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    Fluidics platform and method for sample preparation and analysis
    4.
    发明授权
    Fluidics platform and method for sample preparation and analysis 有权
    流体平台和样品制备和分析方法

    公开(公告)号：US08808643B1

    公开(公告)日：2014-08-19

    申请号：US13228391

    申请日：2011-09-08

    申请人： W. Henry Benner ,  John M. Dzenitis ,  William J Benett ,  Brian R. Baker

    发明人： W. Henry Benner ,  John M. Dzenitis ,  William J Benett ,  Brian R. Baker

    IPC分类号： B01L3/02

    CPC分类号： B01L3/502715 ,  B01L3/502738 ,  B01L2300/0864 ,  B01L2400/0622

    摘要： Herein provided are fluidics platform and method for sample preparation and analysis. The fluidics platform is capable of analyzing DNA from blood samples using amplification assays such as polymerase-chain-reaction assays and loop-mediated-isothermal-amplification assays. The fluidics platform can also be used for other types of assays and analyzes. In some embodiments, a sample in a sealed tube can be inserted directly. The following isolation, detection, and analyzes can be performed without a user's intervention. The disclosed platform may also comprises a sample preparation system with a magnetic actuator, a heater, and an air-drying mechanism, and fluid manipulation processes for extraction, washing, elution, assay assembly, assay detection, and cleaning after reactions and between samples.

    摘要翻译： 本文提供了流动平台和样品制备和分析方法。 流体学平台能够使用诸如聚合酶链反应测定和环介导等温扩增测定之类的扩增测定法从血液样品中分析DNA。 流体学平台也可用于其他类型的测定和分析。 在一些实施例中，密封管中的样品可以直接插入。 无需用户干预即可执行以下隔离，检测和分析。 所公开的平台还可以包括具有磁性致动器，加热器和空气干燥机构的样品制备系统，以及用于在反应之后和样品之间的萃取，洗涤，洗脱，测定组装，测定检测和清洁的流体操纵过程。

    Thermal Cycler
    6.
    发明申请
    Thermal Cycler 审中-公开
    热循环仪

    公开(公告)号：US20090209030A1

    公开(公告)日：2009-08-20

    申请号：US12415623

    申请日：2009-03-31

    申请人： William J. Benett ,  James B. Richards ,  Paul L. Stratton ,  Elizabeth K. Wheeler ,  Peter Krulevitch ,  Steve Visuri ,  John M. Dzenitis

    发明人： William J. Benett ,  James B. Richards ,  Paul L. Stratton ,  Elizabeth K. Wheeler ,  Peter Krulevitch ,  Steve Visuri ,  John M. Dzenitis

    IPC分类号： C12M1/02 ,  H05K3/00

    CPC分类号： B01L7/52 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2300/1844 ,  Y10T29/49124

    摘要： A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit material or a circuit board material. The second thermalcycler body section has a second face. A second cavity portion is formed in the second face. When the first cavity portion and the second cavity portion are positioned together they form a cavity. A thermalcycler unit is positioned in the cavity. The first thermalcycler body section and the second thermalcycler body section are connected together with the first face and the face opposed to each other and the thermalcycler unit operatively connected to the first cavity portion and the second cavity portion.

    摘要翻译： 热循环器正在构造具有柔性电路材料或电路板材料的第一热循环体主体部分。 第一热循环体主体部分具有第一面。 第一空腔部分形成在第一面中。 第二个热循环器主体部分由柔性电路材料或电路板材料构成。 第二热循环器本体部分具有第二面。 第二空腔部分形成在第二面中。 当第一空腔部分和第二空腔部分位于一起时，它们形成空腔。 热循环器单元位于空腔中。 第一热循环器主体部分和第二热循环器主体部分与第一面和彼此相对的面连接在一起，并且热循环器单元可操作地连接到第一腔部分和第二腔部分。

    Detection and quantification system for monitoring instruments
    7.
    发明授权
    Detection and quantification system for monitoring instruments 失效
    监测仪器检测和量化系统

    公开(公告)号：US07412356B1

    公开(公告)日：2008-08-12

    申请号：US11700686

    申请日：2007-01-30

    申请人： John M. Dzenitis ,  Claudia K. Hertzog ,  Anthony J. Makarewicz ,  Bruce D. Henderer ,  Vincent J. Riot

    发明人： John M. Dzenitis ,  Claudia K. Hertzog ,  Anthony J. Makarewicz ,  Bruce D. Henderer ,  Vincent J. Riot

    IPC分类号： G06F19/00 ,  G06F17/40

    CPC分类号： G16H50/80 ,  G06F19/00

    摘要： A method of detecting real events by obtaining a set of recent signal results, calculating measures of the noise or variation based on the set of recent signal results, calculating an expected baseline value based on the set of recent signal results, determining sample deviation, calculating an allowable deviation by multiplying the sample deviation by a threshold factor, setting an alarm threshold from the baseline value plus or minus the allowable deviation, and determining whether the signal results exceed the alarm threshold.

    摘要翻译： 一种通过获得一组最近的信号结果来检测实际事件的方法，基于最近信号结果的集合计算噪声或变化的测量值，基于最近信号结果的集合计算预期的基准值，确定样本偏差，计算 通过将样本偏差乘以阈值因子，从基线值设置警报阈值加上或减去允许偏差，以及确定信号结果是否超过警报阈值来允许偏差。

    DETECTION AND QUANTIFICATION SYSTEM FOR MONITORING INSTRUMENTS
    8.
    发明申请
    DETECTION AND QUANTIFICATION SYSTEM FOR MONITORING INSTRUMENTS 失效
    用于监测仪器的检测和定量系统

    公开(公告)号：US20080183433A1

    公开(公告)日：2008-07-31

    申请号：US11700686

    申请日：2007-01-30

    申请人： John M. Dzenitis ,  Claudia K. Hertzog ,  Anthony J. Makarewicz ,  Bruce D. Henderer ,  Vincent J. Riot

    发明人： John M. Dzenitis ,  Claudia K. Hertzog ,  Anthony J. Makarewicz ,  Bruce D. Henderer ,  Vincent J. Riot

    IPC分类号： H04B15/00

    CPC分类号： G16H50/80 ,  G06F19/00

    摘要： A method of detecting real events by obtaining a set of recent signal results, calculating measures of the noise or variation based on the set of recent signal results, calculating an expected baseline value based on the set of recent signal results, determining sample deviation, calculating an allowable deviation by multiplying the sample deviation by a threshold factor, setting an alarm threshold from the baseline value plus or minus the allowable deviation, and determining whether the signal results exceed the alarm threshold.

    摘要翻译： 一种通过获得一组最近的信号结果来检测实际事件的方法，基于最近信号结果的集合计算噪声或变化的测量值，基于最近信号结果的集合计算预期的基准值，确定样本偏差，计算 通过将样本偏差乘以阈值因子，从基线值设置警报阈值加上或减去允许偏差，以及确定信号结果是否超过警报阈值来允许偏差。