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公开(公告)号:US06407281B1
公开(公告)日:2002-06-18
申请号:US09600253
申请日:2000-08-25
申请人: Yasuyoshi Ueda , Hiroshi Murao , Takeshi Kondo , Noboru Ueyama , Hajime Manabe , Kenji Yoneda , Akira Nishiyama
发明人: Yasuyoshi Ueda , Hiroshi Murao , Takeshi Kondo , Noboru Ueyama , Hajime Manabe , Kenji Yoneda , Akira Nishiyama
IPC分类号: C07C32100
CPC分类号: C07C319/28 , C07B2200/07 , C07C319/20 , Y02P20/55 , C07C323/59
摘要: A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided. A process for producing an optically active cysteine derivative which comprises synthesizing a D-form or L-form optically active cysteine derivative of the general formula (2) shown below (R1 represents an amino-protecting group of the urethane or acyl type, R0 represents a hydrogen atom or, taken together with R1, an amino-protecting group, R2 represents an alkyl, aryl or aralkyl group, R3 represents a univalent organic group and * represents the position of an asymmetric carbon) by reacting the corresponding D-form or L-form optically active amino acid derivative of the general formula (1) shown below with an alcohol of the general formula (3) shown below and a strong acid and/or a thionyl halide and recovering the above cysteine derivative (2) from the reaction mixture, the procedural series from reaction to recovery being carried out under conditions such that the medium contacting the above optically active cysteine derivative (2) is within the range from acidic to weakly basic to thereby recover the above cysteine derivative (2) from the reaction mixture while suppressing the decomposition and racemization thereof.
摘要翻译: 提供一种制造光学活性半胱氨酸衍生物的方法,该方法具有高光学纯度和良好的质量,其在经济上是有利的并且即使在商业规模下也具有高生产率。1.一种光学活性半胱氨酸衍生物的制备方法,其包括合成D型或L型 (2)的光学活性半胱氨酸衍生物(R1表示氨基甲酸酯或酰基型氨基保护基,R 0表示氢原子,或与R 1一起形成氨基保护基,R2表示 烷基,芳基或芳烷基,R 3表示一价有机基团,*表示不对称碳的位置),通过使下述通式(1)的相应的D型或L型光学活性氨基酸衍生物与 如下所示的通式(3)的醇和强酸和/或亚硫酰卤并从反应混合物中回收上述半胱氨酸衍生物(2),程序 在与上述光学活性半胱氨酸衍生物(2)接触的介质在酸性至弱碱性的范围内,从反应混合物中回收上述半胱氨酸衍生物(2)的条件下进行反应回收的ural系列,同时抑制 其分解和外消旋化。
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公开(公告)号:US20160334722A1
公开(公告)日:2016-11-17
申请号:US15134575
申请日:2016-04-21
申请人: Keiji MAKABE , Tsuneyasu Nagatomo , Kohsuke Satoh , Junichi Watanabe , Kenji Yoneda , Daichi Hisakuni
发明人: Keiji MAKABE , Tsuneyasu Nagatomo , Kohsuke Satoh , Junichi Watanabe , Kenji Yoneda , Daichi Hisakuni
IPC分类号: G03G9/00
CPC分类号: G03G9/0821 , G03G9/0819 , G03G9/0827 , G03G9/08755 , G03G9/08764 , G03G15/08 , G03G21/18
摘要: A toner includes a base particle; and an external additive covering the base particle. The toner includes a tetrahydrofuran (THF)-insoluble component having a glass transition temperature determined from a DSC curve when heated for the second time of from −50° C. to 10° C. and an average circularity not greater than 0.98, and satisfies the following relation: Bt−0.025×Ct≦1.80 wherein Bt represents a BET specific surface area [m2/g]; and Ct represents a coverage [%] of the external additive covering the base particle.
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公开(公告)号:US20160266507A1
公开(公告)日:2016-09-15
申请号:US15052160
申请日:2016-02-24
申请人: Junichi WATANABE , Kenji Yoneda , Kohsuke Satoh , Tsuneyasu Nagatomo , Keiji Makabe , Daichi Hisakuni
发明人: Junichi WATANABE , Kenji Yoneda , Kohsuke Satoh , Tsuneyasu Nagatomo , Keiji Makabe , Daichi Hisakuni
IPC分类号: G03G9/00
CPC分类号: G03G9/0819 , G03G9/0821 , G03G9/0827 , G03G9/08755 , G03G9/09725
摘要: A toner includes a base particle comprising a crystalline polyester resin; and an external additive which is a group of silica particles having a number-average particle diameter of from 0.01 μm to 0.11 μm on the surface of the toner. A number ratio of the silica particles having a circularity not less than 0.8 is 20% or more in the total number of the silica particles.
摘要翻译: 调色剂包括包含结晶聚酯树脂的基础颗粒; 以及作为调色剂表面的数均粒径为0.01μm〜0.11μm的一组二氧化硅粒子的外部添加剂。 圆形度不小于0.8的二氧化硅颗粒的数量比在二氧化硅颗粒的总数中为20%以上。
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公开(公告)号:US20140213549A9
公开(公告)日:2014-07-31
申请号:US13809115
申请日:2011-07-08
申请人: Tsuyoshi Nakamura , Hidenori Namiki , Naoki Terasaka , Akiko Shima , Masahiko Hagihara , Noriaki Iwase , Katsunori Takata , Osamu Kikuchi , Kazunari Tsuboike , Hiroyuki Setoguchi , Kenji Yoneda , Hidetoshi Sunamoto , Koji Ito
发明人: Tsuyoshi Nakamura , Hidenori Namiki , Naoki Terasaka , Akiko Shima , Masahiko Hagihara , Noriaki Iwase , Katsunori Takata , Osamu Kikuchi , Kazunari Tsuboike , Hiroyuki Setoguchi , Kenji Yoneda , Hidetoshi Sunamoto , Koji Ito
IPC分类号: C07D401/14 , C07D417/14 , C07F7/18 , C07D413/14
CPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07F7/1804
摘要: The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.
摘要翻译: 本发明提供了具有优异的CETP抑制活性并可用作药物的取代的吡啶化合物或其药学上可接受的盐。 本发明提供由通式(I)表示的化合物,其中R 1为H,任选取代的烷基,OH,任选取代的烷氧基,烷基磺酰基,任选取代的氨基,羧基,任选取代的羰基,CN,卤代,任选取代的苯基, 任选取代的芳族杂环基,任选取代的饱和杂环基,任选取代的饱和杂环氧基或任选取代的饱和杂环基羰基等,等等。
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公开(公告)号:US08685986B2
公开(公告)日:2014-04-01
申请号:US13260946
申请日:2010-03-30
IPC分类号: C07D401/12 , A61K31/44
CPC分类号: A61K31/506 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/501 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要: The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R1, R2, R3, Y, and Z are defined in the specification.
摘要翻译: 本发明提供一种用于治疗或预防青光眼的医药组合物,其包含由式(1)表示的吡啶基氨基乙酸化合物:其中R1,R2,R3,Y和Z在本说明书中定义。
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公开(公告)号:US20140005143A2
公开(公告)日:2014-01-02
申请号:US13809115
申请日:2011-07-08
申请人: Tsuyoshi Nakamura , Hidenori Namiki , Naoki Terasaka , Akiko Shima , Masahiko Hagihara , Noriaki Iwase , Katsunori Takata , Osamu Kikuchi , Kazunari Tsuboike , Hiroyuki Setoguchi , Kenji Yoneda , Hidetoshi Sunamoto , Koji Ito
发明人: Tsuyoshi Nakamura , Hidenori Namiki , Naoki Terasaka , Akiko Shima , Masahiko Hagihara , Noriaki Iwase , Katsunori Takata , Osamu Kikuchi , Kazunari Tsuboike , Hiroyuki Setoguchi , Kenji Yoneda , Hidetoshi Sunamoto , Koji Ito
IPC分类号: C07D401/14 , C07D417/14 , C07F7/18 , C07D413/14
CPC分类号: C07D401/14 , C07D413/14 , C07D417/14 , C07F7/1804
摘要: The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.
摘要翻译: 本发明提供了具有优异的CETP抑制活性并可用作药物的取代的吡啶化合物或其药学上可接受的盐。 本发明提供由通式(I)表示的化合物,其中R 1为H,任选取代的烷基,OH,任选取代的烷氧基,烷基磺酰基,任选取代的氨基,羧基,任选取代的羰基,CN,卤代,任选取代的苯基, 任选取代的芳族杂环基,任选取代的饱和杂环基,任选取代的饱和杂环氧基或任选取代的饱和杂环基羰基等,等等。
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公开(公告)号:US08591063B2
公开(公告)日:2013-11-26
申请号:US13266354
申请日:2010-12-27
申请人: Kenji Yoneda
发明人: Kenji Yoneda
CPC分类号: F21V29/02 , F21K9/232 , F21V3/00 , F21V25/04 , F21V29/74 , F21V29/773 , F21V29/83 , F21Y2115/10
摘要: The present invention is intended to thermally isolate an LED and a control part from each other to make it difficult to thermally influence each other, and also to optimize fin shapes suitable for allowable temperatures of the both respectively, and is provided with: a first housing that contains an LED board; a second housing that contains an LED control part; a connecting member that connects the first housing and the second housing to each other; a fan mechanism that is provided between the first housing and the second housing; heat dissipation fins that are provided around the fan mechanism in the first housing; and an air path of which one end opening is formed at a position facing to an air inlet side of the fan mechanism in the second housing, and the other opening is formed on a surface different from an opposed surface of the second housing.
摘要翻译: 本发明旨在将LED和控制部件彼此热隔离,使得难以彼此热影响,并且还优选分别适合于两者的允许温度的翅片形状,并且设置有:第一壳体 包含一个LED板; 第二壳体,其包含LED控制部件; 连接构件,其将所述第一壳体和所述第二壳体彼此连接; 风扇机构,其设置在所述第一壳体和所述第二壳体之间; 设置在第一壳体中的风扇机构周围的散热片; 在第二壳体的与风扇机构的空气入口侧相对的位置上形成有一个端部开口的空气路径,另一个开口形成在与第二壳体的相对表面不同的表面上。
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公开(公告)号:US20120201023A1
公开(公告)日:2012-08-09
申请号:US13500468
申请日:2010-09-15
申请人: Kenji Yoneda
发明人: Kenji Yoneda
CPC分类号: F21V15/013 , F21K9/27 , F21S4/00 , F21V3/06 , F21V7/005 , F21V17/16 , F21V19/004 , F21V29/507 , F21V29/75 , F21V29/763 , F21V29/777 , F21V29/83 , F21Y2103/10 , F21Y2115/10
摘要: In order to enable heat from luminous objects to be effectively radiated, and assembly to be simplified to facilitate downsizing and the like, a linear light irradiating device is configured such that a luminous object mounting board is contained in a bottom-equipped groove-like containing space in a body in a bending state of being elastically deformed, and also on the basis of an elastic restoring force of the board, a back surface of a luminous object mounting region in the board or vicinity of the back surface is pressed against and brought into close contact with a fore end surface of an intervening object that has thermal conductivity and is made to protrude from an inner circumferential surface of the containing space.
摘要翻译: 为了使得发光体的热量得到有效辐射,并且组装简化以便于小型化等,线性光照射装置被构造成使得发光体安装板被包含在底部装有槽状的容纳 弹性变形的弯曲状态下的身体的空间,并且基于板的弹性恢复力,背面的板或附近的发光体安装区域的背面被按压并带动 与具有导热性并从容纳空间的内周面突出的中间物体的前端面紧密接触。
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公开(公告)号:US08058631B2
公开(公告)日:2011-11-15
申请号:US12637272
申请日:2009-12-14
申请人: Masahiko Niwayama , Kenji Yoneda
发明人: Masahiko Niwayama , Kenji Yoneda
CPC分类号: H01J37/3171 , H01J37/026 , H01J37/304 , H01J2237/24535 , H01J2237/30472 , H01L21/28035
摘要: A semiconductor manufacturing includes: an ion source and a beam line for introducing an ion beam into a target film which is formed over a wafer with an insulating film interposed therebetween; a flood gun for supplying the target film with electrons for neutralizing charges contained in the ion beam; a rotating disk for subjecting the target film to mechanical scanning of the ion beam in two directions composed of r-θ directions; a rear Faraday cage for measuring the current density produced by the ion beam; a disk-rotational-speed controller and a disk-scanning-speed controller for changing the scanning speed of the target film; and a beam current/current density measuring instrument for controlling, according to the current density, the scanning speed of the target film.
摘要翻译: 半导体制造包括:离子源和用于将离子束引入到晶片之间的绝缘膜之间形成的靶膜的离子束; 用于向目标膜提供用于中和离子束中的电荷的电子的洪水枪; 旋转盘,用于对目标膜进行离子束的机械扫描,所述两个方向由r-和tt组成; 方向; 用于测量由离子束产生的电流密度的后法拉第笼; 盘转速控制器和用于改变目标膜的扫描速度的盘扫描速度控制器; 以及用于根据电流密度控制目标膜的扫描速度的束电流/电流密度测量仪器。
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公开(公告)号:US20110086500A1
公开(公告)日:2011-04-14
申请号:US12842616
申请日:2010-07-23
申请人: Kenji Yoneda , Hiroko Kubo
发明人: Kenji Yoneda , Hiroko Kubo
IPC分类号: H01L21/266 , G21K1/08
CPC分类号: G21K5/04 , G21K5/10 , H01L21/266 , H01L27/1461 , H01L27/14612 , H01L27/1463 , H01L27/14689
摘要: An impurity is implanted by ion implantation into an object to be processed. The ion implantation is performed using an ion beam which is diverged after being temporarily converged.
摘要翻译: 通过离子注入将杂质植入待处理物体中。 使用在暂时收敛之后发散的离子束进行离子注入。
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