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公开(公告)号：US08703101B2
公开(公告)日：2014-04-22
申请号：US13388360
申请日：2010-08-03
IPC分类号： A61K49/00
CPC分类号： G01N33/84 , G01N2800/40
摘要： The present disclosure provides devices and rapid methods to acquire a wound sample to detect and measure NOx, and optionally, one or more other analytes that are indicative of the status of a wound.
摘要翻译： 本公开提供了用于获取伤口样品以检测和测量NO x的装置和快速方法，以及可选地，指示伤口状态的一种或多种其它分析物。
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公开(公告)号：US20120135444A1
公开(公告)日：2012-05-31
申请号：US13388360
申请日：2010-08-03
CPC分类号： G01N33/84 , G01N2800/40
摘要： The present disclosure provides devices and rapid methods to acquire a wound sample to detect the presence of NOx and, optionally, one or more other analytes that are indicative of the status of a wound.
摘要翻译： 本公开提供了用于获取伤口样品以检测NOx的存在的装置和快速方法，以及可选地，指示伤口状态的一种或多种其它分析物。
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公开(公告)号：US20110097814A1
公开(公告)日：2011-04-28
申请号：US12743522
申请日：2008-11-20
申请人： G. Marco Bommarito , Joseph J. Stoffel , Vinod P. Menon , Brinda B. Lakshmi , Timothy J. Diekmann , Gustavo H. Castro , Paul J. Cobian , Raj Rajagopal , Patrick A. Mach
发明人： G. Marco Bommarito , Joseph J. Stoffel , Vinod P. Menon , Brinda B. Lakshmi , Timothy J. Diekmann , Gustavo H. Castro , Paul J. Cobian , Raj Rajagopal , Patrick A. Mach
CPC分类号： B01L3/5027 , B01L3/5023 , B01L2200/0684 , B01L2300/0825 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , G01N33/542 , G01N33/54366
摘要： The application discloses embodiments of detection devices including a sensor component in a flow path between a first flow path portion and a second flow path portion. In embodiments described, the sensor component includes a receptor in a polymerized composition. The receptor is configured to bind with an analyte in a test sample. Upon binding the sensor component undergoes a detectable change in response to interaction of the analyte with the receptor.
摘要翻译： 本申请公开了一种检测装置的实施例，其包括在第一流路部分和第二流路部分之间的流动路径中的传感器部件。 在所描述的实施方案中，传感器组分包括聚合组合物中的受体。 受体被配置为与测试样品中的分析物结合。 当结合时，传感器组件响应于分析物与受体的相互作用而经历可检测的变化。
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公开(公告)号：US20100317021A1
公开(公告)日：2010-12-16
申请号：US12515745
申请日：2007-11-20
申请人： Patrick A. Mach , G. Marco Bommarito , Ryan Patrick Simmers , Brinda B. Badri , Joseph J. Stoffel , Vinod P. Menon
发明人： Patrick A. Mach , G. Marco Bommarito , Ryan Patrick Simmers , Brinda B. Badri , Joseph J. Stoffel , Vinod P. Menon
CPC分类号： G01N33/54386
摘要： The invention relates to devices and methods for analyzing a sample (and preferably preparing a sample), which is particularly used in analysis, such as analysis of a sample for a bacterium of interest.
摘要翻译： 本发明涉及用于分析样品（并且优选制备样品）的装置和方法，其特别用于分析中，例如用于感兴趣的细菌的样品的分析。
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公开(公告)号：US08677843B2
公开(公告)日：2014-03-25
申请号：US12867146
申请日：2009-02-10
申请人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
发明人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
IPC分类号： G01N1/10
CPC分类号： G01N1/02 , A61B10/0045 , G01N2001/028
摘要： A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.
摘要翻译： 样品采集装置包括毛细管阵列，该毛细管阵列构造成吸取样品并通过毛细管作用保留样品。 毛细管阵列可以耦合到细长构件，例如杆或中空管，其限定沿第一方向延伸的纵向轴线。 在一些实施例中，毛细管阵列限定沿与第一方向不同的第二方向延伸的主要样本采集表面。 可以选择毛细管阵列保留的主要样品采集表面积与最大体积的比率以使毛细管阵列和样品之间的物理结合最小化。 在一些实施例中，装置可以包括反馈机构，以指示使用样本采集装置施加到样本源的相对压力。 此外，在一些实施例中，样品采集装置可以包括抽吸源以帮助将样品吸入毛细管阵列。
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公开(公告)号：US20110146419A1
公开(公告)日：2011-06-23
申请号：US12867146
申请日：2009-02-10
申请人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
发明人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
CPC分类号： G01N1/02 , A61B10/0045 , G01N2001/028
摘要： A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.
摘要翻译： 样品采集装置包括毛细管阵列，该毛细管阵列构造成吸取样品并通过毛细管作用保留样品。 毛细管阵列可以耦合到细长构件，例如杆或中空管，其限定沿第一方向延伸的纵向轴线。 在一些实施例中，毛细管阵列限定沿与第一方向不同的第二方向延伸的主要样本采集表面。 可以选择毛细管阵列保留的主要样品采集表面积与最大体积的比率以使毛细管阵列和样品之间的物理结合最小化。 在一些实施例中，装置可以包括反馈机构，以指示使用样本采集装置施加到样本源的相对压力。 此外，在一些实施例中，样品采集装置可以包括抽吸源以帮助将样品吸入毛细管阵列。
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7.发明申请METHOD OF ANALYZING A SAMPLE FOR A BACTERIUM USING DIACETYLENE-CONTAINING POLYMER SENSOR 审中-公开使用含有二乙烯基聚合物传感器分析细菌样品的方法公开(公告)号：US20110091903A1
公开(公告)日：2011-04-21
申请号：US12743518
申请日：2008-11-20
申请人： G. Marco Bommarito , Sridhar V. Dasaratha , Brinda B. Lakshmi , Robert E. Brennan, JR. , Joseph J. Stoffel , Joseph P. Hensler , Triet M. Lu , Patrick A. Mach , Chunmei Guo , Mara S. Reif-Wenner , Heather M. Webb
发明人： G. Marco Bommarito , Sridhar V. Dasaratha , Brinda B. Lakshmi , Robert E. Brennan, JR. , Joseph J. Stoffel , Joseph P. Hensler , Triet M. Lu , Patrick A. Mach , Chunmei Guo , Mara S. Reif-Wenner , Heather M. Webb
IPC分类号： G01N33/53
CPC分类号： C12Q1/04 , G01N33/54326 , G01N33/56911 , G01N33/586 , G01N2333/31
摘要： The invention relates to methods of analyzing a sample for a bacterium of interest. In particular, the methods involve an initial capture process that includes the use of one or more antibodies having antigenic specificities for one or more distinct analytes characteristic of the specific bacterium. After initial capture of a specific bacterium, techniques of analyzing involve colorimetric techniques, particularly using colorimetric sensors that include polydiacetylene (PDA) materials.
摘要翻译： 本发明涉及分析感兴趣的细菌的样品的方法。 特别地，所述方法包括初始捕获过程，其包括使用一种或多种具有针对特定细菌特征的一种或多种不同分析物具有抗原特异性的抗体。 在初步捕获特定细菌后，分析技术涉及比色技术，特别是使用包含聚二乙炔（PDA）材料的比色传感器。
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公开(公告)号：US08349580B2
公开(公告)日：2013-01-08
申请号：US13394353
申请日：2010-08-30
申请人： Joseph J. Stoffel , Louis C. Haddad
发明人： Joseph J. Stoffel , Louis C. Haddad
CPC分类号： C12Q1/37 , G01N2333/96433 , G01N2333/96486 , G01N2333/96494 , G01N2333/966
摘要： A method for testing efficacy of a protease enzyme assay, the method comprising providing an enzyme which acts as a surrogate enzyme control for the protease enzyme; combining the surrogate enzyme control with an assay substrate for the protease enzyme; and determining a change in the assay substrate resulting from the surrogate enzyme control acting on the assay substrate; wherein the protease enzyme is selected from the group consisting of metalloproteinases, serine proteases, and cysteine proteases; a method for conducting a protease enzyme assay using the method for testing efficacy; a kit including an enzyme which acts as a surrogate enzyme control for a protease enzyme in testing efficacy of a protease enzyme assay; and a method of releasing the kit are provided.
摘要翻译： 一种用于测试蛋白酶测定的功效的方法，所述方法包括提供用作蛋白酶的替代酶对照的酶; 将替代酶控制与用于蛋白酶的测定底物组合; 以及确定由作用在测定底物上的替代酶控制产生的测定底物的变化; 其中所述蛋白酶选自金属蛋白酶，丝氨酸蛋白酶和半胱氨酸蛋白酶; 使用测试功效的方法进行蛋白酶测定的方法; 一种试剂盒，其包括在测试蛋白酶测定的功效中用作蛋白酶的替代酶对照的酶; 并提供了释放试剂盒的方法。
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公开(公告)号：US20120164675A1
公开(公告)日：2012-06-28
申请号：US13394353
申请日：2010-08-30
申请人： Joseph J. Stoffel , Louis C. Haddad
发明人： Joseph J. Stoffel , Louis C. Haddad
CPC分类号： C12Q1/37 , G01N2333/96433 , G01N2333/96486 , G01N2333/96494 , G01N2333/966
摘要： A method for testing efficacy of a protease enzyme assay, the method comprising providing an enzyme which acts as a surrogate enzyme control for the protease enzyme; combining the surrogate enzyme control with an assay substrate for the protease enzyme; and determining a change in the assay substrate resulting from the surrogate enzyme control acting on the assay substrate; wherein the protease enzyme is selected from the group consisting of metalloproteinases, serine proteases, and cysteine proteases; a method for conducting a protease enzyme assay using the method for testing efficacy; a kit including an enzyme which acts as a surrogate enzyme control for a protease enzyme in testing efficacy of a protease enzyme assay; and a method of releasing the kit are provided.
摘要翻译： 一种用于测试蛋白酶测定的功效的方法，所述方法包括提供用作蛋白酶的替代酶对照的酶; 将替代酶控制与用于蛋白酶的测定底物组合; 以及确定由作用在测定底物上的替代酶控制产生的测定底物的变化; 其中所述蛋白酶选自金属蛋白酶，丝氨酸蛋白酶和半胱氨酸蛋白酶; 使用测试功效的方法进行蛋白酶测定的方法; 一种试剂盒，其包括在测试蛋白酶测定的功效中用作蛋白酶的替代酶对照的酶; 并提供了释放试剂盒的方法。
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公开(公告)号：US20110179887A1
公开(公告)日：2011-07-28
申请号：US12867100
申请日：2009-02-12
申请人： Paul J. Cobian , G. Marco Bommarito , Bernard A. Gonzalez , Tushar A. Kshirsagar , Patrick A. Mach , Tera M. Nordby , Gustavo H. Castro , Joseph J. Stoffel , Murat Okcay , Scott A. Burton
发明人： Paul J. Cobian , G. Marco Bommarito , Bernard A. Gonzalez , Tushar A. Kshirsagar , Patrick A. Mach , Tera M. Nordby , Gustavo H. Castro , Joseph J. Stoffel , Murat Okcay , Scott A. Burton
IPC分类号： G01N1/10
CPC分类号： A61B10/0291 , A61B10/0051 , A61B17/32002 , A61B2010/0054 , A61B2010/0208 , A61B2017/320008
摘要： A sample acquisition device includes a body comprising a plurality of sample acquisition regions defined by at least a first wall and a second wall oriented nonparallel to the first wall. In some embodiments, the body defines a plurality of apertures that define a plurality of sample acquisition regions. In other embodiments, the walls extend from the body, and the sample acquisition regions are defined between the walls. The sample acquisition regions may be configured in some embodiments such that a user may acquire a sample by rotating the body in a first direction relative to a sample source and may release the sample by rotating the body in a second direction that is substantially opposite to the first direction. When rotated in the first direction, at least one of the first or second walls defines a surface that is inclined into a sample acquisition region.
摘要翻译： 样品采集装置包括主体，其包括由至少第一壁和不平行于第一壁定向的第二壁限定的多个样品采集区域。 在一些实施例中，主体限定了限定多个样本采集区域的多个孔。 在其他实施例中，壁从主体延伸，并且样品采集区域被限定在壁之间。 可以在一些实施例中配置样本采集区域，使得用户可以通过相对于样本源沿第一方向旋转身体来获取样本，并且可以通过沿与第二方向基本上相反的第二方向旋转身体来释放样本 第一个方向 当沿第一方向旋转时，第一或第二壁中的至少一个限定了倾斜成样品采集区域的表面。
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