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11 条记录 (耗时 0.016 秒)

    HIGH STRENGTH INTRAOSSEOUS IMPLANTS
    3.
    发明申请
    HIGH STRENGTH INTRAOSSEOUS IMPLANTS 有权

    公开(公告)号：US20220000588A1

    公开(公告)日：2022-01-06

    申请号：US17476182

    申请日：2021-09-15

    申请人： UNIVERSITY OF CENTRAL OKLAHOMA

    发明人： Vagan TAPALTSYAN ,  Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  Rami Mohanad Mahdi ALKHALEELI ,  Niyaf Nidhal Kadhem ALKADHEM

    IPC分类号： A61C8/02 ,  A61K6/891 ,  A61K6/898 ,  A61C13/00 ,  A61C8/00

    摘要： The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

    HIGH STRENGTH INTRAOSSEOUS IMPLANTS
    4.
    发明申请
    HIGH STRENGTH INTRAOSSEOUS IMPLANTS 有权

    公开(公告)号：US20210338383A1

    公开(公告)日：2021-11-04

    申请号：US17374700

    申请日：2021-07-13

    申请人： UNIVERSITY OF CENTRAL OKLAHOMA

    发明人： Vagan TAPALTSYAN ,  Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  Rami Mohanad Mahdi ALKHALEELI ,  Niyaf Nidhal Kadhem ALKADHEM

    IPC分类号： A61C8/02 ,  A61C8/00 ,  A61C13/00 ,  A61K6/891 ,  A61K6/898

    摘要： The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

    NANOFIBER COATING TO IMPROVE BIOLOGICAL AND MECHANICAL PERFORMANCE OF JOINT PROSTHESIS
    5.
    发明申请
    NANOFIBER COATING TO IMPROVE BIOLOGICAL AND MECHANICAL PERFORMANCE OF JOINT PROSTHESIS 审中-公开

    公开(公告)号：US20190142593A1

    公开(公告)日：2019-05-16

    申请号：US16248122

    申请日：2019-01-15

    申请人： UNIVERSITY OF CENTRAL OKLAHOMA

    发明人： Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  William Paul SNOW

    IPC分类号： A61F2/28 ,  D01D5/00 ,  D01F1/10 ,  D01F6/62 ,  A61F2/30

    摘要： The present invention provides a process to functionalize nanofiber membrane (NFM) on a total joint replacement (TJR) implant surface to support bone ingrowth and reduce macrophage-associated inflammation, the process comprising amending the implant surface by laser cutting microgrooves greater than 100 μm in depth to protect functional PCL NFM from applied loading, induce a higher amount of osteoblast cell function, increase implant-bone contact area, and serve as a reservoir for the local delivery of biomolecules to increase osseointegration of the implant; depositing aligned fibers on the implant surface, the fibers aligned in the direction of the microgrooves and collected in layers until a thickness less than 30 μm is reached and preferably in the range of 1 μm to 10 μm. Biofunctionalized NFM are used to indirectly attach biomolecules on said implant surface, or extracellular matrix proteins with biomolecules are immobilized and deposited on the PCL NFM coated implant.

    ENGINEERED INTERVERTEBRAL DISC (IVD) FOR DEGENERATED DISC DISEASE
    7.
    发明申请
    ENGINEERED INTERVERTEBRAL DISC (IVD) FOR DEGENERATED DISC DISEASE 审中-公开
    工程化椎间盘（IVD）用于变性疾病

    公开(公告)号：US20160374820A1

    公开(公告)日：2016-12-29

    申请号：US15188654

    申请日：2016-06-21

    申请人： UNIVERSITY OF CENTRAL OKLAHOMA

    发明人： Morshed KHANDAKER ,  Shahram RIAHINEZHAD

    IPC分类号： A61F2/44 ,  A61L27/56 ,  A61L27/34 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  A61L27/26

    CPC分类号： A61F2/441 ,  A61F2002/4495 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3817 ,  A61L27/3856 ,  A61L27/52 ,  A61L2400/12 ,  A61L2430/38 ,  C08L83/04 ,  C08L71/02 ,  C08L67/04 ,  C08L89/06

    摘要： The present invention provides a process by which both non-tissue engineered and tissue engineered cartilaginous-like structures can be fabricated. The process of the present invention provides a method to produce electrospun nanofiber-anchored NP gels. The present invention provides a functional design for novel engineered IVD. The present invention provides a method for fabrication of both non-tissue and tissue engineered IVDs. These cartilaginous-like structures can be used to produce replacements for degenerated natural IVD. The method of the present invention uses electrospun PCL nanofiber mesh to anchor the NP. The method of the present invention can create angle-ply AF structure around the circumference of NP to mimic the architecture of native IVD. The method of the present invention anchors the top and bottom sides of NP by using non-woven aligned or random nanofiber mesh to create scaffold for the generation of endplate (EP) tissue.

    摘要翻译： 本发明提供了可以制造非组织工程化和组织工程化软骨样结构两者的方法。 本发明的方法提供了一种生产电纺丝纳米纤维锚定NP凝胶的方法。 本发明提供了用于新颖工程IVD的功能设计。 本发明提供了用于制造非组织和组织工程IVD的方法。 这些软骨样结构可用于产生退化天然IVD的替代物。 本发明的方法使用电纺丝PCL纳米纤维网来锚定NP。 本发明的方法可以在NP周围产生角层AF结构，以模拟本机IVD的结构。 本发明的方法通过使用无纺布对准或随机的纳米纤维网来锚定NP的顶侧和底侧，以产生用于产生终板（EP）组织的支架。