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公开(公告)号：US20100211271A1
公开(公告)日：2010-08-19
申请号：US12705842
申请日：2010-02-15
申请人： Toshio Yasutake , Fuminori Kato , Jouji Nishioka , Tomohiko Adachi , Lodewijk Wijffels , Oliver Nehls
发明人： Toshio Yasutake , Fuminori Kato , Jouji Nishioka , Tomohiko Adachi , Lodewijk Wijffels , Oliver Nehls
CPC分类号： B62D6/003 , B60T8/1755 , B60T2260/02
摘要： A motion control device of a vehicle comprises: a steering angle controller which controls a steering angle of a steered wheel so that an actual turning controlling variable becomes a target turning controlling variable; and a braking force controller which controls a vehicle braking force so that the actual turning controlling variable becomes the target turning controlling variable. The control of the steering angle controller is stopped by detecting a timing with which the braking force controller detects an oversteering state of the vehicle to start a braking force control.
摘要翻译： 车辆的运动控制装置包括：转向角控制器，其控制转向轮的转向角，使得实际转弯控制变量成为目标转向控制变量; 以及制动力控制器，其控制车辆制动力，使得实际转向控制变量成为目标转向控制变量。 通过检测制动力控制器检测到车辆的过度转向状态以开始制动力控制的定时来停止对转向角控制器的控制。
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公开(公告)号：US08326496B2
公开(公告)日：2012-12-04
申请号：US12705842
申请日：2010-02-15
申请人： Toshio Yasutake , Fuminori Kato , Jouji Nishioka , Tomohiko Adachi , Lodewijk Wijffels , Oliver Nehls
发明人： Toshio Yasutake , Fuminori Kato , Jouji Nishioka , Tomohiko Adachi , Lodewijk Wijffels , Oliver Nehls
IPC分类号： G06F7/00
CPC分类号： B62D6/003 , B60T8/1755 , B60T2260/02
摘要： A motion control device of a vehicle comprises: a steering angle controller which controls a steering angle of a steered wheel so that an actual turning controlling variable becomes a target turning controlling variable; and a braking force controller which controls a vehicle braking force so that the actual turning controlling variable becomes the target turning controlling variable. The control of the steering angle controller is stopped by detecting a timing with which the braking force controller detects an oversteering state of the vehicle to start a braking force control.
摘要翻译： 车辆的运动控制装置包括：转向角控制器，其控制转向轮的转向角，使得实际转弯控制变量成为目标转向控制变量; 以及制动力控制器，其控制车辆制动力，使得实际转向控制变量成为目标转向控制变量。 通过检测制动力控制器检测到车辆的过度转向状态以开始制动力控制的定时来停止对转向角控制器的控制。
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公开(公告)号：US08234043B2
公开(公告)日：2012-07-31
申请号：US12705858
申请日：2010-02-15
CPC分类号： B62D6/002 , B60T8/1755 , B60T2260/02 , B60W10/184 , B62D6/003
摘要： A motion control device of a vehicle comprises: a steering angle controller which controls a steering angle of a steering wheel so that an actual turning control variable becomes a target turning control variable; and a braking force controller which controls a vehicle braking force so that the actual turning control variable becomes the target turning control variable. The braking force controller selectively uses, as a steering angle signal for control, a first steering angle signal which reflects a steering angle compensation quantity compensated by the steering angle controller at the time of the oversteering of the vehicle is reflected, and a second steering angle signal which does not reflect the steering angle compensation quantity.
摘要翻译： 车辆的运动控制装置包括：转向角控制器，其控制方向盘的转向角，使得实际转弯控制变量成为目标转向控制变量; 以及制动力控制器，其控制车辆制动力，使得实际转向控制变量成为目标转向控制变量。 制动力控制器选择性地使用反映在车辆过度转向时反映由转向角控制器补偿的转向角补偿量的第一转向角信号作为用于控制的转向角信号，并且第二转向角信号 信号，其不反映转向角补偿量。
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公开(公告)号：US20100211269A1
公开(公告)日：2010-08-19
申请号：US12705858
申请日：2010-02-15
CPC分类号： B62D6/002 , B60T8/1755 , B60T2260/02 , B60W10/184 , B62D6/003
摘要： A motion control device of a vehicle comprises: a steering angle controller which controls a steering angle of a steering wheel so that an actual turning control variable becomes a target turning control variable; and a braking force controller which controls a vehicle braking force so that the actual turning control variable becomes the target turning control variable. The braking force controller selectively uses, as a steering angle signal for control, a first steering angle signal which reflects a steering angle compensation quantity compensated by the steering angle controller at the time of the oversteering of the vehicle is reflected, and a second steering angle signal which does not reflect the steering angle compensation quantity.
摘要翻译： 车辆的运动控制装置包括：转向角控制器，其控制方向盘的转向角，使得实际转弯控制变量成为目标转向控制变量; 以及制动力控制器，其控制车辆制动力，使得实际转向控制变量成为目标转向控制变量。 制动力控制器选择性地使用反映在车辆过度转向时反映由转向角控制器补偿的转向角补偿量的第一转向角信号作为用于控制的转向角信号，并且第二转向角信号 信号，其不反映转向角补偿量。
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公开(公告)号：US20120244560A1
公开(公告)日：2012-09-27
申请号：US13498392
申请日：2010-09-29
申请人： Fuminori Kato , Yoshitaka Kondo
发明人： Fuminori Kato , Yoshitaka Kondo
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/92 , G01N33/6893 , G01N2333/4703 , G01N2800/125 , G01N2800/245 , G01N2800/32 , G01N2800/368 , G01N2800/50
摘要： This invention relates to a monoclonal antibody against a human HIG-1 polypeptide, the antibody binding to at least one epitope included in the amino acid sequence at positions 1-19 of a human HIG-1 polypeptide; an antibody fragment derived from the antibody; a DNA comprising a base sequence encoding a variable region of the antibody; an expression vector comprising the DNA; a cell line producing the antibody; a reagent for detecting a human HIG-1 polypeptide comprising the antibody or the antibody fragment, and a method for detecting a human HIG-1 polypeptide using the antibody or the antibody fragment.
摘要翻译： 本发明涉及针对人HIG-1多肽的单克隆抗体，所述抗体与人HIG-1多肽的位置1-19处的氨基酸序列中包含的至少一个表位结合; 衍生自抗体的抗体片段; 包含编码抗体可变区的碱基序列的DNA; 包含DNA的表达载体; 产生抗体的细胞系; 用于检测包含抗体或抗体片段的人HIG-1多肽的试剂，以及使用该抗体或抗体片段检测人HIG-1多肽的方法。
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6.发明授权Aniline derivatives or salts thereof and cytokine production inhibitors containing the same 失效苯胺衍生物或其盐和含有它们的细胞因子产生抑制剂公开(公告)号：US07132546B2
公开(公告)日：2006-11-07
申请号：US10451101
申请日：2001-12-21
IPC分类号： C07D213/64
CPC分类号： C07D213/40 , A61K31/04 , A61K31/15 , A61K31/167 , A61K31/18 , A61K31/428 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/505 , A61K31/5375 , C07C233/65 , C07C233/66 , C07C233/75 , C07C233/76 , C07C233/80 , C07C235/56 , C07C235/64 , C07C245/08 , C07C255/57 , C07C311/21 , C07C311/46 , C07C311/51 , C07C323/42 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/71 , C07D213/74 , C07D213/75 , C07D213/76 , C07D239/47 , C07D241/44 , C07D277/46 , C07D277/52 , C07D277/62 , C07D277/66 , C07D277/82 , C07D295/135 , C07D401/12
摘要： The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: [wherein A is CO or SO2; Cy is an aryl group or a heterocyclic group; each of R1 and R2 which are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an amino group which may be substituted or a —B-Q group; R3 is a -M1-M2-R5 group; R4 is a hydrogen atom or an alkyl group which may be substituted; x is an integer of from 0 to 5; y is an integer of from 0 to 4; and z is an integer of from 0 to 1].
摘要翻译： 本发明提供含有作为活性成分的式（I）的苯胺衍生物或其盐的细胞因子产生抑制剂：其中A为CO或SO 2; Cy是芳基或杂环基; R 1和R 2彼此独立的是卤素原子，氰基，硝基，可以被取代的烷基， 可被取代的烯基，可被取代的炔基，可被取代的环烷基，可被取代的环烯基，可被取代的芳基，可被取代的杂环基，氨基 其可以被取代或-BQ基团; R 3是一个-M 1 -M 2 -OR 5基团; R 4是氢原子或可被取代的烷基; x为0〜5的整数; y为0〜4的整数; z为0〜1的整数]。
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7.发明授权Thioamides and salts thereof and cytokine production inhibitors containing both 有权硫胺及其盐和含有这两者的细胞因子产生抑制剂公开(公告)号：US07632865B2
公开(公告)日：2009-12-15
申请号：US10588859
申请日：2005-02-16
申请人： Fuminori Kato , Hirohiko Kimura , Kiyoshi Tamai , Kazuhiro Yamamoto , Mitsuo Sano , Shinya Mori , Takashi Okada , Toshihiko Ueki , Kumiko Azuma
发明人： Fuminori Kato , Hirohiko Kimura , Kiyoshi Tamai , Kazuhiro Yamamoto , Mitsuo Sano , Shinya Mori , Takashi Okada , Toshihiko Ueki , Kumiko Azuma
IPC分类号： A61K31/165 , C07C327/42
CPC分类号： C07D239/34 , C07C233/66 , C07C233/69 , C07C233/71 , C07C233/78 , C07C323/42 , C07C327/48 , C07C2603/74 , C07D213/83 , C07D239/42
摘要： To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions.A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
摘要翻译： 提供可用作预防或治疗药物的细胞因子产生抑制剂，用于伴有过度活化的免疫功能的疾病。 1.一种细胞因子产生抑制剂，含有作为活性成分的式（I）所示的硫代酰胺化合物或其盐：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2; M2是氨基，O，S或单键; R1是卤素，烷基等; R2，R3，R4和R5各自独立地为H，烷基等; R6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。
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8.发明授权Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts 失效含有稠合杂环化合物或其盐的糖尿病的预防或治疗药物公开(公告)号：US07067520B2
公开(公告)日：2006-06-27
申请号：US10416164
申请日：2001-11-15
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P3/06 , A61P9/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The present invention provides a preventive or therapeutic medicine for diabetes containing as an active ingredient a fused-heterocyclic compound of the formula (I′) or its salt: [wherein G is CN, NO2, CO2R4, CHO, SO2NRaRb or CONRaRb; R1 is a halogen atom, a —O—R5 group or a —S—R5 group; R2 is a halogen atom, a —O—R5 group (wherein R5 is as defined above) or an amino group which may be substituted; and each of R8 and R10 which are independent of each other, is a hydrogen atom, a halogen atom or an alkyl group].
摘要翻译： 本发明提供了含有作为活性成分的式（I'）的稠合杂环化合物或其盐的糖尿病预防或治疗药物：[其中G为CN，NO 2，CO， 2，2，4，4，...，...，...，... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... > a R b ; R 1是卤素原子，-O-R 5基团或-S-R 5+基团; R 2是卤原子，-OR 5基团（其中R 5如上定义）或可被取代的氨基 ; 并且彼此独立的R 8和R 10各自为氢原子，卤原子或烷基]。
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9.发明申请Thioamides and Salts Thereof and Cytokine Production Inhibitors Containing Both 有权硫胺及其盐及含有两者的细胞因子抑制剂公开(公告)号：US20070219215A1
公开(公告)日：2007-09-20
申请号：US10588859
申请日：2005-02-16
申请人： Fuminori Kato , Hirohiko Kimura , Kiyoshi Tamai , Kazuhiro Yamamoto , Mitsuo Sano , Shinya Mori , Takashi Okada , Toshihiko Ueki , Kumiko Azuma
发明人： Fuminori Kato , Hirohiko Kimura , Kiyoshi Tamai , Kazuhiro Yamamoto , Mitsuo Sano , Shinya Mori , Takashi Okada , Toshihiko Ueki , Kumiko Azuma
IPC分类号： A61K31/496 , A61K31/16 , A61K31/44 , C07D213/00 , C07D401/00 , C07C327/02 , A61K31/445
CPC分类号： C07D239/34 , C07C233/66 , C07C233/69 , C07C233/71 , C07C233/78 , C07C323/42 , C07C327/48 , C07C2603/74 , C07D213/83 , C07D239/42
摘要： To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
摘要翻译： 提供可用作预防或治疗药物的细胞因子产生抑制剂，用于伴有过度活化的免疫功能的疾病。 含有式（I）所示的硫代酰胺化合物或其盐作为活性成分的细胞因子产生抑制剂：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2。 M 2是氨基，O，S或单键; R 1是卤素，烷基等; R 2，R 3，R 4和R 5各自独立地为H，烷基等; R 6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。
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10.发明授权Medical composition containing nitroetheneamine Derivative or salt there of as active constituent 失效含有硝基乙烯胺的药物组合物作为活性成分的衍生物或盐公开(公告)号：US06596863B2
公开(公告)日：2003-07-22
申请号：US10133752
申请日：2002-04-29
申请人： Fuminori Kato , Keizo Miyata , Hirohiko Kimura , Kazuhiro Yamamoto , Hiroyuki Ikegami , Hiromi Takeo
发明人： Fuminori Kato , Keizo Miyata , Hirohiko Kimura , Kazuhiro Yamamoto , Hiroyuki Ikegami , Hiromi Takeo
IPC分类号： C07D21376
CPC分类号： C07D495/04 , A61K31/00 , A61K31/428 , C07C243/16 , C07C243/20 , C07C243/22 , C07C243/28 , C07C243/38 , C07C251/76 , C07C251/80 , C07C251/86 , C07C257/06 , C07C281/02 , C07C311/49 , C07C311/51 , C07C323/36 , C07C327/58 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/40 , C07D213/53 , C07D213/74 , C07D213/77 , C07D215/38 , C07D231/38 , C07D231/56 , C07D233/52 , C07D239/42 , C07D239/52 , C07D239/94 , C07D241/44 , C07D251/46 , C07D263/58 , C07D277/82 , C07D295/125 , C07D295/30 , C07D307/40 , C07D307/52 , C07D307/88 , C07D317/58 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/22 , C07D401/12 , C07D405/12 , C07D471/04
摘要： Process for producing a nitroetheneamine derivative or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula with a compound of the formula R6—CH2NO2 to obtain a compound of the formula and reacting the resulting compound with a compound of the formula
摘要翻译： 制备硝基乙烯胺衍生物或其立体异构体，其互变异构体或其盐的方法包括使制备式R 6 -CH 2 NO 2的化合物的化合物与式R 6 -CH 2 NO 2化合物反应，得到下式化合物，并使所得化合物与式
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