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公开(公告)号：US20120125107A1
公开(公告)日：2012-05-24
申请号：US13190334
申请日：2011-07-25
申请人： Stanislav Emelianov , Bo Wang , Jignesh Shah , Konstantin Sokolov , Jimmy Su , Yun-Sheng Chen , Wolfgang Frey
发明人： Stanislav Emelianov , Bo Wang , Jignesh Shah , Konstantin Sokolov , Jimmy Su , Yun-Sheng Chen , Wolfgang Frey
IPC分类号： G01H1/08
CPC分类号： A61B8/5223 , A61B5/0095 , A61B5/02007 , A61B6/481 , A61B8/0891 , A61B8/12 , G01N21/1702
摘要： Methods and systems relating to temperature dependent photoacoustic imaging are provided.
摘要翻译： 提供了与温度相关的光声成像有关的方法和系统。
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公开(公告)号：US08904871B2
公开(公告)日：2014-12-09
申请号：US13190334
申请日：2011-07-25
申请人： Stanislav Emelianov , Bo Wang , Jignesh Shah , Konstantin Sokolov , Jimmy Su , Yun-Sheng Chen , Wolfgang Frey
发明人： Stanislav Emelianov , Bo Wang , Jignesh Shah , Konstantin Sokolov , Jimmy Su , Yun-Sheng Chen , Wolfgang Frey
CPC分类号： A61B8/5223 , A61B5/0095 , A61B5/02007 , A61B6/481 , A61B8/0891 , A61B8/12 , G01N21/1702
摘要： The present disclosure relates to methods and systems relating to temperature dependent photoacoustic imaging are provided. In such methods and systems, a tissue sample may be exposed to thermal energy and electromagnetic radiation to generate an acoustic signal, which may be detected. The amplitude of the acoustic signal may be determined and correlated with a tissue property, such as the presence or absence of macrophages or foam cells.
摘要翻译： 本公开涉及与温度依赖性光声成像有关的方法和系统。 在这样的方法和系统中，组织样本可能暴露于热能和电磁辐射以产生可能被检测的声信号。 可以确定声信号的幅度并与组织属性（例如巨噬细胞或泡沫细胞的存在或不存在）相关联。
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公开(公告)号：US20120075619A1
公开(公告)日：2012-03-29
申请号：US13043043
申请日：2011-03-08
CPC分类号： G01B11/22 , G01J3/0218 , G01N21/31 , G01N21/474
摘要： Fiber-optic probes are provided comprising an illumination fiber and a plurality of collection beveled fibers. In some embodiments, the fiber-optic probes may further comprise a collection flat-tip fiber. A system comprising a fiber-optic probe operably connected to a spectrometer, wherein the fiber-optic probe comprises an illumination fiber and a plurality of collection beveled fibers is provided. Associated methods are also provided.
摘要翻译： 提供了包括照明光纤和多个收集斜面光纤的光纤探针。 在一些实施例中，光纤探针还可以包括收集平头纤维。 一种包括可操作地连接到光谱仪的光纤探针的系统，其中所述光纤探针包括照明光纤，并且提供多个收集斜面光纤。 还提供了相关的方法。
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公开(公告)号：US20120065495A1
公开(公告)日：2012-03-15
申请号：US13229112
申请日：2011-09-09
CPC分类号： A61B1/043 , A61B1/00096 , A61B1/00165 , A61B1/0017 , A61B1/0638 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample.
摘要翻译： 成像技术。 使用具有细胞或亚细胞分辨率的内窥镜将辐射从源引导到样品上。 内窥镜包括一根或多根纤维。 纤维具有近端和远端，并且远端是无透镜的。 内窥镜的焦平面基本上在远端的尖端。 来自样品的辐射被引导到检测器上以诊断或监测样品。
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公开(公告)号：US20090068108A1
公开(公告)日：2009-03-12
申请号：US11877476
申请日：2007-10-23
IPC分类号： A61K49/00 , G01N33/543 , A61P35/00
CPC分类号： A61B5/0059 , A61B5/411 , A61B5/415 , A61B5/416 , A61B5/418 , A61K49/00 , A61K49/0017 , A61K49/0058 , A61K49/0067 , B82Y15/00 , B82Y30/00 , G01N33/587 , G01N33/588
摘要： Methods and apparatuses for detecting a condition of a sample (including cervical cancers and pre-cancers) through reflectance and/or fluorescence imaging. A sample is obtained. One or more metallic nanoparticles and/or one or more quantum dots are obtained. The one or more metallic nanoparticles and/or one or more quantum dots are coupled to one or more biomarkers of the sample that are associated with the condition. A reflectance and/or fluorescence image of the sample is then taken. The image(s) exhibit characteristic optical scattering from the one or more metallic nanoparticles and/or characteristic fluorescence excitation from the one or more quantum dots to signal the presence of the one or more biomarkers. In this way, the condition can be readily screened or diagnosed.
摘要翻译： 通过反射和/或荧光成像检测样品（包括宫颈癌和癌前病症）的方法和装置。 获得样品。 获得一种或多种金属纳米颗粒和/或一个或多个量子点。 将一种或多种金属纳米颗粒和/或一个或多个量子点偶联到与该条件相关联的样品的一个或多个生物标志物上。 然后取样品的反射率和/或荧光图像。 该图像表现出来自一种或多种金属纳米颗粒的特征光学散射和/或来自一个或多个量子点的特征荧光激发以发出一个或多个生物标志物的存在。 以这种方式，可以容易地筛选或诊断病症。
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公开(公告)号：US5837552A
公开(公告)日：1998-11-17
申请号：US477288
申请日：1995-06-07
IPC分类号： G01N33/533 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54386 , G01N33/533 , G01N33/553 , Y10S436/805
摘要： Surfaced-enhanced, analytical procedures wherein a surfaced article includes a substrate surface, metal islands, a spacing/coupling agent layer, and binding partner molecules which bond with work piece molecules to be detected. A population of spaced apart metal islands are formed on the substrate and have at least some interconnections formed between them. A continuous layer coats the islands and all surfaces between the islands. The continuous layer includes a coupling agent which immobilizes first binding partner molecules. The first partner molecules bond to the coupling agent and the second binding partner molecules bind to the first binding partner molecules to allow detection of presence or concentration of the work piece binding partner molecules.
摘要翻译： 表面增强的分析程序，其中表面物品包括基底表面，金属岛，间隔/偶联剂层以及与要检测的工件分子结合的结合配偶体分子。 在衬底上形成间隔开的金属岛群，并且在它们之间形成至少一些互连。 连续的层覆盖岛屿和岛屿之间的所有表面。 连续层包括固定第一结合配偶体分子的偶联剂。 第一配偶体分子与偶联剂结合，第二结合配偶体分子与第一结合配偶体分子结合，以检测工件结合配偶体分子的存在或浓度。
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公开(公告)号：US20120065521A1
公开(公告)日：2012-03-15
申请号：US13229059
申请日：2011-09-09
CPC分类号： A61B1/043 , A61B1/00096 , A61B1/00165 , A61B1/0017 , A61B1/0638 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample.
摘要翻译： 成像技术。 使用具有细胞或亚细胞分辨率的内窥镜将辐射从源引导到样品上。 内窥镜包括一根或多根纤维。 纤维具有近端和远端，并且远端是无透镜的。 内窥镜的焦平面基本上在远端的尖端。 来自样品的辐射被引导到检测器上以诊断或监测样品。
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公开(公告)号：US20070173718A1
公开(公告)日：2007-07-26
申请号：US11464777
申请日：2006-08-15
CPC分类号： A61B1/043 , A61B1/00096 , A61B1/00165 , A61B1/0017 , A61B1/0638 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample.
摘要翻译： 成像技术。 使用具有细胞或亚细胞分辨率的内窥镜将辐射从源引导到样品上。 内窥镜包括一根或多根纤维。 纤维具有近端和远端，并且远端是无透镜的。 内窥镜的焦平面基本上在远端的尖端。 来自样品的辐射被引导到检测器上以诊断或监测样品。
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公开(公告)号：US06639674B2
公开(公告)日：2003-10-28
申请号：US09821836
申请日：2001-03-28
IPC分类号： G01J400
CPC分类号： A61B5/444 , A61B5/0075 , A61B5/0084 , A61B5/0088 , G01N21/21
摘要： Methods and apparatus for assessing the size of a scattering element of a sample. Primary radiation is generated from a source. The primary radiation is polarized to produce polarized primary radiation. The polarized primary radiation is directed to the sample to generate reflected radiation. The reflected radiation is directed through a polarizer to produce filtered reflected radiation, the polarizer being configured to select reflected radiation parallel and perpendicular to the polarization of the polarized primary radiation. The filtered radiation is detected, and a depolarization ratio is calculated using the detected filtered radiation. The size of the scattering element is calculated using the depolarization ratio.
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