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公开(公告)号：US4624927A
公开(公告)日：1986-11-25
申请号：US600740
申请日：1984-04-16
IPC分类号： G01N33/53 , C12Q1/56 , G01N33/86 , G01N31/00 , G01N33/556
CPC分类号： G01N33/86 , G01N2333/9108 , G01N2333/91085 , Y10S436/808 , Y10T436/106664
摘要： A reagent for determination of human blood coagulation factor XIII for reversed passive hemagglutination reaction which comprises sensitized erythrocytes prepared by sensitizing animal erythrocytes with specific anti-human factor XIII antibody, and a kit using the reagent are disclosed.
摘要翻译： 公开了一种用于测定用于反向被动血凝反应的人血液凝固因子XIII的试剂，其包括通过用特异性抗人因子XIII抗体对动物红细胞进行敏化制备的致敏红细胞和使用该试剂的试剂盒。
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公开(公告)号：US4340589A
公开(公告)日：1982-07-20
申请号：US237125
申请日：1981-02-18
IPC分类号： A61K47/16 , A61K9/26 , A61K35/14 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/48 , A61K38/55 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/42 , A61L2/00 , A61P7/02 , C07K14/81
CPC分类号： A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42 , A61L2/0023 , C07K14/8128 , A61K38/00
摘要： An antithrombin preparation, secure and stable for a long period of time, can be obtained by freeze-drying an aqueous solution containing antithrombin-III as main component in the presence of an effective quantity of at least one member selected from the group consisting of proteins, sugars, amino acids, inorganic salts and salts of organic acids as stabilizer.
摘要翻译： PCT No.PCT / JP79 / 00154 Sec。 371日期1981年2月18日 102（e）日期1981年2月17日PCT申请日1979年6月18日PCT公布。 公开号WO80 / 02798 日期为1980年12月24日。通过在有效量的至少一种成分的存在下，将含有抗凝血酶III作为主要成分的水溶液冷冻干燥，可以长期稳定稳定的抗凝血酶制剂 选自蛋白质，糖，氨基酸，无机盐和有机酸的盐作为稳定剂。
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3.发明授权Fibronectin-physiologically active substance complex and method of preparation thereof 失效纤连蛋白 - 生理活性物质复合物及其制备方法
公开(公告)号：US4560556A
公开(公告)日：1985-12-24
申请号：US572750
申请日：1984-01-23
申请人： Yoshio Kagitani , Kenji Tanaka , Yasuo Ueda , Yusei Shiraga , Tunetaka Nakajima , Takuji Doi , Takao Ohmura , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yoshio Kagitani , Kenji Tanaka , Yasuo Ueda , Yusei Shiraga , Tunetaka Nakajima , Takuji Doi , Takao Ohmura , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07K14/705 , A61K31/40 , A61K31/43 , A61K31/545 , A61K31/70 , A61K38/00 , A61K38/16 , A61K38/22 , A61K47/48 , C07K14/435 , C07K14/78 , C07K19/00 , A61K35/16 , A61K37/04
CPC分类号： C07K14/78 , A61K47/48292 , A61K38/00 , Y10S530/829 , Y10S530/83
摘要： Physiologically active substances such as antibiotics can preferentially be carried to a morbid part, for example, injured tissue and neoplastic cell proliferation site by administering its complex with fibronectin to repair the morbid part. The complex is prepared by the reaction between the physiologically active substance and the fibronectin with or without intervention of a protein cross-linking agent.
摘要翻译： 生理活性物质如抗生素可以优先通过给予其与纤连蛋白的复合物来修复病态部分而被携带到病态部分，例如损伤组织和肿瘤细胞增殖部位。 该复合物通过蛋白质交联剂的介导或不涉及生理活性物质与纤连蛋白之间的反应来制备。
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4.发明授权1H-pyrrolo-[2,1-C][1,4]benzodiazepine-2-acrylamide compounds having antitumor activity 失效具有抗肿瘤活性的1H-吡咯并[2,1-C] [1,4]苯并二氮杂-2-丙烯酰胺化合物
公开(公告)号：US4587052A
公开(公告)日：1986-05-06
申请号：US578032
申请日：1984-02-08
申请人： Yasuo Ueda , Yusei Shiraga , Satoshi Morimoto , Yoshio Kagitani , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yasuo Ueda , Yusei Shiraga , Satoshi Morimoto , Yoshio Kagitani , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Benzodiazepine derivative represented by the following general formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 is --COR.sup.4 (R.sup.4 is a carboxylic acid residue) or an alkyl or aralkyl group (these groups have a substituent selected from a carboxyl group, an amino group and a cyano group), R.sup.2 is a lower alkyl group and R.sup.3 is a hydrogen atom or a lower alkyl group.The above compound is low in toxicity and has an antitumor activity.
摘要翻译： 由下列通式表示的苯并二氮杂衍生物或其药学上可接受的盐：其中R 1为-COR 4（R 4为羧酸残基）或烷基或芳烷基（这些基团具有选自羧基，氨基 基和氰基），R2是低级烷基，R3是氢原子或低级烷基。 上述化合物的毒性低，具有抗肿瘤活性。
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公开(公告)号：US4314935A
公开(公告)日：1982-02-09
申请号：US175744
申请日：1980-08-06
IPC分类号： C12P21/00 , A61K38/21 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/57 , A61K45/02 , C07G7/00
CPC分类号： C07K14/555 , Y10S435/811 , Y10S530/829 , Y10S530/837 , Y10S530/838 , Y10S530/848
摘要： A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolubilized sulfated polysaccharide and then selectively eluting the interferon with an aqueous solution of an inorganic salt.
摘要翻译： 一种用于回收干扰素的方法，其包括将含有由人源诱导的细胞产生的干扰素的溶液与水不溶性硫酸化多糖接触以允许干扰素被吸附在水不溶性硫酸化多糖上，然后选择性地洗脱干扰素 无机盐水溶液。
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公开(公告)号：US4526782A
公开(公告)日：1985-07-02
申请号：US432909
申请日：1982-09-27
CPC分类号： C07K14/56
摘要： Interferon can be recovered simply by contacting an aqueous solution containing interferon which is induced and produced from cells of human origin capable of producing interferon, with a siliceous substance to adsorb interferon on it and eluting the adsorbed interferon with an aqueous solution containing a nonionic surfactant, preferably further containing an acriflavine such as acrinol.
摘要翻译： PCT No.PCT / JP81 / 00030 Sec。 371日期1982年9月27日 102（e）日期1982年9月27日PCT提交1981年2月17日PCT公布。 出版物WO82 / 02834 日本1982年9月2日。通过将含有可产生干扰素的人源细胞诱导和产生的含有干扰素的水溶液与硅质物质接触，可以简单地回收地塞米松，以吸附干扰素并用吸附的干扰素 含有非离子表面活性剂的水溶液，优选还含有吖啶如Acrinol。
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公开(公告)号：US4442037A
公开(公告)日：1984-04-10
申请号：US432938
申请日：1982-09-28
CPC分类号： C07J9/00 , C07J41/0055
摘要： Complexes of albumin combined with organic dibasic acid half esters, such as those of succinic acid and phthalic acid, of 7-hydroxycholesterol are soluble in water and have excellent immunosuppressive and anti-inflammatory action.
摘要翻译： PCT No.PCT / JP81 / 00056 Sec。 371日期1982年9月28日 102（e）日期1982年9月28日PCT提交1981年3月13日PCT公布。 公开号WO82 / 03175 日期为1982年9月30日。与7-羟基胆固醇的琥珀酸和邻苯二甲酸的有机二元酸半酯结合的复合物可溶于水，具有优异的免疫抑制和抗炎作用。
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公开(公告)号：US4343736A
公开(公告)日：1982-08-10
申请号：US280687
申请日：1981-07-06
IPC分类号： C12P21/00 , A61K38/21 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/57 , A61K45/02 , C07G7/00
CPC分类号： C07K14/555 , Y10S435/811 , Y10S530/829 , Y10S530/837 , Y10S530/838 , Y10S530/848
摘要： A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolubilized sulfated polysaccharide and then selectively eluting the interferon with an aqueous solution of an inorganic salt.
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9.发明授权Process for heat treatment of aqueous solution containing human blood coagulation factor XIII 失效含有人凝血因子XIII的水溶液的热处理方法
公开(公告)号：US4327086A
公开(公告)日：1982-04-27
申请号：US245971
申请日：1981-03-20
IPC分类号： A61K35/14 , A61K35/16 , A61K35/50 , A61K38/00 , A61K38/16 , A61L2/00 , C12N9/10 , A61K37/00 , A61K35/48
CPC分类号： C12N9/1044 , A61L2/0023 , A61K38/00
摘要： A process for heat treatment to inactive hepatitis virus in human blood coagulation factor XIII compositions, which is characterized in that the heat treatment at 50.degree. to 80.degree. C. of an aqueous solution containing the human blood coagulation factor XIII is carried out for 3 to 15 hours in the presence of 10% (W/V) or more of at least one principal stabilizer selected from the group consisting of neutral amino acids, monosaccharides and sugar alcohols and 10% (W/V) or more of at least one auxiliary stabilizer selected from the group consisting of salts of organic carboxylic acids having 3 to 10 carbon atoms.
摘要翻译： 一种在人血液凝固因子XIII组合物中对无活性肝炎病毒进行热处理的方法，其特征在于在含有人血液凝固因子XIII的水溶液中在50〜80℃下进行热处理3次 在10％（W / V）以上的至少一种选自中性氨基酸，单糖和糖醇的主要稳定剂和10％（W / V）以上的至少一种辅助剂 选自具有3-10个碳原子的有机羧酸盐的稳定剂。
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10.发明授权Method of preparation of human urine origin colony-stimulating factor and kallikrein 失效制备人尿起源菌群刺激因子和激肽释放酶的方法
公开(公告)号：US4482485A
公开(公告)日：1984-11-13
申请号：US568259
申请日：1984-01-04
申请人： Satoshi Funakoshi , Kazuo Morimoto , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Hajime Yokota
发明人： Satoshi Funakoshi , Kazuo Morimoto , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Hajime Yokota
IPC分类号： C07K14/195 , A61K35/22 , A61K38/00 , A61K38/16 , A61K38/48 , C07K14/005 , C07K14/52 , C07K14/53 , C12N9/64 , C07G7/00
CPC分类号： C12N9/6445 , A61K35/22 , Y10S514/929 , Y10S530/834
摘要： Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting the solution added with a stabilizer such as octyl-phenoxypolyethoxyethanaol or polyethylene glycol both having a molecular weight of 1,000-10,000, to high-performance gel filtration effective in molecular exclusive limit of 10.sup.5 -5.times.10.sup.5 as determined with globular protein.
摘要翻译： 人尿起源的集落刺激因子和激肽释放酶分别以其形式从其水溶液例如尿蛋白浓缩溶液中分离，通过使添加有稳定剂的溶液，例如辛基 - 苯氧基聚乙氧基乙醇或聚乙二醇，其均具有 分子量为1,000-10,000，以高效凝胶过滤效果，分子量极限为105-5×105，用球状蛋白质测定。
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