利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.028 秒)

    METHODS, COMPOSITIONS, DEVICES, AND KITS FOR PERFORMING PHOSPHOLIPID SEPARATION
    7.
    发明申请
    METHODS, COMPOSITIONS, DEVICES, AND KITS FOR PERFORMING PHOSPHOLIPID SEPARATION 有权
    用于进行磷脂分离的方法，组合物，装置和工具

    公开(公告)号：US20130053588A1

    公开(公告)日：2013-02-28

    申请号：US13580884

    申请日：2011-05-20

    申请人： Pamela C. Iraneta ,  Thomas H. Walter ,  Xin Zhang ,  Daniel P. Walsh ,  Kevin D. Wyndham ,  Raymond P. Fish

    发明人： Pamela C. Iraneta ,  Thomas H. Walter ,  Xin Zhang ,  Daniel P. Walsh ,  Kevin D. Wyndham ,  Raymond P. Fish

    IPC分类号： B01D21/26 ,  B01D21/00 ,  C07F9/02

    CPC分类号： C07F9/103 ,  B01D15/22 ,  B01D15/327 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28019 ,  B01J20/28061 ,  B01J20/28069 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3246 ,  B01J20/3293 ,  B01J2220/64 ,  B01L3/5023 ,  B01L3/50255 ,  B01L2300/0681 ,  C07K1/30 ,  G01N2030/8813

    摘要： Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one fit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids. The wetting barrier is adapted to (i) retain the liquid sample and a protein precipitating agent in the sample receiving area under a first force, thereby facilitating the formation of a protein precipitate and a processed sample, and (ii) flow the processed sample through the wetting barrier and separation media under a second force, wherein the second force is greater than the first force, thereby retaining the protein precipitate in the sample receiving area, retaining phospholipids in the separation media, and eluting small molecules.

    摘要翻译： 用于从生物化学样品中分离磷脂和蛋白质与小分子的方法，试剂盒和装置可以具有具有润湿屏障，至少一种配合和分离介质的装置。 例如，设备可以包括限定具有出口和入口的室的至少一个壁; 设置在出口和入口之间的润湿屏障，以便限定位于润湿屏障和出口之间的分离介质空间以及位于润湿屏障和入口之间的样品接收区域; 以及与所述润湿屏障相邻并且对磷脂具有特异性亲和力的分离介质。 润湿屏障适于（i）在第一力下在样品接收区域中保留液体样品和蛋白质沉淀剂，从而有助于蛋白质沉淀物和加工样品的形成，以及（ii）将经处理的样品通过 润湿屏障和分离介质，其中第二力大于第一力，从而将蛋白质沉淀物保留在样品接收区域中，将磷脂保留在分离介质中，并洗脱小分子。

    Antimicrobial Layer For Chromatographic Containers
    9.
    发明申请
    Antimicrobial Layer For Chromatographic Containers 审中-公开
    色谱容器用抗微生物层

    公开(公告)号：US20130195949A1

    公开(公告)日：2013-08-01

    申请号：US13695815

    申请日：2011-06-27

    申请人： Kevin D. Wyndam ,  Edouard S.P. Bouvier ,  Pamela C. Iraneta

    发明人： Kevin D. Wyndam ,  Edouard S.P. Bouvier ,  Pamela C. Iraneta

    IPC分类号： A01N25/08

    CPC分类号： A01N25/08 ,  A01N59/00 ,  A01N59/16 ,  A01N59/24 ,  B01D15/22 ,  B01L3/508 ,  B01L3/5082 ,  B01L2200/141 ,  B01L2300/16 ,  G01N30/02 ,  G01N30/06 ,  G01N2030/027 ,  A01N2300/00 ,  A01N25/10

    摘要： A chromatographic container (1) incorporating an antimicrobial layer (5) or an antimicrobial device (10) with such a layer (15) for use with a standard chromatographic container (11), which layer (5, 15) inhibits, in use, microbial growth. The antimicrobial layer (5, 15) can be on an internal surface of the container (1) or on an exposed surface of the device (10) and may be in the form of a coating, liner or film The layer (5, 15) may be configured for gradual release an antimicrobial agent or chemical additive, for example sodium azide. Additionally or alternatively, the antimicrobial layer (5, 15) may include silver or silver particles, for example nanoparticles of silver.

    摘要翻译： 一种含有抗微生物层（5）或抗微生物装置（10）的色谱容器（1），其具有与标准色谱容器（11）一起使用的这种层（15），该层（5,15）在使用中抑制， 微生物生长。 抗微生物层（5,15）可以在容器（1）的内表面上或装置（10）的暴露表面上，并且可以是涂层，衬垫或膜的形式。层（5,15 ）可以被配置为逐渐释放抗微生物剂或化学添加剂，例如叠氮化钠。 另外或替代地，抗微生物层（5,15）可以包括银或银颗粒，例如银的纳米颗粒。

    Frit for high pressure liquid chromatography
    10.
    发明授权
    Frit for high pressure liquid chromatography 有权
    玻璃料用于高压液相色谱

    公开(公告)号：US08999156B2

    公开(公告)日：2015-04-07

    申请号：US10591377

    申请日：2005-03-04

    申请人： Pamela C. Iraneta ,  Jon Belanger ,  Raymond P. Fisk

    发明人： Pamela C. Iraneta ,  Jon Belanger ,  Raymond P. Fisk

    IPC分类号： G01N30/60

    CPC分类号： G01N30/603

    摘要： A frit (44) includes a porous support structure having a plurality of void spaces, where a plurality of secondary particles (46) are filled in the void spaces, the secondary particles (46) being dimensioned with respect to the void spaces such that the frit (44) retains packing materials with diameters of less than about 2.5 microns. Preferably one or more frits (44) are received in a high pressure liquid chromatography (HPLC) chromatographic column, where the column includes fittings and filter assemblies for receiving frits (44) at its inlet and outlet. The frit (44) can be constructed from a porous support structure with void spaces or pores that are filled with secondary particles (46) smaller those used to manufacture the support. The particles (46) contained in the void spaces are large enough to be retained by the support, but small enough to create a finer network of interconnected channels within the support's void spaces that are capable of retaining sub-2.5 micrometer particles.

    摘要翻译： 玻璃料（44）包括具有多个空隙空间的多孔支撑结构，其中多个二次颗粒（46）填充在空隙空间中，二次颗粒（46）相对于空隙空间的尺寸确定，使得 玻璃料（44）保留直径小于约2.5微米的包装材料。 优选地，一个或多个玻璃料（44）被接收在高压液相色谱（HPLC）色谱柱中，其中色谱柱包括用于在其入口和出口处接收玻璃料（44）的配件和过滤器组件。 玻璃料（44）可以由具有空隙空间或孔的多孔支撑结构构成，其填充有用于制造载体的二次颗粒（46）。 包含在空隙空间中的颗粒（46）足够大以被支撑体保持，但足够小以在支撑件的空隙空间内产生能够保持次2.5微米颗粒的互连通道的更细的网络。