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1.发明申请公开(公告)号：US20100059120A1
公开(公告)日：2010-03-11
申请号：US12208445
申请日：2008-09-11
申请人： Wei-Cheng Tian , Jeffrey Bernard Fortin , Jun Xie , Barbara Grossman , Oliver Charles Boomhower , Shashi Thutupalli , Long Que
发明人： Wei-Cheng Tian , Jeffrey Bernard Fortin , Jun Xie , Barbara Grossman , Oliver Charles Boomhower , Shashi Thutupalli , Long Que
IPC分类号： G01N33/00
CPC分类号： B01L3/502738 , B01L3/502707 , B01L3/502784 , B01L2200/0605 , B01L2200/0673 , B01L2300/0874 , B01L2300/161 , B01L2400/0415 , B01L2400/043 , B01L2400/0475 , B01L2400/0655 , B01L2400/0672 , Y10T137/0318
摘要： Methods and microfluidic devices for generating and manipulating sample droplets, wherein the devices comprise, a plurality of fluid channels, at least one of which is a sample channel for carrying a fluidic sample material, that is in fluid communication with the carrier fluid channel via an orifice; and an actuated flow interrupter adapted to force a predetermined amount of the sample fluid from the sample channel through the orifice into the carrier fluid channel.
摘要翻译： 用于产生和操纵样品液滴的方法和微流体装置，其中所述装置包括多个流体通道，其中至少一个流体通道是用于承载流体样品材料的样品通道，其经由载体流体通道流体连通 孔; 以及致动流动断路器，其适于将预定量的样品流体从样品通道穿过所述孔进入载体流体通道。
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公开(公告)号：US20090071832A1
公开(公告)日：2009-03-19
申请号：US11857570
申请日：2007-09-19
申请人： Jun Xie , Shashi Thutupalli , Stacey Joy Kennerly , Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Oliver Charles Boomhower
发明人： Jun Xie , Shashi Thutupalli , Stacey Joy Kennerly , Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Oliver Charles Boomhower
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： A microfluidic device with a vertical injection aperture is provided. The microfluidic device comprises a separation channel, an injection aperture disposed adjacent to and in fluid communication with the separation channel. The microfluidic device further comprises a semi-permeable filter disposed adjacent to the injection aperture, wherein the filter is configured to preconcentrate a sample in the injection aperture to form a preconcentrated sample plug during an injection operation, and wherein the sample plug flows downwardly from the injection aperture to the separation channel during an electrophoresis operation.
摘要翻译： 提供具有垂直注射孔的微流体装置。 微流体装置包括分离通道，与分离通道相邻并且与分离通道流体连通地设置的注射孔。 微流体装置还包括邻近喷射孔布置的半渗透过滤器，其中过滤器构造成在注射操作期间预浓缩注入孔中的样品以形成预浓缩样品塞，并且其中样品塞从 在电泳操作期间到分离通道的注射孔径。
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公开(公告)号：US08029743B2
公开(公告)日：2011-10-04
申请号：US11857570
申请日：2007-09-19
申请人： Jun Xie , Shashi Thutupalli , Stacey Joy Kennerly , Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Oliver Charles Boomhower
发明人： Jun Xie , Shashi Thutupalli , Stacey Joy Kennerly , Wei-Cheng Tian , Erin Jean Finehout , Li Zhu , Oliver Charles Boomhower
IPC分类号： B01L3/00 , G01N27/453
CPC分类号： G01N27/447
摘要： A microfluidic device with a vertical injection aperture is provided. The microfluidic device comprises a separation channel, an injection aperture disposed adjacent to and in fluid communication with the separation channel. The microfluidic device further comprises a semi-permeable filter disposed adjacent to the injection aperture, wherein the filter is configured to preconcentrate a sample in the injection aperture to form a preconcentrated sample plug during an injection operation, and wherein the sample plug flows downwardly from the injection aperture to the separation channel during an electrophoresis operation.
摘要翻译： 提供具有垂直注射孔的微流体装置。 微流体装置包括分离通道，与分离通道相邻并且与分离通道流体连通地设置的注射孔。 微流体装置还包括邻近喷射孔布置的半渗透过滤器，其中过滤器构造成在注射操作期间预浓缩注入孔中的样品以形成预浓缩样品塞，并且其中样品塞从 在电泳操作期间到分离通道的注射孔径。
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公开(公告)号：US09102119B2
公开(公告)日：2015-08-11
申请号：US13533192
申请日：2012-06-26
CPC分类号： B32B15/018 , B05D1/38 , B32B9/00 , C22C5/02 , C22C19/03 , C25D7/00 , G03F7/00 , G03F7/0035 , Y10T428/12889 , Y10T428/239
摘要： A device including a protecting material encapsulated metallic beam and a method of encapsulating the metallic beam using the protecting material layer are presented. The device includes a cantilever beam that includes at least about 90 Wt % of a metallic beam material, and 10 Wt % or less of a protecting material. The method of forming an encapsulated metallic beam includes the steps of depositing a first layer of protecting material over a substrate, depositing a second layer of protecting material over the first layer, depositing a metallic beam material over the second layer of protecting material, and encapsulating the beam material with a coating of the protecting material.
摘要翻译： 提出了一种包括保护材料封装的金属束的装置以及使用保护材料层封装金属束的方法。 该装置包括悬臂梁，其包括至少约90重量％的金属梁材料和10重量％或更少的保护材料。 形成封装的金属束的方法包括以下步骤：在衬底上沉积第一层保护材料，在第一层上沉积第二层保护材料，在第二层保护材料上沉积金属束材料，以及将 梁材料具有保护材料的涂层。
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公开(公告)号：US08622223B2
公开(公告)日：2014-01-07
申请号：US12337164
申请日：2008-12-17
申请人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
发明人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
CPC分类号： C23C26/00 , B01D67/0065 , C23C28/00 , C23C28/04 , C25D11/02 , C25D11/045 , C25D11/32 , Y10T428/249953 , Y10T428/249967 , Y10T428/249969
摘要： A method of making a membrane assembly is provided. The method comprises forming an inorganic membrane layer disposed on a substrate, and forming a plurality of macropores in the substrate at least in part using anodization. Further, a membrane assembly is provided. The membrane assembly comprises a filtering membrane that is coupled to an anodized substrate comprising a plurality of macropores.
摘要翻译： 提供制造膜组件的方法。 该方法包括形成设置在基板上的无机膜层，并且至少部分地使用阳极氧化在基板中形成多个大孔。 此外，提供了膜组件。 膜组件包括过滤膜，其与包括多个大孔的阳极化底物耦合。
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公开(公告)号：US08168101B2
公开(公告)日：2012-05-01
申请号：US12544305
申请日：2009-08-20
CPC分类号： B01D69/10 , B01D67/006 , B01D69/02 , B01D71/02 , B01D2325/04
摘要： An inorganic membrane device is provided. The device comprises a substrate having a network of pores, and a membrane layer at least partially coupled to the substrate and having a plurality of pores, wherein the pores have an aspect ratio in a range from about 1:2 to about 1:100.
摘要翻译： 提供无机膜装置。 该装置包括具有孔网络的基底和至少部分地耦合到基底并具有多个孔的膜层，其中孔的纵横比在约1:2至约1:100的范围内。
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公开(公告)号：US20090096088A1
公开(公告)日：2009-04-16
申请号：US11872562
申请日：2007-10-15
申请人： MARCO FRANCESCO AIMI , Chirstopher James Kapusta , Arun Virupaksha Gowda , David Cecil Hays , Oliver Charles Boomhower , Glenn Scott Claydon , Joseph Alfred Iannotti , Christopher Fred Keimel
发明人： MARCO FRANCESCO AIMI , Chirstopher James Kapusta , Arun Virupaksha Gowda , David Cecil Hays , Oliver Charles Boomhower , Glenn Scott Claydon , Joseph Alfred Iannotti , Christopher Fred Keimel
CPC分类号： B81C1/00269 , B81C2203/0118 , B81C2203/019 , B81C2203/032 , H01L2224/16225 , H01L2924/1461 , H01L2924/00
摘要： Multiple microelectromechanical systems (MEMS) on a substrate are capped with a cover using a layer that may function as a bonding agent, separation layer, and hermetic seal. A substrate has a first side with multiple MEMS devices. A cover is formed with through-holes for vias, and with standoff posts for layer registration and separation. An adhesive sheet is patterned with cutouts for the MEMS devices, vias, and standoff posts. The adhesive sheet is tacked to the cover, then placed on the MEMS substrate and heated to bond the layers. The via holes may be metalized with leads for circuit board connection. The MEMS units may be diced from the substrate after sealing, thus protecting them from contaminants.
摘要翻译： 衬底上的多个微电子机械系统（MEMS）用盖子盖住，使用可用作粘合剂，分离层和气密密封的层。 衬底具有具有多个MEMS器件的第一侧。 形成有用于通孔的通孔的盖，并且具有用于层对准和分离的支柱。 图案化粘合片用于MEMS器件，通孔和支柱的切口。 将粘合片粘合到盖上，然后放置在MEMS基板上并加热以粘合层。 通孔可以用电路板连接的引线金属化。 在密封之后，MEMS单元可以从基底切割，从而保护它们免受污染。
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公开(公告)号：US20130344280A1
公开(公告)日：2013-12-26
申请号：US13533192
申请日：2012-06-26
CPC分类号： B32B15/018 , B05D1/38 , B32B9/00 , C22C5/02 , C22C19/03 , C25D7/00 , G03F7/00 , G03F7/0035 , Y10T428/12889 , Y10T428/239
摘要： A device including a protecting material encapsulated metallic beam and a method of encapsulating the metallic beam using the protecting material layer are presented. The device includes a cantilever beam that includes at least about 90 Wt % of a metallic beam material, and 10 Wt % or less of a protecting material. The method of forming an encapsulated metallic beam includes the steps of depositing a first layer of protecting material over a substrate, depositing a second layer of protecting material over the first layer, depositing a metallic beam material over the second layer of protecting material, and encapsulating the beam material with a coating of the protecting material.
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公开(公告)号：US20110042301A1
公开(公告)日：2011-02-24
申请号：US12544305
申请日：2009-08-20
CPC分类号： B01D69/10 , B01D67/006 , B01D69/02 , B01D71/02 , B01D2325/04
摘要： An inorganic membrane device is provided. The device comprises a substrate having a network of pores, and a membrane layer at least partially coupled to the substrate and having a plurality of pores, wherein the pores have an aspect ratio in a range from about 1:2 to about 1:100.
摘要翻译： 提供无机膜装置。 该装置包括具有孔网络的基底和至少部分地耦合到基底并具有多个孔的膜层，其中孔的纵横比在约1:2至约1:100的范围内。
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公开(公告)号：US20100147762A1
公开(公告)日：2010-06-17
申请号：US12337164
申请日：2008-12-17
申请人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
发明人： Anping Zhang , Azar Alizadeh , Joleyn Eileen Balch , Rui Chen , Anthony John Murray , Vicki Herzl Watkins , Oliver Charles Boomhower , Reed Roeder Corderman , Peter Paul Gipp
CPC分类号： C23C26/00 , B01D67/0065 , C23C28/00 , C23C28/04 , C25D11/02 , C25D11/045 , C25D11/32 , Y10T428/249953 , Y10T428/249967 , Y10T428/249969
摘要： A method of making a membrane assembly is provided. The method comprises forming an inorganic membrane layer disposed on a substrate, and forming a plurality of macropores in the substrate at least in part using anodization. Further, a membrane assembly is provided. The membrane assembly comprises a filtering membrane that is coupled to an anodized substrate comprising a plurality of macropores.
摘要翻译： 提供制造膜组件的方法。 该方法包括形成设置在基板上的无机膜层，并且至少部分地使用阳极氧化在基板中形成多个大孔。 此外，提供了膜组件。 膜组件包括过滤膜，其与包括多个大孔的阳极化底物耦合。
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