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1.发明授权Immobilization of biochemical substances on a carrier containing a layer of an olefinic-unsaturated, epoxyfunctional polysiloxane 失效将生化物质固定在含有烯属不饱和环氧官能团聚硅氧烷层的载体上
公开(公告)号：US5494815A
公开(公告)日：1996-02-27
申请号：US34064
申请日：1993-03-22
IPC分类号： C07K17/08 , C07K1/113 , C07K14/37 , C07K14/41 , C07K14/415 , C08L83/04 , C08L83/07 , C12M1/40 , C12N11/08 , C12Q1/00 , G01N27/414 , C12N11/00 , C12N11/14 , G01N33/551
CPC分类号： C12N11/08 , Y10S530/811 , Y10S530/814 , Y10S530/816
摘要： Biochemical substances, such as enzymes, are immobilized using an olefinic-unsaturated, epoxyfunctional polysiloxane. The polysiloxane is applied to a carrier material. The polysiloxane on the carrier is cross-linked by using high-energy radiation or a peroxide to form a polymer matrix. The polymer matrix is treated with an aqueous solution of a biochemical substance that reacts with epoxy groups and becomes immobilized. The polymer matrix is stabilized by the reaction of non-reacted epoxy groups with a compound containing an amino group, a carboxyl group or an amino group and a carboxyl group. The crosslinked polysiloxane can be hydrophilized after cross-linking and prior to immobilization of the biochemical substance by the reaction of a portion of the epoxy groups with a hydrophilic compound.
摘要翻译： 使用烯属不饱和的环氧官能团聚硅氧烷固定生物化学物质，如酶。 将聚硅氧烷应用于载体材料。 通过使用高能辐射或过氧化物将载体上的聚硅氧烷交联以形成聚合物基质。 聚合物基质用生物化学物质的水溶液处理，其与环氧基反应并固化。 聚合物基体通过未反应的环氧基与含有氨基，羧基或氨基和羧基的化合物的反应来稳定。 交联的聚硅氧烷可以在交联之后和通过一部分环氧基与亲水性化合物的反应固定生物化学物质之前亲水化。
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2.发明授权Biosensor containing a biochemical substance immobilized on a layer of an olefinic-unsaturated, epoxyfunctional polyether 失效生物传感器含有固定在烯属不饱和环氧官能团聚醚层上的生物化学物质
公开(公告)号：US5389534A
公开(公告)日：1995-02-14
申请号：US35019
申请日：1993-03-22
IPC分类号： C08G59/02 , C07K17/08 , C08G59/04 , C08L63/10 , C12M1/40 , C12N11/08 , C12Q1/00 , G01N27/327 , G01N27/414 , C12N11/06 , G01N33/545
CPC分类号： C12Q1/002 , Y10S435/817 , Y10S530/815 , Y10S530/816
摘要： A biosensor is prepared having a selective detection system containing a biochemical substance such as an enzyme immobilized by reaction with epoxy groups of an olefinic-unsaturated, epoxyfunctional polyether. Prior to immobilization, the polyether is applied to a carrier and crosslinked by treatment with high-energy radiation or peroxide to form a layer. After reacting the biochemical substance with epoxy groups, non-reacted epoxy groups are reacted with a compound containing an amino group and/or a carboxyl group such as an amino acid. Before immobilizing of the biochemical substance and after crosslinking, the polyether may be hydrophilized by reacting some of the epoxy groups with a hydrophilic compound such as an amino acid.
摘要翻译： 制备具有选择性检测系统的生物传感器，其包含生物化学物质，例如通过与烯属不饱和环氧官能团聚醚的环氧基反应而固定的酶。 在固定之前，将聚醚施加到载体上并通过用高能量辐射或过氧化物处理形成一层交联。 使生化物质与环氧基团反应后，未反应的环氧基与含有氨基和/或羧基的化合物如氨基酸反应。 在生物化学物质固定之前和交联后，聚醚可以通过使一些环氧基团与亲水性化合物如氨基酸反应来亲水化。
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3.发明授权Biosensor containing a biochemical substance immobilized on a layer of olefinic-unsaturated, epoxy functional cross-linked polysiloxane 失效生物传感器含有固定在烯属不饱和环氧官能交联聚硅氧烷层上的生化物质
公开(公告)号：US5407818A
公开(公告)日：1995-04-18
申请号：US35030
申请日：1993-03-22
IPC分类号： C08G77/38 , C07K17/08 , C12M1/40 , C12N11/08 , C12Q1/00 , G01N27/327 , G01N27/414 , C12M11/08 , C08G77/04 , G01N27/26
CPC分类号： C12Q1/002
摘要： A biosensor is prepared having a selective detection system containing a biochemical substance such as an enzyme immobilized on an olefinic-unsaturated, epoxyfunctional polysiloxane. Prior to immobilization of the biochemical substance, the polysiloxane is applied as a layer to a carrier and cross-linked by treatment with high-energy radiation. A biochemical substance is reacted with epoxy groups of the cross-linked polysiloxane. Any non-reacted epoxy groups are reacted with a compound containing an amino group, a carboxyl group or an amino group and a carboxyl group to stabilize. After cross-linking and before reacting of the biochemical substance, the cross-linked polysiloxane can be hydrophilized by reacting some of the epoxy groups with a hydrophilic compound containing a reactive group.
摘要翻译： 制备具有选择性检测系统的生物传感器，其包含固定在烯属不饱和环氧官能团聚硅氧烷上的生物化学物质如酶。 在固化生化物质之前，将聚硅氧烷作为层施加到载体上并通过用高能辐射处理进行交联。 生化物质与交联聚硅氧烷的环氧基反应。 任何未反应的环氧基与含有氨基，羧基或氨基和羧基的化合物反应以稳定。 交联后，在生物化学物质反应之前，交联聚硅氧烷可通过一些环氧基与含有反应性基团的亲水性化合物反应而亲水化。
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4.发明授权
公开(公告)号：US5389533A
公开(公告)日：1995-02-14
申请号：US34319
申请日：1993-03-22
IPC分类号： C07K17/08 , C07K14/37 , C07K14/41 , C07K14/415 , C12M1/40 , C12N11/08 , C12Q1/00 , G01N27/414 , C12N11/06 , G01N33/545 , G01N33/549
CPC分类号： C12N11/08 , Y10S530/815 , Y10S530/816
摘要： Biochemical substances such as enzymes are immobilized by reaction with epoxy groups of an olefinic-unsaturated, epoxyfunctional polyether. Prior to immobilization, the polyether is applied to a carrier and crosslinked by treatment with high-energy radiation or peroxide to form a layer. After reacting the biochemical substance with epoxy groups, non-reacted epoxy groups are reacted with a compound containing an amino group and/or a carboxyl group such as an amino acid. Before immobilizing of the biochemical substance and after crosslinking, the polyether may be hydrophilized by reacting some of the epoxy groups with a hydrophilic compound such as an amino acid.
摘要翻译： 生物化学物质如酶通过与烯属不饱和环氧官能团聚醚的环氧基反应来固定。 在固定之前，将聚醚施加到载体上并通过用高能量辐射或过氧化物处理形成一层交联。 使生化物质与环氧基团反应后，未反应的环氧基与含有氨基和/或羧基的化合物如氨基酸反应。 在生物化学物质固定之前和交联后，聚醚可以通过使一些环氧基团与亲水性化合物如氨基酸反应来亲水化。
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公开(公告)号：US07468608B2
公开(公告)日：2008-12-23
申请号：US10521736
申请日：2003-07-03
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2291/0422 , G01N2291/0426 , G01N2291/045
摘要： A device for detecting at least one substance of a fluid includes at least one piezo-acoustic resonator with at least one piezo layer, an electrode arranged on the piezo-electric layer, at least one other electrode arranged on the piezo-electric layer and a surface section used for sorption of the substance of the fluid. The piezo-electric layer, the electrodes and the surface section are disposed in such a way that electric control of the electrodes leads to an oscillation of the resonator at a resonance frequency which depends upon the amount of the substance which is sorbed on the surface section. The thickness of the pioelectric layer is in the region of 0.5 to 20 μm and the resonance frequency of the oscillation ranges from 500 MHz to 2 GHz. The device is a mass sensor with a piezo-acoustic high-frequency thin film resonator.
摘要翻译： 用于检测流体的至少一种物质的装置包括：至少一个压电声谐振器，具有至少一个压电层，布置在压电层上的电极，布置在压电层上的至少一个其它电极和 用于吸附流体物质的表面部分。 压电层，电极和表面部分以这样的方式设置，使得电极的电控制导致谐振器的振荡以共振频率取决于吸收在表面部分上的物质的量 。 皮电层的厚度在0.5〜20μm的范围内，振荡的共振频率为500MHz〜2GHz。 该装置是具有压电声高频薄膜谐振器的质量传感器。
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公开(公告)号：US5015709A
公开(公告)日：1991-05-14
申请号：US286461
申请日：1988-12-19
申请人： Siegfried Birkle , Hans-Dieter Feucht , Rainer Kamps , Eva Rissel
发明人： Siegfried Birkle , Hans-Dieter Feucht , Rainer Kamps , Eva Rissel
IPC分类号： C08F2/46 , C08G18/64 , C08G18/81 , C08G59/04 , C08G59/14 , C08G59/17 , C08G59/22 , G02B6/38 , H01B3/40
CPC分类号： H01B3/40 , C08G18/6407 , C08G18/8116 , C08G59/04 , C08G59/1444 , C08G59/1466 , C08G59/1477 , C08G59/22 , G02B6/3801 , Y10S525/92 , Y10S525/921 , Y10S525/922
摘要： The invention provides a radiation-curable liquid resin for use as a secondary coating of lightwave guides which is a reaction product of (meth)acrylic acid or -acid chloride or isocyanatoalkyl-(meth)acrylate with a 1:2 addition compound of a diepoxide with a mean molecular weight.ltoreq.1000 and a short-chain .alpha.,.omega. -diol with a mean molecular weight.ltoreq.700 or with a 1:2 addition compound of a diepoxide with a mean molecular weight.ltoreq.400 and a monovalent aliphatic alcohol with a mean molecular weight.ltoreq.200, where the diepoxide is an aliphatic-aromatic or aromatic diglycidylether, an aliphatic or cycloaliphatic diepoxide or a silicon-organodiepoxide, and where the short-chain .alpha.,.omega. -diol is an .alpha..omega. -hydroxy-terminated polyoxyalkylene, an .alpha.,.omega. -hydroxy-terminated polyester, an .alpha.,.omega. -hydroxy-terminated polybutadiene, an .alpha.,.omega. -hydroxyterminated organo-functional polysiloxane or an .alpha.,.omega. -alkanediol with a mean molecular weight.ltoreq.200.
摘要翻译： 本发明提供一种用作光波导二次涂层的可辐射固化液体树脂，它是（甲基）丙烯酸或氯化异氰酸酯基 - （甲基）丙烯酸异氰酸根合烷基酯与二环氧化物加成化合物的反应产物 平均分子量为1000，平均分子量为700的短链α，ω-二醇或具有平均分子量为400的二环氧化物的1:2加成化合物，和 平均分子量为200的一元脂族醇，其中二环氧化物是脂族 - 芳族或芳族二缩水甘油醚，脂族或环脂族二环氧化物或硅 - 有机二环氧化物，其中短链α，ω-二醇是α ω-羟基封端的聚氧化烯，α，ω-羟基封端的聚酯，α，ω-羟基封端的聚丁二烯，α，ω-羟基封端的有机官能聚硅氧烷或α，ω- / = 200。
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公开(公告)号：US4791176A
公开(公告)日：1988-12-13
申请号：US166437
申请日：1988-03-10
申请人： Siegfried Birkle , Recai Sezi , Hans-Dieter Feucht
发明人： Siegfried Birkle , Recai Sezi , Hans-Dieter Feucht
IPC分类号： C08F214/00 , C08F12/00 , C08F14/00 , C08F212/10 , C08F212/14 , C08F230/08 , G03F7/075 , C08F30/08
CPC分类号： G03F7/0758 , C08F212/14 , C08F230/08
摘要： The invention relates to new copolymers of alkenyl phenol or alkenyl phenol ether in combination with alkenyl silanes. These copolymers are useful positive photoresists.
摘要翻译： 本发明涉及链烯基酚或烯基苯酚醚与烯基硅烷的组合的新共聚物。 这些共聚物是有用的阳性光致抗蚀剂。
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8.发明授权公开(公告)号：US08664310B2
公开(公告)日：2014-03-04
申请号：US12443248
申请日：2007-09-26
申请人： Anett Berndt , Florian Eder , Hans-Dieter Feucht
发明人： Anett Berndt , Florian Eder , Hans-Dieter Feucht
IPC分类号： C08K5/541
CPC分类号： G02B1/115 , Y10T428/31507 , Y10T428/31667
摘要： The present disclosure may provide a mixture for use in forming a transparent coating including a silicon alkoxide precursor and an organic polymer. The silicon alkoxide precursor may have a pH level between 1 and 4. The organic polymer may have an average molecular weight between 5,000 and 50,000 Da. The mixture may include 35% to 65% organic polymer by volume. The organic polymer may be removed from the mixture after application leaving a resultant transparent coating, wherein: the resultant coating has a porosity of ≧35% to ≦65%; a thickness in the range from ≧95 nm to ≦135 nm; pores having an average diameter from ≧5 nm to ≦50 nm; and a diameter distribution according to a log-norm distribution with a half-width of ≦10 nm.
摘要翻译： 本公开可以提供用于形成包含硅醇盐前体和有机聚合物的透明涂层的混合物。 硅醇盐前体可以具有1至4的pH水平。有机聚合物可以具有5,000至50,000Da的平均分子量。 该混合物可以包括按体积计35％至65％的有机聚合物。 有机聚合物可以在施用后从混合物中除去留下所得的透明涂层，其中：所得涂层的孔隙率≥35％至65％; > 95nm至135nm范围内的厚度; 平均直径> 5nm至50nm的孔; 以及根据半径为@ 10nm的对数范数分布的直径分布。
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公开(公告)号：US08263331B2
公开(公告)日：2012-09-11
申请号：US11655943
申请日：2007-01-22
CPC分类号： G01N33/54333 , B82Y15/00 , B82Y25/00 , H01F1/0054
摘要： A device and a method are disclosed for the detection and/or for the quantification of an analyte. In at least one embodiment, the device includes a basic matrix and magnetized nanoparticles, which are arranged in moveable fashion in or at the basic matrix and to which catcher molecules that bind specifically to the analyte are anchored. Further, the mobility of the nanoparticle in the basic matrix can be influenced by a binding of the analyte to be detected to the catcher molecules and can be read out magnetically.
摘要翻译： 公开了用于检测和/或定量分析物的装置和方法。 在至少一个实施方案中，该装置包括基本基质和磁化纳米颗粒，其以可移动的方式设置在碱性基质中或基本基质上，并且特异性结合分析物的捕获剂分子被锚固。 此外，纳米颗粒在碱性基质中的迁移率可能受待检测的分析物与捕获剂分子的结合的影响，并且可以磁性地读出。
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10.发明授权
公开(公告)号：US5057587A
公开(公告)日：1991-10-15
申请号：US286472
申请日：1988-12-16
申请人： Siegfried Birkle , Hans-Dieter Feucht , Rainer Kamps , Eva Rissel
发明人： Siegfried Birkle , Hans-Dieter Feucht , Rainer Kamps , Eva Rissel
CPC分类号： C08G59/1466 , C08G18/581 , C08G18/8116 , C08G59/04 , C08G59/1444 , C08G59/1477 , C08G59/22 , H01B3/40
摘要： The invention provides a radiation-curable liquid resin useful as a secondary coating of lightwave guides. The resin is a reaction product of (meth)acrylic acid or glyceroldi (meth)acrylate or Pentaerythritoltri(meth)acrylate with a 2:1 addition compound of a diepoxide and an .alpha., .omega.-diol with a mean molecular weight between 600 and 3000, or, a reaction product of (meth)acrylic acid or -acid chloride or isocyanatoalkyl-(meth)acrylate with a conversion product of the 2:1 addition compound and a low-molecular monovalent alcohol (C.sub.1 to C.sub.10), a low-molecular bivalent alcohol (C.sub.2 to C.sub.4) or water, where the diepoxide is an aromatic diglycidylether and the .alpha.,.omega.-diol is an .alpha., .omega.-hydroxy-terminated polyoxyalkylene, an .alpha., .omega.-hydroxy-terminated polyester, an .alpha.,.omega.-hydroxy-terminated polybutadiene or an .alpha.,.omega.-hydroxy-terminated organo-functional polysiloxane.
摘要翻译： 本发明提供了可用作光波导二次涂层的可辐射固化液体树脂。 树脂是（甲基）丙烯酸或（甲基）丙烯酸甘油酯或季戊四醇三（甲基）丙烯酸酯与二环氧化物的加成化合物和平均分子量在600和3000之间的α，ω-二醇的2:1的加成化合物的反应产物 ，或（甲基）丙烯酸或氯化异氰酸酯基 - （甲基）丙烯酸异氰酸根合烷基酯与2:1加成化合物与低分子一价醇（C1〜C10）的转化产物的反应产物， 分子二价醇（C2至C4）或水，其中二环氧化物是芳族二缩水甘油醚，α，ω-二醇是α，ω-羟基封端的聚氧化烯，α，ω-羟基封端的聚酯，α，ω 羟基封端的聚丁二烯或α，ω-羟基封端的有机官能聚硅氧烷。
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