02-24

    申请号：US12742045

    申请日：2008-11-09

    申请人： Arie Dagan ,  Shimon Slavin ,  Shimon Gatt ,  Jeremy Zahavi

    发明人： Arie Dagan ,  Shimon Slavin ,  Shimon Gatt ,  Jeremy Zahavi

    IPC分类号： C07C215/10 ,  A61K31/13

    CPC分类号： C07C215/12 ,  A61K31/133 ,  A61K31/4745 ,  A61K31/513 ,  C07C215/10 ,  Y02A50/409 ,  Y02A50/411

    摘要： The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

    摘要翻译： 本发明提供了新的表示为式（II）化合物的神经酰胺类似物。 这些新型类似物表现出显着的抗癌作用，因此作为治疗细胞增殖性疾病，神经变性疾病，代谢相关病症，感染性疾病和免疫相关疾病的药物组合物提供。 本发明还提供组合的组合物和试剂盒，其将式（II）的新型神经酰胺类似物与另外的治疗剂组合。

    SYNTHETIC SPHINGOLIPID ANALOGS
    5.
    发明申请
    SYNTHETIC SPHINGOLIPID ANALOGS 审中-公开
    合成弹性体类似物

    公开(公告)号：US20100311841A1

    公开(公告)日：2010-12-09

    申请号：US12742036

    申请日：2008-11-06

    申请人： Arie Dagan ,  Shimon Gatt ,  Shimon Slavin

    发明人： Arie Dagan ,  Shimon Gatt ,  Shimon Slavin

    IPC分类号： A61K31/135 ,  C07C213/00

    CPC分类号： C07C323/32 ,  C07C381/12

    摘要： Therapeutic compounds based on synthetic sphingolipid analogs are provided, particularly alkylthiophenyl substituted ceramide analogs, suitable for treating degenerative, infectious, and other diseases.

    摘要翻译： 提供了基于合成鞘脂类似物的治疗化合物，特别是烷基硫代苯基取代的神经酰胺类似物，其适于治疗退行性，感染性和其它疾病。

    Determination of an analyte in a liquid medium
    6.
    发明授权
    Determination of an analyte in a liquid medium 失效
    液体介质中分析物的测定

    公开(公告)号：US06630309B2

    公开(公告)日：2003-10-07

    申请号：US08983570

    申请日：1998-06-04

    申请人： Itamar Willner ,  Shlomo Levi ,  Yael Cohen ,  Eugenii Katz ,  Arie Dagan

    发明人： Itamar Willner ,  Shlomo Levi ,  Yael Cohen ,  Eugenii Katz ,  Arie Dagan

    IPC分类号： G01N33553

    CPC分类号： G01N33/54373

    摘要： Binding between two members of a recognition pair, e.g. antigen-antibody is determined by utilizing a probe which includes a piezoelectric crystal with electrodes on two opposite faces of the crystal. The crystal carries one or more metal plates which may be the same or different than the electrodes, the metal plates having immobilized thereon a first member of a recognition pair. Binding of a second member of the recognition pair to the first member, or dissociation between the two members and release of the second member from the probe, causes a change of immobilized mass which results in a change to the probe's resonance frequency. The immobilized members may be immobilized on the surface of the metal plates by means of a linking group, having the following general formula (I): Z—R1—Q, wherein Z represents a sulphur-containing moiety which is capable of chemical association with, attachment to or chemisorption onto the metal, R1 represents a connecting group, Q is a functional group which is capable of forming a covalent bond with a moiety of said first member of the recognition pair.

    摘要翻译： 识别对的两个成员之间的绑定，例如 通过利用包含晶体的两个相对面上的电极的压电晶体的探针来测定抗原抗体。 晶体携带一个或多个可以与电极相同或不同的金属板，金属板固定有识别对的第一构件。 识别对的第二个成员与第一个成员的结合，或两个成员之间的解离和第二个成员从探针的释放导致固定的质量的变化，导致探针的共振频率的变化。 可以通过具有以下通式（I）的连接基团将固定化的构件固定在金属板的表面上：ZR 1 -Q，其中Z表示能够化学结合的含硫部分 与金属的附着或化学吸附，R 1表示连接基团，Q是能够与识别对的所述第一成员的部分形成共价键的官能团。

    Synthetic derivatives beta glycolipids and compositions thereof for the treatment of pathologic disorders
    9.
    发明申请
    Synthetic derivatives beta glycolipids and compositions thereof for the treatment of pathologic disorders 有权
    合成衍生物β糖脂及其组合物用于治疗病理性疾病

    公开(公告)号：US20100221358A1

    公开(公告)日：2010-09-02

    申请号：US12587752

    申请日：2009-10-13

    申请人： Yaron Ilan ,  Arie Dagan

    发明人： Yaron Ilan ,  Arie Dagan

    IPC分类号： A61K35/12 ,  C07H15/18 ,  A61K31/7034 ,  A61P1/16 ,  A61P37/06 ,  A61P25/28 ,  A61P9/10 ,  A61P3/06 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00

    CPC分类号： A61K31/70 ,  A61K2300/00

    摘要： The invention relates to novel synthetic derivatives of β-glycolipids and uses thereof as immunomodulators. More particularly, the invention relates to synthetic derivatives of β-glycolipids, specifically, the compounds of any one of Formula I, II III and IV or any mixture or combination thereof, and particularly the ALIB-97 (Formula II) derivative and uses thereof for the treatment of different pathologic disorders, particularly, immune-related hepatic disorders and pathologies associated with the metabolic syndrome.

    摘要翻译： 本发明涉及新型的乙二醇的合成衍生物及其作为免疫调节剂的用途。 更具体地说，本发明涉及乙二醇的合成衍生物，特别是式I，II III和IV中任何一种的化合物或其任何混合物或组合，特别是ALIB-97（式II）衍生物和用途 用于治疗不同的病理学疾病，特别是免疫相关的肝脏疾病和与代谢综合征相关的病理学。