公开(公告)号：US20060281087A1

公开(公告)日：2006-12-14

申请号：US10551164

申请日：2004-03-31

申请人： Shuji Sonezaki ,  Koki Kanehira ,  Shinichi Yagi ,  Yumi Ogami

发明人： Shuji Sonezaki ,  Koki Kanehira ,  Shinichi Yagi ,  Yumi Ogami

IPC分类号： C12Q1/68 ,  C09C1/36 ,  G01N33/555

CPC分类号： A61K41/0019 ,  A61K9/0014 ,  A61K33/24 ,  A61K41/0042 ,  A61K47/02 ,  A61K47/6883 ,  A61K47/6923 ,  A61K47/6929 ,  A61L2/16 ,  B82Y5/00 ,  C07K17/14 ,  G01N33/554

摘要： A titanium dioxide composite having a molecular recognition capacity is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule having an ability to specifically bind to a target molecule to the carboxyl residue of the hydrophilic polymer. Due to the molecule distinguishability, this titanium dioxide complex can bind specifically to an endocrine disrupting chemical, a pathogenic factor, a cancer cell and the like and decompose the same by a photocatalytic function.

摘要翻译： 具有分子识别能力的二氧化钛复合体是通过用亲水性聚合物的羧基与二氧化钛键合而使亲水性聚合物的表面进行改性而得到的， 具有将特异性结合到亲水性聚合物的羧基残基的靶分子的能力。 由于分子的可区分性，这种二氧化钛络合物可以特异性结合内分泌干扰物，致病因子，癌细胞等，并通过光催化功能分解。

公开(公告)号：US20060264520A1

公开(公告)日：2006-11-23

申请号：US10551071

申请日：2004-03-31

申请人： Shuji Sonezaki ,  Toshiaki Banzai ,  Koki Kanehira ,  Shinichi Yagi ,  Yumi Ogami

发明人： Shuji Sonezaki ,  Toshiaki Banzai ,  Koki Kanehira ,  Shinichi Yagi ,  Yumi Ogami

IPC分类号： B01F3/12 ,  C01G23/047 ,  B32B5/16

CPC分类号： C01G23/053 ,  A61K33/24 ,  A61K41/00 ,  B01J31/06 ,  B01J35/004 ,  B82Y30/00 ,  C01G49/06 ,  C01P2002/30 ,  C01P2004/62 ,  C01P2004/64 ,  C02F1/32 ,  C02F2305/10 ,  C09C1/0081 ,  C09C1/3676 ,  Y10T428/2998

摘要： Surface-modified titanium dioxide particles which have a surface chemically modified with a hydrophilic polymer, wherein a carboxyl group of the hydrophilic polymer and titanium dioxide are bound through an ester bonding; and a method for producing the surface-modified titanium dioxide fine particles, which comprises mixing a dispersion comprising titanium dioxide fine particles having a particle size of 2 to 200 nm and a solution of a water-soluble polymer, heating the resultant mixture to a temperature of 80 to 220° C., to thereby bind both the components through an ester bonding, and removing an unbound water-soluble polymer, to purify the resuultant particles. The surface-modified titanium dioxide fine particles exhibit excellent dispersibility and stability in an aqueous solvent over a wide pH region including a neutral range.

摘要翻译： 表面改性的二氧化钛颗粒，其具有用亲水性聚合物化学改性的表面，其中亲水性聚合物和二氧化钛的羧基通过酯键结合; 以及表面改性二氧化钛微粒的制造方法，其特征在于，将包含粒径为2〜200nm的二氧化钛细粒的分散液与水溶性聚合物的溶液混合，将所得混合物加热至 80至220℃，从而通过酯键结合两种组分，并除去未结合的水溶性聚合物，以净化研磨剂颗粒。 表面改性的二氧化钛细颗粒在包括中性范围的宽pH范围内在水性溶剂中表现出优异的分散性和稳定性。

公开(公告)号：US20100136115A1

公开(公告)日：2010-06-03

申请号：US11990040

申请日：2006-08-04

申请人： Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Toshiaki Banzai ,  Yoshinobu Kubota

发明人： Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Toshiaki Banzai ,  Yoshinobu Kubota

IPC分类号： A61K9/14 ,  A61K31/704 ,  A61K38/14 ,  A61P35/00

CPC分类号： A61K41/0028 ,  A61K9/0019 ,  A61K31/704 ,  A61K47/58 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

摘要： Disclosed is a titanium dioxide composite material which can be dispersed in an aqueous solvent stably and can be administered to a living body in a simple manner and in which the pharmacological effect of a therapeutic compound carried on the composite material can be eliminated by irradiation with light. Also disclosed is a dispersion product of the composite material. The composite material comprises titanium dioxide which has a photocatalytic activity and a therapeutic compound attached to the titanium dioxide through a hydrophilic polymer. The composite material is stable in an aqueous solvent and can be administered to a living body in a simple manner. After the composite material is administered to a living body, a site on the living body where the pharmacological effect of the therapeutic compound is not needed to be developed can be irradiated with light to induce the light excitation of titanium dioxide at the site, thereby decomposing the therapeutic compound to reduce any adverse side effect of the therapeutic compound.

摘要翻译： 公开了一种二氧化钛复合材料，其可以稳定地分散在水性溶剂中，并且可以简单的方式施用于生物体，并且通过照射光可以消除携带在复合材料上的治疗化合物的药理作用 。 还公开了复合材料的分散体。 复合材料包括具有光催化活性的二氧化钛和通过亲水性聚合物连接到二氧化钛上的治疗化合物。 复合材料在水性溶剂中稳定，可以以简单的方式施用于生物体。 在将复合材料施用于生物体后，可以用光照射生物体上不需要开发治疗化合物的药理作用的部位，从而在该部位诱导二氧化钛的光激发，从而分解 该治疗化合物用于减少治疗化合物的任何副作用。

公开(公告)号：US08992958B2

公开(公告)日：2015-03-31

申请号：US11883208

申请日：2006-10-26

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai

IPC分类号： A61N7/00 ,  A61K33/30 ,  A61K33/24 ,  A61K41/00 ,  B82Y5/00 ,  A61K9/00 ,  A61K9/19

CPC分类号： A61K33/30 ,  A61K9/0019 ,  A61K9/19 ,  A61K33/24 ,  A61K41/0033 ,  B82Y5/00

摘要： There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.

摘要翻译： 提供超声波治疗增强剂和细胞杀伤剂，其可以通过超声波照射显着改善治疗癌症的效果，同时确保高水平的安全性。 超声波治疗增强剂和细胞杀伤剂包含金属半导体颗粒，并且可以在超声波照射下被激活以杀死或破坏癌细胞。

公开(公告)号：US20090130050A1

公开(公告)日：2009-05-21

申请号：US11883249

申请日：2007-03-22

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Tomomi Nakamura

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Tomomi Nakamura

IPC分类号： A61K47/34 ,  C08G65/331 ,  C08F8/42 ,  B32B5/16

CPC分类号： A61N5/062 ,  A61K9/0009 ,  A61K9/167 ,  A61K33/24 ,  A61K41/0014 ,  A61K41/0019 ,  A61K41/0033 ,  A61K41/0057 ,  A61K47/54 ,  A61K47/542 ,  A61K47/548 ,  A61K47/58 ,  A61K47/59 ,  A61K47/595 ,  A61K47/60 ,  A61K47/6923 ,  A61K51/1244 ,  A61N7/00 ,  A61N2005/0661 ,  B82Y5/00 ,  C01G23/047 ,  C09C1/3676 ,  Y10T428/2982

摘要： Disclosed are titanium oxide composite particles and a dispersion of the titanium oxide composite particles, which can improve retentivity in blood and accumulation in cancer cells while satisfactorily developing the catalytic activity of titanium oxide particles to be excited upon exposure to ultrasonic waves or ultraviolet light. The titanium oxide composite particles comprise titanium oxide particles; and a nonionic hydrophilic polymer bound to the surface of the titanium oxide particles through at least one functional group selected from carboxyl-group, amino group, diol group, salicylic acid group, and phosphoric acid group. The composite particles can be rendered cytotoxic upon ultrasonic or ultraviolet irradiation to efficiently kill cells to be killed, such as cancer cells.

摘要翻译： 本发明公开了氧化钛复合粒子和氧化钛复合粒子的分散体，能够提高血液中的保持性和癌细胞中的积聚，同时令人满意地显现出在暴露于超声波或紫外线时被激发的氧化钛粒子的催化活性。 氧化钛复合颗粒包含氧化钛颗粒; 和通过选自羧基，氨基，二醇基，水杨酸基和磷酸基中的至少一个官能团与氧化钛颗粒的表面结合的非离子亲水性聚合物。 复合颗粒在超声波或紫外线照射下可以呈现细胞毒性，以有效杀死被杀死的细胞，如癌细胞。

公开(公告)号：US08092670B2

公开(公告)日：2012-01-10

申请号：US11992858

申请日：2006-09-28

申请人： Makoto Bekki ,  Hitoshi Ohara ,  Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Hiroshi Ishikawa ,  Yumi Osaki ,  Hiromasa Tokudome ,  Yoko Yamada ,  Masahiro Miyauchi

发明人： Makoto Bekki ,  Hitoshi Ohara ,  Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Hiroshi Ishikawa ,  Yumi Osaki ,  Hiromasa Tokudome ,  Yoko Yamada ,  Masahiro Miyauchi

IPC分类号： G01N27/26 ,  G01N33/48 ,  G01N33/487 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50 ,  G01N33/53 ,  G01N33/533

CPC分类号： G01N33/5438

摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.

摘要翻译： 公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。 该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。 工作电极包括电子接受层，其包含能够响应于光激发而接受从感光染料释放的电子的电子接受物质，其中探针物质被负载在电子接受层的表面上。 电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。 电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。

公开(公告)号：US20090294305A1

公开(公告)日：2009-12-03

申请号：US11992858

申请日：2006-09-28

申请人： Makoto Bekki ,  Hitoshi Ohara ,  Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Hiroshi Ishikawa ,  Yumi Osaki ,  Hiromasa Tokudome ,  Yoko Yamada ,  Masahiro Miyauchi

发明人： Makoto Bekki ,  Hitoshi Ohara ,  Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Hiroshi Ishikawa ,  Yumi Osaki ,  Hiromasa Tokudome ,  Yoko Yamada ,  Masahiro Miyauchi

IPC分类号： G01N27/26 ,  G01F1/64

CPC分类号： G01N33/5438

摘要： A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.

摘要翻译： 公开了一种方法，电极，测量单元和测量装置，其可以使用光电流以高灵敏度，简单和准确的方式检测和定量地确定具有特定粘合特性的分析物。 该方法包括使工作电极和对电极与电解质介质接触，其中工作电极通过探针物质固定在其上的分析物，并且其中分析物与致敏染料结合; 用光照射工作电极对光敏染料进行光刺激; 并且检测在工作电极和对电极之间流动的光电流，其中通过将电子从光激发敏化染料转移到工作电极而产生光电流。 工作电极包括电子接受层，其包含能够响应于光激发而从感光染料中释放的电子的受电子物质，其中探针物质被负载在电子接受层的表面上。 电子接受物质是具有比敏化染料的最低未占据分子轨道（LUMO）的能级更低的氧化物半导体。 电解质介质包括电解质和至少一种选自非质子溶剂和质子溶剂的溶剂，其中电解质包含能够提供氧化的致敏染料与电子的盐。

公开(公告)号：US20080262349A1

公开(公告)日：2008-10-23

申请号：US11883208

申请日：2006-10-26

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai

IPC分类号： A61N7/00

CPC分类号： A61K33/30 ,  A61K9/0019 ,  A61K9/19 ,  A61K33/24 ,  A61K41/0033 ,  B82Y5/00

摘要： There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.

摘要翻译： 提供超声波治疗增强剂和细胞杀伤剂，其可以通过超声波照射显着改善治疗癌症的效果，同时确保高水平的安全性。 超声波治疗增强剂和细胞杀伤剂包含金属半导体颗粒，并且可以在超声波照射下被激活以杀死或破坏癌细胞。

公开(公告)号：US20080261805A1

公开(公告)日：2008-10-23

申请号：US11883212

申请日：2006-03-27

申请人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai ,  Junji Kameshima

发明人： Koki Kanehira ,  Shuji Sonezaki ,  Yumi Ogami ,  Toshiaki Banzai ,  Junji Kameshima

IPC分类号： B01J31/06 ,  B05D7/00

CPC分类号： A61K9/5146 ,  A61K9/1676 ,  A61K33/24 ,  A61K41/0042 ,  B01J21/063 ,  B01J35/0013 ,  B01J35/004 ,  B82Y30/00 ,  C01G23/047 ,  C01P2002/84 ,  C01P2004/64 ,  C09C1/3676

摘要： Photocatalytic titanium dioxide particles are disclosed having improved dispersibility into an aqueous solvent not only under neutral physiological conditions in vivo but also over a wide pH range, and improved cell affinity and cell uptake property. The photocatalytic titanium dioxide particles comprise particles comprising photocatalytic titanium dioxide and a cationic hydrophilic polymer modifying surfaces of the photocatalytic titanium dioxide particles, wherein the hydrophilic polymer is bonded to the photocatalytic titanium dioxide particles. The photocatalytic titanium dioxide particles are very useful for medical applications, such as destruction of cancer cells.

摘要翻译： 公开了光催化二氧化钛颗粒，其不仅在体内中性生理条件下而且在宽pH范围内都具有改进的水溶剂分散性，并且改善了细胞亲和力和细胞摄取性能。 光催化二氧化钛颗粒包含包含光催化二氧化钛和光催化二氧化钛颗粒的阳离子亲水聚合物改性表面的颗粒，其中亲水性聚合物与光催化二氧化钛颗粒结合。 光催化二氧化钛颗粒对于医疗应用非常有用，例如癌细胞的破坏。

公开(公告)号：US08431143B2

公开(公告)日：2013-04-30

申请号：US12889753

申请日：2010-09-24

申请人： Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Toshiaki Banzai ,  Yoshinobu Kubota

发明人： Shuji Sonezaki ,  Koki Kanehira ,  Yumi Ogami ,  Toshiaki Banzai ,  Yoshinobu Kubota

IPC分类号： A61P33/00 ,  A61K47/48 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/70 ,  A61K9/10 ,  A61K31/704 ,  A61K47/02 ,  A01N25/32 ,  A01N43/04

CPC分类号： A61K41/0028 ,  A61K9/0019 ,  A61K31/704 ,  A61K47/58 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

摘要： A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of a pharmaceutical compound supported thereon by light irradiation and a dispersion thereof. A composite is used in which a pharmaceutical compound is bound to titanium dioxide having photocatalytic activity through a hydrophilic polymer. The composite is stable in an aqueous solvent and easily administered into a living body, and adverse drug reactions of the pharmaceutical compound can be reduced by administering the composite into the body and irradiating the composite with a light to photoexcite the titanium dioxide to decompose the pharmaceutical compound in a region where the drug efficacy of the pharmaceutical composition is not required.

摘要翻译： 提供二氧化钛复合体，其可以稳定地分散在水性溶剂中，并且容易地施用到人体等生物体中，并且可以通过光照射及其分散来消除其上负载的药物化合物的药物功效。 使用其中药物化合物通过亲水性聚合物与具有光催化活性的二氧化钛结合的复合物。 该复合材料在水性溶剂中稳定，容易投入生物体中，通过将复合体投入体内照射复合体，对该复合体进行光照射，可以降低药物化合物的药物不良反应，使二氧化钛分解， 在不需要药物组合物的药物功效的区域中的化合物。