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    METHOD FOR DETERMINING RHEUMATOID ARTHRITIS ACTIVITY INDICATOR, AND BIOMARKER USED THEREIN
    2.
    发明申请
    METHOD FOR DETERMINING RHEUMATOID ARTHRITIS ACTIVITY INDICATOR, AND BIOMARKER USED THEREIN 审中-公开
    用于测定流感嗜血杆菌活性指示剂的方法及其使用的生物标志物

    公开(公告)号：US20150045244A1

    公开(公告)日：2015-02-12

    申请号：US14358517

    申请日：2011-11-17

    申请人： Tsutomu Takeuchi ,  Koichi Amano ,  Yohei Ishizawa ,  Seiji Nakamura ,  Motohiko Tanino ,  Yuko Hata

    发明人： Tsutomu Takeuchi ,  Koichi Amano ,  Yohei Ishizawa ,  Seiji Nakamura ,  Motohiko Tanino ,  Yuko Hata

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158

    摘要： The object of the invention is to find a simple biomarker with high reproducibility with regard to a method for evaluating the activity of the condition and progression of rheumatoid arthritis disease and provide an effective evaluation method therefor. The invention is to provide a method for determining the value of a rheumatoid arthritis-linked indicator in a subject, the method being characterized by comprising a step for measuring the amount of expression of the FAM20A gene in blood collected from the subject, a step for analyzing the measured amount of expression using a gene expression profile that is prepared in advance and correlates with the indicator and a step for estimating the value of the indicator in the subject on the basis of the analysis results.

    摘要翻译： 本发明的目的是找到关于用于评价类风湿性关节炎疾病状态和进展的活性的方法的高再现性的简单生物标志物，并提供其有效的评估方法。 本发明提供一种测定受试者中类风湿性关节炎相关指标值的方法，该方法的特征在于包括测量受试者收集的血液中FAM20A基因表达量的步骤， 使用预先准备并与指标相关的基因表达谱和基于分析结果估计受试者中的指标值的步骤来分析测量的表达量。

    STEP UNIT
    3.
    发明申请
    STEP UNIT 有权
    步骤单位

    公开(公告)号：US20120222914A1

    公开(公告)日：2012-09-06

    申请号：US13510146

    申请日：2010-11-17

    申请人： Toshihiko Ishida ,  Tsutomu Takeuchi

    发明人： Toshihiko Ishida ,  Tsutomu Takeuchi

    IPC分类号： B60R3/02

    CPC分类号： B60R3/02 ,  E05D15/0652 ,  E05F15/643 ,  E05Y2201/10 ,  E05Y2201/434 ,  E05Y2201/652 ,  E05Y2201/684 ,  E05Y2800/205 ,  E05Y2900/531

    摘要： A step unit includes: a step member which is provided with a pair of lower rails extending in an opening and closing direction of a slide door of the vehicle; and a rail plate member which is provided to a cutout formed in a part of either of the lower rails and which continuously connects the lower rails in the opening and closing direction. The step member is molded using a resin material and is provided with an insertion hole which vertically penetrates through the step member at a position corresponding to the cutout; and a support extension section which is extended from a side end of the cutout of the lower rail. The rail plate member is mounted to the step member by being inserted so as to penetrate through the insertion hole from above the step member.

    摘要翻译： 台阶单元包括：台阶构件，其设置有沿车辆的滑动门的开闭方向延伸的一对下轨道; 以及轨道板构件，其设置在形成在任一个下轨道的一部分中的切口，并且沿开闭方向连续地连接下轨道。 台阶部件使用树脂材料成形，并且在与切口对应的位置处设置有垂直地穿过台阶部件的插入孔; 以及从下轨道的切口的侧端延伸的支撑延伸部。 轨板构件通过插入从而从台阶构件的上方穿过插入孔安装到台阶构件。

    ELECTROMAGNETIC CLUTCH
    4.
    发明申请
    ELECTROMAGNETIC CLUTCH 失效
    电磁离合器

    公开(公告)号：US20110227436A1

    公开(公告)日：2011-09-22

    申请号：US12671852

    申请日：2008-10-15

    申请人： Toshihiko Ishida ,  Tsutomu Takeuchi ,  Naoya Oku

    发明人： Toshihiko Ishida ,  Tsutomu Takeuchi ,  Naoya Oku

    IPC分类号： H02K7/108

    CPC分类号： F16D27/06 ,  E05F15/611 ,  E05Y2201/216 ,  E05Y2201/246 ,  E05Y2201/462 ,  E05Y2900/531 ,  H02K5/141 ,  H02K7/1085 ,  H02K7/1166

    摘要： An electromagnetic clutch includes a motor, a worm wheel rotatably driven by a motor, a rotor having an electromagnetic coil and rotatable about a same rotational axis as the worm wheel, an armature that is mounted to the worm wheel and is pulled into contact with the rotor upon application of electric power to the electromagnetic coil, so that the armature is rotated with the rotor, a cover member configured to cover the rotor and the armature, and a power supply mechanism disposed between the cover member and the rotor and connected to a power source for supplying power to the electromagnetic coil. The power supply mechanism includes a fixed frame body having a first power supply portion for receiving the power from the power source and fixed to the cover member, a rotary frame body having a second power supply portion in contact with the first power supply portion for supplying the power to the electromagnetic coil, the rotary frame body being fixed to the rotor and rotatably engaged with the fixed frame body; and a plate-like conducting member provided in the cover member, the conducting member coming into contact with a portion of the first power supply portion projecting from the fixed frame body.

    摘要翻译： 电磁离合器包括电动机，由电动机可旋转地驱动的蜗轮，具有电磁线圈并且可绕与蜗轮相同的旋转轴线旋转的转子，安装到蜗轮并与其接触的电枢 在电磁线圈施加电力时使电枢转动，盖构件覆盖转子和电枢的盖构件以及设置在盖构件和转子之间并连接到电枢的电源机构 用于向电磁线圈供电的电源。 电源机构包括：固定框体，具有用于从电源接收电力并固定到盖构件的第一电源部;具有与第一电源部接触的第二电源部的旋转框体， 电磁线圈的动力，旋转框架体固定在转子上并与固定框架体旋转接合; 以及设置在所述盖构件中的板状导电构件，所述导电构件与从所述固定框架体突出的所述第一电力供应部的一部分接触。

    DRIVING DEVICE
    5.
    发明申请
    DRIVING DEVICE 有权
    驱动装置

    公开(公告)号：US20110121693A1

    公开(公告)日：2011-05-26

    申请号：US12947253

    申请日：2010-11-16

    申请人： Toshihiko ISHIDA ,  Tsutomu Takeuchi ,  Shigeyuki Miyazaki ,  Shin Sakai

    发明人： Toshihiko ISHIDA ,  Tsutomu Takeuchi ,  Shigeyuki Miyazaki ,  Shin Sakai

    IPC分类号： H02K11/00

    CPC分类号： E05F15/603 ,  E05Y2201/216 ,  E05Y2201/246 ,  E05Y2201/462

    摘要： A driving device includes a first rotating member, an armature member being movable and rotatable together with, a second rotating member being rotatable relative to the armature member, a magnetic force generating portion for generating a magnetic force for attracting the armature member toward the second rotating member in order to establish a connection between the armature member and the second rotating member so as to be integrally rotatable, a sensor magnet fixed to the second rotating member, a sensor provided for detecting a change of the magnetic field and a fixing member formed with a first claw portion engaged with the second rotating member and a second claw portion engaged with the sensor magnet while being press-fitted thereto in a radial direction thereof, wherein the sensor magnet is fixed to the second rotating member by means of the fixing member.

    摘要翻译： 一种驱动装置，包括第一旋转构件，电枢构件，其能够相对于电枢构件可旋转地移动并且可旋转;磁力产生部，用于产生用于吸引电枢构件朝向第二旋转的磁力 构件，以便建立电枢构件和第二旋转构件之间的一体可旋转的连接;固定到第二旋转构件的传感器磁体，用于检测磁场变化的传感器和形成有 与第二旋转构件接合的第一爪部和与传感器磁体接合的第二爪部，同时沿其径向压配合，其中传感器磁体通过固定构件固定到第二旋转构件。

    Antihuman Baff Antibody
    6.
    发明申请
    Antihuman Baff Antibody 审中-公开
    抗人Baff抗体

    公开(公告)号：US20080050381A1

    公开(公告)日：2008-02-28

    申请号：US11661260

    申请日：2005-08-30

    申请人： Tsutomu Takeuchi ,  Keiko Yoshimoto

    发明人： Tsutomu Takeuchi ,  Keiko Yoshimoto

    IPC分类号： A61K39/395 ,  A61P5/00 ,  C07K16/18 ,  C12N5/06 ,  G01N33/577

    CPC分类号： G01N33/68 ,  A61K2039/505 ,  C07K14/70575 ,  C07K16/241 ,  G01N33/564 ,  G01N33/74 ,  G01N2500/00

    摘要： An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.

    摘要翻译： 具有对应于人BAFF（属于TNF家族的B细胞活化因子）的134位至146位的氨基酸序列AVQGPEETVT QDC（以单字母​​氨基酸编码表示）的肽的抗体，其优选为单克隆抗体 抗体; 制备上述抗体的方法; 含有该抗体的药物组合物; 抗体的利用; 以及使用抗体筛选对BAFF的抑制作用或活化作用的方法。

    Acceleration detecting device
    8.
    发明授权
    Acceleration detecting device 失效
    加速度检测装置

    公开(公告)号：US06172313B2

    公开(公告)日：2001-01-09

    申请号：US09210991

    申请日：1998-12-15

    申请人： Kazunori Sakamoto ,  Tateki Kawamura ,  Tsutomu Takeuchi ,  Koichi Fujita

    发明人： Kazunori Sakamoto ,  Tateki Kawamura ,  Tsutomu Takeuchi ,  Koichi Fujita

    IPC分类号： H01H3514

    CPC分类号： H01H35/14

    摘要： An acceleration detecting device includes a hollow housing having a side wall, a bottom wall and an opening and a cover closing the opening of the hollow housing. A weight is pivotally mounted in the hollow housing to be rotated about a locus in response to an applied acceleration. Also positioned within the housing is a contact assembly to be electrically-closed by the rotated weight. A plastic main body is held in the hollow housing along the side wall to support the contact assembly and keep the contact assembly spaced from the locus of the weight during the rotation of the weight. The plastic main body which supports the contact assembly may have a wider support along the side wall of the hollow housing, which is independent from fixture of the cover. Therefore, the contact assembly may be supported by the hollow housing through the main body in a more reliable manner. Further, the weight may rotate without any interference to the contact assembly because the contact assembly is kept off the locus of the weight.

    摘要翻译： 加速度检测装置包括具有侧壁，底壁和开口以及封闭中空壳体的开口的盖的中空壳体。 重物枢转地安装在中空壳体中，以响应于所施加的加速度围绕轨迹旋转。 还设置在壳体内的是通过旋转的重量而被电闭合的接触组件。 塑料主体沿着侧壁被保持在中空壳体中，以支撑接触组件，并且在重量旋转期间保持接触组件与重物的轨迹间隔开。 支撑接触组件的塑料主体可以沿着中空壳体的侧壁具有更宽的支撑，其与盖的固定件无关。 因此，接触组件可以以更可靠的方式通过主体由中空壳体支撑。 此外，重量可以旋转而不会对接触组件产生任何干扰，因为接触组件被保持在重量的轨迹之外。

    Body frame for vehicles
    9.
    发明授权
    Body frame for vehicles 失效
    车身车架

    公开(公告)号：US4735275A

    公开(公告)日：1988-04-05

    申请号：US916232

    申请日：1986-10-07

    申请人： Takeshi Tsukahara ,  Tsutomu Takeuchi ,  Kikuo Murase

    发明人： Takeshi Tsukahara ,  Tsutomu Takeuchi ,  Kikuo Murase

    IPC分类号： B62K5/00 ,  B62K5/06 ,  B62K11/02 ,  B62D61/08

    CPC分类号： B62K11/04 ,  B62K5/01 ,  B62K5/027 ,  B62K5/06

    摘要： A vehicle which may be three-wheeled or four-wheeled, for instance, a buggy comprises a front wheel and a wishbone suspension for supporting the front wheel and a power unit. The body frame comprises a left subframe, a right subframe of essentially quadrilateral configuration, each subframe having an upper side, a front side, a lower side and a rear side. A reinforcing bar connects the front side and the lower side. The subframes form a first loop. The reinforcing bar forms a second loop with the upper side, the rear side, the front side and the lower side. The second loop is within the first loop. The first loop supports the front wheel wishbone suspension and the second loop supports the power unit. The front side has an upper portion and a lower portion and the lower side has a forward portion and a rear portion and the second loop is formed by the upper side, the upper portion of the front side, the rear portion of the lower side and the rear side. A down bar connects the upper bar to the lower side and intersects the reinforcing bar at a point P. The wishbone suspension is supported by the reinforicng bar and the lower side forwardly of point P and the power unit is supported rearwardly of the point P by the reinforcing bar and the lower side.

    摘要翻译： 可以是三轮或四轮的车辆，例如婴儿车包括前轮和用于支撑前轮的动力悬挂和动力单元。 身体框架包括左子框架，基本上为四边形配置的右子框架，每个子框架具有上侧，前侧，下侧和后侧。 钢筋连接前侧和下侧。 子帧形成第一个循环。 钢筋与上侧，后侧，前侧和下侧形成第二回路。 第二个循环在第一个循环内。 第一回路支撑前轮叉骨悬挂，第二回路支撑动力单元。 前侧具有上部和下部，下侧具有前部和后部，第二环由上侧，前侧的上部，下侧的后部和 后方。 下杆将上杆连接到下侧，并在点P处与钢筋相交。叉骨悬挂由加强杆支撑，点P的下侧支撑，动力单元由点P向后支撑， 钢筋和下侧。

    ANTIHUMAN BAFF ANTIBODY
    10.
    发明申请
    ANTIHUMAN BAFF ANTIBODY 审中-公开
    抗人BAFF抗体

    公开(公告)号：US20140024055A1

    公开(公告)日：2014-01-23

    申请号：US14045478

    申请日：2013-10-03

    申请人： KEIKO YOSHIMOTO ,  TSUTOMU TAKEUCHI ,  KOWA COMPANY, LTD.

    发明人： Tsutomu Takeuchi ,  Keiko Yoshimoto

    IPC分类号： G01N33/68

    CPC分类号： G01N33/68 ,  A61K2039/505 ,  C07K14/70575 ,  C07K16/241 ,  G01N33/564 ,  G01N33/74 ,  G01N2500/00

    摘要： An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO. 1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.

    摘要翻译： 具有如SEQ ID NO：1所示的具有氨基酸序列AVQGPEETVT QDC（以单字母​​氨基酸编码表示）的肽的抗体。 1对应于人BAFF（属于TNF家族的B细胞激活因子）中的134位至146位的蛋白质，其优选为单克隆抗体; 制备上述抗体的方法; 含有该抗体的药物组合物; 抗体的利用; 以及使用抗体筛选对BAFF的抑制作用或活化作用的方法。