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    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus
    1.
    发明申请
    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus 有权
    疫苗施用方法，新的猫科动物病毒和用于免疫动物抗猫病毒和猫疱疹病毒的治疗

    公开(公告)号：US20070031454A1

    公开(公告)日：2007-02-08

    申请号：US11494825

    申请日：2006-07-28

    申请人： David Lowery ,  Sing Rong ,  Paul Guimond ,  Paula Clare ,  Cassius Tucker ,  Thomas Newby

    发明人： David Lowery ,  Sing Rong ,  Paul Guimond ,  Paula Clare ,  Cassius Tucker ,  Thomas Newby

    IPC分类号： A61K39/125 ,  A61K48/00

    CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2750/10034 ,  C12N2750/14334 ,  C12N2770/16021 ,  C12N2770/16022 ,  C12N2770/16034 ,  G01N33/56983 ,  G01N2469/10

    摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

    摘要翻译： 本发明涉及用于免疫猫对猫科动物病毒的疫苗。 本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。 本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体 包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。 本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。 还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。 该方法包括给予猫治疗有效量的第一和第二FCV疫苗。 第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。 第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。 也可以给予第三次疫苗管理。 本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒 称为猫科鼻气管炎病毒。

    Steel-on-steel and compliant-on-steel calendered magnetic recording media, and methods of making
    2.
    发明申请
    Steel-on-steel and compliant-on-steel calendered magnetic recording media, and methods of making 审中-公开
    钢制钢和合金钢压延磁记录介质及其制造方法

    公开(公告)号：US20060188754A1

    公开(公告)日：2006-08-24

    申请号：US11408743

    申请日：2006-04-21

    申请人： David Lowery ,  Mark Larson ,  Stephen Ebner ,  Ryosuke Isobe ,  Guy Tadlock

    发明人： David Lowery ,  Mark Larson ,  Stephen Ebner ,  Ryosuke Isobe ,  Guy Tadlock

    IPC分类号： G11B5/716 ,  B05D5/12

    CPC分类号： G11B5/8404

    摘要： A method for producing a magnetic recording medium includes applying a non-magnetic back coat to a substrate, applying a magnetic front coat to the substrate, in-line calendering the coated substrate using opposed rolls, at least one of the rolls being a generally compliant roll, and off-line calendering the substrate using opposed, generally non-compliant rolls. The off-line calendering optionally includes steel-on-steel calendering and the method optionally includes only one off-line calendering pass and only one in-line calendering pass. Calendering the coated substrate optionally occurs using at least one nip, the calendering including calendering the coated substrate through a final nip including generally non-compliant rolls. Other methods, and magnetic recording media produced by such methods, also are disclosed.

    摘要翻译： 一种磁记录介质的制造方法，其特征在于，在基板上涂敷非磁性后涂层，向基板施加磁性前涂层，使用相对的辊对涂布的基板进行一体压延，至少一个辊是大体顺从的 辊和离线压制基板，使用相对的，通常不兼容的辊。 离线压延可选地包括钢 - 钢压延，并且该方法可选地仅包括一个离线压延过程，并且仅包括一个在线压延过程。 任选地使用至少一个压区进行压延涂覆的基材，所述压延包括通过包括通常不顺从的辊的最终辊隙压延涂覆的基材。 还公开了通过这些方法制造的其它方法和磁记录介质。

    G protein-coupled receptor-like receptors and modulators thereof
    5.
    发明申请
    G protein-coupled receptor-like receptors and modulators thereof 失效
    G蛋白偶联受体样受体及其调节剂

    公开(公告)号：US20050176069A1

    公开(公告)日：2005-08-11

    申请号：US10650467

    申请日：2003-08-28

    申请人： David Lowery ,  Timothy Geary ,  Teresa Kubiak ,  Martha Larsen

    发明人： David Lowery ,  Timothy Geary ,  Teresa Kubiak ,  Martha Larsen

    IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C07K14/70571

    摘要： The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

    摘要翻译： 本发明提供神经肽配体，G蛋白偶联受体和筛选受体活性调节剂的方法。 鉴定的调节剂，包括神经肽配体模拟物，可用作不同范围的生物杀灭剂和杀生物剂，从限制于特定无脊椎寄生虫的致死活性到广泛无脊椎动物（包括蠕虫和昆虫）的广谱无脊椎寄生虫寄生虫。

    Magnetic recording medium having improved durability for high density applications
    6.
    发明申请
    Magnetic recording medium having improved durability for high density applications 有权
    对于高密度应用具有改善的耐久性的磁记录介质

    公开(公告)号：US20070254190A1

    公开(公告)日：2007-11-01

    申请号：US11413821

    申请日：2006-04-28

    申请人： Adam Brodd ,  Bruce Edwards ,  Brian Brong ,  David Lowery

    发明人： Adam Brodd ,  Bruce Edwards ,  Brian Brong ,  David Lowery

    IPC分类号： G11B5/708 ,  B05D5/12 ,  B05D3/12 ,  G11B5/716

    CPC分类号： G11B5/70 ,  G11B5/708 ,  G11B5/714 ,  G11B5/733 ,  G11B5/84

    摘要： A magnetic recording tape includes an elongated substrate and a magnetic side. The magnetic side includes a support layer formed over the substrate and a magnetic recording layer formed over the support layer to define a magnetic recording surface opposite the substrate. The magnetic recording layer includes magnetic particles and a lubricant and supports a net uncompressed density of at least 30 MB/in2. The magnetic side has an extracted BET surface area of greater than 1.0 m2/g.

    摘要翻译： 磁记录带包括细长基板和磁侧。 磁性侧包括形成在衬底上的支撑层和形成在支撑层上方的磁记录层，以限定与衬底相对的磁记录表面。 磁记录层包括磁性颗粒和润滑剂，并且支持至少30MB / in 2的净压缩密度。 磁性面具有大于1.0m 2 / g的提取的BET表面积。

    Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
    8.
    发明申请
    Drosophila g protein coupled receptors, nucleic acids, and methods related to the same 审中-公开
    果蝇g蛋白偶联受体，核酸和与之相关的方法

    公开(公告)号：US20060198841A1

    公开(公告)日：2006-09-07

    申请号：US10523893

    申请日：2003-08-06

    申请人： David Lowery ,  Valdin Smith ,  Teresa Kubiak ,  Martha Larsen

    发明人： David Lowery ,  Valdin Smith ,  Teresa Kubiak ,  Martha Larsen

    IPC分类号： G01N33/567 ,  A61K39/395 ,  A01N43/90

    CPC分类号： C07K14/705 ,  C07K14/43581 ,  C12N2799/021

    摘要： The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologues in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphan Drosophila short neuropeptide F receptor with its cognate peptide ligands.

    摘要翻译： 本发明提供了果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。 此外，本发明提供表达载体，宿主细胞及其生产方法。 本发明还提供了用于鉴定其他物种中的同系物和用作潜在杀虫剂的DmGPCR激动剂/拮抗剂的方法。 本发明还提供了结合DmGPCR的方法，用于鉴定DmGPCR表达和活性的调节剂的方法，用DmGPCR抗体控制昆虫群体的方法，DmGPCR反义多核苷酸，DmGPCR结合配偶体或调节剂，以及预防或治疗方法 与外寄生物相关的疾病或病症。 具体地，本发明公开了孤儿果蝇短神经肽F受体与其同源肽配体的匹配。

    Optical media with laminated inkjet receptor
    9.
    发明申请
    Optical media with laminated inkjet receptor 审中-公开
    具有层压喷墨受体的光学介质

    公开(公告)号：US20060132576A1

    公开(公告)日：2006-06-22

    申请号：US11169321

    申请日：2005-06-28

    申请人： David Lowery ,  Gary Featherstone ,  Arne Boberg

    发明人： David Lowery ,  Gary Featherstone ,  Arne Boberg

    IPC分类号： B41J3/407

    CPC分类号： B41M5/52 ,  G11B7/24094 ,  G11B7/26 ,  G11B7/265 ,  G11B23/40

    摘要： Aspects of the present invention relate to an inkjet printable optical recording medium for sale to consumers. The optical medium includes an optical recording media and an inkjet receptive laminate. The optical recording media includes at least a transparent base material. The inkjet receptive laminate is bonded to the optical media and provides an inkjet receptive surface. With this in mind, the inkjet receptive laminate is characterized as exhibiting a Waterfast Optical Density Loss Percent Value of not more than 10%. In other embodiments, the Waterfast Optical Density Loss Percent Value is not less than 5%. In other embodiments, the inkjet receptive surface has a Dmin Value of not more than 0.10, a Brightness Value of at least 90%, and/or a BFR Value of not more than 16.

    摘要翻译： 本发明的方面涉及一种用于销售给消费者的可喷墨印刷光学记录介质。 光学介质包括光学记录介质和受墨层压板。 光学记录介质至少包括透明基材。 喷墨接受层压板结合到光学介质上并提供喷墨受体表面。 考虑到这一点，喷墨接受层压体的特征在于表现出不超过10％的耐水光密度损失百分比值。 在其他实施例中，防水光密度损失百分比值不小于5％。 在其它实施例中，受墨表面的Dmin值不大于0.10，亮度值至少为90％，和/或BFR值不大于16。