公开(公告)号：US20080039579A1

公开(公告)日：2008-02-14

申请号：US11658093

申请日：2005-07-20

申请人： Yoshiharu Kimura ,  Zhen Tang ,  Kazuki Fukushima ,  Kiyotsuna Toyohara ,  Ryuji Nonokawa ,  Yasuhito Maeda ,  Masayuki Takada ,  Yuka Komazawa ,  Tsuyoshi Aoki

发明人： Yoshiharu Kimura ,  Zhen Tang ,  Kazuki Fukushima ,  Kiyotsuna Toyohara ,  Ryuji Nonokawa ,  Yasuhito Maeda ,  Masayuki Takada ,  Yuka Komazawa ,  Tsuyoshi Aoki

IPC分类号： C08G63/08 ,  C08K7/02 ,  C08L31/02

CPC分类号： C08G63/08 ,  C08G63/06 ,  C08J5/045 ,  C08J2367/04

摘要： It is an object of the present invention to provide polylactic acid containing a stereocomplex crystal and having excellent moldability, a high molecular weight, high crystallinity and a high melting point and a process for manufacturing the same. It is another object of the present invention to provide a composition comprising the polylactic acid and a molded product of the polylactic acid. The present invention is characterized from polylactic acid having a weight average molecular weight of 80,000 to 500,000 and a melting peak at 195° C. or higher which accounts for 80% or more of the total of melting peaks in the temperature elevation step when measured by a differential scanning calorimeter (DSC) and a process for manufacturing the same.

摘要翻译： 本发明的目的是提供含有立体络合物晶体的聚乳酸，并且具有优异的成型性，高分子量，高结晶度和高熔点及其制造方法。 本发明的另一个目的是提供包含聚乳酸和聚乳酸的模塑产品的组合物。 本发明的特征在于重均分子量为80,000〜500,000的聚乳酸和195℃以上的熔融峰，当温度升高步骤中的熔融峰的总量为80％以上时，其通过 差示扫描量热计（DSC）及其制造方法。

公开(公告)号：US08304490B2

公开(公告)日：2012-11-06

申请号：US11658093

申请日：2005-07-20

申请人： Yoshiharu Kimura ,  Zhen Tang ,  Kazuki Fukushima ,  Kiyotsuna Toyohara ,  Ryuji Nonokawa ,  Yasuhito Maeda ,  Masayuki Takada ,  Yuka Komazawa ,  Tsuyoshi Aoki

发明人： Yoshiharu Kimura ,  Zhen Tang ,  Kazuki Fukushima ,  Kiyotsuna Toyohara ,  Ryuji Nonokawa ,  Yasuhito Maeda ,  Masayuki Takada ,  Yuka Komazawa ,  Tsuyoshi Aoki

IPC分类号： C08G63/08 ,  C08G63/88 ,  C08G63/06 ,  C08L67/04

CPC分类号： C08G63/08 ,  C08G63/06 ,  C08J5/045 ,  C08J2367/04

摘要： It is an object of the present invention to provide polylactic acid containing a stereocomplex crystal and having excellent moldability, a high molecular weight, high crystallinity and a high melting point and a process for manufacturing the same. It is another object of the present invention to provide a composition comprising the polylactic acid and a molded product of the polylactic acid. The present invention is characterized from polylactic acid having a weight average molecular weight of 80,000 to 500,000 and a melting peak at 195° C. or higher which accounts for 80% or more of the total of melting peaks in the temperature elevation step when measured by a differential scanning calorimeter (DSC) and a process for manufacturing the same.

摘要翻译： 本发明的目的是提供含有立体络合物晶体的聚乳酸，并且具有优异的成型性，高分子量，高结晶度和高熔点及其制造方法。 本发明的另一个目的是提供包含聚乳酸和聚乳酸的模塑产品的组合物。 本发明的特征在于重均分子量为80,000〜500,000，熔点在195℃以上的聚乳酸，当温度升高步骤中的熔融峰的总量为80％以上时，其通过 差示扫描量热计（DSC）及其制造方法。

公开(公告)号：US09284404B2

公开(公告)日：2016-03-15

申请号：US13619958

申请日：2012-09-14

申请人： James Hedrick ,  Kazuki Fukushima ,  Yi Yan Yang

发明人： James Hedrick ,  Kazuki Fukushima ,  Yi Yan Yang

IPC分类号： A61K9/107 ,  C08G63/64 ,  A61K31/14 ,  C08G64/18 ,  C08G64/30

CPC分类号： C08G63/64 ,  A61K9/1075 ,  A61K31/14 ,  C08G64/18 ,  C08G64/30 ,  Y10S977/773 ,  Y10S977/904

摘要： Biodegradable cationic block copolymers are disclosed, comprising a hydrophilic block comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a hydrophobic block comprising second repeat units derived from a second cyclic carbonyl monomer by ring-opening polymerization; an optional endcap group; and a chain fragment derived from an initiator for the ring opening polymerization. The cationic block copolymers form aqueous micelle mixtures suitable for antimicrobial applications.

公开(公告)号：US08450043B2

公开(公告)日：2013-05-28

申请号：US12894412

申请日：2010-09-30

申请人： Daniel J. Coady ,  Urs T. Duerig ,  Jane E. Frommer ,  Kazuki Fukushima ,  James L. Hedrick ,  Armin W. Knoll

发明人： Daniel J. Coady ,  Urs T. Duerig ,  Jane E. Frommer ,  Kazuki Fukushima ,  James L. Hedrick ,  Armin W. Knoll

IPC分类号： G03F7/00 ,  G03F7/004 ,  G03F7/40

CPC分类号： B32B3/00 ,  G03F7/0002 ,  Y10T428/24355

摘要： The invention concerns a method for patterning a surface of a material. A substrate having a polymer film thereon is provided. The polymer is a selectively reactive polymer (e.g., thermodynamically unstable): it is able to unzip upon suitable stimulation. A probe is used to create patterns on the film. During the patterning, the film is locally stimulated for unzipping polymer chains. Hence, a basic idea is to provide a stimulus to the polymeric material, which in turn spontaneously decomposes e.g., into volatile constituents. For example, the film is thermally stimulated in order to break a single bond in a polymer chain, which is sufficient to trigger the decomposition of the entire polymer chain.

公开(公告)号：US08226985B2

公开(公告)日：2012-07-24

申请号：US12695991

申请日：2010-01-28

申请人： Kazuki Fukushima ,  James Lupton Hedrick ,  Alshakim Nelson ,  Daniel Paul Sanders

发明人： Kazuki Fukushima ,  James Lupton Hedrick ,  Alshakim Nelson ,  Daniel Paul Sanders

IPC分类号： A61K9/14 ,  A61K48/00 ,  A61K47/00

CPC分类号： C08G71/02 ,  A61K47/6923 ,  A61K47/6929 ,  C08G71/04

摘要： A composition comprises a surface modified nanoparticle comprising a core comprising a material selected from the group consisting of organic materials, organometallic materials, inorganic materials, metals, metal oxides, and combinations thereof; and a surface branch covalently linked to the core having the general formula (3):

摘要翻译： 组合物包含表面改性的纳米颗粒，其包含芯，其包含选自有机材料，有机金属材料，无机材料，金属，金属氧化物及其组合的材料; 和共价连接到具有通式（3）的芯的表面支链：

公开(公告)号：US08709466B2

公开(公告)日：2014-04-29

申请号：US13333930

申请日：2011-12-21

申请人： Daniel Joseph Coady ,  Amanda Catherine Engler ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Jeremy Pang Kern Tan ,  Yi Yan Yang

发明人： Daniel Joseph Coady ,  Amanda Catherine Engler ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Jeremy Pang Kern Tan ,  Yi Yan Yang

IPC分类号： A61K9/00 ,  A61K31/357 ,  C12N15/88 ,  C08G63/08

CPC分类号： A01N37/44 ,  A01N33/12 ,  A61K48/0041 ,  C08G83/004 ,  C12N15/88 ,  A01N25/10 ,  A01N2300/00

摘要： A cationic star polymer is disclosed of the general formula (1): I′P′]w′  (1), wherein w′ is a positive number greater than or equal to 3, I′ is a dendritic polyester core covalently linked to w′ independent peripheral linear cationic polymer chains P′. Each of the chains P′ comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.

摘要翻译： 公开了通式（1）的阳离子星形聚合物：I'P'] w'（1），其中w'是大于或等于3的正数，I'是与w共价连接的树枝状聚酯芯 '独立的外围线性阳离子聚合物链P'。 每个链P'包含阳离子重复单元，其包含i）选自脂族碳酸酯，脂族酯，脂族氨基甲酸酯，脂族脲，脂族硫代氨基甲酸酯，脂族二硫代碳酸酯及其组合的骨架官能团，和ii） 侧链包含季胺基。 季胺基包括与i）正电荷氮和ii）芳环直接共价连接的二价亚甲基。

公开(公告)号：US08642086B2

公开(公告)日：2014-02-04

申请号：US13077005

申请日：2011-03-31

申请人： Daniel Joseph Coady ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Yi Yan Yang

发明人： Daniel Joseph Coady ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Yi Yan Yang

IPC分类号： A61K9/00 ,  A61K31/765

CPC分类号： A61K31/78 ,  A01N33/12 ,  A61K31/77 ,  A61K47/34 ,  A61L15/26 ,  A61L15/28 ,  A61L15/46 ,  A61L17/10 ,  A61L17/12 ,  A61L29/043 ,  A61L29/06 ,  A61L31/10 ,  A61L2300/40 ,  Y02A50/473 ,  A01N25/10 ,  A01N2300/00 ,  C08L71/02 ,  C08L67/04

摘要： A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.

摘要翻译： 物质组合物包含包含聚碳酸酯链片段的阳离子聚合物，所述聚碳酸酯链片段包含包含含有季胺基团的侧链部分的重复单元; 和包含聚酯链段和聚（环氧烷）链段的无电荷聚合物; 其中i）阳离子聚合物和非带电聚合物是两亲性的和生物相容的，ii）阳离子聚合物和非带电聚合物通过在水中的非共价相互作用形成混合络合物，和iii）混合络合物是更有效的 当使用其他相同条件进行测试时，与单体阳离子聚合物和非带电聚合物相比，抗微生物剂对抗至少革兰氏阴性微生物。

公开(公告)号：US20130281515A1

公开(公告)日：2013-10-24

申请号：US13449643

申请日：2012-04-18

申请人： Daniel Joseph Coady ,  Amanda Catherine Engler ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Shaoqiong Liu ,  Hareem Tariq Maune ,  Alshakim Nelson ,  Jed Walter Pitera ,  Yi Yan Yang

发明人： Daniel Joseph Coady ,  Amanda Catherine Engler ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Shaoqiong Liu ,  Hareem Tariq Maune ,  Alshakim Nelson ,  Jed Walter Pitera ,  Yi Yan Yang

IPC分类号： A61K48/00 ,  C12N5/07 ,  C07C69/96 ,  A61P31/04 ,  A61P31/10 ,  C07C275/42 ,  A61K31/17 ,  B82Y5/00 ,  B82Y30/00

CPC分类号： A61K31/14 ,  A61K31/17 ,  B82Y5/00 ,  B82Y30/00 ,  C07C275/40 ,  C12N15/87

摘要： A cationic bis-urea compound is disclosed of formula (1): wherein: each m is independently an integer of 0 to 4, each k is independently 0 or 1, each Z′ is a monovalent radical independently selected from the group consisting of hydroxyl (*—OH), carboxyl (*—COOH), cyano (*—CN), nitro (*—NO2), sulfonate (*—SO3−), trifluoromethyl (*—CF3), halides, amine groups, ketone groups, alkyl groups comprising 1 to 6 carbons, alkoxy groups comprising 1 to 6 carbons, thioether groups comprising 1 to 6 carbons, and combinations thereof, each L′ is independently a divalent alkylene group comprising 1 to 6 carbons, wherein a *-[-L′-]k- is a single bond when k is 0, each Y′ is independently a monovalent non-polymeric radical comprising a positive charged amine, and each X′ is independently a negative charged counterion.

摘要翻译： 公开了式（1）的阳离子双脲化合物：其中：每个m独立地为0至4的整数，每个k独立地为0或1，每个Z'是独立地选自羟基的一价基团 （* -OH），羧基（* -COOH），氰基（* -CN），硝基（* -NO 2），磺酸酯（* -SO 3 - ），三氟甲基 包含1至6个碳的烷基，包含1至6个碳原子的烷氧基，含1至6个碳的硫醚基及其组合，每个L'独立地为包含1至6个碳的二价亚烷基，其中a * - [ - L ' - ] k-当k为0时为单键，每个Y'独立地为包含带正电胺的单价非聚合基团，并且每个X'独立地为负电荷的抗衡离子。

公开(公告)号：US08541477B2

公开(公告)日：2013-09-24

申请号：US13040550

申请日：2011-03-04

申请人： Abdullah M Alabdulrahman ,  Hamid A Almegren ,  Fares D Alsewailem ,  Phillip Joe Brock ,  Daniel Joseph Coady ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Hans Werner Horn ,  Julia Elizabeth Rice

发明人： Abdullah M Alabdulrahman ,  Hamid A Almegren ,  Fares D Alsewailem ,  Phillip Joe Brock ,  Daniel Joseph Coady ,  Kazuki Fukushima ,  James Lupton Hedrick ,  Hans Werner Horn ,  Julia Elizabeth Rice

IPC分类号： C08J11/04

CPC分类号： C07C67/03 ,  C07C69/82

摘要： A method comprises forming a reaction mixture comprising a terephthalate polyester, a glycol comprising 2 to 5 carbons, and an amidine organocatalyst; and heating the reaction mixture at a temperature of about 120° C. or more to depolymerize the terephthalate polyester, thereby forming a terephthalate reaction product comprising a monomeric dihydroxy terephthalate diester; wherein the terephthalate reaction product contains terephthalate oligomers in an amount less than the amount of terephthalate oligomers that would result from i) substituting the amidine organocatalyst with an equimolar amount of a guanidine catalyst and ii) depolymerizing the terephthalate polyester under otherwise identical reaction conditions.

摘要翻译： 一种方法包括形成包含对苯二甲酸酯聚酯，含有2-5个碳原子的二醇和脒有机催化剂的反应混合物; 在约120℃以上的温度下加热反应混合物以使对苯二甲酸酯聚酯解聚，从而形成包含单体二羟基对苯二酸酯二酯的对苯二甲酸酯反应产物; 其中对苯二甲酸酯反应产物含有对苯二甲酸酯低聚物的量小于由i）用等摩尔量的胍催化剂代替脒有机催化剂而产生的对苯二甲酸酯低聚物的量，和ii）在其它相同的反应条件下使对苯二甲酸酯聚酯解聚。

公开(公告)号：US08536291B2

公开(公告)日：2013-09-17

申请号：US13543120

申请日：2012-07-06

申请人： Kazuki Fukushima ,  James L. Hedrick ,  Sung-Ho Kim ,  Robert M. Waymouth

发明人： Kazuki Fukushima ,  James L. Hedrick ,  Sung-Ho Kim ,  Robert M. Waymouth

IPC分类号： C08G64/18

CPC分类号： C08G64/18 ,  C08G64/0208 ,  C08J3/075 ,  C08J2369/00

摘要： Block copolymers include hydrophobic and hydrophilic blocks having repeating units derived from ring opening polymerization of one or more cyclic carbonate monomers. The carbonate monomers are independently selected from compounds of formula (II): wherein each Q′ and Qa group independently represents a hydrogen, an alkyl group, a halide, a carboxy group, an ester group, an amide group, an aryl group, an alkoxy group, or a foregoing Q′ or Qa group substituted with a carboxy group or an ester group, at least one Q′ and Qa group includes an ester group; each Y independently represents O, S, NH, or NQ″; n is an integer from 0 to 6, wherein when n is 0, carbons labeled 4 and 6 are linked together by a single bond; each Q″ group independently represents an alkyl group, an aryl group, or a foregoing Q″ group substituted with a carboxy group, or an ester group.

摘要翻译： 嵌段共聚物包括具有衍生自一种或多种环状碳酸酯单体的开环聚合的重复单元的疏水性和亲水嵌段。 碳酸酯单体独立地选自式（II）的化合物：其中每个Q'和Qa基团独立地表示氢，烷基，卤素，羧基，酯基，酰胺基，芳基， 烷氧基或由羧基或酯基取代的上述Q'或Qa基团，至少一个Q'和Qa基团包括酯基; 每个Y独立地表示O，S，NH或NQ“; n为0〜6的整数，n为0时，标记为4和6的碳通过单键连接在一起; 每个Q“基团独立地表示被羧基或酯基取代的烷基，芳基或上述Q”基。