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公开(公告)号：US6043491A
公开(公告)日：2000-03-28
申请号：US133667
申请日：1998-08-12
申请人： Yoichi Ose , Kiyomi Yoshinari , Hideo Todokoro , Mitsugu Sato
发明人： Yoichi Ose , Kiyomi Yoshinari , Hideo Todokoro , Mitsugu Sato
IPC分类号： H01J37/244 , H01J37/28
CPC分类号： H01J37/28 , H01J37/244 , H01J2237/026 , H01J2237/0475
摘要： A scanning electron microscope in the present invention, by employing a retarding method and suppressing interferences between an electron beam and secondary electrons or back scattered electrons, makes it possible to obtain a clearer SEM image with a higher resolution. In the scanning electron microscope in the present invention, a shield electrode 117 is provided for shielding the electron beam 104 from electric fields of an energy analyzer 118 and a detector 121, and the energy analyzer 118 and the detector 121 are located in contact with an electron beam aperture 115 and the shield electrode 117.
摘要翻译： 本发明的扫描型电子显微镜，通过采用延迟方法，抑制电子束与二次电子或背散射电子之间的干扰，能够得到更清晰的具有更高分辨率的SEM图像。 在本发明的扫描型电子显微镜中，设有屏蔽电极117，用于将电子束104与能量分析器118和检测器121的电场进行屏蔽，能量分析器118和检测器121位于与 电子束孔115和屏蔽电极117。
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公开(公告)号：US6140641A
公开(公告)日：2000-10-31
申请号：US089088
申请日：1998-06-02
CPC分类号： H01J49/424 , H01J49/4275
摘要： An numerical analysis time which is assigned to mass select one ion species having a specific mass-to-charge ratio mass selected is divided into the first part time and the second part time, and a dipole auxiliary electric field capable of spatially reducing a spread is superimposed in the first part time of the numerical analysis time and a quadrupole auxiliary voltage capable of rapidly emitting ions when position coordinates are large is superimposed in the second part of the time. Therefore, the initial spatial spread is reduced in the first part time and the trajectories of ions is rapidly amplified in the second part time, and the ions are emitted. Thus, the entire mass sweep time can be reduced and a high-resolution numerical analysis can be accelerated.
摘要翻译： 分配给质量选择具有特定质荷比质量的一种离子种类的数值分析时间被划分为第一部分时间和第二部分时间，并且能够空间上减小扩散的偶极子辅助电场是 在数值分析时间的第一部分时间叠加，并且当位置坐标较大时能够快速发射离子的四极辅助电压被叠加在时间的第二部分中。 因此，初始空间扩展在第一部分时间缩短，离子轨迹在第二部分时间内迅速放大，离子发射。 因此，可以减少整个质量扫描时间，并且可以加速高分辨率数值分析。
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公开(公告)号：US6121610A
公开(公告)日：2000-09-19
申请号：US167892
申请日：1998-10-07
申请人： Kiyomi Yoshinari , Yoichi Ose , Yoshiaki Kato
发明人： Kiyomi Yoshinari , Yoichi Ose , Yoshiaki Kato
CPC分类号： H01J49/424 , H01J49/4295
摘要： By preventing the trapping efficiency of ions from largely depending on the mass-to-charge ratio, an ion trap mass spectrometer suitable for obtaining a high sensitive mass spectrum is provided. Ions of a specimen to be mass analyzed generated at an external ion source pass through an ion transportation portion and then injected into a space (ion trap volume) between the ring electrode and the end cap electrodes. An RF trap voltage power source applies an RF frequency V.multidot.cos .OMEGA.t between the ring electrode and the end cap electrodes to form a radio frequency electric field in the ion trap volume. The RF trap voltage is changed so that the optimum trap frequency is in inverse proportion to 1/2 power of a mass-to-charge ratio while the ions are being trapped in the radio frequency electric field formed in the ion trap volume.
摘要翻译： 通过防止离子在很大程度上取决于质荷比的捕获效率，提供了适于获得高灵敏质谱的离子阱质谱仪。 在外部离子源处产生的待质量分析的样品的离子通过离子输送部分，然后注入到环形电极和端盖电极之间的空间（离子阱体积）中。 RF陷波电压电源在环形电极和端盖电极之间施加RF频率VxCOS OMEGA t，以在离子阱体积中形成射频电场。 改变RF陷波电压，使得最佳陷波频率与质荷比的1/2功率成反比，同时离子被捕获在形成于离子阱体积中的射频电场中。
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公开(公告)号：US5756993A
公开(公告)日：1998-05-26
申请号：US754356
申请日：1996-11-22
CPC分类号： H01J49/025 , G01N30/72
摘要： A sample separated through a pre-processor part having a gas chromatography (GC) or a liquid chromatography (LC) and a moving bed eliminating part is ionized by an ion source and mass-analyzed by a mass-analyzing part. The mass-analyzed ions are deflected and focused by a deflecting portion and a focusing portion in a deflecting and focusing part, and is detected by an ion detecting part. The result of detection is processed by a data processing part.
摘要翻译： 通过具有气相色谱（GC）或液相色谱（LC）和移动床消除部分的预处理器部分分离的样品通过离子源离子化并通过质量分析部分进行质量分析。 质量分析的离子被偏转部分和聚焦部分偏转和聚焦在偏转和聚焦部分中，并由离子检测部分检测。 检测结果由数据处理部分处理。
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公开(公告)号：US5532483A
公开(公告)日：1996-07-02
申请号：US403980
申请日：1995-03-15
申请人： Yoichi Ose , Kiyomi Yoshinari , Masayoshi Yano , Tadao Mimura
发明人： Yoichi Ose , Kiyomi Yoshinari , Masayoshi Yano , Tadao Mimura
摘要： An ion beam having a good converging property and a good quality is provided by satisfying the limitations controlling both angle of dispersion and the width of beam at the same time. The voltage 12d of a repeller electrode 1f in an ion source of electron bombardment type is input to an ion source state monitor 11 and the ion source state monitor 11 output a predicted value 12e of the voltage applied to an extractor electrode 1g to an extractor power source 9. As for the extractor electrode system, the width of a slit in the acceleration electrode 1b is made larger than the width of a slit of the extractor electrode 1g, and the extractor electrode 1g is set in a position apart from the acceleration electrode 1b by the distance nearly equal to the distance between the acceleration electrode 1b and the ion generating region 2a. By doing so, the electric field leaked from the slit of the acceleration electrode 1b to the inside of the ionization chamber 1a expands to the vicinity of the ion generating region. As the result, the ion beam 2 is effectively extracted to pass through the slits in the acceleration electrode 1b and the extractor 1g. The amount of the current passing through the slits is measured with an ion current monitor 8a and the voltage 12f of a converging electrode 1d is adjusted so that the value of the current becomes the maximum.
摘要翻译： 通过满足同时控制分散角和宽度的限制来提供具有良好的会聚特性和良好质量的离子束。 电子轰击型离子源中的斥极电极1f的电压12d被输入到离子源状态监视器11，离子源状态监视器11将施加到抽出电极1g的电压的预测值12e输出到提取电力 对于提取器电极系统，使加速电极1b中的狭缝的宽度大于提取电极1g的狭缝的宽度，并且将提取电极1g设置在离开加速电极1的位置 1b的距离几乎等于加速电极1b和离子产生区域2a之间的距离。 通过这样做，从加速电极1b的狭缝向电离室1a的内部泄漏的电场扩大到离子产生区域附近。 结果，有效地提取离子束2以通过加速电极1b和提取器1g中的狭缝。 通过离子电流监视器8a测量通过狭缝的电流量，调节会聚电极1d的电压12f，使得电流值变为最大值。
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6.发明授权
公开(公告)号：US5623144A
公开(公告)日：1997-04-22
申请号：US598890
申请日：1996-02-09
申请人： Kiyomi Yoshinari , Yoichi Ose , Yoshiaki Kato
发明人： Kiyomi Yoshinari , Yoichi Ose , Yoshiaki Kato
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/427
摘要： A mass spectrometer and a mass spectrometry method having a high ion selection efficiency are provided. The mass spectrometer comprises an ion trap, a sample introducing device, an electron gun, a detector, a power supply for applying voltage to the ion trap, a control device for controlling the power supply and the electron gun, a mass analyzing device for performing mass spectrometry based on a detected signal of the detector. Using an auxiliary power supply, direction of an auxiliary electric field generated between end cap electrodes is made to point only toward the detector. In this occasion, by setting the cycle of the auxiliary voltage near the oscillation cycle of interest ion species in the axial direction, the interest ion species are synchronized with the auxiliary electric field to be certainly unstabilized in the detector side.
摘要翻译： 提供了具有高离子选择效率的质谱仪和质谱法。 质谱仪包括离子阱，样品引入装置，电子枪，检测器，用于向离子阱施加电压的电源，用于控制电源和电子枪的控制装置，用于执行的质量分析装置 基于检测器的检测信号的质谱。 使用辅助电源，使端帽电极之间产生的辅助电场的方向仅指向检测器。 在这种情况下，通过将辅助电压的周期设定在轴向的兴趣离子种类的振荡周期附近，兴趣离子种类与辅助电场同步，在检测器侧肯定不稳定。
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公开(公告)号：US07544930B2
公开(公告)日：2009-06-09
申请号：US11624248
申请日：2007-01-18
IPC分类号： H01J49/00
CPC分类号： H01J49/02 , H01J49/004
摘要： The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of m/z regions are set up for carrying out the mass analysis with the all ions included therein being dissociated collectively for each m/z region so as to obtain measurement MS2 data. By comparing the measurement MS2 data with reference MS2 data stored in a reference data base, a difference thereof is detected. For the m/z region with a differential component detected, the mass analysis is carried out collectively without dissociation for the all ions included therein so as to obtain measurement MS1 data. By comparing the measurement MS1 data with the reference MS1 data, a difference thereof is detected. From the difference thereof, a parent ion considered to be the differential component factor is presumed for carrying out the mass analysis with the same being dissociated.
摘要翻译： 本发明提供一种能够通过串联型质量分析以高效率进行差示分析的串联式质量分析系统。 建立预定数量的m / z区域以进行质量分析，其中包含的全部离子为每个m / z区域共同解离，以获得测量MS2数据。 通过将测量MS2数据与参考数据库中存储的参考MS2数据进行比较，检测其差异。 对于检测到差分成分的m / z区域，对于其中包含的所有离子，不分离地进行质量分析，以获得测量MS1数据。 通过将测量MS1数据与参考MS1数据进行比较，检测其差异。 从它们的差异来看，推测认为是差分成分因子的母离子用于进行相同解离的质量分析。
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公开(公告)号：US20060043281A1
公开(公告)日：2006-03-02
申请号：US11210965
申请日：2005-08-25
CPC分类号： H01J49/04 , G01N30/24 , G01N30/467 , G01N30/7206 , G01N30/724 , G01N30/8658 , H01J49/0027
摘要： In a method for mass spectrometry, a plurality of juxtaposed chromatography apparatus connected to a mass spectrometer start eluting at a predetermined time difference and the following mass spectrometer conducts mass spectrometry. A chromatogram in a preceding chromatography apparatus is analyzed on real time base and results of the analysis are used on real time base to change an elusion condition of a succeeding chromatography apparatus. A mass spectrometric system suitable for carrying out the method is also provided.
摘要翻译： 在质谱法中，与质谱仪连接的多个并置色谱装置开始以预定的时间差洗脱，随后的质谱仪进行质谱分析。 在实时基础上分析先前色谱装置中的色谱图，并将实时分析结果用于改变后续色谱装置的脱色条件。 还提供了适用于实施该方法的质谱系统。
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公开(公告)号：US06977373B2
公开(公告)日：2005-12-20
申请号：US10846529
申请日：2004-05-17
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译： 一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地 在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。
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公开(公告)号：US07932486B2
公开(公告)日：2011-04-26
申请号：US12330374
申请日：2008-12-08
申请人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
发明人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
IPC分类号： H01J49/26
CPC分类号： G01N33/6851 , G01N33/6848 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
摘要翻译： 在通过串联质谱法对蛋白质或肽进行结构分析期间，作为串联质谱目标，可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的，从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和来自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式，可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程，并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱（MSn）的MSn的每个步骤中被有效地利用，使得用于确定下一个分析内容的流程和为母体离子的选择 例如，MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此，用户关注的目标可以进行串联质谱，无需浪费测量。
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