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26 条记录 (耗时 0.029 秒)

    Method and apparatus for dynamic power management
    1.
    发明授权
    Method and apparatus for dynamic power management 有权
    动态电源管理方法和装置

    公开(公告)号：US08954764B2

    公开(公告)日：2015-02-10

    申请号：US13412501

    申请日：2012-03-05

    申请人： Victor Pinto ,  Eyal Raz

    发明人： Victor Pinto ,  Eyal Raz

    IPC分类号： G06F1/26 ,  G06F1/32

    CPC分类号： H03K19/0016

    摘要： An integrated circuit (IC) includes a first power supply node that is arranged to receive a first power supply signal. The IC also includes process detection circuits. Each process detection circuit provides a process detection output signal such that a value associated with the process detection output signal is a function of process variation at a location of the process detection circuit outputting the process detection signal. The IC also includes a processing unit that executes processor-executable instructions to provide at least one voltage control signal, based, at least in part, on the process detection signals. The voltage control signal(s) include a first voltage control signal is associated with a target voltage for the first power supply signal.

    摘要翻译： 集成电路（IC）包括被配置为接收第一电源信号的第一电源节点。 该IC还包括处理检测电路。 每个处理检测电路提供处理检测输出信号，使得与处理检测输出信号相关联的值是输出处理检测信号的处理检测电路的位置处的处理变化的函数。 IC还包括处理单元，其执行处理器可执行指令以至少部分地基于处理检测信号来提供至少一个电压控制信号。 电压控制信号包括与第一电源信号的目标电压相关联的第一电压控制信号。

    METHOD AND APPARATUS FOR DYNAMIC POWER MANAGEMENT
    2.
    发明申请
    METHOD AND APPARATUS FOR DYNAMIC POWER MANAGEMENT 有权
    动力电力管理方法与装置

    公开(公告)号：US20130232347A1

    公开(公告)日：2013-09-05

    申请号：US13412501

    申请日：2012-03-05

    申请人： Victor Pinto ,  Eyal Raz

    发明人： Victor Pinto ,  Eyal Raz

    IPC分类号： G06F1/26

    CPC分类号： H03K19/0016

    摘要： An integrated circuit (IC) includes a first power supply node that is arranged to receive a first power supply signal. The IC also includes process detection circuits. Each process detection circuit provides a process detection output signal such that a value associated with the process detection output signal is a function of process variation at a location of the process detection circuit outputting the process detection signal. The IC also includes a processing unit that executes the processor-executable instructions to provide at least one voltage control signal, based, at least in part, on the process detection signals. The voltage control signal(s) include a first voltage control signal is associated with a target voltage for the first power supply signal.

    摘要翻译： 集成电路（IC）包括被配置为接收第一电源信号的第一电源节点。 该IC还包括处理检测电路。 每个处理检测电路提供处理检测输出信号，使得与处理检测输出信号相关联的值是输出处理检测信号的处理检测电路的位置处的处理变化的函数。 IC还包括处理单元，其执行处理器可执行指令以至少部分地基于处理检测信号提供至少一个电压控制信号。 电压控制信号包括与第一电源信号的目标电压相关联的第一电压控制信号。

    Inhibitors of DNA Immunostimulatory Sequence Activity
    3.
    发明申请
    Inhibitors of DNA Immunostimulatory Sequence Activity 审中-公开
    DNA的抑制剂免疫刺激序列活性

    公开(公告)号：US20110034541A1

    公开(公告)日：2011-02-10

    申请号：US12697917

    申请日：2010-02-01

    申请人： Eyal Raz ,  Mark Roman

    发明人： Eyal Raz ,  Mark Roman

    IPC分类号： A61K48/00 ,  C07H21/00 ,  C12N15/85 ,  C40B30/06 ,  C12Q1/68

    CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K14/4703 ,  C12N15/117 ,  C12N2310/111 ,  C12N2310/17 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/33 ,  C12N2310/334 ,  C12N2310/3513 ,  C12Q1/6883 ,  Y02A50/41 ,  Y02A50/423

    摘要： The invention consists of oligonucleotides which inhibit the immunostimulatory activity of ISS-ODN (immunostimulatory sequence oligodeoxynucleotides) as well as methods for their identification and use. The oligonucleotides of the invention are useful in controlling therapeutically intended ISS-ODN adjuvant activity as well as undesired ISS-ODN activity exerted by recombinant expression vectors, such as those used for gene therapy and gene immunization. The oligonucleotides of the invention also have anti-inflammatory activity useful in reducing inflammation in response to infection of a host with ISS-ODN containing microbes, in controlling autoimmune disease and in boosting host Th2 type immune responses to an antigen. The invention also encompasses pharmaecutically useful conjugates of the oligonucleotides of the invention (including conjugate partners such as antigens and antibodies).

    摘要翻译： 本发明由抑制ISS-ODN（免疫刺激性寡脱氧核苷酸）的免疫刺激活性的寡核苷酸以及鉴定和使用的方法组成。 本发明的寡核苷酸可用于控制治疗性意图的ISS-ODN佐剂活性以及重组表达载体（例如用于基因治疗和基因免疫的那些）所产生的不期望的ISS-ODN活性。 本发明的寡核苷酸还具有抗炎活性，其可用于在控制具有含有ISS-ODN的微生物的宿主的感染中，在控制自身免疫疾病和促进对抗原的宿主Th2型免疫应答中减少炎症。 本发明还包括本发明的寡核苷酸的药物有用的缀合物（包括缀合物如抗原和抗体）。

    Agents that modulate DNA-PK activity and methods of use thereof
    9.
    发明授权
    Agents that modulate DNA-PK activity and methods of use thereof 失效
    调节DNA-PK活性的药剂及其使用方法

    公开(公告)号：US06893821B2

    公开(公告)日：2005-05-17

    申请号：US09848986

    申请日：2001-05-04

    申请人： Eyal Raz ,  Augusto Lois ,  Kenji Takabayashi

    发明人： Eyal Raz ,  Augusto Lois ,  Kenji Takabayashi

    IPC分类号： A61K31/7088 ,  C12Q1/48 ,  G01N33/68 ,  C12Q1/68 ,  A61K38/00 ,  C07H21/00 ,  C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/63

    CPC分类号： A61K31/7088 ,  C12Q1/485 ,  G01N33/6869

    摘要： The present invention provides methods for modulating cell death in a eukaryotic cell, and methods for reducing DNA damage in a eukaryotic cell. The methods generally comprise modulating a biological activity of DNA-PK in a cell. The invention further provides methods of treating a condition related to cell death in an individual. The invention further provides methods of identifying agents which modulate a biological activity of DNA-PK, as well as agents identified by the methods. Methods of modulating an immune response using an identified agent are also provided.

    摘要翻译： 本发明提供了调节真核细胞中细胞死亡的方法，以及用于减少真核细胞中的DNA损伤的方法。 所述方法通常包括调节细胞中DNA-PK的生物活性。 本发明还提供了治疗个体中与细胞死亡有关的病症的方法。 本发明还提供鉴定调节DNA-PK的生物活性的试剂以及通过该方法鉴定的试剂的方法。 还提供了使用鉴定的药剂调节免疫应答的方法。