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1.发明授权Artificial dura mater having cell adhesiveness and a process for producing the same 有权具有细胞粘附性的人造硬膜及其制造方法公开(公告)号：US06872759B2
公开(公告)日：2005-03-29
申请号：US10122305
申请日：2002-04-16
申请人： Yoshiaki Suzuki , Masaya Iwaki , Makoto Kaibara , Masami Kamio
发明人： Yoshiaki Suzuki , Masaya Iwaki , Makoto Kaibara , Masami Kamio
CPC分类号： A61L27/16 , A61L27/18 , A61L2400/18 , Y10T428/31 , C08L27/18 , C08L67/04
摘要： The present invention provides a material having adhesiveness to bone and/or fascia, which is composed of a polymeric material comprising carbon as a constituent element, and at least a part of a surface of which is modified by ion bombardment. The material of the present invention is applicable as a prosthesis in surgery of spinal diseases and as a prosthesis in surgery on thoracic organs and abdominal organs or musculoskeleton in addition to the application thereof to the artificial dura mater.
摘要翻译： 本发明提供了一种对骨和/或筋膜具有粘合性的材料，其由包含碳作为构成元素的聚合材料组成，其表面的至少一部分通过离子轰击而被改性。 本发明的材料除了应用于人造硬脑膜之外，还适用于脊柱疾病手术中的假体和用于胸部器官和腹部器官或肌肉骨骼的手术中的假体。
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公开(公告)号：US5308704A
公开(公告)日：1994-05-03
申请号：US933358
申请日：1992-08-19
申请人： Yoshiaki Suzuki , Masahiro Kusakabe , Jae-Suk Lee , Makoto Kaibara , Masaya Iwaki , Hiroyuki Sasabe
发明人： Yoshiaki Suzuki , Masahiro Kusakabe , Jae-Suk Lee , Makoto Kaibara , Masaya Iwaki , Hiroyuki Sasabe
CPC分类号： B29C59/16 , B29C2035/0872 , B29K2025/00 , B29K2075/00 , Y10T428/315 , Y10T428/31551 , Y10T428/31855
摘要： A cell adhesive material with excellent cell adhesion and cell proliferating property and a method for producing the same are provided. The adhesion and proliferation of cells can be improved remarkably by the surface modification of a cell adhesive material comprising a polymer material containing carbon as a constituting element, such as polystyrene or segmented polyurethane, wherein at least a part of the surface is modified by ion bombardment through ion implantation. The method for producing such cell adhesive material comprises implanting ions into at least a part of the surface of the polymer material. The cell adhesive material and the method for producing the same are promising for application to cell culture petri dishes and hybrid-type medicinal materials.
摘要翻译： 提供了具有优异的细胞粘附性和细胞增殖性的细胞粘合剂材料及其制造方法。 通过包含含有碳作为构成元素的聚合物材料如聚苯乙烯或分段聚氨酯的电池粘合剂材料的表面改性，可以显着改善电池的粘附和增殖，其中表面的至少一部分被离子轰击 通过离子注入。 制造这种电池粘合剂材料的方法包括将离子注入到聚合物材料表面的至少一部分中。 细胞粘合剂材料及其制备方法有望用于细胞培养培养皿和混合型药物。
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公开(公告)号：US08268300B2
公开(公告)日：2012-09-18
申请号：US13024718
申请日：2011-02-10
申请人： Hiroshi Ujiie , Yoshiaki Suzuki , Masaya Iwaki , Takanori Uchida
发明人： Hiroshi Ujiie , Yoshiaki Suzuki , Masaya Iwaki , Takanori Uchida
IPC分类号： A61K31/74
CPC分类号： A61L31/04 , A61K31/00 , A61L2400/18 , A61L2430/36
摘要： It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material for treating aneurysms, which is composed of a polymer material containing carbon as a constitutional element, and which is produced by modifying at least a portion of the surface thereof by ion bombardment.
摘要翻译： 本发明的一个目的是提供一种通过离子束的照射改善了组织相容性的聚合物材料，其防止了具有破裂风险的动脉瘤的实际破裂。 本发明提供一种治疗动脉瘤的材料，其由含有碳作为构成元素的高分子材料构成，其通过离子轰击改性其表面的至少一部分而制成。
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公开(公告)号：US06709491B2
公开(公告)日：2004-03-23
申请号：US10227297
申请日：2002-08-26
IPC分类号： B01D7164
CPC分类号： B01D67/009 , B01D53/228 , B01D67/0009 , B01D67/0032 , B01D67/0072 , B01D71/64 , B01D2323/12 , B01D2325/022 , Y02C20/20 , Y10S55/05
摘要： The object of the present invention is to provide a novel gas separation membrane having a high gas permeability and a high gas selectivity, and a method of producing the same. The present invention provides a gas separation membrane comprising a polymeric material soluble in an organic solvent, wherein at least a part of the surface is modified by ion bombardment.
摘要翻译： 本发明的目的在于提供一种气体透过性高，气体选择性高的新型气体分离膜及其制造方法。 本发明提供了一种气体分离膜，其包含可溶于有机溶剂的聚合材料，其中表面的至少一部分被离子轰击改性。
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公开(公告)号：US07722934B2
公开(公告)日：2010-05-25
申请号：US10525724
申请日：2003-08-29
IPC分类号： B05D3/06
CPC分类号： A61L27/16 , A61L17/12 , A61L17/14 , A61L24/001 , A61L24/04 , A61L27/14 , A61L27/18 , A61L27/50 , A61L27/507 , A61L2400/18 , Y10T428/3154 , C08L27/18 , C08L67/04
摘要： An object of the present invention is to provide a means for improving the affinity of an in vivo embedded material such as an artificial blood vessel or an artificial dura mater with a tissue adhesive, so as to quickly prevent the leakage of the blood or spinal fluid. The present invention provides a polymeric material used in combination with a tissue adhesive, which comprises carbon or silicon as a constitutional element, and at least a portion of the surface of which is modified by ion bombardment.
摘要翻译： 本发明的目的是提供一种用于提高体内嵌入材料如人造血管或人造硬膜与组织粘合剂的亲和力的方法，以便快速防止血液或脊髓液泄漏 。 本发明提供了与组织粘合剂组合使用的聚合物材料，其包含碳或硅作为构成元素，其表面的至少一部分通过离子轰击而被改性。
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公开(公告)号：US5906824A
公开(公告)日：1999-05-25
申请号：US856751
申请日：1997-05-15
申请人： Yoshiaki Suzuki , Aiko Nakao , Masaya Iwaki , Masahiro Kusakabe , Hiroshi Nakajima , Sanzo Kaneko , Hiroyuki Honda
发明人： Yoshiaki Suzuki , Aiko Nakao , Masaya Iwaki , Masahiro Kusakabe , Hiroshi Nakajima , Sanzo Kaneko , Hiroyuki Honda
CPC分类号： A61L33/128 , A61K41/00 , A61L33/122 , A61L33/124
摘要： An antithrombogenic material whose stickiness to cells is maintained but whose stickiness to blood platelet is inhibited, is disclosed, which comprises a substrate and a biopolymer material coated on said substrate, the antithrombogenic material being obtained by irradiating the biopolymer material with ion beam to maintain its stickiness to a cell but reduce its stickiness to a blood platelet. In accordance with the present invention, there is also provided a method for producing the antithrombogenic material.
摘要翻译： 本发明公开了一种抗血栓形成材料，其对细胞的粘性被保持，但是其对血小板的粘性被抑制，其包括基材和涂覆在所述基材上的生物聚合物材料，抗血栓形成材料通过用离子束照射生物聚合物材料获得， 对细胞的粘性，但减少其对血小板的粘性。 根据本发明，还提供了一种制造抗血栓形成材料的方法。
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公开(公告)号：US20070185570A1
公开(公告)日：2007-08-09
申请号：US10568694
申请日：2004-08-18
申请人： Hiroshi Ujiie , Yoshiaki Suzuki , Masaya Iwaki , Takanori Uchida
发明人： Hiroshi Ujiie , Yoshiaki Suzuki , Masaya Iwaki , Takanori Uchida
IPC分类号： A61F2/06
CPC分类号： A61L31/04 , A61K31/00 , A61L2400/18 , A61L2430/36
摘要： It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material for treating aneurysms, which is composed of a polymer material containing carbon as a constitutional element, and which is produced by modifying at least a portion of the surface thereof by ion bombardment.
摘要翻译： 本发明的一个目的是提供一种通过离子束的照射改善了组织相容性的聚合物材料，其防止了具有破裂风险的动脉瘤的实际破裂。 本发明提供一种治疗动脉瘤的材料，其由含有碳作为构成元素的高分子材料构成，其通过离子轰击改性其表面的至少一部分而制成。
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公开(公告)号：US20060155041A1
公开(公告)日：2006-07-13
申请号：US10525724
申请日：2003-08-29
CPC分类号： A61L27/16 , A61L17/12 , A61L17/14 , A61L24/001 , A61L24/04 , A61L27/14 , A61L27/18 , A61L27/50 , A61L27/507 , A61L2400/18 , Y10T428/3154 , C08L27/18 , C08L67/04
摘要： An object of the present invention is to provide a means for improving the affinity of an in vivo embedded material such as an artificial blood vessel or an artificial dura mater with a tissue adhesive, so as to quickly prevent the leakage of the blood or spinal fluid. The present invention provides a polymeric material used in combination with a tissue adhesive, which comprises carbon or silicon as a constitutional element, and at least a portion of the surface of which is modified by ion bombardment.
摘要翻译： 本发明的目的是提供一种用于提高体内嵌入材料如人造血管或人造硬膜与组织粘合剂的亲和力的方法，以便快速防止血液或脊髓液泄漏 。 本发明提供了与组织粘合剂组合使用的聚合物材料，其包含碳或硅作为构成元素，其表面的至少一部分通过离子轰击而被改性。
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公开(公告)号：US5891192A
公开(公告)日：1999-04-06
申请号：US861994
申请日：1997-05-22
CPC分类号： A61L33/128 , A61B17/1215 , A61B17/12181 , A61L27/34 , A61L31/10 , A61L33/122 , A61L33/126 , A61B17/12022
摘要： Ion-implanted protein-coated occlusion coils are described which have essentially the same dimensions as untreated coils and exhibit altered surface properties, e.g., thrombogenicity, endothelial cellular migration and adhesion, relative to untreated coils thus making them particularly useful in treating wide-necked brain aneurysms.
摘要翻译： 描述了离子注入的蛋白质包被的闭塞线圈，其具有与未处理的线圈基本上相同的尺寸，并且相对于未处理的线圈表现出改变的表面性质，例如血栓形成，内皮细胞迁移和粘附，因此使得它们特别可用于治疗宽颈大脑 动脉瘤
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公开(公告)号：US4698233A
公开(公告)日：1987-10-06
申请号：US872278
申请日：1986-06-10
申请人： Shigeo Ohira , Masaya Iwaki
发明人： Shigeo Ohira , Masaya Iwaki
CPC分类号： C23C14/48
摘要： Process for producing an aluminum material having an aluminum nitride surface layer which comprises implanting the surface of an aluminum substrate with nitrogen ions while maintaining a nitrogen atmosphere under reduced pressure in the vicinity of the surface of the aluminum substrate. The aluminum nitride modified layer contains substantially no impurities such as oxygen. It is a feature of this invention to perform ion implantation in a properly controlled nitrogen atmosphere at a proper degree of vacuum in the range of about 10.sup.-7 to 10.sup.-5 Torr.
摘要翻译： 一种具有氮化铝表面层的铝材的制造方法，其包括在铝基板的表面附近保持氮气气氛的同时，保持氮气气氛下的氮离子的铝基板的表面。 氮化铝改性层基本上不含氧等杂质。 本发明的一个特征是在适当控制的氮气气氛中以适当的真空度在约10-7至10-5乇的范围内进行离子注入。
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