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32 条记录 (耗时 0.033 秒)

    Substratum for cell culture and a method for culturing and isolating cells using same
    1.
    发明授权
    Substratum for cell culture and a method for culturing and isolating cells using same 失效
    用于细胞培养的底物和使用其培养和分离细胞的方法

    公开(公告)号：US4559304A

    公开(公告)日：1985-12-17

    申请号：US521083

    申请日：1983-08-08

    申请人： Shunji Kasai ,  Toshihiro Akaike ,  Teruo Miyata

    发明人： Shunji Kasai ,  Toshihiro Akaike ,  Teruo Miyata

    IPC分类号： C12N5/06 ,  C12N5/00 ,  C12R1/91

    CPC分类号： C12N5/0068 ,  C12N2533/54 ,  Y10S435/948

    摘要： A substratum for cell culture which comprises a chemically modified collagen rich in either positive or negative charges when under culture conditions. The substratum is prepared by modifying the amino groups or carboxyl groups of collagen. The chemically modified collagen enhances the adherence and proliferation of animal cells much more actively than unmodified collagen in the presence or absence of bovine fetus serum. The cultured animal cells can be detached efficiently from the chemically modified collagen. This allows for highly selective isolation and recovery of the cultured animal cells which can be accomplished without incurring any injury from the chemically modified collagen.

    摘要翻译： 用于细胞培养的基质，其包含在培养条件下富含正电荷或负电荷的化学修饰的胶原。 通过改变胶原蛋白的氨基或羧基来制备底物。 在牛胎儿血清存在或不存在下，化学修饰的胶原蛋白比未修饰的胶原蛋白更积极地增强动物细胞的粘附和增殖。 培养的动物细胞可以从化学改性的胶原中有效分离。 这允许高度选择性地分离和回收培养的动物细胞，其可以在不引起化学改性的胶原蛋白的任何损伤的情况下完成。

    Tetrafluoroethylene polymer and aqueous dispersion thereof
    3.
    发明授权
    Tetrafluoroethylene polymer and aqueous dispersion thereof 有权
    四氟乙烯聚合物及其水分散体

    公开(公告)号：US07820775B2

    公开(公告)日：2010-10-26

    申请号：US12296865

    申请日：2007-04-13

    申请人： Shunji Kasai ,  Makoto Ono ,  Taku Yamanaka ,  Yasuhiko Sawada

    发明人： Shunji Kasai ,  Makoto Ono ,  Taku Yamanaka ,  Yasuhiko Sawada

    IPC分类号： C08F14/18

    CPC分类号： C08F114/26 ,  C08F14/26 ,  C08F214/26 ,  Y10T428/3154 ,  Y10T428/31544 ,  C08F2/22

    摘要： The invention provides a TFE polymer capable of providing stretched materials excellent in membrane homogeneity. The present invention is related to a tetrafluoroethylene polymer having stretchability and non-melt-processability and having a standard specific gravity of 2.140 to 2.165, wherein, with regard to the heat-of-fusion curve obtained by subjecting the tetrafluoroethylene polymer in the form of an unbaked polymer to be measured having no history of being heated to a temperature of 300° C. or higher to differential scanning calorimetry at a programming rate of 2° C./minute, the ratio S2/S1 is not lower than 0.90.

    摘要翻译： 本发明提供能够提供膜均匀性优异的拉伸材料的TFE聚合物。 本发明涉及具有拉伸性和非熔融加工性，标准比重为2.140〜2.165的四氟乙烯聚合物，其中，对于通过使四氟乙烯聚合物以 在2℃/分钟的编程速度下，将没有被加热到300℃以上的温度的历史记录到差示扫描量热法中，待测量的未焙烧聚合物的比例S2 / S1不低于0.90。

    Carboxylic acids
    4.
    发明授权
    Carboxylic acids 失效
    羧酸

    公开(公告)号：US07253178B2

    公开(公告)日：2007-08-07

    申请号：US10469173

    申请日：2002-03-27

    申请人： Hitoshi Harada ,  Masanobu Shinoda ,  Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    发明人： Hitoshi Harada ,  Masanobu Shinoda ,  Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    IPC分类号： A61K31/435 ,  A61K31/44 ,  C07D211/72 ,  C07D211/70

    CPC分类号： C07D213/64 ,  C07D213/79

    摘要： The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

    摘要翻译： 本发明提供了可用作胰岛素敏化剂的新型羧酸衍生物，其盐或其水合物，以及包含该衍生物作为有效成分的药物。 更具体地，它提供由式（I）表示的羧酸化合物，其盐或它们的水合物。 在该式中，Ar表示可以具有至少一个取代基的6至14元芳环基团; R 1，R 2，R 3，R 4，R 5， R 6，R 7和R 8彼此相同或不同，并且各自表示氢原子，卤素原子， 羟基，C 1-6烷基或C 1-6烷氧基; X表示氧原子或亚甲基; Y表示由式（II）或（III）表示的基团：（其中Z表示由式（IV）表示的基团：（其中R 9，R 10， >，R 11和R 12彼此相同或不同，并且各自表示氢原子，卤素原子，羟基，C 1 -C 12烷基， 1-6烷基或C 1-6烷氧基））; m为0或1; n为0或1。

    LOW MOLECULAR WEIGHT POLYTETRAFLUOROETHYLENE POWDER AND PREPARATION METHOD THEREFOR
    8.
    发明申请
    LOW MOLECULAR WEIGHT POLYTETRAFLUOROETHYLENE POWDER AND PREPARATION METHOD THEREFOR 有权
    低分子量聚四氟乙烯粉及其制备方法

    公开(公告)号：US20120101214A1

    公开(公告)日：2012-04-26

    申请号：US13260911

    申请日：2010-03-31

    申请人： Taku Yamanaka ,  Masayuki Tsuji ,  Shunji Kasai ,  Yasuhiko Sawada

    发明人： Taku Yamanaka ,  Masayuki Tsuji ,  Shunji Kasai ,  Yasuhiko Sawada

    IPC分类号： C08F214/26 ,  C08F4/30 ,  C09D127/18 ,  C08F4/28

    CPC分类号： C08F14/26 ,  C08F114/26 ,  C08F2/24 ,  C08F2/22 ,  C08F2/18

    摘要： The present invention provides a low-molecular weight polytetrafluoroethylene powder that, when used as an additive in a coating material, etc., can form a coating with excellent texture and gliding properties, while also improving dispersibility and viscosity; and a production process therefor. The present invention is a process for producing a low-molecular weight polytetrafluoroethylene powder, the process comprising: an emulsion polymerization step of polymerizing at least tetrafluoroethylene in the presence of a polymerization initiator and an aqueous medium to produce emulsified particles thereof; an agglomeration step of agglomerating the emulsified particles to form an agglomerated powder thereof; and a suspension polymerization step of polymerizing at least tetrafluoroethylene in the presence of the agglomerated powder, a polymerization initiator, and an aqueous medium.

    摘要翻译： 本发明提供一种低分子量聚四氟乙烯粉末，其在涂料等中作为添加剂使用时，可以形成具有优良质地和滑动性能的涂料，同时还可提高分散性和粘度; 及其生产工艺。 本发明是一种生产低分子量聚四氟乙烯粉末的方法，该方法包括：在聚合引发剂和水性介质存在下聚合至少四氟乙烯以产生其乳化颗粒的乳液聚合步骤; 凝聚步骤，使乳化粒子凝集，形成凝聚粉末; 和在聚集粉末，聚合引发剂和水性介质的存在下聚合至少四氟乙烯的悬浮聚合步骤。

    Cyclic compound and PPAR agonist
    10.
    发明授权
    Cyclic compound and PPAR agonist 失效
    环状化合物和PPAR激动剂

    公开(公告)号：US07371777B2

    公开(公告)日：2008-05-13

    申请号：US10486396

    申请日：2002-08-16

    申请人： Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    发明人： Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    IPC分类号： A61K31/341 ,  C07D307/04

    CPC分类号： C07D213/53 ,  C07C233/87 ,  C07C251/60 ,  C07C2601/02 ,  C07C2601/14 ,  C07D263/32 ,  C07D277/56 ,  C07D307/24 ,  C07D307/30 ,  C07D317/32 ,  C07D339/08 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R1 to R6 are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.; A1 and A2 are the same as or different from each other and each represents a single bond, an oxygen atom, etc.; L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.; W represents a carboxyl group; the partial structure represented by the formula: represents a single bond or a double bond; X represents a single bond, an oxygen atom, —NRx1CQ1O—, etc.; Y represents Y1—Y2— (wherein Y1 represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y2 represents a single bond or a 5 to 14-membered aromatic ring); and the ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.

    摘要翻译： 本发明提供具有优异的PPAR激动剂作用的新化合物。 更具体地，它提供由下式表示的化合物，其盐，其酯或它们的水合物。 其中a，b和c彼此相同或不同，各自表示0〜4; R 1至R 6彼此相同或不同，并且各自表示氢原子，羟基，氰基，卤素原子等; A＆lt; 1＆gt;和＆lt; 2＆gt;相同或不同，各自表示单键，氧原子等; L，M和T各自表示单键，具有1〜6个碳原子的亚烷基等; W表示羧基; 由式表示的部分结构表示单键或双键; X表示单键，氧原子，-O- O 1等。 Y表示Y 1 -Y 2 - （其中Y 1表示具有1〜4个取代基的5〜14元芳香环等。 ; Y 2代表单键或5至14元芳环）; 并且环Z表示具有一至四个选自上述A组的取代基的5至14元芳环，可具有一个或多个杂原子并且可部分饱和。