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    METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS
    2.
    发明申请
    METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS 审中-公开

    公开(公告)号：US20200157615A1

    公开(公告)日：2020-05-21

    申请号：US16783037

    申请日：2020-02-05

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Daniel T. CHIU ,  Bryant S. FUJIMOTO ,  Alexander R. GANSEN ,  Gloria S. YEN ,  Robert M. LORENZ

    IPC: C12Q1/6851 ,  C12Q1/6806

    Abstract: Methods and systems for digital measurements are provided. In an embodiment, the method includes producing a plurality of droplets, wherein at least one of the droplets of the plurality of droplets contains an analyte molecule from a sample; measuring at least a first portion of the plurality of droplets to determine individual volumes of droplets in the first portion of the plurality of droplets; analyzing at least a second portion of the plurality of droplets to determine a number of droplets in the second portion of the plurality of droplets that contain the analyte molecule; and using individual volumes of the droplets in the first portion of the plurality of droplets and the number of droplets in the second portion of the plurality of droplets that contain the analyte molecule to determine the concentration of the analyte molecule in the sample.

    METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS
    4.
    发明申请
    METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS 有权
    用于产生双重乳液的方法和装置

    公开(公告)号：US20160086785A1

    公开(公告)日：2016-03-24

    申请号：US14891620

    申请日：2014-05-30

    Applicant: UNIVERSITY OF WASHINGTON through its CENTER FOR COMMERCIALIZATION

    Inventor： Daniel T. CHIU ,  Bejan HAKIMI ,  Dingsheng LIU ,  Frantisek TURECEK ,  Michael VOLNY ,  Joelle ROLFS

    IPC: H01J49/16 ,  B05B5/025

    CPC classification number: H01J49/165 ,  B05B5/025 ,  B05B5/03 ,  H01J49/0445

    Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.

    Abstract translation: 本公开描述了能够产生多相乳液的装置和方法，包括气相中的双乳液液滴。 本公开还描述了用于将多相乳液液滴源耦合到诸如质谱仪的分析仪器的界面。 本公开进一步描述了使用所描述的装置和接口进行分析的方法，系统和装置，包括质谱法。 本公开还描述了用于产生和使用多相乳液进行分析的方法，系统和装置。

    METHODS, COMPOSITIONS AND SYSTEMS FOR MICROFLUIDIC ASSAYS
    8.
    发明申请
    METHODS, COMPOSITIONS AND SYSTEMS FOR MICROFLUIDIC ASSAYS 审中-公开
    方法，微流控测定的组成和系统

    公开(公告)号：US20160146823A1

    公开(公告)日：2016-05-26

    申请号：US14903012

    申请日：2014-07-01

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Daniel T. CHIU ,  Mengxia ZHAO ,  Wyatt NELSON ,  Perry G. SCHIRO

    IPC: G01N33/574 ,  B01L3/00 ,  G01N33/53

    Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.

    Abstract translation: 本文中提供了用于分析样品中的颗粒的方法和装置。 在一些方面，颗粒可以是分析物，细胞，核酸或蛋白质，并与标签接触，分成等分试样，由排序装置检测并分离。 本文提供的方法和装置可以包括微流体芯片。 在一些方面，所述方法和装置可用于定量样品中的稀有颗粒，例如用于疾病诊断，预后或治疗的癌细胞和其它稀有细胞。

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