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1.发明申请公开(公告)号：US20200340028A1
公开(公告)日：2020-10-29
申请号：US16857563
申请日：2020-04-24
发明人： Craig Martin , Elvan Cavac , Kithmie Harshana Malagodapathiranage , Shuo Sui , Sarah L. Perry , Yasaman Gholamalipour
IPC分类号： C12P19/34 , C12N9/12 , C12N15/113
摘要： Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
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公开(公告)号：US10767060B2
公开(公告)日：2020-09-08
申请号：US15985855
申请日：2018-05-22
IPC分类号： C09K3/00 , C09D11/023 , C09D11/08 , C09D11/10 , C09D11/38 , C09D11/03 , C09D1/00 , C09D4/00 , C09D5/00 , C09D11/00
摘要： The invention provides compositions and methods for ultra-stable coating or printing from aqueous complex coacervates.
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3.发明公开公开(公告)号：US20230265477A1
公开(公告)日：2023-08-24
申请号：US18152367
申请日：2023-01-10
发明人： Craig Martin , Elvan Cavac , Kithmie Harshana Malagodapathiranage , Shuo Sui , Sarah L. Perry , Yasaman Gholamalipour
IPC分类号： C12P19/34 , C12N9/12 , C12N15/10 , C12Q1/6865
CPC分类号： C12P19/34 , C12N9/1247 , C12N15/10 , C12Q1/6865
摘要： Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
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4.发明授权公开(公告)号：US10428444B2
公开(公告)日：2019-10-01
申请号：US15725465
申请日：2017-10-05
IPC分类号： C08L39/04 , D01F6/26 , D01D5/00 , C08F26/04 , C08F12/30 , C08F28/02 , D01F6/44 , D01F6/56 , C08L41/00 , C08L39/00
摘要： The invention provides novel polymer nanofiber or microfiber mats or membranes and methods for their preparation via an aqueous, one-step polyelectrolyte complexation and electrospinning of complex coacervates.
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5.发明申请公开(公告)号：US20190383764A1
公开(公告)日：2019-12-19
申请号：US16444240
申请日：2019-06-18
发明人： Sarah L. Perry , Shou Sui
IPC分类号： G01N27/26 , B01L3/06 , B01L3/00 , C30B7/14 , G01N23/20025 , G01N23/207 , B01D9/00
摘要： The invention provides a novel microfluidic platform for use in electro-crystallization and electro-crystallography experiments. The manufacturing and use of graphene as X-ray compatible electrodes allows the application of electric fields on-chip, during X-ray analysis. The presence of such electric fields can be used to modulate the structure of protein (or other) molecules in crystalline (for X-ray diffraction) or solution form (for X-ray scattering). Additionally, the presence of an electric field can be used to extend the lifetime of fragile samples by expediting the removal of reactive secondary radiation damage species.
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公开(公告)号：US20180214863A1
公开(公告)日：2018-08-02
申请号：US15830768
申请日：2017-12-04
发明人： Shuo Sui , Yuxi Wang , Christos Dimitrakopoulos , Sarah L. Perry
IPC分类号： B01L3/06 , B01L3/00 , C30B7/14 , C30B29/58 , G01N23/20025 , G01N23/207
CPC分类号： B01L3/06 , B01L3/5027 , B01L3/502707 , B01L2200/10 , B01L2200/12 , B01L2300/0609 , B01L2300/0887 , B01L2300/12 , C30B7/14 , C30B29/58 , G01N23/20025 , G01N23/207 , G01N2223/602
摘要： This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in X-ray analysis.
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7.发明授权公开(公告)号：US11578348B2
公开(公告)日：2023-02-14
申请号：US16857563
申请日：2020-04-24
发明人： Craig Martin , Elvan Cavac , Kithmie Harshana Malagodapathiranage , Shuo Sui , Sarah L. Perry , Yasaman Gholamalipour
IPC分类号： C12P19/34 , C12N9/12 , C12N15/10 , C12Q1/6865
摘要： Described herein are synthetic methods for producing sequence-specific RNA oligonucleotides that eliminate impurities produced in prior art methods. In one aspect, an end-protected capture DNA complementary to a portion of the product RNA is employed. In another aspect, the template DNA is covalently or noncovalently linked to the RNA polymerase, either directly or through the use of a nontemplate DNA. In a third aspect, a flow chamber is employed. All of the methods can be used in combination.
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公开(公告)号：US11175244B2
公开(公告)日：2021-11-16
申请号：US16444240
申请日：2019-06-18
发明人： Sarah L. Perry , Shou Sui
IPC分类号： G01N23/20 , G01N23/20008 , G01N23/20025 , G01N23/20066 , G01N23/20091 , G01N23/201 , G01N23/205 , G01N23/207 , B01L3/00 , C30B7/14 , B01L3/06 , B01D9/00 , G01N27/26 , G01N23/2209 , G01N23/223 , G01N23/2204 , G01N23/203 , G01N23/22 , G01N23/2202 , G01N23/2206 , G01N23/2208
摘要： The invention provides a novel microfluidic platform for use in electro-crystallization and electro-crystallography experiments. The manufacturing and use of graphene as X-ray compatible electrodes allows the application of electric fields on-chip, during X-ray analysis. The presence of such electric fields can be used to modulate the structure of protein (or other) molecules in crystalline (for X-ray diffraction) or solution form (for X-ray scattering). Additionally, the presence of an electric field can be used to extend the lifetime of fragile samples by expediting the removal of reactive secondary radiation damage species.
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公开(公告)号：US10792657B2
公开(公告)日：2020-10-06
申请号：US15830768
申请日：2017-12-04
发明人： Shuo Sui , Yuxi Wang , Christos Dimitrakopoulos , Sarah L. Perry
IPC分类号： B01L3/06 , B01L3/00 , C30B7/14 , C30B29/58 , G01N23/20025 , G01N23/207
摘要： This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in X-ray analysis.
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10.发明申请公开(公告)号：US20180334581A1
公开(公告)日：2018-11-22
申请号：US15985855
申请日：2018-05-22
IPC分类号： C09D11/023 , C09D11/10 , C09D11/08
CPC分类号： C09D11/023 , C09D11/03 , C09D11/08 , C09D11/10 , C09D11/38
摘要： The invention provides compositions and methods for ultra-stable coating or printing from aqueous complex coacervates.
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