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公开(公告)号：US20090092650A1
公开(公告)日：2009-04-09
申请号：US11793296
申请日：2005-12-15
CPC分类号： A61K38/31 , A61K9/0021 , A61K9/19 , A61K47/34
摘要： The present invention relates to an octreotide sustained release delivery system for treatment of diseases relating to somatotropin and/or somatostatin. The sustained release delivery system of the invention includes a flowable composition containing an octreotide compound, and an implant containing the octreotide compound. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid and an octreotide compound.
摘要翻译： 本发明涉及用于治疗与生长激素和/或生长抑素有关的疾病的奥曲肽缓释递送系统。 本发明的持续释放递送系统包括含有奥曲肽化合物的可流动组合物和含有奥曲肽化合物的植入物。 可流动组合物可以注射到组织中，随后凝结成为固体或凝胶，整体式植入物。 可流动组合物包括可生物降解的热塑性聚合物，有机液体和奥曲肽化合物。
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2.发明授权公开(公告)号：US08017144B2
公开(公告)日：2011-09-13
申请号：US12257803
申请日：2008-10-24
申请人： Francis Dumont , Richard L. Dunn , Scott A. Jeffers , Richard W. Korsmeyer , Mei Li , Vishwas M. Paralkar , Mingxing Zhou
发明人： Francis Dumont , Richard L. Dunn , Scott A. Jeffers , Richard W. Korsmeyer , Mei Li , Vishwas M. Paralkar , Mingxing Zhou
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61K31/20 , A61K31/44
摘要： The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and an organic solvent. The flowable composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of a bone growth promoting compound to certain tissues.
摘要翻译： 本发明涉及一种用于骨生长促进化合物和用于其形成的可流动组合物的控制释放的改进系统。 可流动组合物由骨生长促进化合物，热塑性聚合物和有机溶剂组成。 可流动组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作用于将骨生长促进化合物递送至某些组织的患者（人和动物）中的植入物。
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公开(公告)号：US06773714B2
公开(公告)日：2004-08-10
申请号：US10373400
申请日：2003-02-24
IPC分类号： A61K900
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US5990194A
公开(公告)日：1999-11-23
申请号：US966133
申请日：1997-11-07
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61K9/00 , A61K9/22 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61K9/08
CPC分类号： A61K9/0024 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/0015 , A61L24/0026 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L26/0019 , A61L26/0066 , A61L26/0076 , A61L26/009 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61F2002/30062 , A61F2002/30583 , A61F2210/0004 , A61F2210/0085 , A61L2300/25 , A61L2300/252 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/604 , Y10S525/937
摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
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公开(公告)号：US5945115A
公开(公告)日：1999-08-31
申请号：US908263
申请日：1997-08-08
申请人： Richard L. Dunn , Arthur J. Tipton
发明人： Richard L. Dunn , Arthur J. Tipton
CPC分类号： A61K9/0024 , A61K47/14 , A61K47/34 , A61K9/0019
摘要： The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.
摘要翻译： 本发明涉及用于控制释放生物活性物质和用于其形成的液体组合物的改进系统。 液体组合物由热塑性聚合物，速率改性剂，生物活性材料和有机溶剂组成。 液体组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作患者（人和动物）中用于将生物活性物质递送至组织或器官的植入物。
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公开(公告)号：US5744153A
公开(公告)日：1998-04-28
申请号：US871492
申请日：1997-06-09
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61F2/00 , A61K9/127 , A61K9/52
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
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公开(公告)号：US5739176A
公开(公告)日：1998-04-14
申请号：US210891
申请日：1994-03-18
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61K9/00 , A61K9/22 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58
CPC分类号： A61K9/0024 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/0015 , A61L24/0026 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L26/0019 , A61L26/0066 , A61L26/0076 , A61L26/009 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61F2002/30062 , A61F2002/30583 , A61F2210/0004 , A61F2210/0085 , A61L2300/25 , A61L2300/252 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/604 , Y10S525/937
摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
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公开(公告)号：US5599552A
公开(公告)日：1997-02-04
申请号：US249630
申请日：1994-05-26
IPC分类号： A61K6/083 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K39/00 , A61K45/00 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/34 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C41/12 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K6/0044 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/406 , A61L2300/412 , A61L2300/602 , A61L2300/604
摘要： The invention is directed to a composition composed of a thermoplastic or thermosetting polymer which is capable of forming a biodegradable and/or bioerodible microporous, solid or gelatinous polymer matrix. The matrix is useful as an implant in animals for enhancing regeneration of cells and tissue, such as bone and nerve cells, or for delivery of biologically-active substances to tissue or organs. The composition is administered to an implant site as a liquid. The invention also includes a method of preventing and treating disorders and diseases, such as bone or nerve growth disorders, or of altering body functions such as birth control, using the compositions and implants of the invention.
摘要翻译： 本发明涉及由热塑性或热固性聚合物组成的组合物，其能够形成可生物降解和/或生物腐蚀性微孔，固体或凝胶状聚合物基质。 该基质可用作动物中的植入物，用于增强细胞和组织的再生，例如骨和神经细胞，或将生物活性物质递送至组织或器官。 将组合物作为液体施用于植入部位。 本发明还包括使用本发明的组合物和植入物来预防和治疗诸如骨骼或神经生长障碍的疾病和疾病或改变身体功能例如避孕的方法。
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公开(公告)号：US4975271A
公开(公告)日：1990-12-04
申请号：US286651
申请日：1988-12-19
IPC分类号： A61K8/02 , A61K9/00 , A61K31/00 , A61K31/155 , A61K31/165 , A61K31/19 , A61K31/415 , A61K31/47 , A61K31/505 , A61K31/60 , A61K31/65 , A61K31/70 , A61K47/22 , A61Q11/00
CPC分类号： A61Q11/00 , A61K31/00 , A61K31/155 , A61K31/165 , A61K31/19 , A61K31/415 , A61K31/47 , A61K31/505 , A61K31/60 , A61K31/65 , A61K31/70 , A61K47/22 , A61K8/02 , A61K9/0014 , A61K9/0063 , Y10S514/90 , Y10S514/901 , Y10S514/912 , Y10S514/946 , Y10S514/947
摘要： A muscosal delivery system is provided for use in treating periodontal disease. The system is composed of a chemotherapeutic agent dissolved in a skin-penetration enhancer. The solution of chemotherapeutic agent and skin-penetration enhancer is placed into the periodontal pocket where the agent is transported into the surrounding gingival tissue by means of the penetration enhancer.
摘要翻译： 提供肌肉输送系统用于治疗牙周病。 该系统由溶解在皮肤渗透增强剂中的化学治疗剂组成。 将化学治疗剂和皮肤渗透增强剂的溶液置于牙周袋中，其中通过渗透增强剂将药剂运送到周围的牙龈组织中。
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公开(公告)号：US4650488A
公开(公告)日：1987-03-17
申请号：US610965
申请日：1984-05-16
CPC分类号： A61L27/58 , A61F11/002 , A61L27/18 , A61F2210/0004 , A61L2430/14
摘要： A prosthetic device formed of a biodegradable material and useful as a ventilation tube for insertion between the middle ear and the outer ear. The device includes a shaft with an axial passage, an inner flange and an outer flange. At least a portion of the outer surface of the shaft is tapered, with the taper increasing from the inner to the outer flange. The larger diameter outer flange and any attached portion of the shaft are, therefore, forced outwardly when the tapered portion of the shaft is in contact with animal tissue biodegrades before other portions of the prosthesis.
摘要翻译： 由可生物降解的材料形成并且可用作用于插入中耳和外耳之间的通气管的假体装置。 该装置包括具有轴向通道的轴，内凸缘和外凸缘。 轴的外表面的至少一部分是锥形的，锥形从内凸缘增加到外凸缘。 因此，当轴的锥形部分在假体的其他部分之前与动物组织生物降解接触时，较大直径的外凸缘和轴的任何附接部分被迫向外。
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