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    Man-made skin composed of two layers: collagen and a poly-alpha-amino acid
    1.
    发明授权
    Man-made skin composed of two layers: collagen and a poly-alpha-amino acid 失效
    人造皮肤由两层组成：胶原蛋白和聚-α-氨基酸

    公开(公告)号：US4642118A

    公开(公告)日：1987-02-10

    申请号：US741835

    申请日：1985-06-06

    申请人： Yoshimitsu Kuroyanagi ,  Teruo Miyata ,  Manabu Seno

    发明人： Yoshimitsu Kuroyanagi ,  Teruo Miyata ,  Manabu Seno

    IPC分类号： A61L27/00 ,  A61F2/10 ,  A61L27/34 ,  A61L27/60

    CPC分类号： A61L27/60 ,  A61L27/34

    摘要： This invention concerns a double-layered man-made skin which is prepared by laminating a collagen sponge sheet and a poly-.alpha.-amino acid membrane that has a good affinity with tissue cells and an appropriate permeability for moisture. When the man-made skin is applied on burns, cuts or wounds, the fibroblasts proliferate in the collagen sponge sheet forming a three-dimensional structure, while the epidermal cells proliferate in the region between the poly-.alpha.-amino acid membrane and a collagen sponge sheet. The poly-.alpha.-amino acid membrane plays a role in protecting affected part and in providing an optimum condition for the proliferation of fibroblasts and epidermal cells, and then it falls off as the epidermis completely regenerates. On the other hand, the collagen sponge sheet assimilates in the living tissue after having played a general role of the dermis.

    摘要翻译： 本发明涉及一种双层人造皮肤，其通过层叠胶原海绵片和与组织细胞具有良好亲和性并具有适当的渗透性的聚-α-氨基酸膜制备。 当人造皮肤应用于烧伤，切口或伤口时，成纤维细胞在形成三维结构的胶原海绵片中增殖，而表皮细胞在聚-α-氨基酸膜和胶原之间的区域中增殖 海绵片。 聚-α-氨基酸膜在保护受影响部位和为成纤维细胞和表皮细胞增殖提供最佳条件方面发挥作用，随着表皮完全再生，其脱落。 另一方面，在发挥真皮的一般作用后，胶原蛋白海绵片在活组织中被吸收。

    Method of producing an artifical skin
    4.
    发明授权
    Method of producing an artifical skin 失效
    生产人造皮肤的方法

    公开(公告)号：US4883487A

    公开(公告)日：1989-11-28

    申请号：US34958

    申请日：1987-04-06

    申请人： Katsutoshi Yoshizato ,  Toshio Taira ,  Teruo Miyata

    发明人： Katsutoshi Yoshizato ,  Toshio Taira ,  Teruo Miyata

    IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/10 ,  A61L27/24 ,  A61L27/60

    CPC分类号： A61L27/24 ,  A61F2/105 ,  A61L27/60 ,  A61F2310/00365 ,  Y10S623/901

    摘要： An artifical skin comprising an insoluble atelocollagen sheet and an epidermal cell layer cultured only on one surface of the sheet, and a method of producing the same are disclosed, which method includes the steps of: forming an insoluble atelocollagen sheet; inoculating epidermal cells only on one surface of the atelocollagen sheet; and suspending the atelocollagen sheet in a liquid culture medium to culture the epidermal cells, thereby forming an epidermal cell layer.

    摘要翻译： 公开了包含不溶性胶原蛋白片和仅在片材的一个表面上培养的表皮细胞层的人造皮肤及其制造方法，该方法包括以下步骤：形成不溶性胶原蛋白片; 仅在表皮细胞上接种atelocollagen片的一个表面; 并将所述胶原蛋白片悬浮在液体培养基中以培养表皮细胞，由此形成表皮细胞层。

    Production process of an antithrombogenic and antiadhesive material for medical use
    5.
    发明授权
    Production process of an antithrombogenic and antiadhesive material for medical use 失效
    用于医疗用途的抗血栓形成和抗粘附材料的生产工艺

    公开(公告)号：US4690973A

    公开(公告)日：1987-09-01

    申请号：US885782

    申请日：1986-07-15

    申请人： Yasuharu Noishiki ,  Kazuhiko Kodaira ,  Masayasu Furuse ,  Teruo Miyata ,  Takeaki Miyamoto ,  Hiraku Ito

    发明人： Yasuharu Noishiki ,  Kazuhiko Kodaira ,  Masayasu Furuse ,  Teruo Miyata ,  Takeaki Miyamoto ,  Hiraku Ito

    IPC分类号： A61L33/10 ,  A61L33/00 ,  A61M25/00 ,  C08H1/06 ,  C08L89/04 ,  C08L89/06

    CPC分类号： A61L33/0023 ,  Y10S128/08

    摘要： This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.

    摘要翻译： 本发明涉及可有利地用作人造血管，人造瓣膜，心血管器官接枝片，人造心导管等的抗血栓形成和抗粘附材料的生产方法。 本发明的要点基本上是将缩水甘油三烷基铵卤化物如缩水甘油基三甲基氯化铵与含有纯胶原或胶原和其他组分如粘多糖的材料进行反应，以便在材料的胶原分子中引入阳离子季铵官能团， 肝素与阳离子官能团的离子组合引入。 同时，在上述化学处理之前，通过从牛的跟腱中除去胶原蛋白之外的蛋白质从狗的血管中制备，通过粉碎，从人羊膜中通过在蒸馏水中冲洗或从聚酯针织管中涂覆其内部制备材料 以胶原蛋白粉为例。

    Regenerated fiber collagen condom and method of preparation
    6.
    发明授权
    Regenerated fiber collagen condom and method of preparation 失效
    再生纤维胶原避孕套及其制备方法

    公开(公告)号：US4349026A

    公开(公告)日：1982-09-14

    申请号：US125538

    申请日：1980-02-28

    申请人： Teruo Miyata

    发明人： Teruo Miyata

    IPC分类号： A61F6/04 ,  A61F5/42

    CPC分类号： A61F6/04 ,  Y10S128/08

    摘要： A novel collagen condom consists of isotropically-strong, crosslinked, regenerated fiber collagen. A method of preparation involves the steps of at least twice dipping a mandrel into an acidic collagen dispersion; slowly removing the mandrel under spinning conditions; neutralizing and drying the membrane between dippings; crosslinking the finally dried membrane while on the mandrel and removing the membrane from the mandrel.

    摘要翻译： 一种新型胶原蛋白避孕套由各向同性，交联，再生的纤维胶原组成。 制备方法包括将心轴至少两次浸入酸性胶原分散体中的步骤; 在纺丝条件下慢慢取出心轴; 蘸液中和干燥膜; 在芯棒上交联最终干燥的膜，并从心轴上除去膜。

    Substratum for cell culture and a method for culturing and isolating cells using same
    10.
    发明授权
    Substratum for cell culture and a method for culturing and isolating cells using same 失效
    用于细胞培养的底物和使用其培养和分离细胞的方法

    公开(公告)号：US4559304A

    公开(公告)日：1985-12-17

    申请号：US521083

    申请日：1983-08-08

    申请人： Shunji Kasai ,  Toshihiro Akaike ,  Teruo Miyata

    发明人： Shunji Kasai ,  Toshihiro Akaike ,  Teruo Miyata

    IPC分类号： C12N5/06 ,  C12N5/00 ,  C12R1/91

    CPC分类号： C12N5/0068 ,  C12N2533/54 ,  Y10S435/948

    摘要： A substratum for cell culture which comprises a chemically modified collagen rich in either positive or negative charges when under culture conditions. The substratum is prepared by modifying the amino groups or carboxyl groups of collagen. The chemically modified collagen enhances the adherence and proliferation of animal cells much more actively than unmodified collagen in the presence or absence of bovine fetus serum. The cultured animal cells can be detached efficiently from the chemically modified collagen. This allows for highly selective isolation and recovery of the cultured animal cells which can be accomplished without incurring any injury from the chemically modified collagen.

    摘要翻译： 用于细胞培养的基质，其包含在培养条件下富含正电荷或负电荷的化学修饰的胶原。 通过改变胶原蛋白的氨基或羧基来制备底物。 在牛胎儿血清存在或不存在下，化学修饰的胶原蛋白比未修饰的胶原蛋白更积极地增强动物细胞的粘附和增殖。 培养的动物细胞可以从化学改性的胶原中有效分离。 这允许高度选择性地分离和回收培养的动物细胞，其可以在不引起化学改性的胶原蛋白的任何损伤的情况下完成。