公开(公告)号：US20080077179A1

公开(公告)日：2008-03-27

申请号：US11986470

申请日：2007-11-21

申请人： Stuart Edwards ,  Thomas Wehman ,  Theodore Parker ,  Eugene Skalnyi ,  Theodore Kucklick ,  John Evans

发明人： Stuart Edwards ,  Thomas Wehman ,  Theodore Parker ,  Eugene Skalnyi ,  Theodore Kucklick ,  John Evans

IPC分类号： A61B17/04

CPC分类号： A61B17/00491 ,  A61B17/0057 ,  A61B17/3415 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/1485 ,  A61B18/1487 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/00495 ,  A61B2017/005 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672 ,  A61B2017/22067 ,  A61B2017/3492 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00494 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/064 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2218/002 ,  A61M3/0279 ,  A61M16/0858 ,  A61M25/0662 ,  A61M25/1002 ,  A61M2016/0027 ,  A61M2025/1052 ,  A61M2025/1086

摘要： A closure device is provided for sealing a puncture in a body vessel. The closure device includes an energy delivery device for delivering energy to tissue adjacent the vessel puncture which enhances an adhesiveness of the tissue to a closure composition precursor. The closure device includes a sealer/dilator for dilating tissue adjacent a vessel puncture, at least one closure composition precursor lumen within the sealer/dilator having an entrance port adjacent the proximal end of the sealer/dilator through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen and an exit port adjacent the distal end of the sealer/dilator through which the one or more fluent closure composition precursors can be delivered outside the vessel adjacent the vessel puncture, and a plugging catheter for positioning within the vessel puncture, the plugging catheter extending distally from the sealer/dilator and including at least one position sensing mechanism such that the exit port of the closure composition precursor lumen is outside the vessel when the at least one position sensing mechanism is detected outside the vessel.

摘要翻译： 提供封闭装置用于密封身体容器中的穿刺。 闭合装置包括能量递送装置，用于将能量递送到邻近容器穿刺的组织，这提高了组织与封闭组合物前体的粘附性。 闭合装置包括用于扩张邻近容器穿刺的组织的封闭器/扩张器，密封器/扩张器内的至少一个闭合组合物前体管腔具有邻近密封器/扩张器的近端的入口端口，通过该封闭器/扩张器的一个或多个流体封闭组合物前体 可以将其输送到闭合组合物前体管腔和邻近密封剂/扩张器远端的出口，一个或多个流体封闭组合物前体可通过该出口端口被输送到与血管穿刺相邻的血管外部， 容器穿刺，插塞导管从密封剂/扩张器向远端延伸并且包括至少一个位置感测机构，使得当在容器外部检测到至少一个位置感测机构时，闭合组合物前体腔的出口在容器外部 。

公开(公告)号：US20050149116A1

公开(公告)日：2005-07-07

申请号：US11055440

申请日：2005-02-10

申请人： Stuart Edwards ,  Ronald Lax ,  Theodore Parker ,  Thomas Wehrman ,  Theodore Kucklick ,  Eugene Skalnyi

发明人： Stuart Edwards ,  Ronald Lax ,  Theodore Parker ,  Thomas Wehrman ,  Theodore Kucklick ,  Eugene Skalnyi

IPC分类号： A61B17/00 ,  A61B17/34 ,  A61B17/42 ,  A61B18/00 ,  A61B18/04 ,  A61B18/14 ,  A61B18/18 ,  A61F2/958 ,  A61M3/02 ,  A61M16/04 ,  A61M25/06 ,  A61B17/08

CPC分类号： A61B18/148 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/3415 ,  A61B18/1482 ,  A61B18/1485 ,  A61B18/1487 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/00495 ,  A61B2017/005 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/22067 ,  A61B2017/3492 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00494 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/064 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2218/002 ,  A61M3/0279 ,  A61M16/0481 ,  A61M16/0858 ,  A61M25/0662 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1086

摘要： Systems and methods introduce a closure material to seal a vessel puncture site. The system and methods provide a catheter adapted for passage through a tissue puncture and sized to occupy substantially all the tissue puncture. The catheter includes a lumen in fluid communication with a fluid delivery port adjacent the catheter distal end. One or more dispensers are in fluid communication with the catheter lumen for dispensing first and second fluid compositions in the catheter lumen. An actuator causes the first and second fluid compositions to be dispensed from the dispensers and mixed by flowing the first and second fluid compositions through a static mixer. The first and second fluid compositions are dispensed from the fluid delivery port as a fluid mixture that reacts in situ to form a nonfluent closure composition adjacent the vessel puncture site.

摘要翻译： 系统和方法引入封闭材料以密封容器穿刺部位。 该系统和方法提供适于通过组织穿刺的导管，并且尺寸适于占据基本上所有的组织穿刺。 导管包括与邻近导管远端的流体输送端口流体连通的内腔。 一个或多个分配器与导管内腔流体连通，用于分配导管内腔中的第一和第二流体组合物。 致动器使得第一和第二流体组合物从分配器分配并通过使第一和第二流体组合物流过静态混合器而混合。 第一和第二流体组合物作为流体混合物从流体输送端口分配，其在原位反应以在血管穿刺部位附近形成非流体封闭组合物。

公开(公告)号：US20060254603A1

公开(公告)日：2006-11-16

申请号：US11491763

申请日：2006-07-24

申请人： Stuart Edwards ,  Ronald Lax ,  Theodore Parker ,  Thomas Wehman ,  Theodore Kucklick

发明人： Stuart Edwards ,  Ronald Lax ,  Theodore Parker ,  Thomas Wehman ,  Theodore Kucklick

IPC分类号： A61B18/18

CPC分类号： A61B17/00491 ,  A61B17/0057 ,  A61B17/3415 ,  A61B18/14 ,  A61B18/1482 ,  A61B18/1487 ,  A61B2017/00084 ,  A61B2017/00495 ,  A61B2017/005 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672 ,  A61B2017/3441 ,  A61B2017/3492 ,  A61B2018/0063 ,  A61B2090/064 ,  A61M25/0662

摘要： A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.

摘要翻译： 一种用于通过穿孔在容器中将导管引入容器并用于密封穿刺的装置。 该装置包括细长体，其具有近端和远端，其尺寸设置成包括穿刺的组织部位内。 细长主体包括大小适于允许导管通过效用管腔输送的应用腔。 实用管腔定位在细长体内，从而将细长体定位在组织部位内，允许通过效用腔输送的导管进入血管。 细长体还包括具有入口的封闭腔。 封闭组合物可通过入口端口输送到封闭腔。 闭合腔还包括邻近细长体的远端的出口。 输送到闭合腔内的封闭组合物可以通过出口传送到穿刺附近的组织部位。

公开(公告)号：US20050245926A1

公开(公告)日：2005-11-03

申请号：US11175471

申请日：2005-07-06

申请人： Stuart Edwards ,  David Utley ,  Ronald Lax ,  Theodore Kucklick ,  Peter Muller

发明人： Stuart Edwards ,  David Utley ,  Ronald Lax ,  Theodore Kucklick ,  Peter Muller

IPC分类号： A61B18/00 ,  A61B18/14

CPC分类号： A61B18/14 ,  A61B17/32 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00916 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1472 ,  A61B2018/183 ,  A61B2090/3614 ,  A61B2090/3782

摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.

摘要翻译： 括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。 引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。 能量输送装置联接到引入构件。 保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。

公开(公告)号：US20070112341A1

公开(公告)日：2007-05-17

申请号：US11651750

申请日：2007-01-10

申请人： Stuart Edwards ,  David Utley ,  Ronald Lax

发明人： Stuart Edwards ,  David Utley ,  Ronald Lax

IPC分类号： A61B18/18

CPC分类号： A61B5/04884 ,  A61B18/1477 ,  A61B18/1485 ,  A61B90/39 ,  A61B2018/00553 ,  A61B2018/00738 ,  A61B2018/046 ,  A61B2090/3925 ,  A61B2560/0242

摘要： An apparatus to treat a sphincter has a support member. A sphincter electropotential mapping device includes a mapping electrode. The sphincter electropotential mapping device is coupled to the support member and configured to detect aberrant myoelectric activity of the sphincter.

摘要翻译： 治疗括约肌的装置具有支撑构件。 括约肌电位映射装置包括映射电极。 括约肌电位映射设备耦合到支撑构件并且被配置为检测括约肌的异常肌电活动。

公开(公告)号：US20060047331A1

公开(公告)日：2006-03-02

申请号：US11058845

申请日：2005-02-15

申请人： Ronald Lax ,  Gary Fanton ,  Stuart Edwards

发明人： Ronald Lax ,  Gary Fanton ,  Stuart Edwards

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61B18/148 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00452 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/143 ,  A61B2018/1472 ,  A61B2018/1497 ,  A61B2018/1861 ,  A61N1/40

摘要： An apparatus and method are provided for control contraction of tissue that includes collagen fibers. The apparatus includes a handpiece, and an electrode with an electrode proximal end associated with the handpiece. A distal end of the electrode has a geometry that delivers a controlled amount of energy to the tissue for a desired contraction of the collagen fibers. This is achieved while dissociation and breakdown of the collagen fibers is minimized. The handpiece, with electrode, is adapted to be introduced through an operating cannula in percutaneous applications. Additionally, an operating cannula may be included in the apparatus and be attached to the handpiece. The apparatus and method provides for a desired level of contraction of collagen soft tissue without dissociation or breakdown of collagen fibers.

公开(公告)号：US20050189271A1

公开(公告)日：2005-09-01

申请号：US11114602

申请日：2005-04-26

申请人： Claudio Cerutti ,  Artemio Affaticati ,  Stuart Edwards

发明人： Claudio Cerutti ,  Artemio Affaticati ,  Stuart Edwards

IPC分类号： B65G47/46 ,  B07C5/36 ,  B65G1/137 ,  B65G17/34 ,  B65G43/08 ,  B65G47/52 ,  B65G47/10

CPC分类号： B07C3/02 ,  B07C5/36 ,  B65G17/345 ,  B65G43/08 ,  B65G47/52 ,  B65G2201/02 ,  B65G2201/0288 ,  Y10S209/912

摘要： An article sortation system includes a plurality of transport units which are movable along a conveying path between induction stations and discharge stations along each side of the conveying path. Each transport unit has side by side loading and support capability and is operable to receive packages from induction stations and discharge the packages at an appropriate discharge station. The system includes a control which determines the destination of articles and resolves blocking conditions between articles at the induction stations or at the transport units. The system may include a reinduction station for receiving an article from a transport unit and reinducting the article onto a transport unit, in order to resolve a blocking condition between a pair of articles on the respective transport unit.

公开(公告)号：US20050010203A1

公开(公告)日：2005-01-13

申请号：US10910333

申请日：2004-08-03

申请人： Stuart Edwards ,  Ronald Lax ,  Ingemar Lundquist ,  Hugh Sharkey

发明人： Stuart Edwards ,  Ronald Lax ,  Ingemar Lundquist ,  Hugh Sharkey

IPC分类号： A61B5/01 ,  A61B10/00 ,  A61B10/02 ,  A61B10/06 ,  A61B17/00 ,  A61B17/22 ,  A61B17/24 ,  A61B17/28 ,  A61B17/34 ,  A61B18/00 ,  A61B18/08 ,  A61B18/14 ,  A61B18/18 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61F7/00 ,  A61M1/00 ,  A61M3/02 ,  A61M25/00 ,  A61M25/092 ,  A61M25/14 ,  A61N1/06 ,  A61N1/40 ,  A61N5/02 ,  A61N5/04 ,  A61N5/06 ,  A61B18/04

CPC分类号： A61N5/02 ,  A61B10/02 ,  A61B10/0241 ,  A61B18/00 ,  A61B18/082 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/148 ,  A61B18/1485 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/24 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/00106 ,  A61B2017/00274 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22072 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61B2017/248 ,  A61B2017/2939 ,  A61B2017/3488 ,  A61B2018/00005 ,  A61B2018/00011 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00196 ,  A61B2018/0022 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/0075 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00869 ,  A61B2018/00886 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00946 ,  A61B2018/00982 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/128 ,  A61B2018/1412 ,  A61B2018/1425 ,  A61B2018/1861 ,  A61B2018/2238 ,  A61B2090/0814 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2090/3925 ,  A61F2007/0054 ,  A61M3/0279 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/008 ,  A61M25/0082 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/0089 ,  A61M2025/009 ,  A61M2025/0096 ,  A61M2025/018 ,  A61N1/06 ,  A61N1/40 ,  A61N1/403 ,  A61N5/04 ,  A61N5/045

摘要： A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue. It can also include a fiber optic cable for laser treatment. The catheter can include one or more inflatable balloons located adjacent to the stylet port for anchoring the catheter or dilation. Ultrasound transponders and temperature sensors can be attached to the probe end and/or stylet. The stylet guide can define a stylet path from an axial orientation in the catheter through a curved portion to a lateral orientation at the stylet port.

公开(公告)号：US06440128B1

公开(公告)日：2002-08-27

申请号：US09304784

申请日：1999-05-04

申请人： Stuart Edwards ,  John Gaiser ,  David Utley ,  Scott West ,  Jay Chin

发明人： Stuart Edwards ,  John Gaiser ,  David Utley ,  Scott West ,  Jay Chin

IPC分类号： A61B1818

CPC分类号： A61B18/1485 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00065 ,  A61B2018/00214 ,  A61B2018/00238 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1472 ,  A61B2218/002 ,  A61B2218/007

摘要： An assembly for treating tissue at or near the sphincter includes a support structure for deployment in a tissue region, and a an electrode carried by the support structure. The support structure includes a spine with a lumen having an exit port, the electrode being deployable from the exit port. The spine also includes a cooling lumen and as aspiration lumen to provide and remove fluids, respectively.

摘要翻译： 用于在括约肌处或附近处理组织的组件包括用于展开在组织区域中的支撑结构和由支撑结构承载的电极。 支撑结构包括具有出口的内腔的脊柱，电极可从出口端部分展开。 脊柱还包括冷却腔和分别用于提供和移除流体的抽吸腔。

公开(公告)号：US20050159743A1

公开(公告)日：2005-07-21

申请号：US11079697

申请日：2005-03-14

申请人： Stuart Edwards ,  David Utley ,  Ronald Lax ,  John Gaiser

发明人： Stuart Edwards ,  David Utley ,  Ronald Lax ,  John Gaiser

IPC分类号： A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18 ,  A61F7/00 ,  A61F7/12

CPC分类号： A61B18/1492 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/18 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00047 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00684 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2218/002

摘要： A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.

摘要翻译： 用于治疗括约肌的方法提供具有液体状态的聚合物材料。 该方法还提供了具有远端的导管，由远端承载的组织刺穿装置，以及耦合到组织刺穿装置的能量输送装置。 组织穿刺装置具有内腔。 该方法将导管引入食道并刺穿组织穿刺装置内的外括约肌组织表面。 该方法使组织穿刺装置进入内部括约肌组织部位，并将液体状态下的聚合物材料通过内腔输送到内括约肌组织部位。 该方法将能量传递到组织刺穿装置，以将聚合物材料转变成内部括约肌组织部位内的较少液体状态，从而改变括约肌。