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53 条记录 (耗时 0.059 秒)

    Quinoline compound
    6.
    发明授权
    Quinoline compound 失效
    喹啉化合物

    公开(公告)号：US07183415B2

    公开(公告)日：2007-02-27

    申请号：US10493427

    申请日：2002-10-24

    申请人： Yuji Ishihara ,  Makoto Kamata ,  Shiro Takekawa ,  Nobuhiro Suzuki ,  Koki Kato

    发明人： Yuji Ishihara ,  Makoto Kamata ,  Shiro Takekawa ,  Nobuhiro Suzuki ,  Koki Kato

    IPC分类号： C07D215/38 ,  C07D215/14

    CPC分类号： C07D401/06 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07D215/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

    摘要： A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.

    摘要翻译： 一种化合物，其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂，并且其由下式表示：其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同，各自为氢原子或任选具有取代基的烃基，或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基（CO除外）的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基，并且当环B还具有取代基时，取代基可以与R 1连接形成环，或其盐或其前药， 被提供。

    Amine derivative
    7.
    发明申请
    Amine derivative 失效
    胺衍生物

    公开(公告)号：US20060128690A1

    公开(公告)日：2006-06-15

    申请号：US10545120

    申请日：2004-02-12

    申请人： Yuji Ishihara ,  Makoto Kamata ,  Shiro Takekawa

    发明人： Yuji Ishihara ,  Makoto Kamata ,  Shiro Takekawa

    IPC分类号： A61K31/55 ,  A61K31/401 ,  A61K31/445

    CPC分类号： C07D211/16 ,  A61K31/55 ,  C07C233/73 ,  C07C235/42 ,  C07D207/09 ,  C07D207/12 ,  C07D211/14 ,  C07D213/82 ,  C07D233/24 ,  C07D295/135

    摘要： The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s) or a pyridyl optionally having substituent(s); Ra1, Ra2, Ra3 and Ra4 are the same or different and each is a hydrogen atom, an optionally halogenated C1-6 alkyl or the like; Ar is a monocyclic aromatic ring optionally having substituent(s); Y is an optionally halogenated alkylene group; and R1 and R2 are (1) the same or different and each is a hydrogen atom or a C1-6 alkyl, (2) R1 and R2 form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, or (3) R1 and Y form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, and R2 is a hydrogen atom or a C1-6 alkyl; provided that when the nitrogen-containing heterocycle formed by R1 and R2 together with the adjacent nitrogen atom is a piperazine, or when R is a C1-4 alkyl, Ar1 is a cyclic group having substituent(s), or a salt thereof, having a melanin-concentrating hormone antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like.

    摘要翻译： 本发明提供由下式表示的化合物：其中Ar 1是任选具有取代基的环状基团; R是氢原子，任选卤代的C 1-6烷基，任选具有取代基的苯基或任选具有取代基的吡啶基; Ra 1，R 2，R 3，R 3和R 4相同或不同，各自为氢原子 ，任选卤代的C 1-6烷基等; Ar是任选具有取代基的单环芳环; Y是任选卤代的亚烷基; 且R 1和R 2均为（1）相同或不同，并且各自为氢原子或C 1-6烷基，（ 2）R 1和R 2 2形成任选具有取代基的氮杂环与相邻的氮原子，或（3）R 1， Y和Y形成任选具有取代基的氮杂环与相邻的氮原子一起形成，R 2是氢原子或C 1-6 烷基; 条件是当由R 1和R 2与相邻氮原子一起形成的含氮杂环是哌嗪时，或当R是C 1〜 4个烷基，Ar 1是具有取代基的环状基团或其盐，其具有黑色素浓缩激素拮抗作用并且可用作预防或治疗的药剂 肥胖等。

    FRONT UNDERFLOOR STRUCTURE OF VEHICLE
    10.
    发明申请
    FRONT UNDERFLOOR STRUCTURE OF VEHICLE 有权
    车辆底部结构

    公开(公告)号：US20130026783A1

    公开(公告)日：2013-01-31

    申请号：US13639211

    申请日：2011-04-07

    申请人： Takeshi Kakiuchi ,  Masahiro Ataka ,  Youhei Ogawa ,  Kazuaki Nakajima ,  Yuji Ishihara

    发明人： Takeshi Kakiuchi ,  Masahiro Ataka ,  Youhei Ogawa ,  Kazuaki Nakajima ,  Yuji Ishihara

    IPC分类号： B62D35/02

    CPC分类号： B62D35/02 ,  Y02T10/88

    摘要： A front underfloor structure of a vehicle includes front deflectors disposed forward of front tires, respectively. The front deflectors each include a front apex portion disposed at a position closer to the vehicle front than a leading edge surface of each of the front tires when straight, and disposed at a position closer to a vehicle center line than an inner surface of each of the front tires when straight; an outer end portion disposed at a position closer to the vehicle rear than the front apex portion, and disposed at a position outward in the vehicle width direction of the front apex portion; and a second flow redirection surface connecting the front apex portion and the outer end portion, and being configured such that, when struck by air traveling from the vehicle front, the second flow redirection surface redirects a flow of the traveling air outward in the vehicle.

    摘要翻译： 车辆的前地板结构包括分别设置在前轮胎前方的前偏转器。 前导向器各自包括设置在比前轮胎的前边缘更靠近车辆前方的位置处的前顶部部分，其在直线时位于比每个前轮胎的内表面更靠近车辆中心线的位置 前轮胎直线时; 设置在比前顶点更靠近车辆后方的位置，并且设置在前顶点部的车宽方向外侧的位置; 以及连接前顶点部和外端部的第二流向重定向面，并且被构造成当从车辆前方行进的空气撞击时，第二流向重定向面将行进空气的流动重新引导到车辆外部。