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公开(公告)号：US20080239306A1
公开(公告)日：2008-10-02
申请号：US11693277
申请日：2007-03-29
申请人： William Scott Sutherland , Anis Zribi , Long Que , Glenn Scott Claydon , Stacey Joy Kennerly , Ayan Banerjee , Shivappa Ningappa Goravar , Shankar Chandrasekaran , David Cecil Hays , Victor Samper , Dirk Lange , Marko Baller , Min-Yi Shih , Sandip Maity
发明人： William Scott Sutherland , Anis Zribi , Long Que , Glenn Scott Claydon , Stacey Joy Kennerly , Ayan Banerjee , Shivappa Ningappa Goravar , Shankar Chandrasekaran , David Cecil Hays , Victor Samper , Dirk Lange , Marko Baller , Min-Yi Shih , Sandip Maity
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0232 , G01J3/0237 , G01J3/027 , G01J3/0289 , G01J3/10 , G01J3/1895 , G01J3/44 , G02B26/02 , G02B26/0808 , G02B26/0816
摘要： A system and method for managing optical power for controlling thermal alteration of a sample undergoing spectroscopic analysis is provided. The system includes a moveable laser beam generator for irradiating the sample and a beam shaping device for moving and shaping the laser beam to prevent thermal overload or build up in the sample. The moveable laser beam generator includes at least one beam shaping device selected from the group consisting of at least one optical lens, at least one optical diffractor, at least one optical path difference modulator, at least one moveable mirror, at least one Micro-Electro-Mechanical Systems (MEMS) integrated circuit (IC), and/or a liquid droplet. The system also includes an at least two degree of freedom (2 DOF) moveable substrate platform and a controller for controlling the laser beam generator and the substrate platform, and for analyzing light reflected from the sample.
摘要翻译： 提供了一种用于管理用于控制进行光谱分析的样品的热变化的光功率的系统和方法。 该系统包括用于照射样品的可移动激光束发生器和用于移动和成形激光束的光束整形装置，以防止样品中的热过载或积聚。 可移动激光束发生器包括至少一个光束成形装置，其选自由至少一个光学透镜，至少一个光学衍射器，至少一个光程差调制器，至少一个可动反射镜，至少一个微电极 机电系统（MEMS）集成电路（IC）和/或液滴。 该系统还包括至少两个自由度（2自由度）可移动基板平台和用于控制激光束发生器和基板平台的控制器，并用于分析从样品反射的光。
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公开(公告)号：US20110153226A1
公开(公告)日：2011-06-23
申请号：US12641705
申请日：2009-12-18
申请人： Sridhar Venkataraman Dasaratha , Thirukazhukundram Subrahmaniam Vignesh , William Scott Sutherland , Young Kyo Lee
发明人： Sridhar Venkataraman Dasaratha , Thirukazhukundram Subrahmaniam Vignesh , William Scott Sutherland , Young Kyo Lee
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N2201/1293 , G06F19/707
摘要： Methods, systems and computer program products for identifying components of an unknown mixture using spectral analysis techniques. The method includes comparing the spectrum of the unknown mixture with the spectra of library compounds to obtain candidate mixture combinations. A model is generated for each of the candidate mixture combinations based on a modeling metric. A residual spectrum is computed corresponding to each of the candidate mixture combinations by removing the spectrum of each of the compounds of the candidate mixture combination from the spectrum of the unknown mixture. One or more potential compounds are identified by comparing the residual spectrum with the spectrum of library compounds. The potential compounds are added to the candidate mixture combinations to generate an updated list of the candidate mixture combinations. The search algorithm repeats the steps described above on the updated candidate mixture combinations, until a first termination condition is satisfied.
摘要翻译： 用于使用光谱分析技术识别未知混合物的组分的方法，系统和计算机程序产品。 该方法包括将未知混合物的光谱与文库化合物的光谱进行比较以获得候选混合物组合。 基于建模度量为每个候选混合物组合生成模型。 通过从未知混合物的光谱去除候选混合物组合的每种化合物的光谱，对应于每种候选混合物组合计算残留光谱。 通过比较残留光谱和文库化合物的光谱来鉴定一种或多种潜在的化合物。 将潜在化合物加入到候选混合物组合中以产生候选混合物组合的更新列表。 搜索算法重复上述关于更新的候选混合组合的步骤，直到满足第一终止条件。
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公开(公告)号：US07502105B2
公开(公告)日：2009-03-10
申请号：US10941565
申请日：2004-09-15
IPC分类号： G01J3/44
CPC分类号： G01N21/274 , G01J3/0232 , G01J3/44 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： An apparatus for generating a Raman signal of a test sample is disclosed. The apparatus includes a first optical path, a second optical path, a first station, and a second station. The first optical path is adapted for coupling with a radiation source that produces a test beam at the first optical path. The first station is responsive to the test beam and is adapted to house a test standard. The second station is responsive to the test beam and is adapted to house the test sample. In response to the test beam, Raman radiation from the test standard and the test sample are combined and directed to the second optical path, which is adapted for coupling with a spectrometer and a detector for producing a Raman spectrum of the test sample.
摘要翻译： 公开了一种用于产生测试样品的拉曼信号的装置。 该装置包括第一光路，第二光路，第一台和第二台。 第一光路适于与在第一光路处产生测试光束的辐射源耦合。 第一个工作站响应测试梁并适应测试标准。 第二站响应于测试梁并适于容纳测试样品。 响应于测试光束，来自测试标准的拉曼辐射和测试样品被组合并引导到第二光路，其适于与用于产生测试样品的拉曼光谱的光谱仪和检测器耦合。
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公开(公告)号：US08271209B2
公开(公告)日：2012-09-18
申请号：US12641705
申请日：2009-12-18
申请人： Sridhar Venkataraman Dasaratha , Thirukazhukundram Subrahmaniam Vignesh , William Scott Sutherland , Young Kyo Lee
发明人： Sridhar Venkataraman Dasaratha , Thirukazhukundram Subrahmaniam Vignesh , William Scott Sutherland , Young Kyo Lee
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N2201/1293 , G06F19/707
摘要： Methods, systems and computer program products for identifying components of an unknown mixture using spectral analysis techniques. The method includes comparing the spectrum of the unknown mixture with the spectra of library compounds to obtain candidate mixture combinations. A model is generated for each of the candidate mixture combinations based on a modeling metric. A residual spectrum is computed corresponding to each of the candidate mixture combinations by removing the spectrum of each of the compounds of the candidate mixture combination from the spectrum of the unknown mixture. One or more potential compounds are identified by comparing the residual spectrum with the spectrum of library compounds. The potential compounds are added to the candidate mixture combinations to generate an updated list of the candidate mixture combinations. The search algorithm repeats the steps described above on the updated candidate mixture combinations, until a first termination condition is satisfied.
摘要翻译： 用于使用光谱分析技术识别未知混合物的组分的方法，系统和计算机程序产品。 该方法包括将未知混合物的光谱与文库化合物的光谱进行比较以获得候选混合物组合。 基于建模度量为每个候选混合物组合生成模型。 通过从未知混合物的光谱去除候选混合物组合的每种化合物的光谱，对应于每种候选混合物组合计算残留光谱。 通过比较残留光谱和文库化合物的光谱来鉴定一种或多种潜在的化合物。 将潜在化合物加入到候选混合物组合中以产生候选混合物组合的更新列表。 搜索算法重复上述关于更新的候选混合组合的步骤，直到满足第一终止条件。
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公开(公告)号：US20090168052A1
公开(公告)日：2009-07-02
申请号：US11966332
申请日：2007-12-28
申请人： Michael Craig Burrell , Frank Mondello , Tracy Lynn Paxon , William Scott Sutherland , Christopher Montalbano , Gregory Montalbano , Aaron Klein
发明人： Michael Craig Burrell , Frank Mondello , Tracy Lynn Paxon , William Scott Sutherland , Christopher Montalbano , Gregory Montalbano , Aaron Klein
IPC分类号： G01N1/00
CPC分类号： G01N21/65 , G01N1/405 , G01N21/658
摘要： A portable substance identification system and method are configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. An embodiment of the portable substance identification system includes a portable substance identification device containing a Raman spectrometer, and a collection stem that includes a dry collector. One or more reservoirs for a liquid medium and /or a reagent can be formed in a cartridge that is configured to couple with a portable substance identification device. The cartridge has a chamber in which the reagent, liquid medium, and a detection target picked up by the dry collector are mixed. A magnet, positioned at a slant angle, can be used to form at least one pellet of aggregated magnetic particles within a pellet forming area of the chamber. The pellet is formed to maximize its surface area.
摘要翻译： 便携式物质识别系统和方法被配置为比使用先前物质识别系统和/或先前物质识别技术更快，更准确地识别至少一个检测目标。 便携式物质识别系统的实施例包括含有拉曼光谱仪的便携式物质识别装置和包括干燥收集器的收集杆。 用于液体介质和/或试剂的一个或多个储存器可以形成在配置成与便携式物质识别装置联接的盒中。 该盒具有混合由干燥收集器拾取的试剂，液体介质和检测对象的室。 以倾斜角定位的磁体可以用于在腔室的颗粒形成区域内形成至少一个聚集的磁性颗粒颗粒。 形成颗粒使其表面积最大化。
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公开(公告)号：US20130297254A1
公开(公告)日：2013-11-07
申请号：US13464278
申请日：2012-05-04
申请人： Thirukazhukundram Subrahmaniam Vignesh , William Scott Sutherland , Young Kyo Lee , Sridhar Venkataraman Dasaratha
发明人： Thirukazhukundram Subrahmaniam Vignesh , William Scott Sutherland , Young Kyo Lee , Sridhar Venkataraman Dasaratha
CPC分类号： G01J3/28 , F04C2270/041 , G01J3/457 , G01J2003/2833 , G01N21/65 , G01N2021/0118 , G01N2201/0221 , G01N2201/1293 , G16C20/20
摘要： A spectrometer for identifying a mixture is provided. The spectrometer includes a detector configured to generate a signal based on an interaction of light with a sample of the mixture, and a memory device having a library and a correlation matrix stored therein, wherein the library includes a plurality of spectra, each spectrum associated with a respective compound, and wherein the correlation matrix includes a correlation between each possible pair of spectra in the library. The spectrometer further includes a processor coupled to the memory device and configured to determine a spectrum of the mixture based on the signal generated by the detector, calculate a correlation vector that includes a correlation between the mixture spectrum and each spectrum in the library, and identify the mixture based on the correlation matrix and the correlation vector.
摘要翻译： 提供了用于识别混合物的光谱仪。 光谱仪包括检测器，其被配置为基于光与混合物的样本的相互作用产生信号，以及具有存储在其中的库和相关矩阵的存储器件，其中所述库包括多个光谱，每个光谱与 相应的化合物，并且其中所述相关矩阵包括所述文库中每个可能的光谱对之间的相关性。 光谱仪还包括耦合到存储器件并且被配置为基于由检测器产生的信号来确定混合谱的处理器的处理器，计算包括混合谱和库中每个频谱之间的相关性的相关矢量，并且识别 基于相关矩阵和相关向量的混合。
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公开(公告)号：US07852470B2
公开(公告)日：2010-12-14
申请号：US11966332
申请日：2007-12-28
申请人： Michael Craig Burrell , Frank Mondello , Tracy Lynn Paxon , William Scott Sutherland , Christopher Montalbano , Gregory Montalbano , Aaron Klein
发明人： Michael Craig Burrell , Frank Mondello , Tracy Lynn Paxon , William Scott Sutherland , Christopher Montalbano , Gregory Montalbano , Aaron Klein
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N1/405 , G01N21/658
摘要： A portable substance identification system and method are configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. An embodiment of the portable substance identification system includes a portable substance identification device containing a Raman spectrometer, and a collection stem that includes a dry collector. One or more reservoirs for a liquid medium and/or a reagent can be formed in a cartridge that is configured to couple with a portable substance identification device. The cartridge has a chamber in which the reagent, liquid medium, and a detection target picked up by the dry collector are mixed. A magnet, positioned at a slant angle, can be used to form at least one pellet of aggregated magnetic particles within a pellet forming area of the chamber. The pellet is formed to maximize its surface area.
摘要翻译： 便携式物质识别系统和方法被配置为比使用先前物质识别系统和/或先前物质识别技术更快，更准确地识别至少一个检测目标。 便携式物质识别系统的实施例包括含有拉曼光谱仪的便携式物质识别装置和包括干燥收集器的收集杆。 用于液体介质和/或试剂的一个或多个储存器可以形成在配置成与便携式物质识别装置联接的盒中。 该盒具有混合由干燥收集器拾取的试剂，液体介质和检测对象的室。 以倾斜角定位的磁体可以用于在腔室的颗粒形成区域内形成至少一个聚集的磁性颗粒颗粒。 形成颗粒使其表面积最大化。
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公开(公告)号：US20090002699A1
公开(公告)日：2009-01-01
申请号：US11769920
申请日：2007-06-28
CPC分类号： G01J3/02 , B82Y15/00 , G01J3/0264 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N33/54326 , G01N33/588 , G01N2333/32
摘要： A device for identifying an unknown substance includes an optical source configured to direct a laser excitation beam at the unknown substance. A detector is configured to detect scattered light from the unknown substance and generate at least one signal representative of a scattering spectrum corresponding to at least one chemical within the unknown substance. A microprocessor is in signal communication with the detector and configured to generate a pattern representative of the at least one chemical in response to the at least one signal received from the detector to identify the chemical composition of the unknown substance. The device is configured to complete a bioassay to identify a biological nature of the unknown substance.
摘要翻译： 用于识别未知物质的装置包括被配置为将激光激发光束引导到未知物质的光源。 检测器被配置为检测来自未知物质的散射光，并产生代表对应于未知物质内的至少一种化学物质的散射光谱的至少一个信号。 微处理器与检测器进行信号通信，并被配置为响应于从检测器接收的至少一个信号产生表示至少一种化学品的图案，以识别未知物质的化学成分。 该装置被配置成完成生物测定以鉴定未知物质的生物学性质。
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公开(公告)号：US07991627B2
公开(公告)日：2011-08-02
申请号：US11443825
申请日：2006-05-31
申请人： George Martin Hutchinson , Neal Joseph Sandy , Russel Craig Ward , Ronald Peter Makin , William Scott Sutherland
发明人： George Martin Hutchinson , Neal Joseph Sandy , Russel Craig Ward , Ronald Peter Makin , William Scott Sutherland
CPC分类号： A61M5/142 , A61M5/168 , A61M5/1723 , A61M2205/18 , A61M2205/502 , A61M2205/52 , A61M2205/60 , G01N21/35 , G01N21/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G06Q50/24
摘要： The present invention is a system and method of pre-delivery drug identification. The system and method is implemented where drugs are being administered, such as in a hospital or clinic, and identifies the drug being administered to the patient before the drug reaches the patient. The system and method may utilize a sensor used for other physiologic monitoring to identify the drug. After identification, the system and method is configured to cross-reference the identified drug with the patient's prescription and allergy information, and to prevent delivery to the patient, if necessary. The system and method also utilizes data collected from the patient with a physiological monitor or a ventilator sensor to further determine whether the drug is appropriate for the patient. The method and system may also include an override system for medical personnel. The method described may be carried out by a software application.
摘要翻译： 本发明是预先递送药物鉴定的系统和方法。 该系统和方法是在药物被施用的情况下实施的，例如在医院或诊所中，并且在药物到达患者之前识别给予患者的药物。 该系统和方法可以利用用于其他生理监测的传感器来鉴定药物。 鉴定后，系统和方法被配置成与所述患者的处方和过敏信息交叉引用所鉴定的药物，并且如有必要，防止递送给患者。 该系统和方法还利用从生理监测器或呼吸机传感器收集患者的数据，以进一步确定药物是否适合患者。 该方法和系统还可以包括用于医务人员的超控系统。 所描述的方法可以由软件应用来执行。
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公开(公告)号：US07847932B2
公开(公告)日：2010-12-07
申请号：US11966279
申请日：2007-12-28
申请人： Michael Craig Burrell , Frank Mondello , Tracy Lynn Paxon , William Scott Sutherland , Christopher Montalbano , Gregory Montalbano , Aaron Klein
发明人： Michael Craig Burrell , Frank Mondello , Tracy Lynn Paxon , William Scott Sutherland , Christopher Montalbano , Gregory Montalbano , Aaron Klein
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N2021/651 , G01N2201/0221
摘要： Portable substance identification system and method are configured to identify at least one detection target faster and with greater accuracy than is possible using prior substance identification systems and/or prior substance identification techniques. An embodiment of the portable substance identification system includes a portable substance identification device containing a Raman spectrometer, and a collection stem that includes a collector. One or more reservoirs for a liquid medium and/or at least one reagent can be formed in the collection stem. The cartridge can include a chamber in which the reagents, liquid medium, and at least one detection target picked up by the collector are mixed. A magnet, positioned at a slant angle, can be used to form at least one pellet of aggregated magnetic particles within a pellet forming area of the chamber. The pellet is formed to maximize its surface area.
摘要翻译： 便携式物质识别系统和方法配置成比使用先前物质识别系统和/或先前物质识别技术更快，更准确地识别至少一个检测目标。 便携式物质识别系统的实施例包括包含拉曼光谱仪的便携式物质识别装置和包括收集器的收集杆。 用于液体介质和/或至少一种试剂的一个或多个储存器可以形成在收集杆中。 药筒可以包括其中混合有由试剂，液体介质和由收集器拾取的至少一个检测目标的室。 以倾斜角定位的磁体可以用于在腔室的颗粒形成区域内形成至少一个聚集的磁性颗粒颗粒。 形成颗粒使其表面积最大化。
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