公开(公告)号：US5117052A

公开(公告)日：1992-05-26

申请号：US669387

申请日：1991-03-14

申请人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Hiroshi Naganawa ,  Masa Hamada ,  Yasuhiko Muraoka ,  Takayuki Aoyama

发明人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Hiroshi Naganawa ,  Masa Hamada ,  Yasuhiko Muraoka ,  Takayuki Aoyama

IPC分类号： C07C65/40 ,  C12P15/00

CPC分类号： C07C65/40 ,  C12P15/00 ,  C07C2103/24

摘要： Benastatins A and B which are novel and physiologically active substances having the formula ##STR1## wherein R represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, exhibit a potent immunomodifier activity, a glutathione transferase inhibition activity and an anti-microorganism activity and are therefore extremely useful for various drugs.

公开(公告)号：US5162500A

公开(公告)日：1992-11-10

申请号：US613759

申请日：1990-12-07

申请人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Keiji Ogawa ,  Machiko Nagai ,  Yasuhiko Muraoka ,  Makoto Tsuda

发明人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Keiji Ogawa ,  Machiko Nagai ,  Yasuhiko Muraoka ,  Makoto Tsuda

IPC分类号： A61K38/00 ,  C07C229/22 ,  C07C271/22 ,  C07K5/02 ,  C07K7/02

CPC分类号： C07C229/22 ,  C07C271/22 ,  C07K5/0202 ,  C07K7/02 ,  A61K38/00

摘要： A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.

公开(公告)号：US4742155A

公开(公告)日：1988-05-03

申请号：US801809

申请日：1985-11-26

申请人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Yasuhiko Muraoka ,  Takaaki Nishikiori

发明人： Hamao Umezawa ,  Takaaki Aoyagi ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Yasuhiko Muraoka ,  Takaaki Nishikiori

IPC分类号： C12P21/04 ,  A61K35/74 ,  A61K38/00 ,  A61P37/06 ,  A61P37/08 ,  C07K7/06 ,  C07K7/64 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12N9/99 ,  C12P21/02 ,  C12R1/085 ,  C07K5/12

CPC分类号： C07K7/06 ,  C12R1/085 ,  A61K38/00 ,  Y10S930/27

摘要： Plipastatin represented by the general formula ##STR1## wherein R.sub.1 is --C.sub.13 H.sub.27 or --C.sub.14 H.sub.29 ; and R.sub.2 is Ala or Val, or salts thereof, which is prepared by culturing a Plipastatin-producing strain belonging to the genus Bacillus to produce and accumulate Plipastatin in a cultured broth and then isolating Plipastatin from the cultured broth. Plipastatin exhibits an enzyme inhibiting activity against phospholipase A.sub.2, C and D and which will be useful as an immunosuppressive agent or as a type I anti-allergic agent.

摘要翻译： 由通式 + TR 表示的普伐他汀，其中R1为-C13H27或-C14H29; R2是Ala或Val或其盐，其通过培养属于芽孢杆菌属的Plipastatin产生菌株在培养的肉汤中产生并积累Plipastatin，然后从培养的肉汤中分离Plipastatin来制备。 Plipastatin对磷脂酶A2，C和D具有酶抑制活性，可用作免疫抑制剂或I型抗过敏剂。

公开(公告)号：US5359138A

公开(公告)日：1994-10-25

申请号：US905792

申请日：1992-06-29

申请人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Keiji Ogawa ,  Machiko Nagai ,  Yasuhiko Muraoka ,  Makoto Tsuda

发明人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Keiji Ogawa ,  Machiko Nagai ,  Yasuhiko Muraoka ,  Makoto Tsuda

IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K7/02 ,  C07C229/00 ,  A61K37/00 ,  A61K37/02 ,  C07K5/00

CPC分类号： C07K5/0202 ,  C07K7/02 ,  A61K38/00

摘要： A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.

摘要翻译： 已经从属于链霉菌的微生物的培养基中分离出一种新的生物活性物质，后抑制素。 该新物质是具有新结构的肽化合物，其中肽链具有酮基。 因此，物质具有高内肽酶抑制活性。 可以在肽链中化学合成具有酮基的后抑制素相关化合物。 这些化合物还具有内肽酶抑制活性。

公开(公告)号：US06214340B1

公开(公告)日：2001-04-10

申请号：US09554362

申请日：2000-05-12

申请人： Tomio Takeuchi ,  Masa Hamada ,  Yasuhiko Muraoka ,  Tetsuo Akiyama ,  Masatoshi Abe ,  Hiroshi Naganawa ,  Yoshikazu Takahashi

发明人： Tomio Takeuchi ,  Masa Hamada ,  Yasuhiko Muraoka ,  Tetsuo Akiyama ,  Masatoshi Abe ,  Hiroshi Naganawa ,  Yoshikazu Takahashi

IPC分类号： C12N120

CPC分类号： C12N9/99 ,  A61K38/00 ,  C07K14/36 ,  C12P1/06 ,  C12R1/465

摘要： This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having an ability to produce the physiologically active substance sulphostin, producing and accumulating this substance in the cultures, and harvesting it from the cultures.

摘要翻译： 本发明提供具有强二肽基肽酶IV抑制活性的生理活性物质。 通过培养属于链霉菌属的微生物并且具有生产生理活性物质硫酸钙的能力，在培养物中产生和积累该物质，并从培养物中收获生物活性物质硫酸钙得到。

公开(公告)号：US5021549A

公开(公告)日：1991-06-04

申请号：US232852

申请日：1988-08-16

申请人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Shigemi Yoshida

发明人： Tomio Takeuchi ,  Takaaki Aoyagi ,  Masa Hamada ,  Hiroshi Naganawa ,  Shigemi Yoshida

IPC分类号： C07K5/08 ,  A61K38/00 ,  A61K38/55 ,  A61P37/04 ,  C07K5/02 ,  C07K5/023 ,  C07K14/195 ,  C07K14/36 ,  C07K14/41 ,  C12N9/99 ,  C12P21/02 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07K5/0202

摘要： New physiologically active substances, named probestin and prostatin, respectively, are produced from a new microorganism, Streptomyces azureus MH663-2F6 strain identified as FERM P-9541 or FERM BP-1963. Probestin and prostatin have an activity inhibitory to aminopeptidase M and also have immunopotentiating properties.

公开(公告)号：US5096924A

公开(公告)日：1992-03-17

申请号：US531109

申请日：1990-05-31

申请人： Masaaki Ishizuka ,  Hiroyuki Kumagai ,  Tsutomu Sawa ,  Hiroshi Naganawa ,  Hironobu Iinuma ,  Kunio Isshiki ,  Masa Hamada ,  Kenji Maeda ,  Tomio Takeuchi

发明人： Masaaki Ishizuka ,  Hiroyuki Kumagai ,  Tsutomu Sawa ,  Hiroshi Naganawa ,  Hironobu Iinuma ,  Kunio Isshiki ,  Masa Hamada ,  Kenji Maeda ,  Tomio Takeuchi

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P35/00 ,  C07D311/76 ,  C12N1/20 ,  C12P17/06 ,  C12R1/625

CPC分类号： C12P17/06 ,  C07D311/76

摘要： As a new antibiotic is provided a compound, now nominated as MI43-37F11 substance, which has formula ##STR1## This MI43-37F11 substance has an antitumor activity, an activity to enhance the production of interleukin-1 in vivo in a mammalian, and an activity to activate a macrophage in vivo in a mammalian. MI43-37F11 substance may be produced by cultivation of Streptoverticillium eurocidicum MI43-37F11 strain identified as FERM BP-2783.

公开(公告)号：US4049497A

公开(公告)日：1977-09-20

申请号：US747470

申请日：1976-12-06

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Masaaki Ishizuka ,  Hiroshi Naganawa

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Shinichi Kondo ,  Masaaki Ishizuka ,  Hiroshi Naganawa

IPC分类号： C07G11/00

CPC分类号： A61K36/06 ,  C07G11/00 ,  Y10S435/886

摘要： There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).

摘要翻译： 已经公开了两种以前称为MC916-A和MC916-B的新抗生素，现在称为新西霉素A和新霉素B，其是白血病细胞生长的有效抑制剂，例如。 白血病L-1210细胞在小鼠中。 它们通过Frep-P 2452链霉菌（A.T.C.C. 31123）的对照发酵生产。

公开(公告)号：US5215981A

公开(公告)日：1993-06-01

申请号：US720758

申请日：1991-07-01

申请人： Tomio Takeuchi ,  Yoshikazu Takahashi ,  Masa Hamada ,  Hiroshi Naganawa ,  Kiyoshi Sato

发明人： Tomio Takeuchi ,  Yoshikazu Takahashi ,  Masa Hamada ,  Hiroshi Naganawa ,  Kiyoshi Sato

IPC分类号： C07D493/10 ,  C12P17/18

CPC分类号： C07D493/10 ,  C12P17/181

摘要： In this invention, a new microbial strain which is a strain of Actinomycetes and belongs to the genus Actinomadura, namely Actinomadura sp. MI215-NF3 strain is cultured, and MI215-NF3 substance, a novel antibiotic classifiable as a polyether antibiotic, is recovered from the resultant culture. MI215-NF3 substance and its salts obtained according to this invention are useful for therapeutic treatment of chicken coccidiosis and also have useful antibacterial activities against certain species of bacteria.

公开(公告)号：US4565861A

公开(公告)日：1986-01-21

申请号：US567792

申请日：1984-01-03

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Takeshi Uchida ,  Masaya Imoto

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Takeshi Uchida ,  Masaya Imoto

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465

摘要： An anthracycline, serirubicin, of the formula: ##STR1## wherein R represents the substituent: ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, serirubicin, and then recovering the anthracycline compound, serirubicin, from the cultured medium. This serirubicin, or an acid addition salt of the serirubicin, can be contained as the active ingredient in anti-tumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.

摘要翻译： 蒽环霉素，维拉霉素，其结构式如下：其中R表示取代基：IMAMA是通过包括在需氧条件下在合适的培养基中培养链霉菌属菌株的方法产生的，所述菌株具有产生 蒽环霉素化合物，苏维菌素，然后从培养基中回收蒽环霉素化合物，丝衣霉素。 作为抗肿瘤剂和用于治疗由革兰氏阳性微生物诱导的感染的药物组合物，可以含有这种苏维菌素或者苏维菌素的酸加成盐作为活性成分，从而获得了良好的效果。